Research Project
Grant-in-Aid for Young Scientists (B)
Hypophosphatasia(HPP) is caused by mutation of the gene encoding tissue non-specific alkaline phosphatase (TNALP). Physiological function of TNALP has been investigated for years nevertheless the cellular mechanisms affecting calcification remain unclear. In this study we elucidated the bone metabolism of HPP model mice by bone morphomety to evaluate influence TNALP in the cells involving ossification.The osteoblasts decreased significantly in KO mice. In regard to the osteoclasts there were no differences. Trabecular bone width and bone volume / tissue volume of KO mice showed significant decrease in KO mice. Thinning of hypertrophic chondrocytes layer was shown in KO mice though the thick chondrocytes layer observed. These results indicate that TNALP effects the cell number of osteoblast and chondrocyte layer in KO mice. Therefore the lack of TNALP causes retarded bone mineralization in the HPP model mice.
All 2017 2016
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Open Access: 1 results, Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)
Inter national Journal of Oral-Medical Sciences
Volume: Vol.15 No.3.4 Pages: 126-138
Open Journal of Stomatology
Volume: Vol.7 No.1 Issue: 01 Pages: 91-103
10.4236/ojst.2017.71005
