• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of ApoA-I/HDL binding protein for the treatment of atherosclerosis(Fostering Joint International Research)

Research Project

Project/Area Number 16KK0203
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionOsaka Medical and Pharmaceutical University (2022)
The University of Tokushima (2016-2017)

Principal Investigator

Okuhira Keiichiro  大阪医科薬科大学, 薬学部, 教授 (10425671)

Project Period (FY) 2017 – 2022
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Keywords動脈硬化 / 脂質 / リポタンパク質 / 薬学
Outline of Final Research Achievements

High-density lipoprotein (HDL) is known to show preventive effects against atherosclerotic diseases such as myocardial infarction and ischemic stroke by releasing lipids from lesions and suppressing inflammation. In this study, we demonstrated that ApoA-I binding protein (AIBP), a protein that binds to HDL, has anti-inflammatory effects, suggesting that recombinant AIBP protein can be used as a therapeutic agent against atherosclerosis.

Academic Significance and Societal Importance of the Research Achievements

HDLが動脈硬化に対して予防的・抑制的に働くことは知られているが、HDLを利用することによって動脈硬化を治療する薬はまだ実現していない。本研究によって得られた研究成果の学術的・社会的意義は、HDLの作用を増強すると考えられるAIBPの機能が明らかとなり、微生物によって作成されたAIBPタンパク質が動脈硬化に対する予防や治療に利用されうることが示されたという点にある。

Report

(2 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (6 results)

All 2022 2018

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Massachusetts General Hospital / Harvard Medical School(米国)2018

    • Related Report
      2022 Annual Research Report
  • [Journal Article] FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages2022

    • Author(s)
      Tachibana Koki、Kusumoto Kohshi、Ogawa Mai、Ando Hidenori、Shimizu Taro、Ishima Yu、Ishida Tatsuhiro、Okuhira Keiichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 23 Pages: 14617-14617

    • DOI

      10.3390/ijms232314617

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The magnetic field treated wild-type mice, and in untreated Abca1-null mice reduced the adult-neurogenesis at the hippocampal dentate gyrus2022

    • Author(s)
      Maki Tsujita, Hiroshi Takase, Keito Furuie, Motonari Tsubaki, Keiichiro Okuhira, Frank J Gonzalez, Natsuko Kumamoto, Shinya Ugawa
    • Organizer
      ABC2023 - 9th FEBS Special Meeting ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ApoA-1 binding protein の加齢に伴う血清中濃度の変化およびその抗炎症作用2022

    • Author(s)
      立花洸季, 楠本嵩志, 前橋梨花, 樹山友絵, 永尾綾菜, 辻田麻紀, 異島優, 石田竜弘, 奥平桂一郎
    • Organizer
      フォーラム2022 衛生薬学・環境トキシコロジー
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗炎症タンパク質ApoA-1 binding protein の加齢に伴う血清中濃度の変化2022

    • Author(s)
      立花洸季, 楠本嵩志, 前橋梨花, 樹山友絵, 永尾綾菜, 辻田麻紀, 異島優, 石田竜弘, 奥平桂一郎
    • Organizer
      第95回日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] SulforaphaneはPRDM16経路を介して白色脂肪細胞のベージュ化を誘導する2022

    • Author(s)
      服部菜々美, 佐久間覚, 奥平桂一郎
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report

URL: 

Published: 2017-03-15   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi