Analysis of regulatory mechanism of hematopoiesis and exploration of the pathogenesis of hematopoietic neoplasms through comprehensive genetic analysis

• Project/Area Number: 17013022
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA Seishi The University of Tokyo, 医学部附属病院, 特任准教授 (60292900)
• Co-Investigator(Kenkyū-buntansha): 熊野 恵城 東京大学, 医学部・附属病院, 助教 (90396721) ; 鈴木 隆浩 東京大学, 医学部附属病院, 寄附講座教員 (40345210)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥64,000,000 (Direct Cost: ¥64,000,000); Fiscal Year 2009: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2008: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2007: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2006: ¥12,800,000 (Direct Cost: ¥12,800,000); Fiscal Year 2005: ¥12,800,000 (Direct Cost: ¥12,800,000)
• Keywords: SNPアレイ / 悪性リンパ腫 / ホジキンリンパ腫 / A20 / 11qUPD / 6q23 / 癌抑制遺伝子 / ゲノム解析 / MDS / CMML / c-Cb1 / チロシンキナーゼ / UPD / 造血器腫瘍 / ゲノム / マイクロアレイ / ゲノムコピー数異常 / 高密度オリゴヌクレオチドアレイ / LOH / アレル不均衡 / CNAG / Blimp1 / 造血システム

Research Abstract

Hematopoietic neoplasms are caused by deregulation of normal components of the hematopoietic system by gene mutations. In fact, many of genetic changes identified as a cause of hematopoietic neoplasms involves those genes implicated in normal regulation of hematopoiesis. In this study, we performed comprehensive genetic analyses of more than 2,000 hematopoietic neoplasms using high-density SNP arrays. We identified a number of genetic alterations involved in the pathogenesis of hematopoietic neoplasms, including gain-of-function mutations of c-CBL in myeloid neoplasms and inactivation mutations of A20 in B-lineage lymphomas, followed by their functional analysis. These findings are thought to contribute not only to our understanding of molecular pathogenesis of hematopoietic cancers, but also to adding our knowledge on regulatory mechanisms of normal hematopoiesis, together with the development of novel diagnostics and therapeutics for these neoplasms.

Research Products

• [Journal Article] Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. (2010)
  • Author(s): Thoennissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB, Lasho T, Weiss T, Nowak D, Koren-Michowitz M, Kato M, Sanada M, Shih LY, Nagler A, Raynaud SD, Muller-Tidow C, Mesa R, Haferlach T, Gillil, DG, Tefferi A, Ogawa S, Koeffler HP.
  • Journal Title: Blood.
• [Journal Article] SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations. (2010)
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  • Journal Title: Blood. 115 Pages: 1049-1053
• [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. (2010)
  • Author(s): Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
  • Journal Title: Blood.
• [Journal Article] Derivation of functional mature neutrophils from human embryonic stem cells. (2009)
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  • Journal Title: Blood. 113 Pages: 6584-6592
  • NAID: 120007131544
• [Journal Article] High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. (2009)
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  • Journal Title: Mol Cancer Res. 7 Pages: 665-677
• [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. (2009)
  • Author(s): Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S
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• [Journal Article] Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. (2009)
  • Author(s): Nowak D, Le Toriellec E, Stern MH, Kawamata N, Akagi T, Dyer MJ, Hofmann WK, Ogawa S, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 518-527
• [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. (2009)
  • Author(s): Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: Cancer Sci. 100 Pages: 920-926
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• [Journal Article] HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. (2009)
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  • Journal Title: Blood. 113 Pages: 2851-2858
• [Journal Article] Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization. (2009)
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  • Journal Title: Leuk Res. 33 Pages: 569-571
• [Journal Article] Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia. (2009)
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  • Journal Title: Int J Oncol. 34 Pages: 1603-1612
• [Journal Article] Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array. (2009)
  • Author(s): Kawamata N, Ogawa S, Gueller S, Ross SH, Huynh T, Chen J, Chang A, Nabavi-Nouis S, Megrabian N, Siebert R, Martinez-Climent JA, Koeffler HP.
  • Journal Title: Exp Hematol. 37 Pages: 937-946
• [Journal Article] Hepatoblastoma in a patient with sotos syndrome. (2009)
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  • Journal Title: J Pediatr. 155 Pages: 937-939
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas. (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
  • Journal Title: Nature. 459 Pages: 712-716
  • NAID: 40019064821
• [Journal Article] HapMap scanning of novel human minor histocompatibility antigens. (2009)
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  • Journal Title: Blood. 113 Pages: 5041-5048
• [Journal Article] Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. (2009)
  • Author(s): Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: J Immunol. 182 Pages: 6168-6178
• [Journal Article] Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. (2009)
  • Author(s): Akagi T, Shih LY, Ogawa S, Gerss J, Moore SR, Schreck R, Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren A, Song JH, Dugas M, Lehmann S, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 1301-1306
  • NAID: 120001643240
• [Journal Article] Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. (2009)
  • Author(s): Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP.
  • Journal Title: Blood. 113 Pages: 1741-1748
  • NAID: 120001249804
• [Journal Article] Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. (2009)
  • Author(s): Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP.
  • Journal Title: Haematologica. 94 Pages: 213-223
• [Journal Article] Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. (2009)
  • Author(s): Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer SJ, Koeffler HP.
  • Journal Title: Int J Cancer. 125 Pages: 2349-2359
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma (2009)
  • Author(s): 真田昌, et al.
  • Journal Title: Nature 460 Pages: 904-908
  • Peer Reviewed
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): 加藤元博, et al.
  • Journal Title: Natur 459 Pages: 712-6
  • Peer Reviewed
• [Journal Article] Hidden abnormalities and novel classification of t(15;17)acute promyelocytic leukemia(APL)based on genomic alterations (2009)
  • Author(s): Akagi, T., et al.
  • Journal Title: Blood 113 Pages: 1741-8
  • Peer Reviewed
• [Journal Article] (2008)
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  • Journal Title: Biol Blood Marrow Transplant. 14 Pages: 75-87
• [Journal Article] Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas. (2008)
  • Author(s): Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod SA, Koeffler HP, Karlan BY.
  • Journal Title: Clin Cancer Res. 14 Pages: 7645-7651
• [Journal Article] ERCC5 is a novel biomarker of ovarian cancer prognosis. (2008)
  • Author(s): Walsh CS, Ogawa S, Karahashi H, Scoles DR, Pavelka JC, Tran H, Miller CW, Kawamata N, Ginther C, Dering J, Sanada M, Nannya Y, Slamon DJ, Koeffler HP, Karlan BY.
  • Journal Title: J Clin Oncol. 26 Pages: 2952-2958
• [Journal Article] Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma. (2008)
  • Author(s): Tanaka Y, Kanai F, Tada M, Tateishi R, Sanada M, Nannya Y, Ohta M, Asaoka Y, Seto M, Shiina S, Yoshida H, Kawabe T, Yokosuka O, Ogawa S, Omata M.
  • Journal Title: J Hepatol. 49 Pages: 746-757
• [Journal Article] AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. (2008)
  • Author(s): Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
  • Journal Title: Leukemia.
• [Journal Article] Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays. (2008)
  • Author(s): Suzuki M, Kato M, Yuyan C, Takita J, Sanada M, Nannya Y, Yamamoto G, Takahashi A, Ikeda H, Kuwano H, Ogawa S, Hayashi Y.
  • Journal Title: Cancer Sci. 99 Pages: 564-570
  • NAID: 10024003876
• [Journal Article] Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate. (2008)
  • Author(s): Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S.
  • Journal Title: Proc Natl Acad Sci U S A. 105 Pages: 7839-7844
  • NAID: 120007138253
• [Journal Article] Exploration of the genetic basis of GVHD by genetic association studies. (2008)
  • Author(s): Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Takehiko S.
  • Journal Title: Biol Blood Marrow Transplant. 15 Pages: 39-41
• [Journal Article] Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution, single nucleotide polymorphism array. (2008)
  • Author(s): Lin LJ, Asaoka Y, Tada M, Sanada M, Nannya Y, Tanaka Y, Tateishi K, Ohta M, Seto M, Sasahira N, Kawabe T, Zheng CQ, Kanai F, Ogawa S, Omata M.
  • Journal Title: Oncology. 75 Pages: 102-112
• [Journal Article] Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia. (2008)
  • Author(s): Lehmann S, Ogawa S, Raynaud SD, Sanada M, Nannya Y, Ticchioni M, Bastard C, Kawamata N, Koeffler HP.
  • Journal Title: Cancer. 112 Pages: 1296-1305
• [Journal Article] Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. (2008)
  • Author(s): Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S.
  • Journal Title: Pigment Cell Research.
• [Journal Article] Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA. (2008)
  • Author(s): Kawase T, Nannya Y, Torikai H, Yamamoto G, Onizuka M, Morishima S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y.
  • Journal Title: Blood. 111 Pages: 3286-3294
• [Journal Article] Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP.
  • Journal Title: Proc Natl Acad Sci U S A. 105 Pages: 11921-11926
• [Journal Article] Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP.
  • Journal Title: Blood. 111 Pages: 776-784
• [Journal Article] Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray. (2008)
  • Author(s): Kawamata N, Ogawa S, Yamamoto G, Lehmann S, Levine RL, Pikman Y, Nannya Y, Sanada M, Miller CW, Gillil, DG, Koeffler HP.
  • Journal Title: Exp Hematol. 36 Pages: 1471-1479
• [Journal Article] Chronic phase of ETV6-ABL1 positive CML responds to imatinib. (2008)
  • Author(s): Kawamata N, Dashti A, Lu D, Miller B, Koeffler HP, Schreck R, Moore S, Ogawa S.
  • Journal Title: Genes Chromosomes Cancer. 47 Pages: 919-921
• [Journal Article] HapMap scanning of novel human minor histocompatibility antigens. (2008)
  • Author(s): Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T, Togari H, Riddell SR, Kodera Y, Morisima Y, Kuzushima K, Ogawa S, Akatsuka Y.
  • Journal Title: Blood.
• [Journal Article] AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis. (2008)
  • Author(s): Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.
  • Journal Title: J Immunol. 180 Pages: 4402-4408
• [Journal Article] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. (2008)
  • Author(s): Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
  • Journal Title: Cell Stem Cell. 3 Pages: 207-220
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma. (2008)
  • Author(s): Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
  • Journal Title: Nature. 455 Pages: 971-974
• [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma (2008)
  • Author(s): Chen Y, et.al.
  • Journal Title: Nature 455 Pages: 971-974
  • Peer Reviewed
• [Journal Article] Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarrav (2008)
  • Author(s): Kawamata N, et.al.
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 11921-11926
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of pediatric acute lymphobla stic leukemias by high-resolution single nucleotide poly moralism oligonucleotide genomic microarrav (2008)
  • Author(s): Kawamata N, et.al.
  • Journal Title: Blood 111 Pages: 776-784
  • Peer Reviewed
• [Journal Article] Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray (2008)
  • Author(s): Kawamata N, et. al.
  • Journal Title: Blood 111 Pages: 776-784
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• [Journal Article] Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development (2007)
  • Author(s): Kawazu M, et. al.
  • Journal Title: Journal of Immunology 179 Pages: 5335-5345
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• [Journal Article] Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays (2007)
  • Author(s): Yamamoto G, et. al.
  • Journal Title: American Journal of Human Genetics 81 Pages: 114-26
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• [Journal Article] Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project (2007)
  • Author(s): Nannya Y, et. al.
  • Journal Title: Human Molecular Genetics 16 Pages: 3494-505
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• [Journal Article] Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays. (2007)
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  • Journal Title: Cancer Research. 67 Pages: 2544-2551
• [Journal Article] Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells. (2006)
  • Author(s): Suzuki T, et al.
  • Journal Title: Stem Cells 24 Pages: 2456-2465
• [Journal Article] AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematoboiesis. (2006)
  • Author(s): Nakagawa M, et al.
  • Journal Title: Blood 108 Pages: 3329-3334
• [Journal Article] Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization. (2006)
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  • Journal Title: Genes Chromosomes Cancer 45 Pages: 482-494
• [Journal Article] CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cells (2006)
  • Author(s): Haraguchi K, et al.
  • Journal Title: Leuk Lymphoma 47 Pages: 2218-2223
• [Journal Article] Genome-wide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization. (2006)
  • Author(s): Hosoya N, Ogawa S, et al.
  • Journal Title: Genes Chromosomes Cancer 45 Pages: 482-494
• [Journal Article] A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. (2005)
  • Author(s): Nannya Y, Ogawa S, et al.
  • Journal Title: Cancer Res. 65 Pages: 6071-6079
• [Journal Article] Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation. (2005)
  • Author(s): Hosoya N, Ogawa S, et al.
  • Journal Title: Genes Chromosomes Cancer 42 Pages: 269-279
• [Journal Article] Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia : analysis in adults and children. (2005)
  • Author(s): Lee SY, Ogawa S, et al.
  • Journal Title: Leukemia 19 Pages: 1841-1843
• [Journal Article] Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery. (2005)
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  • Journal Title: Exp.Hematol. 33 Pages: 1459-1469
• [Journal Article] Functional Domains of Runx1 Are Differentially Required for CD4 Repression, TCR{beta} Expression, and CD4/8 Double-Negative to CD4/8 Double-Positive Transition in Thymocyte Development. (2005)
  • Author(s): Kawazu M, Ogawa S, et al.
  • Journal Title: J.Immunol. 174 Pages: 3526-3533
• [Journal Article] Therapy of relapsed leukemia after allogeneic hematopoietic cell transplant with T cells specific for minor histocompatibility antigens.
  • Author(s): Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR.
  • Journal Title: Blood. (in press)
• [Journal Article] Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation.
  • Author(s): Villalobos I, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S.
  • Journal Title: Blood. (in press)
• [Journal Article] Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer.
  • Author(s): Tada M, Kanai F, Tanaka Y, Sanada M, Nannya Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Imazeki F, Yoshida H, Ogawa S, Yokosuka O, Omata M.
  • Journal Title: Cancer Sci. (in press)
  • NAID: 10026592643
• [Journal Article] CBL mutations in juvenile myelomonocytic leukemia, but not in pediatric myelodysplastic syndrome.
  • Author(s): Shiba N, Kato M, Myoung-ja P, Sanada M, Ito E, Fukushima K, Sako M, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Leukemia. (in press)
• [Journal Article] Genomic profiling of adult acute lymphoblastic leukemia (ALL) by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric ALL.
  • Author(s): Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato K, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler H.
  • Journal Title: Haematologica. (in press)
• [Journal Article] Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
  • Author(s): Ogawa S, Shih L, Suzuki T, Otsu M, Nakauchi H, Koeffler H, Sanada M.
  • Journal Title: Clinical Cancer Research. (in press)
• [Journal Article] Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
  • Author(s): Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
  • Journal Title: Cell Cycle. (in press)
• [Journal Article] Impact of highly conserved HLA haplotype on acute graft-versus-host disease.
  • Author(s): Morishima S, Ogawa S, Matsubara A, Kawase T, Nannya Y, Kashiwase K, Satake M, Saji H, Inoko H, Kato S, Kodera Y, Sasazuki T, Morishima Y.
  • Journal Title: Blood. (in press)
• [Journal Article] Gastric Cancer Cell Line Hs746T Harbors a Splice Site Mutation of c-Met Causing Juxtamembrane Domain Deletion.
  • Author(s): Asaoka Y, Toda M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K.
  • Journal Title: Biochem Biophys Res Commun. (in press)
• [Presentation] Genome-wide analysis identifies frequent inactivation of A20 in B-cell malignant lymphomas (2009)
  • Author(s): 加藤元博, ら
  • Organizer: the 14th Congress of the European Hematology Association
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2009-06-05
• [Presentation] Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozy gous C-Cb1 mutations Tiahtly Associated with 11a-UPD (2008)
  • Author(s): Masashi S
  • Organizer: 第50回米国血液学会
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2008-12-08
• [Presentation] SNP Chip Analysis of Myelodysplastic Syndromes Disclosed High Frequency of Uniparental Disomy and a Novel Dominant Mutation as the Target of 11q UPD. (2007)
  • Author(s): Sanada M, et. al.
  • Organizer: The 49th Annual Meeting of American Siciety of Hematology
  • Place of Presentation: 米国アトランタ
  • Year and Date: 2007-12-11
• [Book] Method in Molecular Biology 369 Comparative Genomics Volume 2 (2008)
  • Author(s): Ogawa S, et. al.
  • Publisher: Humana Press (Editor Nicholas Bergman H)
• [Remarks]
  • URL: http://www.genome.umin.jp/
• [Remarks]
  • URL: http://www.genome.umin.ac.jp