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Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis

Research Project

Project/Area Number 17016035
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

HASHIDA Mitsuru  Kyoto University, 薬学研究科, 教授 (20135594)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Fumiyoshi  京都大学, 薬学研究科, 准教授 (30243041)
NISHIKAWA Makiya  京都大学, 薬学研究科, 准教授 (40273437)
KAWAKAMI Shigeru  京都大学, 薬学研究科, 講師 (20322307)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥99,800,000 (Direct Cost: ¥99,800,000)
Fiscal Year 2009: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2008: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2007: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2006: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2005: ¥20,600,000 (Direct Cost: ¥20,600,000)
KeywordsDDS / 癌ターゲティング / イメージング / 遺伝子治療 / 癌 / 薬物キャリア / 免疫療法 / CpGオリゴ / 分化誘導量表 / レチノイン酸誘導体 / 腹膜播種 / 量子ドット / CpG / がん / 活性酸素消去酵素 / NFκB / カタラーゼ / ターゲティング / リボソーム / 高分子ミセル / 癌転移
Research Abstract

Anti tumor therapy, which generally applicapable for several tumors, has never established, because of the diversity of distribution and condition of tumor cells or the hurdle of targeted delivery of antitumor drugs. In this study, we established the visualization and quantitative method using bioimaging, which became the foundation for non-invasive analysis of the process or tumor proliferation and metastasis. Furthermore, based on the concept of DDS, we developed the carrier for antitumor drugs or gene medicine and apply them for antitumor therapy.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (61 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (46 results) (of which Peer Reviewed: 34 results) Presentation (15 results)

  • [Journal Article] Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice.2010

    • Author(s)
      S. Zhou, S. Kawakami, F. Yamashita, M. Hashida
    • Journal Title

      Cancer Letters 287(1)

      Pages: 75-81

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice2010

    • Author(s)
      Shuwen Zhou, et al
    • Journal Title

      Cancer Letters 287(1)

      Pages: 75-81

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase.2009

    • Author(s)
      K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 137(2)

      Pages: 110-115

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.2009

    • Author(s)
      T. Okuda, S. Kawakami, Y. Higuchi, Y. Oka, T. Satoh, M. Yokoyama, F. Yamashita, M. Hashida
    • Journal Title

      International Journal of Pharmaceutics 373(1-2)

      Pages: 100-106

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles2009

    • Author(s)
      Tomoyuki Okuda, et al
    • Journal Title

      International Journal of Pharmaceutics 373(1-2)

      Pages: 100-106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase2009

    • Author(s)
      Kenji Hyoudou, et al
    • Journal Title

      Journal of Controlled Release 137(2)

      Pages: 110-115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen perpxide-mediated nuclear KappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.2008

    • Author(s)
      Y. Kobayashi, M. Nishikawa, K. Hyoudou, F. Yamashita, M. Hashida
    • Journal Title

      Cancer Science 99(8)

      Pages: 1546-1552

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SOD derivatives prevent metastatic tumor gtowth aggravated by tumor removal.2008

    • Author(s)
      K. Hyoudou, M. Nishikawa, Y. Kobayashi, M. Ikemura, F. Yamashita, M. Hashida
    • Journal Title

      Clinical & Experimental Metastasis 25(5)

      Pages: 531-536

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.2008

    • Author(s)
      T. Okuda, S. Kawakami, M. Yokoyama, T. Yamamoto, F. Yamashita, M. Hashida
    • Journal Title

      International Journal of Pharmaceutics 357

      Pages: 318-322

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mannosylated semiconductor quantum dots for the labeling of macrophage.2008

    • Author(s)
      Y. Higuchi, M. Oka, S. Kawakami, M. Hashida
    • Journal Title

      Journal of Controlled Release 125(2)

      Pages: 131-136

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor effect of all-trans retinoic acid loaded polymeric micelles in solid tumor bearing mice.2008

    • Author(s)
      N. Chansri, S. Kawakami, M. Yokoyama, T. Yamamoto, P. Charoensit, M. Hashida
    • Journal Title

      Pharmaceutical Research 25(2)

      Pages: 428-434

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mannosylated semiconductor quantum dots for the labeling of macrophage2008

    • Author(s)
      Yuriko Higuchi, et.al.
    • Journal Title

      Journal of Controlled Release 125(2)

      Pages: 131-136

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen perpxide-mediated nuclear KappaB activation in both liver and tumor cells during initial stages of hepatic metastasis2008

    • Author(s)
      Yuki Kobayashi, et.al.
    • Journal Title

      Cancer Science 99(8)

      Pages: 1546-15521

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Block copcilymer design for stable encapsulation of N-(4-hydroxvnhenyl)retinamide into polymeric micelles in mice2008

    • Author(s)
      Tomoyuki Okuda, et.al.
    • Journal Title

      International Journal of Pharmaceutics 357

      Pages: 318-322

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SOD derivatives preVent metastatic tumor gtowth aggravated by tumor removal2008

    • Author(s)
      Kenji Hyoudou, et.al.
    • Journal Title

      Clinical & Experimental Metastasis 25(5)

      Pages: 531-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor effect of all-trans retinoic acid loaded polymeric micelles in solid tumor bearing mice2008

    • Author(s)
      Narin Chansri, et. al.
    • Journal Title

      Pharmaceutical Research 25(2)

      Pages: 428-434

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity.2007

    • Author(s)
      S. Ma, M. Nishikawa, K. Hyoudou, R. Takahashi, M. Ikemura, Y. Kobayashi, F. Yamashita, M. Hashida
    • Journal Title

      Kidney International 72(12)

      Pages: 1474-1482

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells.2007

    • Author(s)
      K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 122(2)

      Pages: 151-158

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.2007

    • Author(s)
      K. Hyoudou, M. Nishikawa, Y. Kobayashi, S. Mukai, M. Ikemura, Y. Kuramoto, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 119

      Pages: 121-127

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of in vivo NF-kappaB activation during liver inflammation in mice: prevention by catalase delivery.2007

    • Author(s)
      K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
    • Journal Title

      Molecular Pharmacology 71(2)

      Pages: 446-453

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity2007

    • Author(s)
      Shen-Feng Ma, et. al.
    • Journal Title

      Kidney International 72(12)

      Pages: 1474-1482

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells2007

    • Author(s)
      Kenji Hyoudou, et. al.
    • Journal Title

      Journal of Controlled Release 122(2)

      Pages: 151-158

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice2007

    • Author(s)
      Kenji Hyoudou, et. al.
    • Journal Title

      Journal of Controlled Release 119

      Pages: 121-127

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice.2006

    • Author(s)
      T. Okuda, S. Kawakami, N. Akimoto, T. Niidome, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 116(3)

      Pages: 330-336

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase.2006

    • Author(s)
      K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
    • Journal Title

      Clinical & Experimental Metastasis 23(5-6)

      Pages: 269-278

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of pulmonary metastasis by all-trans retinoic acid incorporated in cationic liposomes in mice.2006

    • Author(s)
      S. Suzuki, S. Kawakami, N. Chansri, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 116(1)

      Pages: 58-63

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.2006

    • Author(s)
      K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Umeyama, F. Yamashita, M. Hashida
    • Journal Title

      Free Radical Biology & Medicine 41(9)

      Pages: 1449-1458

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.2006

    • Author(s)
      T. Okuda, S. Kawakami, T. Maeie, T. Niidome, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 114(1)

      Pages: 69-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid conntaining galactosylated liposomes for hepatocellular carcinoma-selective targeting.2006

    • Author(s)
      T. Terada, M. Iwai, S. Kawakami, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Controlled Release 111(3)

      Pages: 333-342

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of in vivo NF-kappaB activation during liver inflammation in mice : prevention by catalase delivery2006

    • Author(s)
      Kenji Hyoudou et al.
    • Journal Title

      Molecular Pharmacology 71(2)

      Pages: 446-453

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal2006

    • Author(s)
      Kenji Hyoudou et al.
    • Journal Title

      Free Radical Biology & Medicine 41(9)

      Pages: 1449-1458

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase2006

    • Author(s)
      Kenji Hyoudou et al.
    • Journal Title

      Clinical & Experimental Metastasis 23(5-6)

      Pages: 269-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice2006

    • Author(s)
      Tatsuya Okuda et al.
    • Journal Title

      Journal of Controlled Release 116(3)

      Pages: 330-336

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration2006

    • Author(s)
      Tatsuya Okuda et al.
    • Journal Title

      Journal of Controlled Release 114(1)

      Pages: 69-77

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes2006

    • Author(s)
      Sachiko Suzuki et al.
    • Journal Title

      Journal of Controlled Release 116(1)

      Pages: 58-63

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-2006

    • Author(s)
      T.Terada et al.
    • Journal Title

      Journal of Controlled Release 111(3)

      Pages: 333-342

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex.2005

    • Author(s)
      S. Fumoto, S. Kawakami, K. Shigeta, Y. Higuchi, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 315(2)

      Pages: 484-493

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration.2005

    • Author(s)
      S. Kawakami, P. Opanasopit, M. Yokoyama, N. Chansri, T. Yamamoto, T. Okano, F. Yamashita, M. Hashida
    • Journal Title

      Journal of Pharmaceutical Sciences 94(2)

      Pages: 2606-2615

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes.2005

    • Author(s)
      M. Nishikawa, K. Hyoudou, Y. Kobayashi, Y. Umeyama, Y. Takamura, M. Hashida
    • Journal Title

      Journal of Controlled Release 109

      Pages: 101-107

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue-specific characteristics of in vivo electric gene transfer by tissue and intravenous injection of plasmid DNA.2005

    • Author(s)
      O. Thanaketpaisarn, M. Nishikawa, F. Yamashita, M. Hashida
    • Journal Title

      Pharmaceutical Research 22(6)

      Pages: 883-891

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation.2005

    • Author(s)
      M. Sakai, M. Nishikawa, O. Thanaketpaisarn, F. Yamashita, M. Hashida
    • Journal Title

      Gene Therapy 12(7)

      Pages: 607-616

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation2005

    • Author(s)
      M.Sakai et al.
    • Journal Title

      Gene Therapy 12(7)

      Pages: 607-616

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tissue-specific characteristics of in vivo electric gene transfer by tissue and intravenous infection of plasmid DNA2005

    • Author(s)
      O.Thanaketpaisarn et al.
    • Journal Title

      Pharmaceutical Research 22(6)

      Pages: 883-891

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes2005

    • Author(s)
      M.Nishikawa et al.
    • Journal Title

      Journal of Controlled Release 109(1-3)

      Pages: 101-107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration2005

    • Author(s)
      S.Kawakami et al.
    • Journal Title

      Journal of Pharmaceutical Sciences 94(12)

      Pages: 2606-2615

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by2005

    • Author(s)
      S.Fumoto et al.
    • Journal Title

      Journal of Pharmacological and Experimental Therapeutics 315(2)

      Pages: 484-493

    • Related Report
      2005 Annual Research Report
  • [Presentation] CpG DNA lipoplex経鼻投与による肺転移・腹膜播種抑制の機構解明2010

    • Author(s)
      周舒文, 川上茂, 山下富義, 橋田充
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] CpGDNA lipoplexp経鼻投与による肺転移・腹膜播種抑制の機構解明2010

    • Author(s)
      周舒文, 川上茂, 山下富義, 橋田充
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 医療薬学のカッティングエッジ:時空世界に思いを込めて2009

    • Author(s)
      橋田充
    • Organizer
      第19回日本医療薬学会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009

    • Author(s)
      増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2009-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009

    • Author(s)
      増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京ドームホテル(東京都)
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enhanced growth inhibition of metastatic lung tumor by intravenous injection of IL12-ATRA-lipoplexes in mice2009

    • Author(s)
      Pensri Charoensit, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] カタラーゼデリバリーによる癌の接着抑制2008

    • Author(s)
      古林裕貴、西川元也、橋田充
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] カタラーゼデリバリーによる癌の接着抑制2008

    • Author(s)
      古林裕貴、西川元也、橋田充
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intranasally Administered CpG DNA /Cationic Liposome Complexes Prevents Lung Metastases in Mice2008

    • Author(s)
      Shuwen Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Organizer
      第11回国際リポソーム研究会議
    • Place of Presentation
      横浜シンポジア(神奈川)
    • Year and Date
      2008-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Glycosylated liposomes for drug nucleic acids delivery2008

    • Author(s)
      Shigeru Kawakami, Yuriko Higuchi, Mitsuru Hashida
    • Organizer
      第11回国際リポソーム研究会議
    • Place of Presentation
      横浜シンポジア(神奈川)
    • Year and Date
      2008-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Glycosylated liposomes for drug nucleic acids delivery2008

    • Author(s)
      Shigeru Kawakami, Yuriko Higuchi, Mitsuru Hashids
    • Organizer
      第11回国際リポソーム研究会議
    • Place of Presentation
      黄浜シンポジア
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intranasally Administered CpG DNA/Cationic Liposome Complexes Prevents Lun Metastases in Mice2008

    • Author(s)
      Shuwen-Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Organizer
      第11回国際リポソーム研究会議
    • Place of Presentation
      横浜シンポジア
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗体-アミノ酸デンドリマーコンジュゲートによるHER2選択的細胞内デリバリー2008

    • Author(s)
      宮野拓也、川上茂、新留琢郎、橋田充
    • Organizer
      第24回日本dds学会
    • Place of Presentation
      六本木アカデミーヒルズ(東京)
    • Year and Date
      2008-06-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗体-アミノ酸デンドリマーコンジュゲートによるHER2選択的細胞内デリバリー2008

    • Author(s)
      宮野拓也、川上茂、新留琢郎、橋田充
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 樹状細胞選択的遺伝子送達キャリアを用いた新規DNAワクチン療法の開発2006

    • Author(s)
      川上茂、橋田充
    • Organizer
      第65回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2006-09-29
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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