A personality-based examination of the health-illness continuum: association with gene expression profiles
Project/Area Number |
16KT0198
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 特設分野 |
Research Field |
Complex Systems Disease Theory
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
Hori Hiroaki 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 行動医学研究部, 室長 (10554397)
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Research Collaborator |
KUNUGI Hiroshi
YOSHIDA Fuyuko
NAKAMURA Seiji
KIM Yoshiharu
HIGUCHI Teruhiko
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Project Period (FY) |
2016-07-19 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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Keywords | 遺伝子発現プロファイル / パーソナリティ / ストレス / 潜在プロフィール分析 / バイオインフォマティクス / うつ病 / 遺伝子発現 / ネットワーク / 個別化予防 |
Outline of Final Research Achievements |
Etiology of depression or its putative major risk factor, i.e., stress vulnerability, is not clear. In this study we first targeted a general population and examined an association between stress vulnerability classification determined based on an individual’s psychological profile and blood-based gene expression profiles. A few genes involved in stress vulnerability were selected through detailed data analyses. These selected genes showed similar expression patterns in depressed patients as well. These findings suggest a continuum of etiology between stress vulnerability and depression.
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Academic Significance and Societal Importance of the Research Achievements |
現代はストレス社会ともいわれ、うつ病患者も増加しており、メンタルヘルスの向上は喫緊の課題となっている。昨今導入されたストレスチェック制度には一定の意義が認められるものの、本人の主観的報告に依拠しているという問題があり、客観的なストレス評価法およびうつ病診断法の開発が待たれる。本研究の成果は、ストレス脆弱性およびうつ病のバイオマーカー候補を同定し、うつ病の発症予測法や個別化予防法の創出へと寄与しうるものである。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits2018
Author(s)
Narita-Ohtaki R, Hori H, Itoh M, Lin M, Niwa M, Ino K, Imai R, Ogawa S, Sekiguchi A, Matsui M, Kunugi H, Kamo T, Kim Y
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Journal Title
Journal of Affective Disorders
Volume: 印刷中
Pages: 306-312
DOI
Related Report
Peer Reviewed
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[Journal Article] Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder2018
Author(s)
Imai R, Hori H, Itoh M, Lin M, Niwa M, Ino K, Ogawa S, Ishida M, Sekiguchi A, Matsui M, Kunugi H, Akechi T, Kamo T, Kim Y
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Journal Title
Journal of Psychiatric Research
Volume: 102
Pages: 192-200
DOI
Related Report
Peer Reviewed
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[Presentation] Inflammatory markers in adult women with Post-traumatic Stress Disorder (PTSD)2017
Author(s)
Hori H, Itoh M, Lin M, Niwa M, Ino K, Imai R, Ogawa S, Sekiguchi A, Kunugi H, Kamo T, Kim H
Organizer
13th World Congress of Biological Psychiatry
Related Report
Int'l Joint Research
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[Presentation] PTSD女性患者における炎症マーカー2017
Author(s)
堀 弘明, 伊藤真利子, 林 明明, 丹羽まどか, 井野敬子, 今井理紗, 小川 成, 関口 敦, 功刀 浩, 加茂登志子, 金 吉晴
Organizer
第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
Related Report
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[Patent(Industrial Property Rights)] 気分障害を検出する方法2017
Inventor(s)
功刀浩, 堀弘明, 中村誠二, 石澤洋平, 的場亮, 松原謙一
Industrial Property Rights Holder
功刀浩, 堀弘明, 中村誠二, 石澤洋平, 的場亮, 松原謙一
Industrial Property Rights Type
特許
Filing Date
2017
Related Report
Overseas