• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel strategy targeted for fibrocytes migration to treat connective tissue diseases related lung fibrosis

Research Project

Project/Area Number 16K21197
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Collagenous pathology/Allergology
Research InstitutionThe University of Tokushima

Principal Investigator

KAWANO Hiroshi  徳島大学, 病院, 助教 (30771571)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords線維細胞 / インテグリン / 膠原病肺 / CD49c
Outline of Final Research Achievements

In this study, we aimed to clarify the function of integrin CD49c, which is an adhesion molecule expressed on fibrocytes, and to develop new treatment for connective tissue diseases related lung fibrosis focused on controlling migration of fibrocytes. After confirming the expression of CD49c in human fibrocytes, the expression pattern of CD49c in mouse fibrocytes was examined, but it was difficult to analyze the expression pattern by flow cytometry. In order to isolate fibrocytes derived from mouse lungs as living cells, a new fibrocyte identification method was found. In the future, we will isolate these cells and analyze the expression pattern and function of CD49c, and further plan to identify fibrocyte-specific markers applied to novel treatment strategy.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi