New dental treatment using osteoporosis treatment drug

• Project/Area Number: 16K20545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nihon University
• Principal Investigator: TSUNORI Katsuyoshi 日本大学, 歯学部, 専修医 (40772736)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: インプラント / 骨再生 / 骨粗鬆症 / PTH / 歯科インプラント / 骨増生

Outline of Final Research Achievements

PTH, a bone formation promoting agent, was used in osteoporosis model rats (OVX rats) to examine the effect on bone regeneration, bone augmentation and surrounding bone of the implant. Bone regeneration and bone augmentation for bone loss created in rat parietal bone were examined using OVX rats with ovaries removed. As a result, in OVX rats, it was shown that bone regeneration and bone augmentation in the extraosseous direction are inhibited compared to healthy rats. In addition, it was demonstrated that administration of PTH to OVX rat significantly promotes bone hyperplasia compared to healthy rats. Implant surrounding bone suggested the establishment of osseointegration in OVX rats by administration of PTH.

Research Products

• [Journal Article] Enhancement of Bone Augmentation in Osteoporotic Conditions by the Intermittent Parathyroid hormone : An Animal Study in the Calvarium of Ovariectomized Rat (2018)
  • Author(s): Tatsuya Kubota, Akira Hasuike,
  • Journal Title: The international Journal of ORAL & Maxillofacial Implants Volume: -
  • Peer Reviewed
• [Journal Article] Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model (2017)
  • Author(s): Tatsuya Kubota, Akira Hasuike, Yasumasa Ozawa, Takanobu Yamamoto, Katsuyoshi Tsunori, Yutaka Yamada, Shuichi Sato
  • Journal Title: Journal of Periodontal & Implant Science Volume: -
  • Peer Reviewed
• [Presentation] Effects of Intermittent Administration of PTH on Guided Bone Augmentation in Ovariectomized Rat Calvaria. (2017)
  • Author(s): Tatsuya Kubota, Akira Hasuike, Katsuyoshi Tsunori, Yasumasa Ozawa, Naoya Tsukune, Shuichi Sato
  • Organizer: Osteology Symposium Japan
• [Presentation] Intermittent Administration of parathyroid hormone enhances on Guided Bone Augmentation in osteoporosis rat calvarium. (2017)
  • Author(s): Tatsuya Kubota, Akira Hasuike, Katsuyoshi Tsunori, Masako Naito, Naoya Tsukune, Takonobu Yamamoto, Yasumasa Ozawa, Masatoshi Takane, Masakazu Saito, Shuichi Sato
  • Organizer: 103rd American Academy of Periodontology
• [Presentation] Guide Bone Augmentation in the Calvarium of Ovariectomized Rat model (2017)
  • Author(s): Tatsuya Kubota, Akira Hasuike, Katsuyoshi Tsunori, Naoya Tsukune, Takanobu Yamamoto, Masako Naito, Shuichi Sato
  • Organizer: 26th European Association for Osseointegration
• [Presentation] Effects of the Intermittent Administration of PTH on Guided Bone Augmentation in the Calvarium of Ovariectomized Rat (2017)
  • Author(s): Akira Hasuike, Tatsuya Kubota, Katsuyoshi Tsunori, Masako Naito, Shuichi Sato
  • Organizer: 26th European Association for Osseointegration
• [Presentation] Regenerative ability of augmented bone in rat calvarial guided bone augmentation model. (2017)
  • Author(s): Katsuyoshi Tsunori, Naoya Tsukune, Tatsuya Kubota, Akira Hasuike, Shuichi Sato
  • Organizer: 26th European Association for Osseointegration
• [Presentation] Effect of osteoporosis on bone augmentation in ovariectomized rat calvarium. (2016)
  • Author(s): Tatsuya Kubota, Katsuyoshi Tsunori, Yasumasa Ozawa, Takanobu Yamamoto, Naoya Tsukune, Akira Hasuike, Sanae Ezawa, Kenji Tanaka, Yoshinori Arai, Shuichi Sato
  • Organizer: 102th American Academy of Periodontology
  • Place of Presentation: San Diego（America）
  • Year and Date: 2016-09-10
  • Int'l Joint Research
• [Presentation] Bone augmentation using bone graft material derived from a rat GBA model. (2016)
  • Author(s): Katsuyoshi Tsunori, Akira Hasuike, Yutaka Yamada, Tatsuya Kubota, Yasumasa Ozawa, Harumi Masuda, Yuichi Mizumura, Shuichi Sato
  • Organizer: 102th American Academy of Periodontology
  • Place of Presentation: San Diego（America）
  • Year and Date: 2016-09-10
  • Int'l Joint Research
• [Presentation] ラットGBAモデルにおいて増生した新生組織の移植骨としての効果 (2016)
  • Author(s): Katsuyoshi Tsunori, Akira Hasuike, Yutaka Yamada, Tatsuya Kubota, Hikaru Numasaki, Shuichi Sato
  • Organizer: 第144回日本歯科保存学会
  • Place of Presentation: 栃木県総合文化センター（栃木県、宇都宮市）
  • Year and Date: 2016-06-09
• [Presentation] ラット頭頂骨の骨増生に対する骨粗鬆症の影響 (2016)
  • Author(s): Tatsuya Kubota, Naoya Tsukune, Katsuyoshi Tsunori, Akira Hasuike, Taro Kojima, Takeshi Fukuda, Naoto Yoshinuma, Naoyuki Sugano, Yoshinori Arai, Shuichi Sato
  • Organizer: 第59回春季日本歯周病学会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島県、鹿児島市）
  • Year and Date: 2016-05-20
• [Presentation] 骨粗鬆症ラット頭頂骨の骨増生に対するPTH (1-34) の影響 (2016)
  • Author(s): 久保田 達也, 津徳 亮成, 小澤 康正, 山本 崇申, 築根 直哉, 蓮池 聡, 佐藤 秀一
  • Organizer: 第68回日本大学歯学会総会・学術大会
  • Place of Presentation: 日本大学歯学部（東京都、千代田区）