Analysis of Structure and Dynamics of Biological Information Networks
Project/Area Number |
17017019
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyoto University |
Principal Investigator |
AKUTSU Tatsuya Kyoto University, 化学研究所, 教授 (90261859)
|
Co-Investigator(Kenkyū-buntansha) |
GOTO Susumu 京都大学, 化学研究所, 准教授 (40263149)
MOCHIZUKI Atsushi 理化学研究所, 望月理論生物学研究室, 主任研究員 (10304726)
TOKITA Keiichirou 大阪大学, サーバーメディアセンター, 准教授 (00263195)
|
Project Period (FY) |
2005 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥82,200,000 (Direct Cost: ¥82,200,000)
Fiscal Year 2009: ¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 2008: ¥18,500,000 (Direct Cost: ¥18,500,000)
Fiscal Year 2007: ¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2006: ¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2005: ¥17,000,000 (Direct Cost: ¥17,000,000)
|
Keywords | 遺伝子ネットワーク / 代謝ネットワーク / タンパク質相互作用 / スケールフリーネットワーク / タンパク質ドメイン / 遺伝子発現 / 大規模進化動力学モデル / 生物情報ネットワーク / スケールフリー / 進化動力学モデル / 緑膿菌 / ブーリアンネットワーク / 形態形成 / 神経細胞 / 遺伝子発現データ / オペロン / ネットワーク定常状態 / 概日リズム / バイオインフォマティクス / システム生物学 / べき乗則 / 遺伝子間相互作用 |
Research Abstract |
We studied genetic, metabolic, and protein-protein interaction networks mainly from a viewpoint of mathematical models. To analyze evolution of proteins and their interactions, we developed a domain-based mathematical model and performed domain combination-based database analysis. To analyze dynamics of networks, we developed a general theory on relations between network structure and its dynamics, and a statistical mechanical theory on large-scale evolutionary dynamical systems. We also developed several computational tools for analyzing network and related data.
|
Report
(6 results)
Research Products
(107 results)
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[Journal Article] Systems biology approaches and tools for investigating cardiovascular disease2009
Author(s)
Wheelock, C.E., Wheelock, A.M., Kawashima, S., Diez, D., Kanehisa, M., van Erk, M., Kleemann, R., Haeggstrom, J.Z., Goto, S.
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Journal Title
Molecular Biosystems 5
Pages: 588-602
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[Journal Article] Prediction of missing enzyme genes in bacterial metabolic network : A reconstruction of lysine degradation pathway of Pseudomonas aeruginosa2007
Author(s)
Yamanishi, Y., Mihara, H., Osaki, M., Muramatsu, H., Esaki, N., Sato, T., Hizukuri, Y., Goto, S., Kanehisa, M.
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Journal Title
FEBS Journal 274
Pages: 2262-2273
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[Journal Article] Characterization of relationships between transcriptional units and operon structures in Bacillus subtilis and Escherichia coli2007
Author(s)
Okuda, S., Kawashima, S., Kobayashi, K., Ogasawara, N., Kanehisa, M., and Goto S.
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Journal Title
BMC Genomics 8(論文番号)
Pages: 48-48
NAID
Related Report
Peer Reviewed
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[Journal Article] Prediction of missing enzyme genes in bacterial metabolic network: A reconstruction of lysine degradation pathway of Pseudomonas aeruginosa2007
Author(s)
Yamanishi, Y., Mihara, H., Osaki, M., Muramatsu, H., Esaki, N., Sato, T., Hizukuri, Y., Goto, S., and Kanehisa, M.
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Journal Title
FEBS Journal 274
Pages: 2262-2273
Related Report
Peer Reviewed
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[Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity2007
Author(s)
Otsuji, M., Ishihara, S., Co, C., Kaibuchi, K., Mochizuki, A., and Kuroda, S.
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Journal Title
PLoS Computational Biology 3
Pages: 1040-1054
Related Report
Peer Reviewed
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[Journal Article] Analysis of the differences in metabolic network expansion between prokaryotes and eukaryotes2006
Author(s)
Tanaka, M., Yamada, T., Itoh, M., Okuda, S., Goto, S., Kanehisa, M.
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Journal Title
Genome Informatics 17
Pages: 230-239
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