Evaluation of longitudinal change in early glaucoma using big data(Fostering Joint International Research)
Project/Area Number |
16KK0208
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Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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Allocation Type | Multi-year Fund |
Research Field |
Ophthalmology
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Research Institution | Saitama Medical University |
Principal Investigator |
Shoji Takuhei 埼玉医科大学, 医学部, 講師 (70637058)
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Research Collaborator |
Weinreb Robert N. カリフォルニア大学サンディエゴ校, ハミルトン緑内障研究所, Distinguished Professor
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Project Period (FY) |
2016 – 2018
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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Keywords | 緑内障 / 光干渉断層計 / 光干渉断層血管撮影 / 縦断解析 / 光干渉断層計アンジオグラフィー / OCT / OCTA / 眼科学 / 解剖学 / 解析・評価 / 画像 |
Outline of Final Research Achievements |
We performed longitudinal analysis of fundus photograh, intraocular pressure, corneal thickness, optical coherence tomography (OCT) data and visual fiield data accumulated for over 20 years in University of California at San Diego, and analysed factors related to glaucoma progression. Moreover, we perfirned cross-sectional and longitudinal analyzes of glaucoma early onset and structural changes, hemodynamic changes and functional changes using optical coherence tomography (OCTA) data accumulated from 2015. We reported that not only the vascular density of radial peripapillary capillaries (RPCs) decreases, but also the macular vascular density associated with retinal ganglion cells decreases with the progress of glaucoma. Blood vessel density in the macular region was found to change over time in advanced glaucoma, suggesting a different progression process from structural change.
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Academic Significance and Societal Importance of the Research Achievements |
緑内障は慢性に進行する不可逆的変化であり、早期発見早期化量が重要であると考えられている。近年の画像機器の進歩により、緑内障進行に関連する、網膜神経節細胞や網膜神経線維層の形態変化が、緑内障の機能変化である視野障害に先行することが知られている。 緑内障は慢性変化のため、長期間にわたる経時的観察が必要であるが、国内で良質なデータベースを保有している施設は少なく、今回の共同研究により、長期経過の中でどのように緑内障初期変化が生じているのかを捉えることができたのは、社会的意義が大きいと考えられる。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The Association between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect and Healthy Eyes2018
Author(s)
Manalastas PIC, Zangwill LM, Daga FB, Christopher MA, Saunders LJ, Shoji T, Akagi T, Penteado RC, Yarmohammadi A, Suh MH, Medeiros FA, Weinreb RN
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Journal Title
J Glaucoma
Volume: 27
Issue: 3
Pages: 227-232
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients2018
Author(s)
Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders LJ, Hasenstab K, Ghahari E, Manalastas PIC, Akagi T, Christopher M, Penteado RC, Weinreb RN
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Journal Title
Am J Ophthalmol
Volume: 189
Pages: 1-9
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Optical Coherence Tomography Angiography Macular Vascular Density Measurements and the Central 10-2 Visual Field in Glaucoma2018
Author(s)
Penteado RC, Zangwill LM, Daga FB, Saunders LJ, Manalastas PIC, Shoji T, Akagi T, Christopher M, Yarmohammadi A, Moghimi S, Weinreb RN
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Journal Title
J Glaucoma
Volume: 印刷中
Issue: 6
Pages: 1-1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Reproducibility of Optical Coherence Tomography Angiography Macular and Optic Nerve Head Vascular Density in Glaucoma and Healthy Eyes2017
Author(s)
Manalastas PIC, Zangwill LM, Saunders LJ, Mansouri K, Belghith A, Suh MH, Yarmohammadi A, Penteado RC, Akagi T, Shoji T, Weinreb RN
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Journal Title
J Glaucoma
Volume: 26
Issue: 10
Pages: 851-859
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma2018
Author(s)
Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
Organizer
American Academy of Ophthalmology (AAO) 2017 Annual Meeting,
Related Report
Int'l Joint Research
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[Presentation] Macular and peripapillary vascular dropout are associated with disease severity in advanced glaucoma2018
Author(s)
Ghahari, Elham; Zangwill, Linda M; Bowd, C; Hasenstab, Kyle A; Hou, Huiyuan; Penteado, Rafaella C; Manalastas, Patricia Isabel C; Moghimi, S; Shoji, Takuhei; Li, Andrew, J; Nguyen, Khoa; Villatoro, George; Yarmohammadi, Adeleh; Weinreb, Robert N.
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] COMPARISON OF SUPERFICIAL VERSUS DEEP MACULA VESSEL DENSITY MEASUREMENTS IN NORMAL, GLAUCOMA SUSPECT, AND GLAUCOMA EYES2018
Author(s)
Manalastas, Patricia Isabel C. Moghimi, Sasan; Zangwill, Linda M.; Christopher, Mark A.; Hasenstab, Kyle A.; Penteado, Rafaella C. Hou, HuiYuan. Shoji, Takuhei. Ghahari, Elham. Li, Andrew, J. Nguyen, Khoa. Villatoro, George. Yarmohammadi, Adeleh. Weinreb, Robert N.
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Progression of primary open angle glaucoma in diabetic and non-diabetic patients2018
Author(s)
Hou H, Shoji T, Zangwill LM, Moghimi S, Saunders L, Hasenstab K, Ghahari E, Manalatas PIC, Akagi T, Christopher M, Penteado R, Weinreb RN
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Cross-sectional association between OCT angiography-measured optic nerve head and macular vessel densities and age in healthy eyes2018
Author(s)
Nguyen K, Manalastas PI, Bowd C, Hasenstab K, Li A, Penteado R, Hou H, Shoji T, Villatoro G, Ghahari E, Moghimi S, Weinreb RN, Zangwill LM
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Comparison of structural and vessel density measurements in eyes with parafoveal scotoma and peripheral nasal step glaucoma2017
Author(s)
Takuhei Shoji, Linda M. Zangwill, Tadamichi Akagi,, Luke J. Saunders, Adeleh Yarmohammadi, Patricia Isabel C. Manalastas, Rafaella Cleto Penteado, Huiyuan Hou, Elham Ghahari, Robert N. Weinreb
Organizer
American Academy of Ophthalmology (AAO) 2017 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] The association between macula and optic nerve head optical coherence tomography angiography (OCT-A) vessel densities in glaucoma, glaucoma suspect and healthy eyes2017
Author(s)
Manalastas P, Zangwill L, Saunders L, Daga F, Christopher M, Yarmohammadi A, Akagi T, Shoji T, Penteado R, Suh MH, Medeiros F, Weinreb R
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
Related Report
Int'l Joint Research
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[Presentation] Relationship between optical coherence tomography and angiography macular vascular density measurements and central visual field damage2017
Author(s)
Penteado R, Zanwill L, Daga F, Christopher M, Yarmohammadi A, Manalastas PI, Akagi T, Shoji T, Medeiros F, Weinreb R
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
Related Report
Int'l Joint Research
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[Presentation] Vessel density is associated with visual field damage in advanced glaucoma eyes2017
Author(s)
Yarmohammadi A, Zangwill L, Saunders L, Diniz-Filho A, Suh MH, Manalastas PI, Belghith A, Akagi T, Shoji T, Penteado R, Medeiros F, Weinreb R
Organizer
The Association for Research in Vision and Ophthalmology (ARVO) 2017 Annual Meeting,
Related Report
Int'l Joint Research
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