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Establishment of single-cell thermodynamics and its expansion(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0105
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionOsaka University (2017, 2019)
Waseda University (2016)

Principal Investigator

Suzuki Madoka  大阪大学, 蛋白質研究所, 講師 (40350475)

Project Period (FY) 2017 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywords生物物理 / ナノ材料 / ナノバイオ / タンパク質 / 細胞 / 組織 / 蛍光顕微鏡 / 細胞・組織 / 蛋白質
Outline of Final Research Achievements

The "base-project" has been going as planned at the single-cell level. The current project aimed to expand the base-project to both larger and smaller scales. The biological significance of the heat as a mean of intra- and intercellular communications ("thermal signaling" hypothesis) has been tested by the project. We have successfully achieved the goal of individual objectives set at the beginning of the current project.

Academic Significance and Societal Importance of the Research Achievements

本国際共同研究課題では、最終的に、1細胞レベルの温度を、組織・個体から細胞内小器官レベルまで、広いスケールで扱う技術の開発と、1細胞レベルの温度がこれらスケールで果たす生理的な役割について検討を進め、「熱シグナル仮説」を強く裏付ける結果を得ることができた。研究代表者を中心として、将来にわたってアジアとヨーロッパをつなぐ研究連携が構築されたと考える。

Report

(2 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2020 2018

All Int'l Joint Research (3 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] シンガポール国立南洋理工大学(シンガポール)2018

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] リューベック大学(ドイツ)2018

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(シンガポール)2018

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The challenge of intracellular temperature2020

    • Author(s)
      Suzuki, M., Plakhotnik, T.
    • Journal Title

      Biophys Rev

      Volume: - Issue: 2 Pages: 593-600

    • DOI

      10.1007/s12551-020-00683-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Nanothermometry using luminescent molecules and nanoparticles in cell biology and physiology.2020

    • Author(s)
      Suzuki, M.
    • Organizer
      Three Wise Men Winter School on Luminescent Nanothermometry for Biomedical Applications
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dual-functionalized fluorescent nanodiamonds as nanoheaters and nanothermometers in cells2020

    • Author(s)
      Chongxia Zhong, Shingo Sotoma, James Chen Yong Kah, Taras Plakhotnik, Yoshie Harada, Madoka Suzuki
    • Organizer
      Biophysical Society the 64th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2017-03-15   Modified: 2021-02-19  

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