Preparation of novel molecular probes for photoacoustic-magneric resonance imaging and disease treatment

Research Project

Project/Area Number	16K21130
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Biomedical engineering/Biomaterial science and engineering Chemical biology
Research Institution	Kyoto University
Principal Investigator	Kimura Yu 京都大学, 工学研究科, 准教授 (90566027)
Research Collaborator	Imai Yuta
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	イメージング / 抗がん剤 / 造影剤 / 分子プローブ / 腫瘍組織 / 磁気共鳴イメージング / 光音響イメージング / セラノスティクス / MRI / ドキソルビシン / ガドリニウム / ナノ粒子 / 光音響 / バイオイメージング / バイオマテリアル
Outline of Final Research Achievements	Novel molecular probes were prepared and their in vitro and in vivo function was evaluated for imaging of tumor tissues with magnetic resonance and photoacoustic dual imaging methods. Magnetic resonance imaging has advantages for noninvasive whole-body imaging and photoacoustic imaging has been developed as a promising three-dimensional imaging modality with high-definition. Through modification of gelatin as a surface modifier of probes, anti-cancer reagent was incorporated into the probes and the biological effect was confirmed by in vivo imaging of cancer tissue with contrast of the probes.
Academic Significance and Societal Importance of the Research Achievements	腫瘍組織を分子プローブにより磁気共鳴イメージングを用いて全身で非侵襲的に観察するとともに，光音響イメージングを用いて高精細に観察することができれば，微小な腫瘍組織の発見や診断確度の向上につながると期待される．さらに抗腫瘍剤を内包することで，腫瘍組織の縮小を行うことができれば，診断と治療を同時に行う新規セラノスティクス分子プローブとしての機能が期待でき，新規観察法および治療法として学術的および社会的意義は高いと考えられる．