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Chemoprevention of colorectal cancer by targeting ACF

Research Project

Project/Area Number 17015039
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionSapporo Medical University

Principal Investigator

YOSHIRO Niitsu  Sapporo Medical University, 分子標的探索講座, 特任教授 (10045502)

Co-Investigator(Kenkyū-buntansha) TETSUJI Takayama  徳島大学, 大学院・ヘルスバイオサイエンス部, 教授 (10284994)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥75,700,000 (Direct Cost: ¥75,700,000)
Fiscal Year 2009: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2008: ¥13,200,000 (Direct Cost: ¥13,200,000)
Fiscal Year 2007: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2006: ¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2005: ¥16,300,000 (Direct Cost: ¥16,300,000)
Keywords大腸癌 / 予防 / ACF
Research Abstract

In the present study, we conducted a chemopreventive trial on colorectal cancer, using ACF, precursors of polyps, as surrogate lesions, and results clearly indicate that administration of sulindac for 2 months gave rise to almost equal effectiveness as those of previously reported trials in which sulindac was administered for years. We also performed animal experiment using mouse colon carcinogenesis model to examine the effect of inhibitor to GST-π which was highly expressed in ACF, and found a dramatic prevention effect on colon cancer development. Thus an approach to target GST-π in ACF is a promising modality for chemoprevention of colorectal cancer.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (31 results) (of which Peer Reviewed: 25 results) Presentation (4 results)

  • [Journal Article] Pure red cell aplasia associated with good^'s syndrome accompanied by decreased stem cell factor production in the bone marrow.2010

    • Author(s)
      Kuribayashi K, Niitsu Y
    • Journal Title

      Intern Medicine 49(5)

      Pages: 377-382

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4.2010

    • Author(s)
      Saito Y, Niitsu Y
    • Journal Title

      J Biol Chem. 285(10)

      Pages: 7006-7015

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms.2009

    • Author(s)
      Hayashi T, Ishiwatari H, Ihara H, Kawano Y, Takada K, Miyanishi K, Kobune M, Takimoto R, Sonoda T, Takayama T, Kato J, Niitsu Y
    • Journal Title

      J Gastroenterol 44(9)

      Pages: 964-75

    • NAID

      10025581446

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer.2009

    • Author(s)
      Sato Y, Niitsu Y
    • Journal Title

      Cancer Chemother Pharmacol. 49(5)

      Pages: 30-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-2 gene transfer potentiates the alpha-galactosylceramide-stimulated antitumor effect by the induction of TRAIL in NKT and NK cells in mouse models of subcutaneous and metastatic carcinoma.2009

    • Author(s)
      Nishihori Y, Niitsu Y.
    • Journal Title

      Cancer Biol Ther. 8(18)

      Pages: 1763-1770

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms.2009

    • Author(s)
      Hayashi T, Niitsu Y.
    • Journal Title

      J Gastroenterol. 44(9)

      Pages: 964-975

    • NAID

      10025581446

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug resistance is dramatically restored by hedgehog inhibitors in CD34+leukemic cells.2009

    • Author(s)
      Kobune M, Niitsu Y
    • Journal Title

      Cancer Sci. 100(5)

      Pages: 948-955

    • NAID

      10025145994

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis.2008

    • Author(s)
      Kukitsu T, Takayama T, Miyanishi K, Nobuoka A, Katsuki S, Sato Y, Takimoto R, Matsunaga T, Kato J, Sonoda T, Sakamaki S
    • Journal Title

      Clin Cancer Res 14(1)

      Pages: 48-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5-fluorouracil in mice2008

    • Author(s)
      Sagawa T
    • Journal Title

      Hepatology 48(3)

      Pages: 828-840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes2008

    • Author(s)
      Suzuki T
    • Journal Title

      Int J Hematol 88(1)

      Pages: 30-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat cells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin2008

    • Author(s)
      Sato T
    • Journal Title

      J Immunol 181(1)

      Pages: 197-207

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis supercedes necrosis in mitochondrial DNA-depleted Jurkat eells by cleavage of receptor-interacting protein and inhibition of lysosomal cathepsin2008

    • Author(s)
      Sato T
    • Journal Title

      J Immunol 181(1)

      Pages: 197-207

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-)cells2008

    • Author(s)
      Kobune M
    • Journal Title

      Exp Hematol 36(9)

      Pages: 1121-1131

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of autoimmune pancreatitis complicated with autoimmune thrombocytopenia and interstitial pneumonia by prednisolone2008

    • Author(s)
      Murase K
    • Journal Title

      Intern Med 47(11)

      Pages: 1033-1038

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of chronic myeloproliferative disease-unclassifiable (CMPD-U) with no chromosomal abnormalities by imatinib mesylate2008

    • Author(s)
      Iyama S
    • Journal Title

      Intern Med 47(8)

      Pages: 791-794

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone2008

    • Author(s)
      Sato Y
    • Journal Title

      Nat Biotechnol 26(4)

      Pages: 431-442

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Phase I trial of arterial infusion chemotherapy with gemcitabine and 5-fluorouracil for unresectable advanced pancreatic cancer after vascular supply distribution via superselective embolization2008

    • Author(s)
      Miyanishi K
    • Journal Title

      Jpn J Clin Onco 38(4)

      Pages: 268-274

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages2008

    • Author(s)
      Fujimi A
    • Journal Title

      Int J Hematol 87(4)

      Pages: 339-350

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case report of a focal nodular hyperplasia-like nodule present in cirrhotic liver2008

    • Author(s)
      Takahashi S
    • Journal Title

      Hepatol Res 36(5)

      Pages: 521-528

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis2008

    • Author(s)
      Kobune M
    • Journal Title

      Stem Cells 26(2)

      Pages: 534-42

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resolution of liver cirrhosis using vitamin A-counpled liposomes to deliver siRNA against a collagen-specific chaperone2008

    • Author(s)
      Sato Y, et. al.
    • Journal Title

      Nature Biotechology 26

      Pages: 431-442

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis2008

    • Author(s)
      Kukitsu T, et. al.
    • Journal Title

      Clinical Cancer Research 14

      Pages: 48-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C2007

    • Author(s)
      Kato J, et. al.
    • Journal Title

      Journal of Gastroenterology 42

      Pages: 830-836

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of protein kinase C {zeta} in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP.2007

    • Author(s)
      Kuribayashi K, Takayama T, Niitsu, et al.
    • Journal Title

      Journal of cell Biology 176

      Pages: 1049-1060

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Colorectal cancer: genetics of development and metastasis.2006

    • Author(s)
      Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y
    • Journal Title

      J Gastroenterol 41(3)

      Pages: 185-92

    • NAID

      10017477036

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Colorectal cancer : genetics of development and metastasis.2006

    • Author(s)
      Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y
    • Journal Title

      Journal Of Gastroenterology 40

      Pages: 185-192

    • NAID

      10017477036

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Amelioration of murine dextran sulfate sodium-induced colitis by ex vivo extracellular superoxide dismutase gene transfer2006

    • Author(s)
      Oku T, Takayama T, Niitsu Y, et al.
    • Journal Title

      Inflammatory Bowel Disease 12

      Pages: 630-640

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness.2005

    • Author(s)
      Takayama T, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y
    • Journal Title

      Clin Gastroenterol Hepatol 3(7Suppl1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant crypt foci : detection, gene abnormalities, and clinical usefulness.2005

    • Author(s)
      Takayama T, Niitsu Y, et al.
    • Journal Title

      Clin Gastroenterol Hepatol. 3

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor.2005

    • Author(s)
      Takimoto R, Kato J, Takayama T et al.
    • Journal Title

      Cancer Biol Ther 4

      Pages: 421-428

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture.2005

    • Author(s)
      Kobune M, Niitsu Y, et al.
    • Journal Title

      Exp Hematol 33

      Pages: 1544-1553

    • Related Report
      2005 Annual Research Report
  • [Presentation] Aberrant Cypt Foci:Detection, Genetic Abnormalities, and Clinical Usefulness2009

    • Author(s)
      新津洋司郎
    • Organizer
      SIDDS
    • Place of Presentation
      KORIA
    • Year and Date
      2009-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Aberrant Cypt Foci : Detection, Genetic Abnormalities, and Clinical Usefulness2009

    • Author(s)
      新津洋司郎
    • Organizer
      SIDDS (Seoul International Digestive Disease Symposium 2009)
    • Place of Presentation
      韓国:ソウルSheraton Grande Walkhill Hotel
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 臨床家からのTranslational Research新津洋司郎2009

    • Author(s)
      新津洋司郎
    • Organizer
      仙台メトロポリタン講演会
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 臨床家からのTranslational Research2009

    • Author(s)
      新津洋司郎
    • Organizer
      仙台メトロポリタン講演会 特別講演
    • Place of Presentation
      仙台メトロポリタン
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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