Analysis of human tumor antigens and immune responses in patients
| Project/Area Number |
17016048
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Okayama University |
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Principal Investigator |
NAKAYAMA Eiichi Okayama University, 大学院・医歯薬学総合研究科, 教授 (60180428)
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| Co-Investigator(Kenkyū-buntansha) |
小野 俊朗 岡山大学, 自然生命科学研究支援センター, 准教授 (50185641)
上中 明子 岡山大学, 大学院・医歯薬学総合研究科, 講師 (50273967)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Toshiro 岡山大学, 大学院・医歯薬総合研究科, 准教授 (50185641)
UENAKA Akiko 岡山大学, 大学院・医歯薬総合研究科, 講師 (50273967)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥74,500,000 (Direct Cost: ¥74,500,000)
Fiscal Year 2009: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2008: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2007: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2006: ¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2005: ¥14,900,000 (Direct Cost: ¥14,900,000)
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| Keywords | がん免疫 / がん・精巣(CT)抗原 / 宿主免疫応答 / 免疫回避 / がんワクチン / がん抗原 / NY-ESO-1 / T細胞エピトープ / 癌免疫 / 癌抗原 / SEREX / 癌・精巣(CT)抗原 / 癌ワクチン / 免疫モニタリング / がん免疫療法 / がん・精巣抗原 / 蛋白ワクチン / がん |
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| Research Abstract |
For cancer vaccine, identification of cancer antigens which are highly specific to cancer and strongly immunogenic in cancer patients is necessary. We found that CCDC62, HERV-K and XAGE-1b are cancer antigens which can be used as vaccine. We also conducted a clinical trial of cancer vaccine using a complex of cholesterol hydrophobized pullulan (CHP) and NY-ESO-1 protein. Immune response was elicited after vaccination in patients and some patients showed favorable clinical course.
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Report
(6 results)
Research Products
(112 results)
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[Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432.2009
Author(s)
A oki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, Imai H, Shiraishi T, Sato E, Wada H, Nakayama E, Takei Y, Katayama N, Shiku H, Kageyama S.
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Journal Title
Vaccine 27
Pages: 6854-6861
Related Report
Peer Reviewed
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[Journal Article] Identification of tHERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity.2008
Author(s)
I shida T, Obata Y, Ohara N, Matsushita H, Sato S, Uenaka A, Saika T, Miyamura T, Chayama K, Nakamura Y, Wada H, Yamashita T, Morishima T, Old LJ, Nakayama E.
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Journal Title
Cancer Immunity 8
Pages: 15-15
Related Report
Peer Reviewed
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[Journal Article] Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination.2008
Author(s)
W ada H, Sato E, Uenaka A, Isobe M, Kawabata R, Nakamura Y, Iwase S, Yonezawa K, Yamasaki M, Miyata H, Doki Y, Shiku H, Jungbluth AA, Ritter G, Murphy R, Hoffman EW, Old LJ, Monden M, Nakayama E.
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Journal Title
Int. J. Cancer 123(10)
Pages: 2362-2369
Related Report
Peer Reviewed
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[Journal Article] Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.2008
Author(s)
T suji K, Hamada T, Uenaka A, Wada H, Sato E, Isobe M, Asagoe K, Yamasaki O, Shiku H, Ritter G, Murphy R, Hoffman E, Old LJ, Nakayama E, Iwatsuki K.
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Journal Title
Cancer Immunol. Immunother. 57(10)
Pages: 1429-1437
Related Report
Peer Reviewed
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[Journal Article] T-cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein.2007
Author(s)
Uenaka A, Wada H, Isobe M, Saika T, Tsuji K, Sato E, Sato S, Noguchi Y, Kawabata R, Yasuda T, Doki Y, Kumon H, Iwatsuki K, Shiku H, Monden M, Jungbluth AA, Ritter G, Murphy R, Hoffman E, Old LJ, Nakayama E
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Journal Title
Cancer Immunity 7
Pages: 9-20
Related Report
Peer Reviewed
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[Journal Article] Identification translation products of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.2007
Author(s)
S ato S, Noguchi Y, Uenaka A, Ohara N, Shimono M, Nakagawa K, Koizumi F, Ishida T, Yoshino T, Shiratori Y, Nakayama E.
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Journal Title
Cancer Immunity 7
Pages: 5-5
Related Report
Peer Reviewed
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[Journal Article] Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients.2007
Author(s)
K awabata R, Wada H, Idobe M, Saika T, Sato S, Uenaka A, Doki Y, Yasuda T, Kumon H, Tsuji K, Iwatsuki K, Ritter G, Murphy R, Hoffman E, Old LJ, Monden M, Nakayama E
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Journal Title
Int. J. Cancer 120
Pages: 2178-2184
Related Report
Peer Reviewed
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[Journal Article] OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer.2006
Author(s)
T ammela J, Uenaka A, Ono T, Noguchi Y, Jungbluth AA, Mhawech-Fauceglia P, Qian F, Schneider S, Sharma S, Driscoll D, Lele S, Old LJ, Nakayama, E, Odunsi K
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Journal Title
Int. J. Oncol. 29
Pages: 903-910
Related Report
Peer Reviewed
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[Journal Article] In vitro stimulation of CD8 and CD4 T-cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein: identification of a new HLA-DR15-binding CD4 T-cell epitope.2006
Author(s)
H asegawa K, Noguchi Y, Koizumi F, Uenaka A, Tanaka M, Shimono M, Nakamura H, Shiku H, Gnjatic S, Murphy R, Hiramatsu Y, Old LJ, Nakayama E
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Journal Title
Clin. Cancer Res. 12
Pages: 1921-1927
Related Report
Peer Reviewed
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[Journal Article] Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients.2005
Author(s)
M atsushita H, Uenaka A, Ono T, Hasegawa K, Sato S, Kozumi F, Nakagawa K, Toda M, Shingo T, Ichikawa T, Noguchi Y, Tamiya T, Furuta T, Kawase T, Date I, Nakayama E
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Journal Title
Cancer Sci. 96
Pages: 801-809
NAID
Related Report
Peer Reviewed
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[Journal Article] XAGE-1 expression inon-small cell lung cancer and antibody response in patients.2005
Author(s)
N akagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Shimono M, Ali Mohamed Ali ElDib, Ono T, Ohara N, Yoshino T, Yamashita K, Tsunoda T, Shimizu N, Nakayama E
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Journal Title
Clin. Cancer Res. 11
Pages: 5496-5503
Related Report
Peer Reviewed
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[Journal Article] Quantitative real-time RT-PCR analysis of NY-ESO-1 and LAGE-1a mRNA expression in normal tissues and tumors, and correlation of the protein expression with the mRNA copy number.2005
Author(s)
S ato S, Noguchi Y, Wada H, Fujita S, Nakamura S, Tanaka R, Nakada T, Hasegawa K, Nakagawa K, Koizumi H, Ono T, Noso K, Jungbluth A, Chen Y-T, Old LJ, Shiratori Y, Nakayama E
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Journal Title
Int. J. Oncol. 26
Pages: 57-63
Related Report
Peer Reviewed
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