The likelihood of underlying Lynch syndrome in upper tract urothelial carcinoma patients
Project/Area Number |
16K20126
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
ITO Masaya 東京医科歯科大学, 医学部附属病院, 非常勤講師 (50727229)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | リンチ症候群 / 腎盂尿管癌 / 泌尿器科 |
Outline of Final Research Achievements |
Upper tract urothelial carcinoma (UTUC) is associated with Lynch syndrome, an autosomal dominant disorder that increases the risk of many types of cancer such as colorectal cancer and gastric cancer. However, this syndrome is not popular among urologists and the characteristics of hereditary UTUC are currently poorly identified. Thus, we have evaluated Japanese UTUC patients at risk for Lynch syndrome based on revised Bethesda criteria. We found that 29% of UTUC patients satisfied at least one of the criteria, suggesting the possibility of Lynch syndrome. Greater awareness of this high probability of underlying Lynch syndrome could yield clinical benefits for both UTUC patients and their family members. Therefore, we have been carrying educational activities at both domestic and international urological society including the annual meeting of American Urological Association so that Lynch syndrome should gain recognition among urologists.
|
Report
(3 results)
Research Products
(1 results)