Development of new therapeutic agents targeting IL-8/CXCR2 network for esophageal squamous cell carcinoma
| Project/Area Number |
16K19954
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
INOUE MASAZUMI 慶應義塾大学, 医学部(信濃町), 助教 (10627136)
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| Research Collaborator |
TAKEUCHI Hiroya
MATSUDA Sachiko
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道扁平上皮癌 / ケモカイン / IL-8 / CXCR2 / 癌 / 食道癌 |
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| Outline of Final Research Achievements |
In this study, we demonstrated that a positive IL-8 and CXCR2 expression correlates significantly with a lower recurrence-free survival rate and overall survival rate in our esophageal squamous cell carcinoma (ESCC) patient population. These results suggest that IL-8/CXCR2 expression in ESCC has a direct impact on the cellular kinetics of ESCC. In vivo, Both internal and external stimulation or inhibition of the IL-8/CXCR2 network resulted in significant enhancement or suppression of cell proliferation in ESCC cell line. In vivo, stimulation or inhibition of the IL-8/CXCR2 network also resulted in enhancement or suppression of ESCC tumor proliferation. Our results demonstrated that stimulation of the IL-8/CXCR2 network clearly enhanced ESCC cell proliferation, while its inhibition obviously suppressed ESCC cell proliferation in vitro. These results indicate that control of IL-8/CXCR2 network signaling may be a new therapeutic strategy for ESCC.
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Report
(3 results)
Research Products
(3 results)
