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Molecular level clarification of the mechanism for animal skin pattern formation

Research Project

Project/Area Number 17017017
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

KONDO Shigeru  Nagoya University, 大学院・生命機能研究科, 教授 (10252503)

Co-Investigator(Kenkyū-buntansha) WATANABE Masakatsu  大阪大学, 大学院・生命機能研究科, 准教授 (90323807)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥89,100,000 (Direct Cost: ¥89,100,000)
Fiscal Year 2009: ¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2008: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2007: ¥17,700,000 (Direct Cost: ¥17,700,000)
Fiscal Year 2006: ¥18,700,000 (Direct Cost: ¥18,700,000)
Fiscal Year 2005: ¥18,900,000 (Direct Cost: ¥18,900,000)
Keywordsゼブラフィッシュ / 反応拡散 / チューリング / パターン形成 / 色素細胞 / Turing pattern / 形態形成 / 皮膚模様 / ネットワーク
Research Abstract

We analyzed the mechanism of skin pattern formation in zebrafish in order to have the substantial evidence to prove the hypothesis, "the basic mechanism of biological pattern formation is the Turing wave". We found,(1)the skin pattern of zebrafish has the specific dynamics of Turing wave, (2)the interactions among the pigment cells satisfies the required conditions for the Turing pattern formation, and (3)the key molecules those critical to the wave formation are gap-junction, Notch-Delta and Kir channels. About 90% of the aim of this project is completed. Now our final goal, the detailed identification of the molecular network of Turing wave, should be very close.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (51 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (19 results) (of which Peer Reviewed: 11 results) Presentation (27 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Interactions between zebrafish pigment cells responsible for the generation of Turing patterns.2009

    • Author(s)
      Nakamasu A, Takahashi G, Kanbe A, Kondo S
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 8429-8434

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical analysis of mechanisms that generate the pigmentation pattern of animals.2009

    • Author(s)
      Kondo S, Shirota H
    • Journal Title

      Semin Cell Dev Biol 20

      Pages: 82-89

    • Related Report
      2009 Final Research Report
  • [Journal Article] Interactions between zebrafish pigment cells responsible for the generation of Turing patterns.2009

    • Author(s)
      Nakamasu A
    • Journal Title

      Proceedings of the National Academy of Sciences 106

      Pages: 8429-8434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How animals get their skin patterns : fish pigment pattern as a live Turing wave.2009

    • Author(s)
      Kondo S
    • Journal Title

      International Journal of Developmental Biology 53

      Pages: 521-856

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Theoretical analysis of mechanisms that generate the pigmentation pattern of animals2009

    • Author(s)
      Kondo S. and Shirota H.
    • Journal Title

      Theoretical analysis of mechanisms that generate the pigmentation pattern of animals 20-1

      Pages: 82-89

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions between Zebrafish Pigment Cells Responsible for the Generation of Turing Patterns2009

    • Author(s)
      Nakamasu A.,Takahashi G., Kanbe A. and Kondo S.
    • Journal Title

      PNAS (掲載決定済)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melanophores in the stripes of adult zebrafish do not have the nature to gather, but disperse when they have the space to move.2008

    • Author(s)
      Takahashi G, Kondo S
    • Journal Title

      Pigment Cell Melanoma Res 21

      Pages: 677-686

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melanophores in the stripes of adult zebrafish do not have the nature to gather, but disperse when they have the space to move2008

    • Author(s)
      Takahashi G. and Kondo S.
    • Journal Title

      Pigment Cell Research 21-6

      Pages: 677-686

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism.2007

    • Author(s)
      Yamaguchi M, Yoshimoto E, Kondo S
    • Journal Title

      Proc Natl Acad Sci U S A 104

      Pages: 4790-4793

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism2007

    • Author(s)
      Yamaguchi M, Yoshimoto E, Kondo S
    • Journal Title

      PNAS Vol. 104 No. 12

      Pages: 4790-4793

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene.2006

    • Author(s)
      Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N
    • Journal Title

      EMBO Rep 7

      Pages: 893-897

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pigment pattern in jaguar/obelix zebrafish is caused by a Kir7. 1 mutation: implications for the regulation of melanosome movement.2006

    • Author(s)
      Iwashita M, Watanabe M, Ishii M, Chen T, Johnson SL, Kurachi Y, Okada N, Kondo S
    • Journal Title

      PLoS Genet 2

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noise-resistant and synchronized oscillation of the segmentation clock.2006

    • Author(s)
      Horikawa K, Ishimatsu K, Yoshimoto E, Kondo S, Takeda H
    • Journal Title

      Nature 441

      Pages: 719-723

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noise-resistant and synchronized oscillation of the segmentation clock2006

    • Author(s)
      Horikawa K, Ishimatsu K, Yoshimoto E, Kondo S, Takeda H
    • Journal Title

      Nature, 2006 Jun 8 441(7094)

      Pages: 719-723

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pigment Pattern in jaguar/obelix zebrafish is caused by a Kir7.1 mutation : implications for the regulation of melanosome movement2006

    • Author(s)
      Iwashita M, Watanabe M, Ishi M, Chen T, Johnson SL, Kurachi Y, Okada N, Kondo S
    • Journal Title

      PloS Genet 2006 Nov24;2(11):e197

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gane2006

    • Author(s)
      Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N
    • Journal Title

      EMBO Rep. Sep;7(9)

      Pages: 893-897

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pigment cell distributions in different tissues of the zebrafish, with special reference to the striped pigment pattern.2005

    • Author(s)
      Hirata M, Nakamura K, Kondo S
    • Journal Title

      Dev Dyn 234

      Pages: 293-300

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pigment cell Distributions in Different Tissues of the Zebrafish, With Special Reference to the Sriped Pigment Pattern2005

    • Author(s)
      Hirata, M., Nakamura, K., Kondo, S.
    • Journal Title

      DEVELOPMENTAL DYNAMICS 234

      Pages: 293-300

    • Related Report
      2005 Annual Research Report
  • [Journal Article] cell-cell Interaction Network That Generattes the Skin Pattern of animal2005

    • Author(s)
      Kondo, S
    • Journal Title

      Genome Informatics 2005 vol.16, No.2

      Pages: 278-291

    • Related Report
      2005 Annual Research Report
  • [Presentation] Connexin41.8による体表模様の制御2009

    • Author(s)
      渡邉正勝
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] コネキシンはゼブラフィッシュのストライプ幅も規定する2009

    • Author(s)
      渡邉正勝
    • Organizer
      日本動物学会第80回大会2009静岡
    • Place of Presentation
      グランシップ(静岡県)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Connexin41.8 contributes melanophore development in zebrafish.2009

    • Author(s)
      Watanabe M
    • Organizer
      第36回国際生理学会世界大会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of zebrafish connexin41.8 for pattern formation.2009

    • Author(s)
      Watanabe M
    • Organizer
      6th European Zebrafish Genetics and Development Meeting
    • Place of Presentation
      ローマ、イタリア
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Turing pattern in the skin of animals.2009

    • Author(s)
      Kondo S
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Turing Pattern in the skin of animals.2009

    • Author(s)
      Kondo S
    • Organizer
      GRC
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-06-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Pigment Pattern Formation in Zebrafish2008

    • Author(s)
      近藤滋、渡邉正勝
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸市
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multi-Cell Simulations of Gastrulation and Somitogenesis in Chick.2008

    • Author(s)
      Kondo S
    • Organizer
      Mathematuical Biosciences Institute Workshop
    • Place of Presentation
      Ohio, USA
    • Year and Date
      2008-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Multi-Cell Simulations of Gastrulation and Somitogenesis in Chick2008

    • Author(s)
      Shigeru Kondo
    • Organizer
      Mathematuical Biosciences Institute Workshop
    • Place of Presentation
      Ohio, USA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell-cell interaction network that generates the skin pattern of zebrafish.2008

    • Author(s)
      Kondo S
    • Organizer
      Frontier in Development Biology meeting
    • Place of Presentation
      Gien, France
    • Year and Date
      2008-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Cell-cell interaction network that generates the skin pattern of zebrafish2008

    • Author(s)
      Shigeru Kondo
    • Organizer
      Frontiers in Development Biology
    • Place of Presentation
      Gien, France
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Zebras did not get the stripes, but lost the uniform color.2008

    • Author(s)
      Kondo S
    • Organizer
      Society for Mathematical Biology Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-08-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Zebras did not get the stripes, but lost the uniform color2008

    • Author(s)
      Shigeru Kondo
    • Organizer
      Annual Meeting of Society for Mathematical Biology Conference
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-08-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Waves Made by Cell-Cell Interaction Form Spatial Patterns in the Animal Body2008

    • Author(s)
      Shigeru Kondo
    • Organizer
      Systems biology : The Challenge of Complexity
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interactions among the zebrafish pigment cells that makes the stripe pattern2008

    • Author(s)
      Shigeru Kondo
    • Organizer
      IPCC-IMRC 2008
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Interaction among the zebrafish pigment cells that makes the stripe pattern.2008

    • Author(s)
      Kondo S
    • Organizer
      IPCC-IMRC2008
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-05-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Pigment Cells Generates the Stripes in Animal's Skin.2008

    • Author(s)
      Kondo S
    • Organizer
      2nd International Systems Radiation Biology Workshop
    • Place of Presentation
      Washington, USA
    • Year and Date
      2008-01-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Interaction Networks of Pigment Cells Generates the Stripes in Animal's Skin2008

    • Author(s)
      Kondo Shigeru
    • Organizer
      2nd International Systems Radiation Biology Workshop
    • Place of Presentation
      Marriott Wardman Park Hotel
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ゼブラフィッシュのストライプ形成機構の解析2007

    • Author(s)
      近藤 滋、渡邉 正勝
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)、
    • Place of Presentation
      パシフィコ横浜 ヨコハマグランドインターコンチネンタル
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] ゼブラフィッシュの黒色素胞に自己集合しようとする性質があるか?2007

    • Author(s)
      近藤 滋、高橋 豪
    • Organizer
      第21回日本色素細胞学会年次学術大会
    • Place of Presentation
      藤田保健衛生大学医学部フジタホール500
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生物におけるTuringパターン-魚の体表に発生するTuring波(反応拡散波)-2007

    • Author(s)
      近藤 滋
    • Organizer
      非線形数理・秋の学校
    • Place of Presentation
      明治大学・秋葉原サテライトキャンパス
    • Year and Date
      2007-09-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 皮膚に発生する化学反応の波=動物の模様2007

    • Author(s)
      近藤 滋
    • Organizer
      第6回皮膚科EBMフォーラム
    • Place of Presentation
      サッポロルネッサンスホテル
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nonlinear dynamics in biological pattern formation: Interactions between pigment cells give rise to Turing patterns in zebrafish.2007

    • Author(s)
      Kondo S
    • Organizer
      Shanghai NSA'07
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2007-06-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Nonlinear dynamics in biological pattern formation: Interactions between pigment cells give rise to Turing patterns in zebrafish2007

    • Author(s)
      Kondo Shigeru
    • Organizer
      Shanghai NSA'07
    • Place of Presentation
      Fudan University
    • Year and Date
      2007-06-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 動的な相互作用が生むパターン形成2007

    • Author(s)
      近藤 滋
    • Organizer
      システムバイオロジー中間報告会
    • Place of Presentation
      下田セントラルホテル
    • Year and Date
      2007-05-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Interactions among the pigment cells give rise to the Turing pattern in the skin of zebrafish.2006

    • Author(s)
      Kondo S
    • Organizer
      IUBMB 2006
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Interactions among the pigment cells that give rise to the stripe pattern.2005

    • Author(s)
      Kondo S
    • Organizer
      2005 West Coast Zebrafish Meeting
    • Place of Presentation
      Eugene, USA
    • Year and Date
      2005-09-26
    • Related Report
      2009 Final Research Report
  • [Book] 振動現象の生物学:リズムと波が生み出す動的な世界2007

    • Author(s)
      近藤滋
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2009 Final Research Report
  • [Book] たかがゲノム、されどゲノム2007

    • Author(s)
      近藤滋
    • Publisher
      東京化学同人
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.bio.nagoya-u.ac.jp/seminar/z3.html

    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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