| Project/Area Number |
16K20285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 自家軟骨細胞培養 / 気管移植 / 馬蹄形気管軟骨 / 気管再建 / 軟骨細胞移植 / 気管軟骨 / 軟骨細胞 / 再生 / 再生医療 |
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| Outline of Final Research Achievements |
In tracheal regeneration, the slow process of epithelialization is often a barrier to the stability and safety of the transplanted trachea. We succeeded in achieving stabile and safe implantation with canine surgery using organotipic tissue consist of chondrocytes and epithelial cells covering on horseshoe-shaped silicon block.
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| Academic Significance and Societal Importance of the Research Achievements |
癌の気管浸潤や、先天的、医原性気管狭窄は、気管孔を開存したままの生活を強いられるため患者のQOLを著しく低下させる。これまでも気管孔の閉鎖を目指し、様々な気管の再建が行われてきた。気管の再建においては、移植後の軟骨細胞の脱分化や気管の内圧の変動が問題になっており、なかかな臨床応用が進んでいない。本研究はより安全で確実に気管の移植を行うための手法になり得ると考える。
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