• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A New Diagnostic System Detecting Serum Autoantibodies to Papillary Thyroid Carcinoma

Research Project

Project/Area Number 16K21173
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Laboratory medicine
Research InstitutionTottori University

Principal Investigator

IZAWA Shoichiro  鳥取大学, 医学部附属病院, 助教 (30572599)

Research Collaborator MATSUZAWA kazuhiko  
MATSUMOTO kazuhisa  
FUKAYA kenji  
FUKUHARA takahiro  
FUJIWARA kazunori  
MIYAKE naritomo  
WAKAHARA makoto  
TAKAGI yuzo  
KOGA atsuro  
YAMAGISHI daisuke  
HINO tomoya  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords甲状腺乳頭癌 / 自己抗体 / エピトープマッピング / WD repeat domain 1 / Fibronectin 1 / WDR1 / 甲状腺癌 / ELISA / 診断 / 合成ペプチド
Outline of Final Research Achievements

Papillary thyroid carcinoma (PTC) is the most frequent histopathological subtype of thyroid carcinoma. Most of the patients with PTC has a good clinical course after surgery. However, small part of PTC is resistant to conventional therapy. PTC is diagnosed by ultrasound manifestation and fine-needle aspiration cytology. Therapeutic plan is determined by the tumor staging system. There is no method to differentiate PTC with the potential to be advanced disease, though active surveillance is an option for patients with low stage disease.
We previously demonstrated autoantibodies to WD repeat domain 1 (WDR1) and Fibronectin 1 (FN1) in the sera. This project established a new diagnostic system for detecting autoantibodies to WDR1 and FN1 by using synthetic peptides originated from their amino acid sequences. We finally determined a set of synthetic peptides that were suitable for detecting advanced PTC. The titer of the autoantibodies were verified by histopathology and tumor staging.

Academic Significance and Societal Importance of the Research Achievements

本研究は血清中に検出しにくい不溶性の細胞内たんぱく質をバイオマーカーとして活用する新たな手法開発につながる可能性があり、甲状腺癌以外の悪性腫瘍をはじめとする他の疾患の治療や経過観察へ応用が期待できる。また本研究内容が実用化されれば、現在超音波診断や穿刺吸引細胞診が中心で、早期に治療の必要性が高い症例の抽出が困難な甲状腺癌の診断において、治療の必要性が高い患者の早期診断治療、経過観察への活用が期待される。さらに自己抗体の抗体価測定に必要な検体は患者血清であることから、本研究が実用化は多数の対象者へ安価かつ簡便に検査を提供可能となり、健康診断等へ活用することも期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2016 Other

All Presentation (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 合成ペプチドを用いた癌特異的自己抗体検出による進行甲状腺癌の血清学的診断法2019

    • Author(s)
      伊澤 正一郎、松本 和久、松澤 和彦、福原 隆宏、三宅 成智、藤原 和典、若原 誠、高木 雄三、古賀 敦朗、日野 智也、大倉 毅、谷口 晋一、山本 一博
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 甲状腺乳頭癌患者血清が特異的に反応する 合成ペプチドを用いた診断システムの開発2016

    • Author(s)
      伊澤 正一郎
    • Organizer
      第4回TR推進合同フォーラム
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Related Report
      2016 Research-status Report
  • [Remarks] 鳥取大学医学部病態情報内科学分野(第一内科)研究紹介

    • Related Report
      2018 Annual Research Report
  • [Remarks] 鳥取大学医学部 病態情報内科(第一内科)研究紹介

    • URL

      http://www2.hosp.med.tottori-u.ac.jp/medicine1/1448/8771.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Patent(Industrial Property Rights)] がんの判定方法2018

    • Inventor(s)
      伊澤 正一郎
    • Industrial Property Rights Holder
      伊澤 正一郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-045806
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi