Development of new strategy for detection of disease denes

• Project/Area Number: 17019063
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokai University
• Principal Investigator: INOKO Hidetoshi Tokai University, 医学部, 教授 (10101932)
• Co-Investigator(Kenkyū-buntansha): MANO Syuhei 名古屋市立大学, 大学院・システム自然科学研究科, 准教授 (20372948)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥156,700,000 (Direct Cost: ¥156,700,000); Fiscal Year 2009: ¥30,200,000 (Direct Cost: ¥30,200,000); Fiscal Year 2008: ¥30,200,000 (Direct Cost: ¥30,200,000); Fiscal Year 2007: ¥32,100,000 (Direct Cost: ¥32,100,000); Fiscal Year 2006: ¥32,400,000 (Direct Cost: ¥32,400,000); Fiscal Year 2005: ¥31,800,000 (Direct Cost: ¥31,800,000)
• Keywords: 相関解析 / マイクロサテライト / 多因子疾患 / 同祖性 / 連鎖解析 / 酵母ツーハイブリッド / ネットワーク / ゲノム創薬 / 関節リウマチ / 糖尿病 / 酵母ツーハイブリッド法 / ネットワーク解析 / 蛋白相互作用 / 関連解析 / ゲノムワイド / 機能解析 / 疾患モデルマウス / 酵母two hvbrid法 / タンパク相互作用 / GWAS / 尋常性乾鮮 / NFKB alternative pathway / 破骨細胞 / 遺伝疫学 / 遺伝的荷重 / NFkB alternative pathway / 多因子性疾患 / 遺伝分散 / モンゴル

Research Abstract

In order to identify susceptible gene for multi-factorial disease such as common disease, we have developed two methods, GWAS (genome-wide association study) using 30,000 microsatellites and detection of linkage between a trait and a marker in a random mating population without pedigree record. Utilizing these new methods, we could identify more than 30 disease susceptible genes. Towards genome-based drug discovery based on these disease genes, we have developed in silico network analysis and new yeast two hybrid system.

Research Products

• [Journal Article] Detecting linkage between a trait and a marker in a random mating population without pedigree record. (2009)
  • Author(s): Mano S, Endo TA, Oka A, Ozawa A, Gojobori T, Inoko H
  • Journal Title: PLoS ONE 4
• [Journal Article] The genetic relationship among Iranian ethnic groups : an anthropological view based on HLA class II gene polymorphism. (2009)
  • Author(s): Farjadian S, Ota M, Inoko H, Ghaderi A
  • Journal Title: Mol Biol Rep 36 Pages: 1943-1950
  • Peer Reviewed
• [Journal Article] HLA-A allele associations with viral MER9-LTR nucleotide sequences at two distinct loci within the MHC alpha block. (2009)
  • Author(s): Kulski JK, Shigenari A, Shiina T, Hosomichi K, Yawata M, Inoko H
  • Journal Title: Immunogenetics 61 Pages: 257-270
  • Peer Reviewed
• [Journal Article] Complex divergence at a microsatellite mazker C1_2_5 in the lineage of HLA-Cw/-B haplotype. (2009)
  • Author(s): Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse TK, Kimura A
  • Journal Title: J Hum Genet 54 Pages: 224-229
  • Peer Reviewed
• [Journal Article] PKC Delta and Epsilon in drug targeting and therapeutics. (2009)
  • Author(s): Yonezawa T, Kurata R, Kimura M, Inoko H
  • Journal Title: Recent Patents on DNA & Gene Sequences 3 Pages: 96-101
  • Peer Reviewed
• [Journal Article] Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus). (2009)
  • Author(s): Kikkawa EF, Tsuda TT, Sumiyama D, Naruse TK, Inoko H, et al.
  • Journal Title: Immunogenetics 61 Pages: 341-352
  • Peer Reviewed
• [Journal Article] Assessment of chromosome 19 for genetic association in severe chronic periodontitis. (2009)
  • Author(s): Tabeta K, Shimada Y, Tai H, Ishihara Y, Noguchi T, Soga Y, Inoko H, et al.
  • Journal Title: J Periodontol 80 Pages: 663-671
  • Peer Reviewed
• [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population. (2009)
  • Author(s): Horie Y, Meguro A, Ota M, Kitaichi N, Inoko H, et al.
  • Journal Title: Rheumatology 48 Pages: 638-642
  • Peer Reviewed
• [Journal Article] Identification of MICA as a Susceptibility Gene for Pulmonary Mycobacterium avium Complex Infection. (2009)
  • Author(s): Shojima J, Tanaka G, Keicho N, Tamiya G, Ando S, Oka A, et al, Inoko H.
  • Journal Title: J Infect Dis 199 Pages: 1707-1715
  • Peer Reviewed
• [Journal Article] HLA-B*15 subtypes in Burmese population by sequence-based typing. (2009)
  • Author(s): Kongmaroeng C, Romphruk A, Ruangwerayut R, Paupairoj C, Inoko H, et al.
  • Journal Title: Tissue Antigens 74 Pages: 164-167
  • Peer Reviewed
• [Journal Article] Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients. (2009)
  • Author(s): Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Inoko H, et al.
  • Journal Title: Mol Vis. 15 Pages: 1115-1119
  • NAID: 120001415121
  • Peer Reviewed
• [Journal Article] Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease. (2009)
  • Author(s): Hinohaza K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Inoko H, et al.
  • Journal Title: Hum Genet 126 Pages: 539-547
  • Peer Reviewed
• [Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque. (2009)
  • Author(s): Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Ioko H, et al.
  • Journal Title: Immunogenetics 61 Pages: 635-468
  • Peer Reviewed
• [Journal Article] Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis. (2009)
  • Author(s): Ikamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Inoko H, et al.
  • Journal Title: Clin Ophthalmol 3 Pages: 183-188
  • Peer Reviewed
• [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population. (2009)
  • Author(s): Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, et al.
  • Journal Title: Clin Ophthalmol 3 Pages: 307-312
  • Peer Reviewed
• [Journal Article] Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. (2009)
  • Author(s): Nakabayashi K, Komaki G, Tajima A, Ando T, Oka A, Inoko H, et al.
  • Journal Title: J Hum Genet 54 Pages: 531-537
  • NAID: 10030731724
  • Peer Reviewed
• [Journal Article] Polymorphisms of NKG2D ligands : diverse iZAET1/ULBP genes in northeastern Thais. (2009)
  • Author(s): Romphruk AV, Romphruk A, Naruse TK, Inoko H, Leelayuwat C.
  • Journal Title: Immunogenetics. 61
  • Peer Reviewed
• [Journal Article] A novel system of polymorphic and diverse NK cell receptors in primates. (2009)
  • Author(s): Averdam A, Petersen B, Rosner C, Neff J, Roos C, Inoko H, et al.
  • Journal Title: PLoS Genet 5
  • Peer Reviewed
• [Journal Article] Genetics of Behcet's disease inside and outside the MHC. (2009)
  • Author(s): Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E, et al.
  • Journal Title: Ann Rheum Dis 69:04:00 Pages: 747-754
  • Peer Reviewed
• [Journal Article] Nutritional and hormonal regulation of uncoupling protein 2. (2009)
  • Author(s): Yonezawa T, Kurata R, Hosomichi K, Kono A, Kimura M, Inoko H.
  • Journal Title: IUBMB Life 61 Pages: 1123-1131
  • Peer Reviewed
• [Journal Article] Indian Genome Variation Consortium : Mapping human genetic diversity in Asia. (2009)
  • Author(s): HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed 1, et al.
  • Journal Title: Science 326 Pages: 1541-1545
  • Peer Reviewed
• [Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan. (2009)
  • Author(s): Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Inoko H, et al.
  • Journal Title: Mol Vis 15 Pages: 2673-2682
  • Peer Reviewed
• [Journal Article] 乾癬のマイクロサテライトによるゲノムワイド関連解析 (2009)
  • Author(s): 岡晃、猪子英俊
  • Journal Title: 実験医学(患いでんしの探索と超高速シークエンス増刊号) 27 Pages: 80-85
  • Peer Reviewed
• [Journal Article] New susceptibility locus for high myopia is linked to the uromodul in-like 1 (UMODL1) gene region on chromosome 21q22.3 (2009)
  • Author(s): Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, et.al.
  • Journal Title: Eve
  • Peer Reviewed
• [Journal Article] An evolutionary origin and selection process of goldfish (2009)
  • Author(s): Komiyama T, Kobayashi H, Tateno Y, Inoko H, et.al.
  • Journal Title: Gene 430 Pages: 5-11
  • Peer Reviewed
• [Journal Article] The HLA genomic loci map : expression, interaction, diversity and disease (2009)
  • Author(s): Shiina T, Hosomichi K, Inoko H. Kulski JK
  • Journal Title: J Hum Genet 54 Pages: 15-39
  • NAID: 10030728683
  • Peer Reviewed
• [Journal Article] Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behget's disease in Japanese patients (2009)
  • Author(s): Tomiyama R, Meguro A, Ota M, Katsuyama Y, Inoko H, et.al.
  • Journal Title: Hum Immunol 70 Pages: 41-44
  • Peer Reviewed
• [Journal Article] Japan Marrow Donation Program (JMDP) : Exploration of the genet is basis of GVHD by genetic association studies (2009)
  • Author(s): Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Inoko H, et.al.
  • Journal Title: Biol Blood Marrow Transplant 5(1 Suppl) Pages: 39-41
  • Peer Reviewed
• [Journal Article] Recombinant DNA technologies for construction of precisely designed transgene constructs (2009)
  • Author(s): Ohtsuka M, Kimura M, Tanaka M. Inoko H
  • Journal Title: Curr Pharm Biotechnol 10 Pages: 244-251
  • Peer Reviewed
• [Journal Article] Complex divergence at a microsatellite marker C1_2_5 in the lineage of HLA-Cw/-B haplotype (2009)
  • Author(s): Shichi D, Ota M, Katsuyama Y, Inoko H, et.al.
  • Journal Title: J Hum Genet (Epub ahead of print)
  • NAID: 10030730018
  • Peer Reviewed
• [Journal Article] A genome-wide association scan for asthma in a general Australian population. (2008)
  • Author(s): Hui J, Oka A, James A, Palmer LJ, Musk AW, Beilby J, Inoko H
  • Journal Title: Hum Genet 123 Pages: 297-306
• [Journal Article] A genome-wide association scan for asthma in a general Australi an population (2008)
  • Author(s): Hui J, Oka A, James A, Palmer LJ, Musk AW, Inoko H, et.al.
  • Journal Title: Hum Genet 123 Pages: 297-306
  • Peer Reviewed
• [Journal Article] Association of the toll-like receptor 4 gene polymorphisms with B ehcet's disease (2008)
  • Author(s): Meguro A, Ota M, Katsuyama Y, Oka A, Inoko H, et.al.
  • Journal Title: Ann Rheum Dis 67 Pages: 725-727
  • Peer Reviewed
• [Journal Article] Major histocompatibility complex (Mhc) class lb gene duplications, organization and expression patterns in mouse strain C57BL/6 (2008)
  • Author(s): Ohtsuka M, Inoko H, Kulski J K, Yoshimura S
  • Journal Title: BMC Genomics 9 Pages: 178-192
  • Peer Reviewed
• [Journal Article] Genome-wide association analysis with selective genotyping identif ies candidate loci for adult height at 8q21. 13 and 15q22. 33-q23 in Mongolians (2008)
  • Author(s): Kimura T, Kobayashi T, Munkhbat B, Oyungerel G, Inoko H, et.al.
  • Journal Title: Hum Genet 123 Pages: 655-660
  • Peer Reviewed
• [Journal Article] Microsatellite diversity and crossover regions within homozygous and heterozygous SLA haplotypes of different pig breeds. (2008)
  • Author(s): Ando A, Uenishi H, Kawata H, Tanaka-Matsuda M, Inoko H, et.al.
  • Journal Title: Immunogenetics 60 Pages: 399-407
  • Peer Reviewed
• [Journal Article] The amphioxus genome illuminates vertebrate origins and cephalo chordate biology (2008)
  • Author(s): Holland LZ, Albalat R, Azumi K, Benito-Gutierrez E, Inoko H, et.al.
  • Journal Title: Genome Res 18 Pages: 1100-1111
  • Peer Reviewed
• [Journal Article] Association of toll-like receptor 4 gene polymorphisms with normal tension glaucoma (2008)
  • Author(s): Shibuya E, Meguro A, Ota M, Kashiwagi K, Inoko H, et.al.
  • Journal Title: Invest Ophthalmol Vis Sci 49 Pages: 4453-4457
  • Peer Reviewed
• [Journal Article] Human endogenous retrovirus (HERVK9) structural polymorphism with haolotvoic HLA-A allelic associations (2008)
  • Author(s): Kulski JK, Shigenari A, Shiina S. Ota M. Inoko H, et.al.
  • Journal Title: Genetics 108 Pages: 446-457
  • Peer Reviewed
• [Journal Article] Re-evaluation of heterogeneity in HLA-B^*510101 associated with Behcet' s disease (2008)
  • Author(s): Takemoto Y, Naruse T, Namba K, Kitaichi N, Inoko H, et.al.
  • Journal Title: Tissu Antigens 72 Pages: 347-353
  • Peer Reviewed
• [Journal Article] Paternity determination of captive bottlenose dolphins (Tursiops tr uncatus) using microsatellite DNA analysis (2008)
  • Author(s): Sumiyama D, Kitamura S, Terasawa F, Hori Y, Inoko H, et.al.
  • Journal Title: J Vet Med Sci 70 Pages: 711-713
  • NAID: 110006839593
  • Peer Reviewed
• [Journal Article] Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity (2008)
  • Author(s): Hosomichi K, Miller MM, Goto RM. Wana Y. Inoko H. et.al.
  • Journal Title: J Immunol 181 Pages: 3393-3399
  • Peer Reviewed
• [Journal Article] Microsatellite analysis of the GLC1B locus on chromosome 2 poin is to NCK2 as a new candidate gene for normal tension glaucom a (2008)
  • Author(s): Akiyama M, Yatsu K, Otarut, Katsuvama Y, Inoko H, et.al.
  • Journal Title: Br J Ophthalmol 92 Pages: 1293-1296
  • Peer Reviewed
• [Journal Article] The genetic relationship among Iranian ethnic groups : an anthrop iological view based on HLA class II gene polymorphism (2008)
  • Author(s): Farjadian S, Ota M, Inoko H, Ghaderi A
  • Journal Title: Mol Biol Reo
  • Peer Reviewed
• [Journal Article] HLAmismatch combinations associated with decreased risk of rela use ; Implications for molecular mechanism (2008)
  • Author(s): Kawase T, Matsuo K, kashiwases K, Inoko H, et.al.
  • Journal Title: Blood 1
  • Peer Reviewed
• [Journal Article] Assignment of the SLA alleles and reproductive potential of selective breeding Duroc pig lines (2008)
  • Author(s): Soe OK, Ohba Y, Imaeda N, Nishii N. Inoko H. et.al.
  • Journal Title: Xenotransplantation 15 Pages: 390-397
  • Peer Reviewed
• [Journal Article] Modulation of some cell surface antigens in the monocyte -like cell line U937 in response to 13 -1, 3-1, 6 gulucan derived from Aureobasidium pullulans (2008)
  • Author(s): Ikewaki N, Tamauchi H, Inoko H
  • Journal Title: Journal of Kyushu University of Health and Welfare 9 Pages: 81-91
  • Peer Reviewed
• [Journal Article] 乾癬のマイクロサテライトによるゲノムワイド関連解析 (2008)
  • Author(s): 岡晃、猪子英俊
  • Journal Title: 医学のあゆみ(臨床ゲノム研究特集号) 225 Pages: 791-797
  • Peer Reviewed
• [Journal Article] Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behget's disease (BD) by a PCR-SSOP-Iuminex method and stratification analysis according to each major symptom of BD (2008)
  • Author(s): Kamiishi T, Itoh Y, Meguro A, Nishida T, Inoko H, et.al.
  • Journal Title: 日本眼科会雑誌 112 Pages: 451-458
  • Peer Reviewed
• [Journal Article] Donner killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR lgand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T Cell-replete unrelated bone marrow transplantation. (2008)
  • Author(s): Yabe, T・Matsuo, T・Hirayasu, K・Kashiwase, K・Kawamura-Ishii, S・Tanaka, H・Ogawa, A・Takanashi, M・Satake, M・Nakajima, K・Tokunaga, K・Inoko, H・Saji, H・Ogawa, S・Juji, T・Sasazuki, T・Kodera, Y・Morishima
  • Journal Title: Biology of Blood and Marrow Transplantation (BBMT) 14 Pages: 75-87
  • Peer Reviewed
• [Journal Article] Microsatellite markers for genome-wide association studies. (2007)
  • Author(s): Bahram S, Inoko H
  • Journal Title: Nature Reviews Genetics 8(2) Pages: 164-164
• [Journal Article] Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism. (2007)
  • Author(s): Ota M, Fukushima H, Kulski JK, Inoko H
  • Journal Title: Nature Protocol 2(11) Pages: 2857-6284
• [Journal Article] Single nucleotide polymorphism detection by polymerase chain reaction-restriction fragment length polymorphism. (2007)
  • Author(s): Ota, M・Fukushima, H・Kulski, JK・Inoko, H
  • Journal Title: Nature Protoc 11 Pages: 2857-2864
  • Peer Reviewed
• [Journal Article] Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. (2007)
  • Author(s): Horie, Y・Kitaichi, N・Takemoto, Y・Inoko, H, et. al.
  • Journal Title: Molecular Vision 13(261-65) Pages: 2334-2338
  • NAID: 120000947114
  • Peer Reviewed
• [Journal Article] Microsatellite markers for genome-wide association studies. (2007)
  • Author(s): Bahram, S・Inoko, H
  • Journal Title: Nature Reviews Genetics 8 Pages: 164-164
  • Peer Reviewed
• [Journal Article] Synergistic association of mitochondrial uncoupling (UCP) genes with schizophrenia. (2007)
  • Author(s): Yasuno, K・Ando, S・Misumi, S・Makino, S・Kulski, JK・Muratake, T・Kaneko, N・Amagane, H・Someya, T・Inoko, H・Suga, H・Kanemoto, K・Tamiya, G
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet ochem 144 Pages: 250-253
  • Peer Reviewed
• [Journal Article] Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. (2007)
  • Author(s): Ota, M・Katsuyama, Y・Hamano, H・Umemura, T・Kimura, A・Yoshizawa, K・Kiyosawa, K・Fukushima, H・Bahram, S・Inoko, H・Kawa, S
  • Journal Title: Immunogenetics 59 Pages: 45-52
  • Peer Reviewed
• [Journal Article] One-step generation of recombineering constructs by asymmetric-end ligation and negative selection. (2007)
  • Author(s): Ohtsuka, M・Mizutani, A・Kikuti, YY・Kulski, JK・Sato, M・Kimura, M・Tanaka, M・Inoko, H
  • Journal Title: Anal Biochem 360 Pages: 306-308
  • Peer Reviewed
• [Journal Article] Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on cheromosome 22 (2007)
  • Author(s): Kikuchi, T・Naruse, TK・Onizuka, M・Li, S・Kimura, T・Oka, A・Morishima, Y・Kulshi, JK・Ichimiya, S・Sato, N・Inoko, H
  • Journal Title: Immunogenetics 59 Pages: 99-108
  • Peer Reviewed
• [Journal Article] Genes in the HLA region indicative for head and neck squamous cell carcinoma. (2007)
  • Author(s): Reinders, J・Rozemuller, EH・van der, Weide P・Oka, A・Slootweg, PJ・Inoko, H・Tilanus, MG
  • Journal Title: Mol Immunol 44 Pages: 848-855
  • Peer Reviewed
• [Journal Article] High-resolution mapping for essential hypertension using microsatellite markers. (2007)
  • Author(s): Yatsu, K・Mizuki, N・Hirawa, N・Oka, A・Itoh, N・Yamane, T・Ogawa, M・Shiwa, T・Tabara, Y・Ohno, S・Soma, M・Hata, A・Nakao, K・Ueshima, H・Ogihara, T・Tomoike, H・Miki, T・Kimura, A・Mano, S・Kulshi, JK・Umemura, S・Inoko, H
  • Journal Title: Hypertension 49 Pages: 446-452
  • Peer Reviewed
• [Journal Article] Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. (2007)
  • Author(s): Morishima, Y・Yabe, T・Matsuo, K・Kashiwase, K・Inoko, H・Saji, H・Yamamoto, K・Maruya, E・Akatsuka, Y・Onizuka, M・Sakamaki, H・Sao, H・Ogawa, S・Kato, S・Juji, T・Sasazuki, T・Kodera, Y
  • Journal Title: Biol Blood Marrow Transplant 13 Pages: 315-328
  • Peer Reviewed
• [Journal Article] Association of autoimmune disease-related gene polymorphisms with chronic graft-versus-host disease. (2007)
  • Author(s): Shimada, M・Onizuka, M・Machida, S・Inoko, H, et. al.
  • Journal Title: BRITISH JOURNAL OF HAEMATOLOGY 139(3) Pages: 458-463
  • Peer Reviewed
• [Journal Article] Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen. (2007)
  • Author(s): Kawase, T・Akatsuka, Y・Torikai, H・Morishima, S・Oka, A・Tsujimura, A・Miyazaki, M・Tsujimura, K・Miyamura, K・Ogawa, S・Inoko, H・Morishima, Y・Kodera, Y・Kuzushima, K・Takahashi, T
  • Journal Title: Blood 110 Pages: 1055-1063
  • Peer Reviewed
• [Journal Article] The COL1A1 gene and high myopia susceptibility in Japanese. (2007)
  • Author(s): Inamori, Y・Ota, M・Inoko, H・Okada, E・Nishizaki, R・Shiota, T・Mok, J・Oka, A・Ohno, S・Mizuki, N.
  • Journal Title: Hum Genet 112 Pages: 151-157
  • Peer Reviewed
• [Journal Article] Human leukocyte antigen may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapy. (2007)
  • Author(s): Kano, T・Mori, T・Furudono, M・Ishikawa, H・Watanabe, H・Kikkawa, E・Warita, T・Onizuka, M・Takahashi, M・Maeda, Y・Naruse, T・Inoko, H・Kimura, A
  • Journal Title: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 58 Pages: 383-387
  • Peer Reviewed
• [Journal Article] Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients. (2007)
  • Author(s): Ito, A・Ota, M・Katsuyama, Y・Inoko, H・Ohno, S・Mizuki, N
  • Journal Title: Tissue Antigens 70 Pages: 423-426
  • Peer Reviewed
• [Journal Article] Association of autoimmune disease-related gene polymorphisms with chronic graft-versus-host disease. (2007)
  • Author(s): Shimada, M・Onizuka, M・Machida, S・Suzuki, R・Kojima, M・Miyamura, K・Kodera, Y・Inoko, H・Ando, K
  • Journal Title: Br J Haematol 139 Pages: 458-463
  • Peer Reviewed
• [Journal Article] A single nucleotide polymorphism analysis of the LAMAAl gene in Japanese patients with high myopia. (2007)
  • Author(s): Sasaki, S・Ota, M・Nishizuka, R・Okada, E・Mok, J・Kimura, T・Oka, A・Katsuyama, Y・Ohono, S・Inoko, H・Mizuki, N
  • Journal Title: Clinical Opthalmology 1 Pages: 289-295
  • Peer Reviewed
• [Journal Article] Lack of association with high myopia and the MYP2 locus in the Japanese population by high resolution analysis on chromosome 18. (2007)
  • Author(s): Yamane, T・Mok, J・Nishizuka, R・Oka, A・Nishizaki, R・Meguro, A・Yonemoto, J・Kulski, JK・Ohono, S・Inoko, H・Mizuki, N
  • Journal Title: Clinical Opthalmology 1 Pages: 311-316
  • Peer Reviewed
• [Journal Article] HLA-DPβ chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy. (2007)
  • Author(s): Shichi, D・Matsumori, A・Naruse, KT・Inoko, H・Kimura, A
  • Journal Title: Int J immunogenetics 35 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Association of Interleukin 17 F gene polymorphisms with chronic graft-versus-host disease. (2007)
  • Author(s): Toyosaki, M・Onizuka, M・Machida, S・Inoko, H, et. al.
  • Journal Title: BONE MARROW TRANSPLANTATION 41
  • Peer Reviewed
• [Journal Article] Association of the toll-like receptor4 gene polymorphisms with Behcet's disease. (2007)
  • Author(s): Meguro, A・Ota, M・Katsuyama, Y・Inoko, H, et. al.
  • Journal Title: ANNALS OF THE RHEUMATIC DISEASES 67(5) Pages: 725-725
  • Peer Reviewed
• [Journal Article] Identification of HLA allele mismatch combinations and amino acid substitiution positions associated with GVL effect after unrelated HSCT: Analysis from the Japan marrow donor program. (2007)
  • Author(s): Kawase, T・Matsuo, K・Kashiwase, K・Inoko, H, et. al.
  • Journal Title: BLOOD 110(11)
  • Peer Reviewed
• [Journal Article] Association of Fc receptor-like protein family with chronic graft-versus-host disease (2007)
  • Author(s): Onizuka, M・Toyosaki, M・Machida, S・Inoko, H, et. al.
  • Journal Title: BLOOD 110(11)
  • Peer Reviewed
• [Journal Article] Exploring genetic basis of GVHD by whole-genome association studies in a large series from the Japan marrow donation program (JMDP) (2007)
  • Author(s): Nannya, Y・Onizuka, M・Kashiwase, K・Inoko, H, et. al.
  • Journal Title: BLOOD 110(11)
  • Peer Reviewed
• [Journal Article] Genetic analysis of craniofacial traits in the medaka (2007)
  • Author(s): Kimura, T・Shimada, A・Sakai, N・Inoko, H, et. al.
  • Journal Title: GENETICS 177(4) Pages: 2379-2388
  • Peer Reviewed
• [Journal Article] Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances (2007)
  • Author(s): Ikewaki, N・Tamauchi, H・Inoko, H.
  • Journal Title: MICROBIOLOGY AND IMMUNOLOGY 51(12) Pages: 1189-1200
  • Peer Reviewed
• [Journal Article] High-risk HLA allele mismatch combinations responsible for severe acutegraft-versus-host disease and implication for its molecular mechanism. (2007)
  • Author(s): Kawase, T・Morishima, Y・Matsuo, K・Inoko, H, et. al.
  • Journal Title: BLOOD 110(7) Pages: 2235-2241
  • Peer Reviewed
• [Journal Article] Lack of association of Toll-like receptor 9 gene polymorphism with Behcet's disease in Japanese patients. (2007)
  • Author(s): Ito, A・Ota, M・Katsuyama, Y・Inoko, H, et. al.
  • Journal Title: TISSUE ANTIGENS 70(5) Pages: 423-426
  • Peer Reviewed
• [Journal Article] Immunological actions of Sophy beta-glucan (beta-1,3-1,6 glucan), currently available commercially as a health food supplement. (2007)
  • Author(s): Ikewaki, N・Fujii, N・Onaka, T, et. al.
  • Journal Title: MICROBIOLOGY AND IMMUNOLOGY 21(9) Pages: 861-873
  • Peer Reviewed
• [Journal Article] A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes. (2007)
  • Author(s): Dijkstra, JM・Katagiri, T・Hosomichi, K・Inoko, H, et. al.
  • Journal Title: IMMUNOGENETICS 59(4) Pages: 305-321
  • Peer Reviewed
• [Journal Article] Effects of a new immunosuppressive agent, beta-SQAG9, in swine kidney transplantation. (2007)
  • Author(s): Tanaka, T・Kitamura, H・Sahara, H・Inoko, H, et. al.
  • Journal Title: TRANSPLANT IMMUNOLOGY 18(1) Pages: 67-71
  • Peer Reviewed
• [Journal Article] Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease. (2007)
  • Author(s): Shiina, T・Briles WE・Goto, RM・Inoko, H, et. al.
  • Journal Title: JOURNAL OF IMMUNOLOGY 178(11) Pages: 7162-7172
  • Peer Reviewed
• [Journal Article] Genetic risk factors for post allogeneic HSCT complication among Japanese population. (2007)
  • Author(s): Onizuka, M・Shimada, M・Kojima, M・Inoko, H, et. al.
  • Journal Title: BONE MARROW TRANSPLANTATION 39
  • Peer Reviewed
• [Journal Article] Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (2007)
  • Author(s): Yasuno K, Ando S, Misumi S, Makino S, Kulski JK, Muratake T, Kaneko N, Amagane H, Someya T, Inoko H, Suga H, Kanemoto K, Tamiya G
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Pages: 1552-4841
• [Journal Article] Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis. (2007)
  • Author(s): Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, Kiyosawa K, Fukushima H, Bahram S, Inoko H, Kawa S
  • Journal Title: Immunogenetics 59 Pages: 45-52
• [Journal Article] One-step generation of recombineering constructs by asymmetric-end ligation and negative selection (2007)
  • Author(s): Ohtsuka M, Mizutani A, Kikuti YY, Kulski JK, Sato M, Kimura M, Tanaka M, Inoko H
  • Journal Title: Anal Biochem 360 Pages: 306-308
• [Journal Article] Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22 (2007)
  • Author(s): Kikuchi T, Naruse TK, Onizuka M, Li S, Kimura T, Oka A, Morishima Y, Kulski JK, Ichimiya S, Sato N, Inoko H
  • Journal Title: Immunogenetics 59 Pages: 99-108
• [Journal Article] A BAC-based contig map of the cynomolgus macaque (Macaca fascicularis) major histocompatibility complex genomic region. (2007)
  • Author(s): Watanabe A, Shiina T, Shimizu S, Hosomichi K, Yanagiya K, Kita YF, Kimura T, Soeda E, Torii R, Ogasawara K, Kulski JK, Inoko H
  • Journal Title: Genomics (2月掲載予定)
• [Journal Article] Regulation of CD93 cell surface expression by protein kinase C isoenzymes (2006)
  • Author(s): Ikewaki N, Kulski JK, Inoko H
  • Journal Title: MICROBIOLOGY AND IMMUNOLOGY 50(2) Pages: 93-103
  • NAID: 10017242915
• [Journal Article] Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease (2006)
  • Author(s): Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto N, Hattori N, Murata M, Toda T
  • Journal Title: Human Molecular Genetics 15(7) Pages: 1151-1158
• [Journal Article] Novel cynomolgus macaque MHC-DPB1 polymorphisms in three South-East Asian populations (2006)
  • Author(s): Sano K, Shiina T, Kohara S, Yanagiya K, Hosomichi K, Shimizu S, Anzai T, Watanabe A, Ogasawara K, Torii R, Kulski JK, Inoko H
  • Journal Title: TISSUE ANTIGENS 67(4) Pages: 297-306
• [Journal Article] Construction of mouse 129/Ola BAC library for targeting experiments using E14 embryonic stem cells (2006)
  • Author(s): Ohtsuka M, Ishii K, Kikuchi YY, Warita T, Suzuki D, Sato M, Kimura M, Inoko H
  • Journal Title: GENES ＆ GENETIC SYSTEMS 81 (2) Pages: 143-146
  • NAID: 10019162105
• [Journal Article] Four-digit allele genotyping of the HLA-A and HLA-B genes in Japanese patients with Behcet's disease by a PCR-SSOP-Luminex method (2006)
  • Author(s): Itoh Y, Inoko H, Kulski JK, Sasaki S, Meguro A, Takiyama N, Nishida T, Yuasa T, Ohno S, Mizuki N
  • Journal Title: TISSUE ANTIGENS 67(5) Pages: 390-394
• [Journal Article] Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey (2006)
  • Author(s): Luo MZ, Kim HR, Kudrna D, Sisneros NB, Lee SJ, Mueller C, Collura K, Zuccolo A, Buckingham EB, Grim SM, Yanagiya K, Inoko H, Shiina T, Flajnik MF, Wing RA, Ohta Y
  • Journal Title: BMC GENOMICS 7
• [Journal Article] Serotonin transporter gene promoter polymorphism and autism : A family-based genetic association study in Japanese population (2006)
  • Author(s): Koishi S, Yamamoto K, Matsumoto H, Koishi S, Enseki Y, Oya A, Asakura A, Aoki Y, Atsumi M, Iga T, Inomata J, Inoko H, Sasaki T, Nanba E, Kato N, Ishii T, Yamazaki K
  • Journal Title: BRAIN ＆ DEVELOPMENT 28 (4) Pages: 257-260
  • NAID: 10020331106
• [Journal Article] Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete {beta}-cell destruction in type 1 diabetes : longitudinal study of residual {beta}-cell function. (2006)
  • Author(s): Nakanishi K, Inoko H
  • Journal Title: Diabetes 55 Pages: 1862-1868
• [Journal Article] The Genomic Sequence and Analysis of the Swine Major Histocompatibility Complex. (2006)
  • Author(s): Renard C, Hart WE, Sehra HK, Beasley HR, Coggill PC, Howe KL, Harrow JL, Gilbert JGR, Sims S, Rogers JR, Ando A, Shigenar A, Shiina T, Inoko H, Chardon P, Beck S
  • Journal Title: Genomics 88 Pages: 96-110
• [Journal Article] Rapid evolution of MHC class I genes in primates generates new disease alleles in man via hitchhiking diversity. (2006)
  • Author(s): Shiina T, Ota M, Shimizu S, Katsuyama Y, Hashimoto N, Takasu M, Anzai T, Kulski JK, Kikkawa E, Naruse T, Kimura N, Yanagiya K, Watanabe A, Hosomichi K, Kohara S, Iwamoto C, Umehara Y, Meyer A, Wanner V, Sano K, Macquin C, Ikeo K, Tokunaga K, Gojobori T, Inoko H, Bahram S
  • Journal Title: Genitics 173 Pages: 1555-1570
• [Journal Article] Genomewide association analysis of human narcolepsy and a new resistance gene. (2006)
  • Author(s): Kawashima M, Tamiya G, Oka A, Hohjoh H, Juji T, Ebisawa T, Honda Y, Inoko H, Tokunaga K
  • Journal Title: Am J Hum Genet 79 Pages: 252-263
• [Journal Article] Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects. (2006)
  • Author(s): Hasumi Y, Inoko H, Mano S, Ota M, Okada E, Kulski JK, Nishizaki R, Mok J, Oka A, Kumagai N, Nishida T, Ohno S, Mizuki N
  • Journal Title: Immunogenetics 58 Pages: 947-953
• [Journal Article] The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken (2006)
  • Author(s): Hosomichi K, Shiina T, Suzuki S, Tanaka M, Shimizu S, Iwamoto S, Hara H, Yoshida Y, Kulski JK, Inoko H, Hanzawa K
  • Journal Title: BMC Genomics 7 Pages: 322-322
• [Journal Article] Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. (2006)
  • Author(s): Horie Y, Takemoto Y, Miyazaki A, Namba K, Kase S, Yoshida K, Ota M, Hasumi Y, Inoko H, Mizuki N, Ohno S
  • Journal Title: Molecular Vision 12 Pages: 1601-1605
  • NAID: 120000947113
• [Journal Article] マイクロサテライト多型とマイナー組織適合抗原 (2006)
  • Author(s): 鬼塚真仁, 菊池智樹, 李素雲, 猪子英俊
  • Journal Title: 分子細胞治療 5 Pages: 76-79
• [Journal Article] 比較ゲノム解析によるHLA領域の進化 (2006)
  • Author(s): 椎名隆, 猪子英俊
  • Journal Title: 分子細胞治療 6 Pages: 51-55
• [Journal Article] Whole genome association study of rheumatoid arthritis using 27, 039 microsatellites. (2005)
  • Author(s): Tamiya G, Shinya M, Imanish T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Gojobori T, Bahram S, Inoko H
  • Journal Title: Hum Mol Genetics 14 Pages: 2305-2321
• [Journal Article] Whole genome association study of rheumatoid arthritis using 27,039 microsatellites. (2005)
  • Author(s): Tamiya G et al.
  • Journal Title: Hum Mol Genetics 14 Pages: 2305-2321
• [Journal Article] The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III - class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. (2005)
  • Author(s): Shichi D et al.
  • Journal Title: Tissue Antigen 66 Pages: 200-208
• [Journal Article] MIC and other NKG2D ligands : from none to too many. (2005)
  • Author(s): Bahram S et al.
  • Journal Title: Curr Opin Immunol 17 Pages: 505-509
• [Journal Article] Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. (2005)
  • Author(s): Kulski JK et al.
  • Journal Title: J Mol Med 83 Pages: 964-975
• [Journal Article] HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushro. (2005)
  • Author(s): Suzuki K et al.
  • Journal Title: Tissue Antigens 65 Pages: 459-466
• [Journal Article] Genomic evolution of MHC class I region in primates. (2005)
  • Author(s): Fukami-Kobayashi K et al.
  • Journal Title: Proc Nat Acad Sci USA 102 Pages: 9230-9234
• [Journal Article] Genome-wide association studies define IL23R/IL12RB2 and IL10 as susceptibility loci for Behcet's disease.
  • Author(s): Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Okada T, Bahram S, 、Ishigatsubo Y, Inoko H
  • Journal Title: Nature Genetics (in press)
• [Presentation] 予防医学におけるHLAと疾患発症機構の因果関係 (2009)
  • Author(s): 猪子英俊
  • Organizer: 第42回中国四国医学検査学会
  • Place of Presentation: 高松
  • Year and Date: 2009-10-31
• [Presentation] Identification of NFKBIL1 as a susceptible locus of rheumatoid arthritis by genome- wide association using microsatellites and its functional analysis in steoclastogenesis. (2009)
  • Author(s): Inoko H
  • Organizer: Simposium in the10th Congress of International Ocular Inflammation Society
  • Year and Date: 2009-06-02
• [Presentation] Identification of NFKBIL 1 as a susceptible locus of rheumatoid arthritis by genome- wide association using microsatellites and its functional analysis in steoclastogenesis. (2009)
  • Author(s): Inoko H
  • Organizer: Simposium "Pathogenesis and epidemiology of lntgraocular inflammation" The 10th Congress of International Ocular lnflammation Society
  • Place of Presentation: チェコ(プラハ)
  • Year and Date: 2009-06-02
• [Presentation] 漢方医学教員養成のための4大学連携によるシステムの構築 (2009)
  • Author(s): 猪子英俊
  • Organizer: 漢方メディカルシンポジウム2009
  • Place of Presentation: 東京
  • Year and Date: 2009-02-07
• [Presentation] HLAの多型性とその生物学的意義 (2009)
  • Author(s): 猪子英俊
  • Organizer: 第1回移植免疫を学ぶ会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-01-30
• [Presentation] ゲノム医学と生活習慣病関連遺伝子の探索 (2009)
  • Author(s): 猪子英俊
  • Organizer: 第15回湘南医学研究会
  • Place of Presentation: 武田クリニック
  • Year and Date: 2009-01-16
• [Presentation] HLA領域の遺伝子構造解析と疾患関連解析 (2009)
  • Author(s): 猪子英俊、細道一善、椎名隆、井ノ上逸朗
  • Organizer: 第18回日本組織適合性学会
  • Place of Presentation: 名古屋
• [Presentation] HLA領域のパーソナルゲノム解析法の開発 (2009)
  • Author(s): 細道一善、猪子英俊、河田寿子、井ノ上逸朗、椎名隆
  • Organizer: 第18回日本組織適合性学会
  • Place of Presentation: 名古屋
• [Presentation] プラスチック基板上での等温増幅反応によるHLAタイピング (2009)
  • Author(s): 奥平裕子、光永滋樹、山口香織、吉川枝里、岡晃、猪子英俊
  • Organizer: 第18回日本組織適合性学会
  • Place of Presentation: 名古屋
• [Presentation] Target transgenesis through pronuclear injection. (2009)
  • Author(s): 大塚正人、三浦浩美、荻原早苗、木村穣、猪子英俊
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Validation of artificial miRNA expression vectors for generation of knockdown mice. (2009)
  • Author(s): 三浦浩美、猪子英俊、木村穣、大塚正人
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] MHC研究の歴史～過去、現在そして未来 (2009)
  • Author(s): 猪子英俊
  • Organizer: 第7回最先端遺伝育種セミナー講演
  • Place of Presentation: 筑波
• [Presentation] HLA多型の魅カー疾患解析のモデル領域 (2009)
  • Author(s): 猪子英俊
  • Organizer: 第54回日本人類遺伝学会招待講演
  • Place of Presentation: 高輪
• [Presentation] 鳥類細胞を用いた環境汚染物質の比較免疫学的研究 (2008)
  • Author(s): 井関直政、椎名隆、割田貴之、木村譲、猪子英俊、その他
  • Organizer: 2008分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] ベーチェット病感受性ゲノム領域に位置するTRIM遺伝子群のSNP関連解析 (2008)
  • Author(s): 倉田里穂、斉藤卓磨、細道一善、目黒明、猪子英俊、その他
  • Organizer: 2008分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Presentation] 医療の中で活用される遺伝子解析 (2008)
  • Author(s): 猪子英俊
  • Organizer: 東洋医学セミナー市民公開講座
  • Place of Presentation: 小田急ホテルセンチルー相模大界
  • Year and Date: 2008-11-29
• [Presentation] Loop-Mediated Isothermal Amplifica Hon法によるambiguhy解決の可能性 (2008)
  • Author(s): 清水佐良子、光永滋樹、吉川枝里、岡晃、猪子英
  • Organizer: 第17回日本組織適合性学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-21
• [Presentation] SLAハプロタイプ固定近交系デュロックブタにおける抗体産生 (2008)
  • Author(s): 安藤麻子、今枝紀明、吉岡豪、岡本宏明、猪子英俊、その他
  • Organizer: 第17回日本組織適合性学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-21
• [Presentation] 日本人サルコイドーシスにおけるBTNL2遺伝子多型の解析 (2008)
  • Author(s): 目黒明、石原麻美、勝山善彦、南田研一、蕪城俊克、猪子英俊、その他
  • Organizer: 第17回日本組織適合性学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2008-09-20
• [Presentation] 生活習慣病などの難病の発症に関わる遺伝子群による罹患予測、及び機能解析による創薬の標的の絞り込み (2008)
  • Author(s): 猪子英俊
  • Organizer: 2008年度健康食品管理士会近畿支部講演会
  • Place of Presentation: 神戸学院大学ポートアイランドキャンパス
  • Year and Date: 2008-05-25
• [Presentation] ほ乳類の主要組織適合遺伝子複合体(MHC)領域における比較ゲノム解析 (2008)
  • Author(s): 椎名隆、細道一善、北夕紀、井関直政、猪子英俊、その他
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] mt DNAを用いた軟骨魚類の網羅的分子進化系統樹解析 (2008)
  • Author(s): 河野あつみ、椎名隆、田中彰、猪子英俊
  • Organizer: 日本進化学会2008年大会
  • Place of Presentation: 東京大学駒場キャンパス
• [Presentation] オキゴンドウMHC領域のゲノム配列決定と比較ゲノム解析 (2008)
  • Author(s): 渡辺舞、細道一善、野口英樹、黒木陽子、猪子英俊、その他
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] ニワトリMHC領域におけるゲノム多様性 (2008)
  • Author(s): 細道一善、鈴木進悟、Ronald M Goto、西堀正英、猪子英俊、その他
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] カニクイザル3集団における主要組織適合遺伝子複合体クラス1遺伝子(Mafa-A)の多型解析とHLA-Aとの比較 (2008)
  • Author(s): 北夕紀、椎名隆、小原栄、小笠原一誠、猪子英俊、その他
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] リウマチモデルカニクイザル作製のための新規マーカーの探索 (2008)
  • Author(s): 小原栄、北夕紀、賓来直人、葛西勇人、鵜藤雅裕、猪子英俊、その他
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] RMCE 法を介入して最終的にmarker-freeな遺伝子導入を行う新手法の開発 (2007)
  • Author(s): 大塚正人、荻原早苗、今井賢治、猪子英俊
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会 合同大会(Biochemistry and Molecular Bioiogy)
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-12-11
• [Presentation] パーキンソン病のゲノムワイド関連解析 (2007)
  • Author(s): 戸田達史、佐竹渉、水田依久子、山本光利、猪子英俊、服部信孝、村田美穂
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会 合同大会(Biochemistry and Molecular Bioiogy)
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-12-11
• [Presentation] マイクロサテライトマーカーを用いたゲノムワイド関連解析により同定された心筋梗塞感受性遺伝子座Ml-1の解析 (2007)
  • Author(s): 日野原邦彦、安波道郎、柴田宏樹、高橋弓子、高橋めぐみ、有村卓朗、宝田茂、笹岡大史、山本健、猪子英俊、山田芳司、和泉徹、中島敏昌、木村影方
  • Organizer: 第30回日本分子生物学会・第80回日本生化学会 合同大会(Biochemistry and Molecular Bioiogy)
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2007-12-11
• [Presentation] ヒト生活習慣病の発症に関わる遺伝子の探索とその意義 (2007)
  • Author(s): 猪子英俊
  • Organizer: 第58回日本染色体学会、第17回染色体コロキウム2007年合同大会ワークショップ
  • Place of Presentation: 葉山
  • Year and Date: 2007-11-28
• [Presentation] 3万個のマイクロサテライト多型を用いたゲノムワイド関連解析 (2007)
  • Author(s): 猪子英俊
  • Organizer: 第52回日本人類遺伝学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-13
• [Presentation] 事後同組成に基づく集団を用いた連鎖解析 (2007)
  • Author(s): 間野修平、遠藤高帆、岡晃、猪子英俊
  • Organizer: 第52回日本人類遺伝学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-09-13
• [Presentation] HLA-DP遺伝子はC型肝炎ウィルス陽性肥大型心筋症と関連する (2007)
  • Author(s): 志知大輔、松森昭、高橋めぐみ、成瀬妙子、猪子英俊、木村影方
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] 造血肝細胞移植成績におよぼす薬剤代謝遺伝子多型の検討 (2007)
  • Author(s): 國井七絵、鬼塚真二、安藤潔、猪子英俊
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] Luminex法を用いたプタMHC-DQB1タイピング法の開発 (2007)
  • Author(s): 安藤麻子、重成敦子、佐藤崇、島田和典、河田寿子、太田正穂、佐田正晴、永谷憲歳、猪子英俊
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] 等温増幅によるHLAのDNAタイピング法の検討 (2007)
  • Author(s): 清水佐良子、吉川枝里、平田浩司、光永滋樹、森川賓、猪子英俊
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] 新たに見出されたHLA-B遺伝子型について (2007)
  • Author(s): 重成敦子、吉川枝里、杉本達哉、土田文子、佐藤薫、吉場史朗、加藤俊一、猪子英俊
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] MHC多型解析によるペンギン類6500万年の進化の足跡-ガラパゴスペンギンDRB様遺伝子多型 (2007)
  • Author(s): 津田とみ、吉川枝里、G 町 Miller 、成瀬妙子、炭山大輔、津田道雄、福田道雄、栗田正徳、村田浩一、猪子英俊
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] 主要組織適合遺伝子複合体(MHC)領域におけるニワトリを含む脊椎動物の間の比較ゲノム解析 (2007)
  • Author(s): 椎名隆、細道一善、北タ紀、渡辺舞、河野あづみ、倉田里穂、柴原悠、佐藤和広、金藤聡美、猪子英俊
  • Organizer: 日本比較免疫学会第19回学術集会シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2007-08-22
• [Presentation] Genome-wide scan of genes for Multi-Factorial Diseases such as common diseases by association analysis using microsatellites (2007)
  • Author(s): 猪子英俊
  • Organizer: 第30回心筋代謝研究会
  • Place of Presentation: 京都
  • Year and Date: 2007-07-14
• [Presentation] シックハウス症候群における Neuropathy Target Esterase(NTE)酵素活性および遺伝子多型 (2007)
  • Author(s): 松坂恭成、津田道雄、大久保朋一、菊池イアーラ幸江、青山美子、角田和彦、坂部貢、猪子英俊、石川哲、木村穣
  • Organizer: 第16回日本臨床環境医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-07
• [Presentation] 生活習慣病のヒトゲノム多様性解析とテーラーメイド医療、ヒトゲノムと疾患-テーラーメイド医療に向けて-シンポジウム基調講演 (2007)
  • Author(s): 猪子英俊
  • Organizer: 第27回日本医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-06
• [Presentation] ヒトNFkBILI遺伝子導入マウスにおけるコラーゲン誘導関節炎(CIA)の抑制効果の検討 (2007)
  • Author(s): 松坂恭成、割田貴之、佐藤健人、中村雅登、猪子英俊、木村穣
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 主要組織適合遺伝子複合体(MHC)領域における比較ゲノム解析 (2007)
  • Author(s): 椎名隆、細道一善、北タ紀、渡混舞、河野あづみ、倉田里穂、柴原悠、佐藤和広、金藤聡美、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] カニクイザルMHC領域に位置するTRIM遺伝子群の多型解析 (2007)
  • Author(s): 倉田里穂、椎名隆、細道一善、金藤聡美、鳥居隆三、小笠原一誠、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] コモンマーモセットMHC領域における比較ゲノム解析 (2007)
  • Author(s): 河野あづみ、椎名隆、小原栄、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 集団遺伝学的方怯によるハンドウイルカ1郡内の親子関係の解析 (2007)
  • Author(s): 北夕紀、渡退舞、田中歩、大泉宏、椎名隆、猪子英俊、岩崎俊秀、田中彰
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] ニワトリMHC領域におけるゲノム多様性 (2007)
  • Author(s): 細道一善、椎名隆、鈴木進悟、Ronald, Goto 、西堀正英、半深恵、Mareia, M, MIUer 、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] プラスチック基板上での等温増幅法を用いた遺伝子多型の検出法の検討 (2007)
  • Author(s): 清水佐良子、光永滋樹、杏藤晋、藤本健太郎、横山兼久、木下健司、藤原一彦、田中正史、森川賓、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] PCR-SSOP-Luminex法によるブタMHC-DRB1,DQB1タイピング法の検討 (2007)
  • Author(s): 安藤麻子、重成敦子、佐藤崇、島田和典、河田寿子、太田正穂、佐田正晴、永谷憲歳、上西博英、猪子英俊
  • Organizer: 第30回日本分子生物学会、第80回日本生化学会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Genome-wide scan of disease gene by association analysis using 30, 000 microsatellites. (2006)
  • Author(s): Inoko H
  • Organizer: The 8th International Meeting on Human Genome Variation on Complex Genome Analysis
  • Year and Date: 2006-09-15
• [Book] 免疫の進化(副題 : シクロスポリン20年の軌跡)(シクロスポリン学術国際シンポジウム編)、Behcet病に対するシクロスポリン治療 (2006)
  • Author(s): 大野重昭, 北市伸義, 南場研一, 猪子英俊, 水木信久, 太田正穂
  • Publisher: 医薬ジャーナル社
• [Book] 予防医学事典(松島綱治、酒井敏行、石川昌、稲寺秀邦編) (2005)
  • Author(s): 佐々木佳奈, 猪子英俊
  • Total Pages: 494
  • Publisher: 朝倉書店
• [Remarks] ホームページ:http://inoko. med. u-tokai. ac. jp 3万個のマイクロサテライトの位置、PCRプライマー、多型頻度などの情報に関するデータベース:
  • URL: http://www.jbirc.aist.go.jp/gdbs
• [Remarks] 3万個のマイクロサテライトの位置、PCRプライマー、多型頻度などの情報に関するデータベース
  • URL: http://www.jbirc.aist.go.jp/gdbs
• [Remarks] 研究室のweb site
  • URL: http://mls.med.u-tokai.ac.jp/
• [Remarks] 研究室のweb site
• [Remarks]
  • URL: http://mls.med.u-tokai.ac.jp/
• [Patent(Industrial Property Rights)] 抗菌剤 (2010)
  • Inventor(s): 猪子英俊、良原栄策、光永滋樹
  • Industrial Property Rights Holder: 東海大学
  • Filing Date: 2010-02-26
• [Patent(Industrial Property Rights)] 抗グラム陰性菌剤 (2009)
  • Inventor(s): 猪子英俊、良原栄策、光永滋樹
  • Industrial Property Rights Holder: 東海大学
  • Filing Date: 2009-06-16
• [Patent(Industrial Property Rights)] 尋常性乾癬検査用マーカー遺伝子 (2008)
  • Inventor(s): 猪子英俊、岡晃
  • Industrial Property Rights Holder: 東海大学、ジェノダイブファーマ
  • Filing Date: 2008-01-25
• [Patent(Industrial Property Rights)] 摂食障害の検査用マーカー遺伝子 (2006)
  • Inventor(s): 猪子英俊, 白澤専二
  • Industrial Property Rights Holder: 東海大学
  • Filing Date: 2006-07-25
• [Patent(Industrial Property Rights)] 高血圧症の検査用マーカー遺伝子 (2005)
  • Inventor(s): 猪子 英俊 他
  • Industrial Property Rights Holder: 東海大学 他
  • Industrial Property Number: 2005-267657
  • Filing Date: 2005
  • Acquisition Date: 2005-08-21