| Project/Area Number |
16K21178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
Laboratory medicine
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| Research Institution | Shimane University |
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Principal Investigator |
Usuda Haruki 島根大学, 医学部, 助教 (30707667)
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| Research Collaborator |
WADA KOICHIRO 島根大学, 医学部, 教授 (90263467)
OKAMOTO TAKAYUKI 島根大学, 医学部, 准教授 (30378286)
TANAKA TETSUYA 島根大学, 医学部, 助教 (10346380)
NIIBAYASHI TOMOMI 島根大学, 医学部, 技術職員 (50529675)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | リーキーガットシンドローム / 腸粘膜バリア / 診断法 / 全身疾患 / 診断法確立 / 腸粘膜透過性 / leaky gut syndrome / 診断法開発 |
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| Outline of Final Research Achievements |
Chronic disruption of gut mucosal barrier let harmful molecules being absorbed and likely to cause systemic diseases. This increased permeability of gut mucosa is called leaky gut syndrome (LGS). However, diagnostic methods for LGS have not been established yet. It is mainly due to lacking animal model of LGS. We succeeded to establish mild, moderate, severe LGS model using mice, then we found promising reagent (named "reagent K") for evaluating LGS with these models. Reagent K could detect LGS occuring in non-alchoholic steatohepatitis (NASH) and Chrohn's diseases in mice at early stage of each disease. Especially, an intestinal mRNA, which closely involved both in inflammation and LGS, is upregulated in Chrohn's disease model mice. It suggests that LGS are involved in pathogenic mechanism of Chrohn's disease.
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