Prediction and prevention of frailty from the lifestyle investigation in rural Japanese community-dwelling older adults
| Project/Area Number |
16KT0012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Neo-Gerontology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
SHINMURA Ken 兵庫医科大学, 医学部, 教授 (70206332)
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| Co-Investigator(Kenkyū-buntansha) |
永井 宏達 兵庫医療大学, リハビリテーション学部, 講師 (00633348)
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| Research Collaborator |
Kusunoki Hiroshi
Hasegawa Yoko
Tamaki Kayoko
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| Project Period (FY) |
2016-07-19 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | フレイル / サルコペニア / バイオマーカー / 食習慣 / 身体活動度 / 口腔機能 / QOL / 骨粗鬆症 / 生活習慣 / miRNA / 老化 / 社会医学 / 栄養学 / マイクロアレイ / 医療・福祉 |
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| Outline of Final Research Achievements |
We performed an interdisciplinary epidemiologic study for the purpose of searching the biomarker which was useful for a diagnosis of frailty, of evaluating the spectrum of each element of which frailty constituted, and of clarifying an impact of lifestyle in older adults who are independently living in the Sasayama-Tamba area, a rural area in the Hyogo prefecture, Japan. The number of participants to this investigation became 914 people in total at the end of 2018 and were approaching to 1,000 people of the aim so far. We evaluated the associations between (1) lifestyle factors (dietary habits and physical activity) and frailty, (2) oral cavity environment and function and frailty and sarcopenia, and (3) the serum cystatin C/ creatinine ratio and sarcopenia by the cross-sectional analysis using the data of 840 participants between November 2015 and December 2017 and reported these results as English and Japanese articles.
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| Academic Significance and Societal Importance of the Research Achievements |
農村地域におけるフレイル・サルコペニアの罹患率がこれまでの都市郊外地域からの報告より低かったことは、研究対象の選択バイアスによる可能性は残るが、農村型ライフスタイルがフレイル・サルコペニア発症に対して抑制的に働く可能性を示唆した。横断的解析によることから、農村型ライフスタイルとフレイルとの因果関係は結論できないが、本研究の成果によって高齢者フレイル対策において、食生活や身体活動度に着目した介入が有用である可能性はより高まった。血清シスタチンC/クレアチニン比測定のような簡便な血液検査でサルコペニアのscreeningが可能になれば、フレイル診療は日常診療においてより身近なものとなる。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The Relationship between Dietary Habits and Frailty in Rural Japanese Community-Dwelling Older Adults: Cross-Sectional Observation Study Using a Brief Self-Administered Dietary History Questionnaire.2018
Author(s)
Tamaki K, Kusunoki H, Tsuji S, Wada Y, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Hasegawa Y, Kishimoto H, Shimomura S, Shinmura K.
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Journal Title
Nutrients
Volume: 10
Issue: 12
Pages: 1982-1982
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between sarcopenia and the serum creatinine/cystatin C ratio in Japanese rural community-dwelling older adults.2018
Author(s)
1.Kusunoki H, Tsuji S, Wada Y, Fukai M, Nagai K, Itoh M, Sano K, Tamaki K, Ohta Y, Amano M, Maeda H, Hasegawa Y, Kishimoto H, Shimomura S, Yoshikawa H, Shinmura K.
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Journal Title
J Cachexia Sarcopenia Muscle Clin Rep
Volume: 3
Pages: 1-14
Related Report
Peer Reviewed / Open Access
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