The effect of duodenal-jejunal bypass on DM and NASH regarding gut immunosystem via FXR.
| Project/Area Number |
16K19896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Metabolic surgery / DJ / microbiota / gut inflammtion / DJB / FXR / 炎症性サイトカイン / microbiome / NASH / Proteobacteria / microbiora |
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| Outline of Final Research Achievements |
12 obese and diabetic rats were divided into three groups; DJB (D group, n=4), Sham (S group, n=4) and Liraglutide injection group (L group, n=4). In postoperative 8 weeks, Blood, gut, liver and stool were harvested.
Blood glucose in D and L group were lower than that in S group. D and L group improved insulin resistance. Furthermore, AST and hyaluronic acids in D group were significantly low and D group showed mild score in NASH grading/staging compared with other two groups. D group changed gut microbiota and increased the proportion of Proteobacteria. However, FXR expression in DJB group was not higher than other two group. Therefore, FXR did not affect improvement of DM and NASH in bypass surgery. In addition, D group showed decrease of IFNγ, IL1β and TNFα and strong expression of claudin-1. So, DJB might maintain the gut barrier function.DJB might improve insulin resistance by change of gut microbiota, suppression of gut inflammation and maintenance of gut barrier function.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Propensity score-matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals.2016
Author(s)
Nakao T, Shimada M, Yoshikawa K, Higashijima J, Tokunaga T, Nishi M, Takasu C, Kashihara H, Suzuka I, Nishizaki T, Okitsu H, Yagi T, Miyake H, Miura M, Fukuyama M, Wada D, Bando Y.
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Journal Title
Journal of Gastroentelorogy and Hepatology
Volume: 31
Issue: 10
Pages: 1700-1704
DOI
Related Report
Peer Reviewed
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