Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
| Project/Area Number |
17016035
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HASHIDA Mitsuru Kyoto University, 薬学研究科, 教授 (20135594)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Fumiyoshi 京都大学, 薬学研究科, 准教授 (30243041)
NISHIKAWA Makiya 京都大学, 薬学研究科, 准教授 (40273437)
KAWAKAMI Shigeru 京都大学, 薬学研究科, 講師 (20322307)
|
|---|
| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥99,800,000 (Direct Cost: ¥99,800,000)
Fiscal Year 2009: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2008: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2007: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2006: ¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 2005: ¥20,600,000 (Direct Cost: ¥20,600,000)
|
|---|
| Keywords | DDS / 癌ターゲティング / イメージング / 遺伝子治療 / 癌 / 薬物キャリア / 免疫療法 / CpGオリゴ / 分化誘導量表 / レチノイン酸誘導体 / 腹膜播種 / 量子ドット / CpG / がん / 活性酸素消去酵素 / NFκB / カタラーゼ / ターゲティング / リボソーム / 高分子ミセル / 癌転移 |
|---|
| Research Abstract |
Anti tumor therapy, which generally applicapable for several tumors, has never established, because of the diversity of distribution and condition of tumor cells or the hurdle of targeted delivery of antitumor drugs. In this study, we established the visualization and quantitative method using bioimaging, which became the foundation for non-invasive analysis of the process or tumor proliferation and metastasis. Furthermore, based on the concept of DDS, we developed the carrier for antitumor drugs or gene medicine and apply them for antitumor therapy.
|
Report
(6 results)
Research Products
(61 results)
