Integrative approach for the cortical control of eye and hand movements
Project/Area Number |
17021041
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Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | National Institute for Physiological Sciences |
Principal Investigator |
ISA Tadashi National Institute for Physiological Sciences, 発達生理学研究系, 教授 (20212805)
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Co-Investigator(Kenkyū-buntansha) |
ENDO Toshiaki 生理学研究所, 発達生理学研究系, 助手 (30353436)
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Project Period (FY) |
2005 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥49,500,000 (Direct Cost: ¥49,500,000)
Fiscal Year 2009: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2008: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2007: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2006: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2005: ¥9,900,000 (Direct Cost: ¥9,900,000)
|
Keywords | 大脳皮質 / 上丘 / 皮質脊髄路 / 脊髄固有細胞 / サッケード / 精密把持 / サル / 盲視 / 眼球サッケード運動 / 作業記憶 / 視覚的意識 / 単一神経細胞活動記録 / 脊髄損傷 / 運動野 / 霊長類 / 遺伝子発現 / 可塑性 / リハビリテーション / サッケード運動 / 上肢運動 / 電気生理学 / 運動学習 / 脳損傷後機能代償 / 上肢到達運動 |
Research Abstract |
After the lesion of the primary visual cortex, visually guided saccadic eye movements towards the targets presented in the affected visual field recovers within 1-2 months in monkeys. After the recovery, the visual signal is processed mainly by the superior colliculus (SC). Under particular circumstances, the direct visual inputs from the retina to the superficial layer of the SC can directly activate the neurons in the intermediate layer of the SC and then the further activation of the saccade generator circuits downstream in the brainstem triggers ultra-short latency saccades named express saccades. After the lesion of the direct cortico-motoneuronal connections from the primary motor cortex to hand motoneurons, dexterous finger movements are once impaired but recover through training within 1-2 months in monkeys. Such recovery is contributed by the indirect cortico-motoneuronal pathway mediated by propriospinal neurons located a few segments rostral to motoneurons.
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Report
(6 results)
Research Products
(115 results)
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[Journal Article] Mice with altered myelin proteolipid protein gene expression show schizophrenia-related behavior accompanied by abnormal neuron-glial interaction and conduction velocity2009
Author(s)
Tanaka H, Tanaka K, Ma J, Isa T, Tanda K, Miyakawa T, Suzuki A, Ishibashi T, Baba H, Shigemoto R, Ono K, Ikenaka K
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Journal Title
Journal of Neuroscience 29
Pages: 8363-8371
Related Report
Peer Reviewed
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[Journal Article] Differentially expressed genes among motor and prefrontal areas of macaque neocortex.2007
Author(s)
Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Sai to K, Tsuboi F, Takahashi M, Isa T, Kojima T
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Journal Title
Biochemical and Biophysical Research Communications 362
Pages: 665-669
Related Report
Peer Reviewed
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[Presentation] 損傷脳の生存戦略2008
Author(s)
伊佐正
Organizer
第16回「脳の世紀」シンポジウム
Place of Presentation
有楽町朝日ホール
Year and Date
2008-09-04
Related Report
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[Presentation] 損傷脳の生存戦略2008
Author(s)
伊佐正
Organizer
国立精神・神経センター神経研究所研究所セミナー
Place of Presentation
国立精神・神経センター
Year and Date
2008-07-22
Related Report
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[Presentation] Time-Dependent Central Compensatory Mechanisms of Finger Dexterity after Spinal Cord Injury.2008
Author(s)
Nishimura, Y, Onoe, H. (RIKEN), Morichika, Y., Perfiliev, S., Tukada, H., Isa, T.
Organizer
The 12th Conference of Peace through Mind/Brain Science
Place of Presentation
Hamamatsu
Year and Date
2008-02-06
Related Report
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