Analysis of the vertebrate development and regeneration system using medaka genome, EST and mutant resources

• Project/Area Number: 17017003
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEDA Hiroyuki The University of Tokyo, 大学院・理学系研究科, 教授 (80179647)
• Co-Investigator(Kenkyū-buntansha): KUDO Akira 東京工業大学, 大学院・生命理工学研究科, 教授 (70178002)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥128,500,000 (Direct Cost: ¥128,500,000); Fiscal Year 2009: ¥30,100,000 (Direct Cost: ¥30,100,000); Fiscal Year 2008: ¥29,100,000 (Direct Cost: ¥29,100,000); Fiscal Year 2007: ¥23,800,000 (Direct Cost: ¥23,800,000); Fiscal Year 2006: ¥23,500,000 (Direct Cost: ¥23,500,000); Fiscal Year 2005: ¥22,000,000 (Direct Cost: ¥22,000,000)
• Keywords: メダカ / ゲノム / EST / 突然変異体 / 変異体 / 繊毛 / 脂肪肝 / Hox / 骨形成 / ゼブラフィッシュ / メダカ突然変異体 / ポジショナルクローニング / メダカヒレ形成 / メダカゲノム / 左右軸 / 器官形成 / Fgf

Research Abstract

The medaka draft genome, together with genomic resources (SNP map, BAC contig, etc.), has been published by the Japanese group in 2007. This greatly facilitated developmental genetics using medaka as a model. In this project, we focused on the medaka developmental mutants isolated by Takeda's and Kudo's laboratories during 2005 to 2009. By the end of this project Takeda and Kudo successfully identified and functionally examined responsible genes for nine mutants (defective in gastrulation, body axes, liver and otolith), and fifteen ones (heart, blood cells, blood vesicle, vertebra, head skeletons, fin morphogenesis and fin regeneration), respectively.

Research Products

• [Journal Article] Pkd111 complexes with Pkd2 on motile cilia and functions to establish the left-right axis. (2011)
  • Author(s): Kamura, K., Kobayashi, D., Uehara, Y., Koshida, S., Iijima, N., Kudo, A., Yokoyama T., Takeda, H.
  • Journal Title: Development 138 Pages: 1121-1129
  • Peer Reviewed
• [Journal Article] Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis. (2011)
  • Author(s): Kamura, K.
  • Journal Title: Development Volume: 138 Pages: 1121-9
  • Peer Reviewed
• [Journal Article] The art of medaka genetics and genomics : what makes them so unique? (2010)
  • Author(s): Takeda, H., Shimada, A.
  • Journal Title: Ann.Rev.Genet. 44 Pages: 217-241
  • Peer Reviewed
• [Journal Article] Single-cell analysis of somatotopic map formation in the zebrafish lateral line system. (2010)
  • Author(s): Sato, A., Koshida, S., Takeda, H.
  • Journal Title: Dev.Dyn. 239 Pages: 2058-2065
  • Peer Reviewed
• [Journal Article] Emergence of traveling wave in the zebrafish segmentation clock. (2010)
  • Author(s): Ishimatsu, K., Takamatsu, A., Takeda, H.
  • Journal Title: Development 137 Pages: 1595-1599
  • Peer Reviewed
• [Journal Article] FAK-mediated extracellular signals are essential for interkinetic nuclear migration and planar divisions in the neuroepithelium. (2010)
  • Author(s): Tsuda, S., Kitagawa, T., Takashima, S., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Naruse, K., Ishikawa, Y., Takeda, H.
  • Journal Title: J.Cell Sci. 123 Pages: 484-496
  • Peer Reviewed
• [Journal Article] Production of Wnt4b by floor plate cells is essential for the segmental patterning of the vertebral column in medaka. (2010)
  • Author(s): Inohaya K, Takano Y, Kudo A.
  • Journal Title: Development 137 Pages: 1807-1813
  • Peer Reviewed
• [Journal Article] FAK-mediated extracellular signals are essential for interkinetic nuclear migration and planar divisions in the neuroepithelium (2010)
  • Author(s): Tsuda, S.
  • Journal Title: Journal of Cell Science Volume: 123 Pages: 484-96
  • Peer Reviewed
• [Journal Article] The art of medaka genetics and genomics : what makes them so unique? (2010)
  • Author(s): Takeda, H.
  • Journal Title: Annual Review of Genetics Volume: 44 Pages: 217-41
  • Peer Reviewed
• [Journal Article] Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. (2009)
  • Author(s): Kii, I., Nishiyama, T., Li, M., Matsumoto, K., Saito, M., Amizuka, N., Kudo, A.
  • Journal Title: J.Biol.Chem. 285 Pages: 13294-13303
  • Peer Reviewed
• [Journal Article] Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons. (2009)
  • Author(s): Hibiya, K., Katsumoto, T., Kondo, T., Kitabayashi, I., Kudo, A.
  • Journal Title: Dev.Biol. 329 Pages: 176-190
  • Peer Reviewed
• [Journal Article] Gene expression and functional analysis of zebrafish larval fin fold regeneration. (2009)
  • Author(s): Yoshinari, N., Ishida, T., Kudo, A., Kawakami, A.
  • Journal Title: Dev.Biol. 325 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Brpfl, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons (2009)
  • Author(s): Hibiya, K
  • Journal Title: Developmental Biology (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Reduced proliferative activity of primary POMOnTl-null myoblasts in vitro (2009)
  • Author(s): Miyagoe-Suzuki, Y.
  • Journal Title: Mechanisms of Development 126 Pages: 107-116
  • Peer Reviewed
• [Journal Article] Gene expression and functional analysis of zebrafish larval fm fold regeneration (2009)
  • Author(s): Yoshinari, N.
  • Journal Title: Developmental Biology 325 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. (2008)
  • Author(s): Omran, H., Kobayashi, D., Olbrich, H., Tsukahara, T., Loges, N.T., Hagiwara, H., Zhang, Q., Leblond, G., Toole, E.O', Hara, C., Mizuno, H., Kawano, H., Fliegauf, M., Yagi, T., Koshida, S., Miyawaki, A., Zentgraf, H., Seithe, H., Reinhardt, R., Watanabe, Y., Kamiya, R., Mitchell, D.R., Takeda, H.
  • Journal Title: Nature 456 Pages: 611-616
  • Peer Reviewed
• [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Shimazaki M, Nakamura K, Kii I, Kashima T, Amizuka N, Li M, Saito M, Fukuda K, Nishiyama T, Kitajima S, Saga Y, Fukayama M, Sata M, Kudo A.
  • Journal Title: J.Exp.Med 205 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Mutation in the abcb7 gene causes abnormal iron and fatty acid metabolism in developing medaka fish (2008)
  • Author(s): Miyake, A.
  • Journal Title: Development, Growth & Differentiation 50 Pages: 703-716
  • Peer Reviewed
• [Journal Article] Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration (2008)
  • Author(s): Nakatani, Y.
  • Journal Title: Development, Growth & Differentiation 50 Pages: 71-83
  • Peer Reviewed
• [Journal Article] Maternal-zygotic medaka mutants for fgfrl reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm (2008)
  • Author(s): Shimada, A.
  • Journal Title: Development 135 Pages: 281-290
  • Peer Reviewed
• [Journal Article] Production of a maternal-zygotic medaka mutant using hybrid sterility (2008)
  • Author(s): Shimada, A.
  • Journal Title: Development, Growth & Differentiation 50 Pages: 421-426
  • Peer Reviewed
• [Journal Article] Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins (2008)
  • Author(s): Omran, H.
  • Journal Title: Nature 456 Pages: 611-616
  • Peer Reviewed
• [Journal Article] Maternal-zygotic medakamutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm. (2008)
  • Author(s): Shimada, A.
  • Journal Title: Development 135 Pages: 281-290
  • Peer Reviewed
• [Journal Article] Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. (2008)
  • Author(s): Nagayoshi, S.
  • Journal Title: Development 135 Pages: 159-169
  • Peer Reviewed
• [Journal Article] UTGB/medaka: genomic resource database for medaka biology. (2008)
  • Author(s): Ahsan, B.
  • Journal Title: Nucleic Acids Res. 36 Pages: 747-752
  • Peer Reviewed
• [Journal Article] Impaired capsule formation of tumors in periostin-null mice. (2008)
  • Author(s): Shimazaki, M.
  • Journal Title: Biochem. Biophys. Res. Com. 367 Pages: 736-742
  • Peer Reviewed
• [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Shimazaki, M.
  • Journal Title: J. Exp. Med. 205 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration. (2008)
  • Author(s): Nakatani, Y.
  • Journal Title: Dev. Growth Differ. 50 Pages: 71-83
  • Peer Reviewed
• [Journal Article] Expression of marker genes during otolith development in medaka. (2008)
  • Author(s): Nemoto, Y.
  • Journal Title: Gene Exp. Patterns 8 Pages: 92-95
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cell lines having high potential for osteoclast-supporting activity express PPARγl and show a-high potential for differ entiation into adipocytes. (2008)
  • Author(s): Takagi, K.
  • Journal Title: J Bone Miner. Metab. 126 Pages: 13-23
  • Peer Reviewed
• [Journal Article] The medaka draft genome and insights into vertebrate genome evolution. (2007)
  • Author(s): Kasahara M, Naruse K, Sasaki S, Nakatani Y, Qu W, Ahsan B, Yamada T, Nagayasu Y, Doi K, Kasai Y., et al
  • Journal Title: Nature 447 Pages: 714-719
  • Peer Reviewed
• [Journal Article] The teleost intervertebral region acts as a growth center of the centrum : in vivo visualization of osteoblasts and their progenitors in transgenic fish (2007)
  • Author(s): Inohaya, K., Takano, Y., Kudo, A.
  • Journal Title: Dev.Dyn. 236 Pages: 3031-3046
  • Peer Reviewed
• [Journal Article] Identification of novel markers expressed during fin regeneration by microarray analysis in medaka fish (2007)
  • Author(s): Nishidate, M., Nakatani, Y., Kudo, A., Kawakami, A.
  • Journal Title: Dev.Dyn. 236 Pages: 2685-2693
  • Peer Reviewed
• [Journal Article] Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. (2007)
  • Author(s): Yokoi, H.
  • Journal Title: Dev. Biol. 304 Pages: 326-337
  • Peer Reviewed
• [Journal Article] Phenotypic analysis of a novel chordin mutant in medaka. (2007)
  • Author(s): Takashima, S.
  • Journal Title: Dev. Dyn. 236 Pages: 2298-2310
  • Peer Reviewed
• [Journal Article] Defective Fin Regeneration in Medaka Fish(Oryzias latipes)with Hypothyroidism. (2007)
  • Author(s): Sekimizu, K.
  • Journal Title: Zoolog. Sci. 24 Pages: 693-699
  • Peer Reviewed
• [Journal Article] The DNA sequence of medaka chromosome LG22. (2007)
  • Author(s): Sasaki, T.
  • Journal Title: Genomics 89 Pages: 124-133
  • Peer Reviewed
• [Journal Article] Reconstruction of the vertebrate ancestral genome reveals dynamic genome reorganization in early vertebrates. (2007)
  • Author(s): Nakatani, Y.
  • Journal Title: Genome Res. 17 Pages: 1254-1265
  • Peer Reviewed
• [Journal Article] The medaka draft genome and insights into vertebrate genome evolution. (2007)
  • Author(s): Kasahara, M.
  • Journal Title: Nature 447 Pages: 714-719
  • Peer Reviewed
• [Journal Article] Coupling cellular oscillators: a mechanism that maintains synchrony against developmental noise in the segmentation clock. (2007)
  • Author(s): Ishimatsu, K.
  • Journal Title: Developmental Dynamics 236 Pages: 1416-1421
  • Peer Reviewed
• [Journal Article] Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates to bone defects on rat calvariae. (2007)
  • Author(s): Kojima, T.
  • Journal Title: Biomedical Res. 28 Pages: 219-229
  • Peer Reviewed
• [Journal Article] The teleost intervertebral region acts as a growth center of the centrum: In vivo visualization of osteoblasts and their progenitors in transgenic fish. (2007)
  • Author(s): Inohaya, K.
  • Journal Title: Developmental Dynamics. 236 Pages: 3031-3046
  • Peer Reviewed
• [Journal Article] Identification of novel markers expressed during finregeneration by microarray analysis in Medaka fish. (2007)
  • Author(s): Nishidate, M.
  • Journal Title: Developmental Dynamics. 236 Pages: 2685-2693
  • Peer Reviewed
• [Journal Article] Histological examinations on the bone regeneration achieved by combining grafting with hydroxyapatite and thermoplastic bioresorbable plates. (2007)
  • Author(s): Kojima, T.
  • Journal Title: J Bone Miner. Metab. 25 Pages: 361-373
  • Peer Reviewed
• [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDCS cells. (2007)
  • Author(s): Kondo, S.
  • Journal Title: J. Cell Sci. 120 Pages: 849-857
  • Peer Reviewed
• [Journal Article] Cellular and molecular processes of regeneration, with special emphasis on fish fins (review) (2007)
  • Author(s): Nakatani, Y.
  • Journal Title: Dev. Growth Differ. 49 Pages: 145-154
• [Journal Article] GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. (2007)
  • Author(s): Moriyama, A.
  • Journal Title: Genesis 45 Pages: 90-100
  • Peer Reviewed
• [Journal Article] Multinucleate osteoclasts in medaka as evidence of active bone remodeling. (2007)
  • Author(s): Nemoto, Y.
  • Journal Title: Bone 40 Pages: 399-408
  • Peer Reviewed
• [Journal Article] The medaka draft genome and new insights into vertebrate genome evolution (2007)
  • Author(s): Kasahara, M.
  • Journal Title: Nature (印刷中)
• [Journal Article] Cellular and molecular processes of regeneration, with special emphasis on fish fins (review) (2007)
  • Author(s): Nakatani, Y.
  • Journal Title: Development Growth and Differentiation 49 Pages: 145-154
• [Journal Article] Noise-resistant and synchronized oscillation of the segmentation clock (2006)
  • Author(s): Horikawa, K., Ishimatsu, K., Yoshimoto, E., Kondo, S., Takeda, H.
  • Journal Title: Nature 441 Pages: 719-723
  • Peer Reviewed
• [Journal Article] Medaka unextented-fin mutants suggest a role for Hoxb8a in cell migration and osteoblast differentiation during appendage formation. (2006)
  • Author(s): Sakaguchi, S., Nakatani, Y., Takamatsu, N., Hori, H., Kawakami, A., Inohaya, K., Kudo, A.
  • Journal Title: Dev.Biol. 293 Pages: 426-438
  • Peer Reviewed
• [Journal Article] Vascular anatomy of the developing medaka, oryzias latipes : A complementary fish model for the cardiovascular research of vertebrate. (2006)
  • Author(s): Fujita, M., Isogai, S., Kudo, A.
  • Journal Title: Dev.Dyn. 235 Pages: 734-746
  • Peer Reviewed
• [Journal Article] Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. (2006)
  • Author(s): Yokoi, H.
  • Journal Title: Developmental Biology 304 Pages: 326-337
• [Journal Article] Medaka unextented-fin mutants suggest a role for Hoxb8a in cell migration and osteoblast differentiation during appendage formation (2006)
  • Author(s): Sakaguchi, S.
  • Journal Title: Developmental Biology 293 Pages: 426-438
• [Journal Article] Noise-resistant and synchronized oscillation of the segmentation clock (2006)
  • Author(s): Horikawa, K.
  • Journal Title: Nature 441(7094) Pages: 719-723
• [Journal Article] The vascular anatomy of the developing medaka, Oryzias latipes : A complementary fish model for the cardiovascular research of vertebrate (2006)
  • Author(s): Fujita, M.
  • Journal Title: Developmental Dynamics 235 Pages: 734-746
• [Journal Article] Development of the endoderm and gut in medaka, Oryzias latipes (2006)
  • Author(s): Kobayashi, D.
  • Journal Title: Development, Growth and Differentiation (印刷中)
• [Journal Article] Transgenic analysis of medaka mesp-b enhancer in somitogenesis (2006)
  • Author(s): Terasaki, H.
  • Journal Title: Development, Growth and Differentiation (印刷中)
• [Journal Article] Medaka unextented-fin mutants suggest a role for Hoxb8a in cell migration and osteoblast differentiation during appendage formation (2006)
  • Author(s): Sakaguchi, S.
  • Journal Title: Developmental Biology (印刷中)
• [Journal Article] Identification of a gene required for de novo DNA methylation of the zebrafish no tail gene (2005)
  • Author(s): Shimoda, N.
  • Journal Title: Developmental Dynamics 233 Pages: 1509-1516
• [Journal Article] Genetic linkage map of medaka with polymerase chain reaction length polymorphisms (2005)
  • Author(s): Kimura, T.
  • Journal Title: Gene 19 Pages: 24-31
• [Journal Article] Retinoic acid-metabolizing enzy ; me Cyp26al is essential for determining territories of hindbrain and spinal cord in zebrafish (2005)
  • Author(s): Emoto, Y.
  • Journal Title: Developmental Biology 278 Pages: 415-427
• [Presentation] Mesodermal origin of scales and fins of the medaka-Insight into origin and evolution of mineralized skeleton in vertebrates (2011)
  • Author(s): Takeda, H.
  • Organizer: JSDB-GFE Joint Meeting of Developmental Bioligy
  • Place of Presentation: Dresden, Germany
• [Presentation] The zic genes as master regulators in dorsoventral patterning of the fish trunk structures (2010)
  • Author(s): Moriyama, Y., Nakamura, R., Kawanishi, T., Shimada, A., Takeda, H.
  • Organizer: 2nd Joint Meeting of the SFBD and JSDB
  • Place of Presentation: Paris, France
• [Presentation] Embryonic origin of osteoblasts in scales and fins of medaka fish (2010)
  • Author(s): Shimada, A., Kawanishi, T., Inohaya, K., Takeda, H.
  • Organizer: 2010 SDB-JSDB Joint Meeting
  • Place of Presentation: Albuquerque, U.S.A.
• [Presentation] zic1 and zic4 expression in the somite regulates dorsalization of the fish trunk structures (2010)
  • Author(s): Kawanishi, T., Moriyama, Y., Nakamura, R., Shimada, A., Takeda, H.
  • Organizer: 2010 SDB-JSDB Joint Meeting
  • Place of Presentation: Albuquerque, U.S.A.
• [Presentation] The zic genes as master regulators in dorsoventral patterning of the fish trunk structures (2010)
  • Author(s): Moriyama, Y.
  • Organizer: 2^<nd> Joint Meeting of the SFBD and JSDB 2010
  • Place of Presentation: パリ(フランス)
• [Presentation] Analyses of the cytoplasmic protein Ktu function in axonemal dynein formation during motile ciliogenesis (2010)
  • Author(s): Matsuo, M.
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸市 神戸ポートアイランド
• [Presentation] Pkd1l1/Pkd2 as nodal flow sensor to regulate left-right asymmetry (2010)
  • Author(s): Kamura, K.
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸市・神戸ポートアイランド
• [Presentation] Live imaging of osteoclast activities in medaka under hypergravity (2009)
  • Author(s): Chatani, M., Kubota, I., Kudo, A.
  • Organizer: ELGRA biennial symposium and general assembly
  • Place of Presentation: Bonn, Germany
• [Presentation] Characterization of medaka C-MYB mutant BENIFUJI, which displays defective hematopoietic progenitor differentiation, an insight into hematopoientic ontogenesis in medaka (2009)
  • Author(s): Moriyama, A., Maruyama, K., Kudo. A.
  • Organizer: 6th European Zebrafish Genetics and Development Meeting
  • Place of Presentation: Italy, Rome
• [Presentation] In-vivo imaging for osteoclasts in medaka, showing the evidence of bone modeling (2008)
  • Author(s): Chatani, M., Inohaya, K., Kudo, A.
  • Organizer: The 8th international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Identification and functional analysis of regeneration-associated molecules using the fin-fold regeneration model in juvenile zebrafish (2008)
  • Author(s): Kawakami, A., Ishida, T., Yoshinari, N., Kudo, A.
  • Organizer: The 8th international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] ゼブラフィッシュのひれ再生におけるJun/JNKシグナルによる細胞増殖の活性化機構 (2008)
  • Author(s): 石田高志
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 心室の拍動不全メダカ変異体hozuki(hoa)におけるストレスに依存した心筋細胞増殖機構の解析 (2008)
  • Author(s): 種田悠佑
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 左右軸から繊毛形成まで : メダカ変異体を用いた遺伝学的解析 (2008)
  • Author(s): 武田洋幸
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] A medaka left-right mutant identifies a novel gene responsible for human primary ciliary dvskinesia (2008)
  • Author(s): Takeda, H.
  • Organizer: Joint Meeting of the French and Japanese Societi es for Developmental Biology
  • Place of Presentation: France
• [Presentation] 脊椎骨融合を示すダルマメダカ変異体の原因遺伝子の解明 (2008)
  • Author(s): 猪早敬二
  • Organizer: 第79回日本動物学会大会
  • Place of Presentation: 福岡
• [Presentation] メダカ体幹部背腹パターン形成とzic遺伝子-Da変異体を用いた解析 (2008)
  • Author(s): 島田敦子
  • Organizer: 第79回日本動物学会大会
  • Place of Presentation: 福岡
• [Presentation] Identification and functional analysis of regeneration-associated molecules using the fin-fold regeneration model in juvenile zebrafish (2008)
  • Author(s): Kawakami, A.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Positional cloning rebeals the brpfl locus in the medaka mutant which displays craniofacial homeosis (2008)
  • Author(s): Hibiya, K.
  • Organizer: The 8^<th> international meeting on zebrafish devel opment and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Gene expression and functional analysis of zebrafish larval fill-fold regenerationゼブラフィッシュ正中膜ひれ再生における遺伝子プロファイリングと関連分子機能の解析 (2008)
  • Author(s): Takashi Ishida
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Characterization of the medaka mutant which displays abnormalities in vertebral body (2008)
  • Author(s): Satoshi Ohisa
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Vertebral bone formation in Mdeakaメダカ脊椎骨形成 (2008)
  • Author(s): 工藤明
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] A mutant medaka fish indentifies a novel cytoplasmic ptotein responsible for human primary ciliary dyskinesia (2008)
  • Author(s): Takeda, H.
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] A critical role of the somite for D-V patterning in the trunk region of medaka (2008)
  • Author(s): Kawanishi, T.
  • Organizer: 第41回日本発生生物学会大会
  • Place of Presentation: 徳島
• [Presentation] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Shimazaki, M.
  • Organizer: Keystone symposia on cellular biology
  • Place of Presentation: Vancouver, USA
• [Presentation] Bone formation in Medaka: Analyses by mutants and bone specific transgenic Medaka. (2008)
  • Author(s): Kudo, A.
  • Organizer: The fourth aquatic animal models of human disease conference
  • Place of Presentation: Durham, USA
• [Presentation] Bone formation in Medaka: Modeling of vertebral bone. (2008)
  • Author(s): Kudo, A.
  • Organizer: The 54th NIBB Conference
  • Place of Presentation: 岡崎
• [Presentation] Different cell types in the regeneration niche and the involvement of JNK signaling during zebrafish fin regeneration. (2007)
  • Author(s): Ishida, T.
  • Organizer: Toin international symposium on biomedical engineering 2007 (BME 07)
  • Place of Presentation: 桐蔭横浜大学
  • Year and Date: 2007-11-02
• [Presentation] Toward the molecular mechanism of tissue regeneration using fish fin model (2007)
  • Author(s): Kawakami, A.
  • Organizer: Toin international symposium on biomedical engineering 2007 (BME 07)
  • Place of Presentation: 桐蔭横浜大学
  • Year and Date: 2007-11-02
• [Presentation] Analysis of medaka mutant namako affected in iron and lipid metabolism (2007)
  • Author(s): Migake, A.
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前大学
• [Presentation] Analysis of tissue-specific enhancer region of the medak a zicl and zic4 genes Da candidates for the medaka spontaneous mutant Double anal fin (2007)
  • Author(s): Moriyama, Y.
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: 弘前大学
• [Presentation] Maternal-zygotic medaka mutant for fgfrl reveal its essential role in the migration of the axial mesoderm but the lateral mesoderm (2007)
  • Author(s): Shimada, A.
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
• [Presentation] New function of Laminin in neural tube morphogenesis-genetic and histological analysis using medaka mutant, tacobo- (2007)
  • Author(s): Tuda, S.
  • Organizer: 第40回日本発生生物学会、第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Appearanceof spatially organized oscillation in the zebrafish segmentation clock (2007)
  • Author(s): Ishimatsu, K.
  • Organizer: 第40回日本発生生物学会、第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Analysis of the medaka mutant, abecobe defective in left-right axis formation (2007)
  • Author(s): Kamura, K
  • Organizer: 第40回日本発生生物学会、第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Maternal-zygotic medaka mutant for fgfrl reveal its essential role in prechordal plate migration but not in mesoderm induction (2007)
  • Author(s): Yabusaki, M.
  • Organizer: 第40回日本発生生物学会、第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] ペリオスチンは力学的負荷依存的骨形成に必須である (2007)
  • Author(s): 中川一樹
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学学会大会合同大会
  • Place of Presentation: 横浜
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体 (2007)
  • Author(s): 猪早 敬二
  • Organizer: 動物学会第78回大会
  • Place of Presentation: 弘前大学
• [Presentation] メダカ骨格形成突然変異体の解析 (2007)
  • Author(s): 大久 敬
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
• [Presentation] メダカ骨格異常変異体の原因遺伝子同定とその解析 (2007)
  • Author(s): 日比谷健太
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体の解析 (2007)
  • Author(s): 猪早 敬二
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
• [Presentation] 破骨細胞特異的トランスジェニックメダカをin-vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷昌宏
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東京大学
• [Presentation] ヒトペリオスチンは線維性骨異形成症に発現し、そのコラーゲン線維形成に関与する。 (2007)
  • Author(s): 西山尚志
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] べリオスチンによって安定化されるフィヒブロネクチンマトリックスは、メカニカルストレス感知機構を担う (2007)
  • Author(s): 喜井勲
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] 破骨細胞が特異的に光るトランスジェニックメダカを用いたin vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷昌宏
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] The Dharma-medaka mutant is defective in formation and/ormaintenance of intervertebral region. (2007)
  • Author(s): Inohaya, K.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Cadherin-11 stabilizes FGF Receptor 1 during craniofacial skeletal development in mice. (2007)
  • Author(s): Kii, I.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Characterization of the medaka mutant which displays abnor malities in vertebral body. (2007)
  • Author(s): Ohisa, S.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Characterization of the medaka mutant that displays abnormalities in craniofacial skeleton and fin ray. (2007)
  • Author(s): Hibiya, K.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Different cell types in the regeneration niche and the involvemen of JNK signaling during zebrafish fin regeneration (2007)
  • Author(s): Ishida T.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Regeneration of fish fin (2007)
  • Author(s): Yuki Nakatani
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Book] 発生遺伝学-脊椎動物のからだと器官のなりたち (2007)
  • Author(s): 武田洋幸, 相賀裕美子
  • Total Pages: 197
  • Publisher: 東京大学出版会
• [Remarks] ホームページ等
  • URL: http://www.biol.s.u-tokyo.ac.jp/users/hassei/
• [Remarks] 新聞発表
• [Remarks] 武田研究室
• [Remarks] 雑誌論文【○!6】について
• [Remarks] 2008年12月9日FujiSankei Buisiness 13頁
• [Remarks] 繊毛異常の遺伝子 メダカ変異で発見
• [Remarks] 2008年12月5日日経産業新聞 9頁「繊毛病 原因遺伝子を特定 東大、変異のメダカから」
• [Remarks] 2008年12月04日 日刊工業新聞32頁
• [Remarks] 東大、繊毛病の原因遺伝子を確認-患者のDNAも解析
• [Remarks] 2008年12月4日 06時03分 時事通信
• [Remarks] 変異メダカから疾患遺伝子発見=細胞表面の繊毛動かず-東大など
• [Remarks] 雑誌論文【○!7】について
• [Remarks] 2007年6月7日 朝日新聞 33面
• [Remarks] 2007年6月7日 朝日新聞 33面
• [Remarks] 2007年6月7日毎日新聞2面
• [Remarks] 2007年6月15日(金) 科学新聞 1面
• [Remarks] 雑誌論文【○!8】について
• [Remarks] 2006年6月8日 日経産業新聞 11頁
• [Remarks] 2006年6月8日 日刊工業新聞 News Web
• [Remarks] 工藤研究室
• [Remarks] 雑誌論文【○!13】について
• [Remarks] 2008年3月2日 毎日新聞
• [Remarks] 心筋を修復し がん増殖を抑制? たんぱく質ペリオスチン研究最前線
• [Remarks] 雑誌論文【○!13】について
• [Remarks] 2008年1月25日 朝日新聞
• [Remarks] 心臓修復するたんぱく質
• [Remarks]
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• [Remarks]
  • URL: http://www.biol.s.u-tokyo.ac.jp/users/hassei/takeda/TOP%20main/TOP.html
• [Remarks]
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• [Patent(Industrial Property Rights)] 心筋壊死を伴う疾患の治療薬及び検査薬 (2008)
  • Inventor(s): 工藤明
  • Industrial Property Rights Holder: 東京工業大学
  • Industrial Property Number: 2008-187851
  • Filing Date: 2008-07-18