Molecular mechanism of the qualify control of proteins

• Project/Area Number: 17028032
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: TOHYAMA Masaya Osaka University, Graduate school of medicine, Professor (40028593)
• Co-Investigator(Kenkyū-buntansha): MORI Yasutake Osaka university, Graduate school of medicine, Associate Professor (00343252) ; INOUE Kiyoshi Osaka university, Graduate school of medicine, Assistant Professor (20342719) ; MATSUZAKI Shinsuke Osaka university, Graduate school of medicine, Assistant Professor (60403193)
• Project Period (FY): 2002 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥49,200,000 (Direct Cost: ¥49,200,000); Fiscal Year 2006: ¥24,600,000 (Direct Cost: ¥24,600,000); Fiscal Year 2005: ¥24,600,000 (Direct Cost: ¥24,600,000)
• Keywords: endoplasmic reticulume (ER) / ER stress / caspase-4 / Alzheimer's disease (AD) / HMGAla / presenilin-2 splice valiants (PS2V) / cell death / therapy / アルツハイマー病 / 蛋白質品質管理機構 / カスペース4 / カスペース3 / カスペース9 / チトクロームC / プレセニリン1変異体 / 神経細胞死 / プレセニリン2スプライシング変種

Research Abstract

In this research, we examined the involvement of to the endoplasmic reticulum (ER) stress in both familial and sporadic Alzheimer's disease (AD). As the resulrts, we showed that familial AD-linked presenilin-1 (PS1) mutation induced the fragility to the ER stress and that one of the presenilin-2 (PS2) splice valiants (PS2V), which were observed in the sporadic AD patient brains, also caused the fragility to the ER stress. Further studies elucidated that hydroxy radicals caused by hypoxia, metals, etc. induced HMGAla protein resulting in the aberrant splicing variant (PS2V). These results suggest the inhibition of HMGAla protein as the new therapy for sporadic AD. Next, we investigated the apoptosis pathway under the ER stress and found that caspase-4 mediates ER stress induced- and β-amyloid induced-apoptotic signaling in human cells. These results suggest the involvement of ER stress and caspase-4 in the cell death observed in AD. Thus, we studied the activation of caspase-4 in the familial AD-linked PS1 mutation (ΔE9). Cleavage of caspase-4 under ER stress was enhanced by the overexpression of the familial AD-linked mutation (ΔE9), showing that caspase-4 is a key caspase involved in the apoptotic signaling of AD. We also showed that the overexpression of caspase-4 induced cleavage of caspase-9 and caspase-3 without releasing cytochrome-c from the mitochondria. These results also suggest that the regulation of activated caspase-4 should be one of the new therapies for AD.

Research Products

• [Journal Article] A novel DISC1-interacting partner DISC1-Binding Zincfinger protein: implication in the modulation of )DISC1-dependent neurite outgrowth (2007)
  • Author(s): Hattori T, Baba K, Matsuzaki S, Honda A, Miyoshi K, Inoue K, Taniguchi M, Hashimoto H, Shintani N, Baba A, Shimizu S, Yukioka F, Kumamoto N, Yamaguchi A, Tohyama M, Katayama T
  • Journal Title: Molecular Psychiatry; 12(4) Pages: 398-407
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel DISCI-interacting partner DISCI-Binding Zincfinger protein : implication in the modulation of DISC1-dependent neurite outgrowth (2007)
  • Author(s): Hattori T, Baba K, Matsuzaki S, Honda A, Miyoshi K, Inoue K, Taniguchi M, Hashimoto H, Shintani N, Baba A, Shimizu S, Yukioka F, KumamotoN, Yamaguchi A, Tohyama M, Katayama T
  • Journal Title: Molecular Psychiatry 12(4) Pages: 398-407
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of pericentrin isoforms in vivo. (2006)
  • Author(s): Miyoshi K, Asanuma M, Miyazaki l, Matsuzaki S, Tohyama M, Ogawa N.
  • Journal Title: Biochem Biophys Res Commun 351(3) Pages: 745-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A secreted type of beta 1, 6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase. (2006)
  • Author(s): Nakahara s, Saito T, Kondo N, Moriwaki K, Noda K, Ihara S, Takahashi M, Ide Y, Gu J, Inohara H, Katayama T, Tohyama M, Kubo T, Taniguchi N, Miyoshi E.
  • Journal Title: FASEB J. 20(14) Pages: 2451-2459
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina. (2006)
  • Author(s): Okuda H, Manabe T, Yanagita T, Matsuzaki S, Bando Y, Katayama T, Wanaka A, Tohyama M.
  • Journal Title: Mol Cell Neurosci. 33(1) Pages: 81-87
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Immunohistochemical and western analyses of protein arginine N-methyltransferase 3 in the mouse brain. (2006)
  • Author(s): Ikenaka K, Miyata S, Mori Y, Koyama Y, Taneda T, Okuda H, Kousaka A, Tohyama M.
  • Journal Title: Neuroscience. 141(4) Pages: 1971-1982
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. (2006)
  • Author(s): Matsuda S, Gomi F, Katayama T, Koyama Y, Tohyama M, Tano Y.
  • Journal Title: Jpn J Ophthalmol. 50(3) Pages: 229-234
  • NAID: 10020385539
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. (2006)
  • Author(s): Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 345(2) Pages: 904-909
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress. (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. 344(2) Pages: 525-530
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Progressive hearing loss in mice carrying a mutation in the p75 gene. (2006)
  • Author(s): Sato T, Doi K, Taniguchi M, Yamashita T, Kubo T, Tohyama M.
  • Journal Title: Brain Res. 1091(1) Pages: 224-234
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] p21Cip1/WAF1 regulates radial axon growth and enhances motor functional recovery inthe injured peripheral nervous system. (2006)
  • Author(s): Tomita K, Kubo T, Matsuda K, Madura T, Yano K, Fujiwara T, Tanaka H, Tohyama M, Hosokawa K.
  • Journal Title: Brain Res. 1081(1) Pages: 44-52
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CARM1 regulates proliferation of PC12 cells by methylating HuD. (2006)
  • Author(s): Fujiwara T, Mori Y, Chu DL, Koyama Y, Miyata s, Tanaka H, YachiK, Kubo T, Yoshikawa H, Tohyama M.
  • Journal Title: Mol Cell Biol. 26(6) Pages: 2273-2285
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of pericentrin isoforms in vivo. (2006)
  • Author(s): Miyoshi K, Asanuma M, Miyazaki I, Matsuzaki S, Tohyama M, Ogawa N.
  • Journal Title: Biochem Biophys Res Commun 345(2) Pages: 904-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase. (2006)
  • Author(s): Nakahara S, Saito T, Kondo N, Moriwaki K, Noda K, Ihara S, Takahashi M, Ide Y, Gu J, Inohara H, Katayama T, Tohyama M, Kubo T, Taniguchi N, Miyoshi E.
  • Journal Title: FASEB J. 20(14) Pages: 2451-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel interaction between HMGAla and StIPl in murine terminally differentiated retina. (2006)
  • Author(s): Okuda H, Manabe T, Yanagita T, Matsuzaki S, Bando Y, Katayama T, Wanaka A, Tohyama M.
  • Journal Title: Mol Cell Neurosci. 33(1) Pages: 81-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. 344(2) Pages: 525-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] p21Cipl/WAFl regulates radial axon growth and enhances motor functional recovery in the injured peripheral nervous system. (2006)
  • Author(s): Tomita K, Kubo T, Matsuda K, Madura T, Yano K, Fujiwara T, Tanaka H, Tohyama M, Hosokawa K.
  • Journal Title: Brain Res. 1081(1) Pages: 44-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CARM1 regulates proliferation of PC12 cells by methylating HuD. (2006)
  • Author(s): Fujiwara T, Mori Y, Chu DL, Koyama Y, Miyata S, Tanaka H, Yachi K, Kubo T, Yoshikawa H, Tohyama M.
  • Journal Title: Mol Cell Biol. 26(6) Pages: 2273-85
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A secreted type of betal,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase. (2006)
  • Author(s): Nakahara S, Saito T, Kondo N, Moriwaki K, Noda K, Ihara S, Takahashi M, Ide Y, Gu J, Inohara H, Katayama T, Tohyama M, Kubo T, Taniguchi N, Miyoshi E
  • Journal Title: FASEB J. 20(14) Pages: 2451-2459
• [Journal Article] Novel interaction between HMGAla and StIP1 in murine terminally differentiated retina. (2006)
  • Author(s): Okuda H, Manabe T, Yanagita T, Matsuzaki S, Bando Y, Katayama T, Wanaka A, Tohyama M
  • Journal Title: Mol Cell Neurosci 33(1) Pages: 81-87
• [Journal Article] Immunohistochemical and western analyses of protein arginine N-methyltransferase 3 in the mouse brain. (2006)
  • Author(s): Ikenaka K, Miyata S, Mori Y, Koyama Y, Taneda T, Okuda H, Kousaka A, Tohyama M
  • Journal Title: Neuroscience 141(4) Pages: 1971-1982
• [Journal Article] Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. (2006)
  • Author(s): Matsuda S, Gomi F, Katayama T, Koyama Y, Tohyama M, Tano Y
  • Journal Title: Jpn J Ophthalmol 50(3) Pages: 229-234
  • NAID: 10020385539
• [Journal Article] Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. (2006)
  • Author(s): Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M
  • Journal Title: Biochem Biophys Res Commun 345(2) Pages: 904-909
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress. (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
  • Journal Title: Biochem Biophys Res Commun. 344(2) Pages: 525-530
• [Journal Article] CARM1 regulates proliferation of PC12 cells by methylating HuD. (2006)
  • Author(s): Fujiwara T., Mori Y., Chu DL., Koyama Y., Miyata S., Tanaka H., Yachi K., Kubo T., Yoshikawa H., Tohyama M.
  • Journal Title: Mol.Cell.Biol. (In press)
• [Journal Article] Local protein synthesis by BDNF is potentiated in hippocampal neurons exposed to ephrins. (2005)
  • Author(s): Miyata S, Mori Y, Fujiwara T, Ikenaka K, Matsuzaki S, Oono K, Katayama T, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 134(2) Pages: 333-337
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart. (2005)
  • Author(s): Aleshin AN, Sawa Y, Kitagawa-Sakakida S, Bando Y, Ono M, Memon IA, Tohyama M, Ogawa S, Matsuda H.
  • Journal Title: J Mol Cell Cardiol. 38(3) Pages: 517-25
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. (2005)
  • Author(s): Matsuda S, Gomi F, Oshima Y, Tohyama M, Tano Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 46(3) Pages: 1062-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] RA410/Sly1 suppresses MPP+and 6-hydroxydopamine-induced cell death in SH-SY5Y cells. (2005)
  • Author(s): Bando Y, Katayama T, Taniguchi M, Ishibashi T, Matsuo N, Ogawa s, Tohyama M.
  • Journal Title: Neurobiol Dis. 18(1) Pages: 143-51
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line. (2005)
  • Author(s): Yanagita T, Manabe T, Okuda H, Matsuzaki S, Bando Y, Katayama T, Tohyama M.
  • Journal Title: Neurosci Lett. 374(1) Pages: 47-52
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor reduced and connective tissue growth fact or induced by triamcinolone in ARPE19 cells under oxidative stress. (2005)
  • Author(s): Matsuda S, Gomi F, Oshima Y, Tohyama M, Tano Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 46(3) Pages: 1062-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] RA410/Slyl suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells. (2005)
  • Author(s): Bando Y, Katayama T, Taniguchi M, Ishibashi T, Matsuo N, Ogawa S, Tohyama M.
  • Journal Title: Neurobiol Dis. 18(1) Pages: 143-51
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Local protein synthesis by BDNF is potentiated in hippocampal neurons exposed to ephrins (2005)
  • Author(s): Miyata S., Mori Y., Fujiwara T., Ikenaka K., Matsuzaki S., Oono K., Katayama T., Tohyama M.
  • Journal Title: Brain Res.Mol.Brain Res. 134 Pages: 333-337
• [Journal Article] Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. (2005)
  • Author(s): Bando Y, Onuki R, Katayama T, Manabe T, Kudo T, Taira K, Tohyama M.
  • Journal Title: Neurochem Int. 46 Pages: 11-18
• [Journal Article] RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells. (2005)
  • Author(s): Bando Y, Katayama T, Taniguchi M, Ishibashi T, Matsuo N, Ogawa S, Tohyama M.
  • Journal Title: Neurobiol Dis 18 Pages: 143-151
• [Journal Article] Vascular Endothelial Growth Factor Reduced and Connective Tissue Growth Factor Induced by Triamcinolone in ARPE19 Cells under Oxidative Stress. (2005)
  • Author(s): Matsuda S, Gomi F, Oshima Y, Tohyama M, Tano Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 46 Pages: 1062-1068
• [Journal Article] Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. (2005)
  • Author(s): Fujitani M, Honda A, Hata K, Yamagishi S, Tohyama M, Yamashita T.
  • Journal Title: Biochem Biophys Res Commun. 327 Pages: 150-154
• [Journal Article] Chimaerins act downstream from neurotrophins in overcoming the inhibition of neuriteout growth produced by myelin-associated glycoprotein. (2004)
  • Author(s): Mizuno T, Yamashita T, Tohyama M.
  • Journal Title: J Neurochem. 91(2) Pages: 395-403
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of neuronal death by ER stress in Alzheimer's disease. (2004)
  • Author(s): Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M.
  • Journal Title: J Chem Neuroanat. 28(1-2) Pages: 67-78
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] JAB1 participates in unfolded protein responses by association and dissociation with IRE1. (2004)
  • Author(s): Oono K, Yoneda T, Manabe T, Yamagishi S, Matsuda S, Hitomi I Miyata S, Mizuno T, Imaizumi K, Katayama T, Tohyama M.
  • Journal Title: Neurochem Int. 765-72 Pages: 765-72
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytoplasmic p21(Cip1/WAF1)enhances axonal regeneration and functional recovery after spinal cord injury in rats. (2004)
  • Author(s): Tanaka H, Yamashita T, Yachi K, Fujiwara T, Yoshikawa H, TohyamaM.
  • Journal Title: Neuroscience. 127(1) Pages: 155-64
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis. (2004)
  • Author(s): Bando Y, Katayama T, Aleshin AN, Manabe T, Tohyama M.
  • Journal Title: Apoptosis. 9(4) Pages: 501-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. (2004)
  • Author(s): Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, lmaizumi K, Tsujimoto Y, Tohyama M.
  • Journal Title: J Cell Biol. 165(3) Pages: 347-56
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Novel function of PS2V : change in conformation of tau proteins. (2004)
  • Author(s): Nishikawa A, Manabe T, Katayama T, Kudo T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 318(2) Pages: 435-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Activation of Rho in the injured axons following spinal cord injury・ (2004)
  • Author(s): Madura T, Yamashita T, Kubo T, Fujitani M, Hosokawa K, Tohyama M.
  • Journal Title: EMBO Rep. 5(4) Pages: 412-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of ARF4L in recycling between endosomes and the plasma membrane. (2004)
  • Author(s): Katayama T, Imaizumi K, Yoneda T, Taniguchi M, Honda A, Manabe T, Hitomi J, Oono K, Baba K, Miyata S, Matsuzaki S, Takatsuji K, Tohyama M.
  • Journal Title: Cell Mol Neurobiol. Pages: 137-47
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nervet ransection. (2004)
  • Author(s): Madura T, Yamashita T, Kubo T, Tsuji L, Hosokawa K, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 123(1-2) Pages: 76-80
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. (2004)
  • Author(s): Hitomi J, Katayama T, Taniguchi M, Honda A, Imaizumi K, Tohyama M.
  • Journal Title: Neurosci Lett. 357(2) Pages: 127-30
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Metals accelerate production of the aberrant splicing isoform of the presenilin-2. (2004)
  • Author(s): Matsuzaki S, Manabe T, Katayama T, Nishikawa A, Yanagita T, OkudaH, Yasuda Y, Miyata S, Meshitsuka S, Tohyama M.
  • Journal Title: J Neurochem. 88(6) Pages: 1345-51
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotesneurite outgrowth. (2004)
  • Author(s): Tsuji L, Yamashita T, Kubo T, Madura T, Tanaka H, Hosokawa K, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 313(4) Pages: 1086-91
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chimaerins act downstream from neurotrophins in overcoming the inhibition of neurite outgrowth produced by myelin-associated glycoprotein. (2004)
  • Author(s): Mizuno T, Yamashita T, Tohyama M.
  • Journal Title: J Neurochem. 91(2) Pages: 395-403
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] JAB1 participates in unfolded protein responses by association and dissociation with IRE1. (2004)
  • Author(s): Oono K, Yoneda T, Manabe T, Yamagishi S, Matsuda S, Hitomi J, Miyata S, Mizuno T, Imaizumi K, Katayama T, Tohyama M.
  • Journal Title: Neurochem Int. 45(5) Pages: 765-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats. (2004)
  • Author(s): Tanaka H, Yamashita T, Yachi K, Fujiwara T, Yoshikawa H, Tohyama M.
  • Journal Title: Neuroscience. 127(1) Pages: 155-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. (2004)
  • Author(s): Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M.
  • Journal Title: J Cell Biol. 165(3) Pages: 347-56
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activation of Rho in the injured axons following spinal cord injury. (2004)
  • Author(s): Madura T, Yamashita T, Kubo T, Fujitani M, Hosokawa K, Tohyama M.
  • Journal Title: EMBO Rep. 5(4) Pages: 412-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of ARF4L in recycling between endosomes and the plasma membrane. (2004)
  • Author(s): Katayama T, Imaizumi K, Yoneda T, Taniguchi M, Honda A, Manabe T, Hitomi J, Oono K, Baba K, Miyata S, Matsuzaki S, Takatsuji K, Tohyama M.
  • Journal Title: Cell Mol Neurobiol. 24(1) Pages: 137-47
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes in mRNA of Slit-Robo GTPase-activating protein 2 following facial nerve transection. (2004)
  • Author(s): Madura T, Yamashita T, Kubo T, Tsuji L, Hosokawa K, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 123(1-2) Pages: 76-80
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metals accelerate production of the aberrant splicing isoform of the presenilin-2. (2004)
  • Author(s): Matsuzaki S, Manabe T, Katayama T, Nishikawa A, Yanagita T, Okuda H, Yasuda Y, Miyata S, Meshitsuka S, Tohyama M.
  • Journal Title: J Neurochem. 88(6) Pages: 1345-51
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth. (2004)
  • Author(s): Tsuji L, Yamashita T, Kubo T, Madura T, Tanaka H, Hosokawa K, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 313(4) Pages: 1086-91
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain. (2003)
  • Author(s): Kawakita A, Yamashita T, Taniguchi M, Koyama Y, Kubo T, Tsuji L, Tohyama M.
  • Journal Title: Brain Res Dev Brain Res. 144(2) Pages: 181-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] GRP94 (94 kDa glucose-regulated protein)suppresses ischemic neuronal cell death against ischemia/reperfusion injury・ (2003)
  • Author(s): Bando Y, Katayama T, Kasai K, Taniguchi M, Tamatani M, Tohyama M.
  • Journal Title: Eur J Neurosci. 18(4) Pages: 829-40
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. (2003)
  • Author(s): Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M.
  • Journal Title: Mol Psychiatry. 8(7) Pages: 685-94
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain. (2003)
  • Author(s): Madura T, Yamashita T, Kubo T, Taniguchi M, Kawakita A, Hosokawa K, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 114(2) Pages: 163-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease. (2003)
  • Author(s): Manabe T, Katayama T, Sato N, Gomi F, Hitomi J, Yanagita T, Kudo T, Honda A, Mori Y, Matsuzaki S, Imaizumi K, Mayeda A, Tohyama M.
  • Journal Title: Cell Death Differ. 10(6) Pages: 698-708
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Recent progress in 'HMGA1a' which causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease (2003)
  • Author(s): Katayama T, Manabe T, Tohyama M.
  • Journal Title: Nippon Rinsho 61(4) Pages: 677-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] PKA phosphorylates the p75 receptor and regulates its localization t0 lipid rafts. (2003)
  • Author(s): Higuchi H, Yamashita T, Yoshikawa H, Tohyama M.
  • Journal Title: EMBO J. 22(8) Pages: 1790-800
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (2003)
  • Author(s): Yamashita T, Tohyama M.
  • Journal Title: Nat Neurosci. 6(5) Pages: 461-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The p75 receptor is required for BDNF-induced differentiation of neural precursor cells. (2003)
  • Author(s): Hosomi S, Yamashita T, Aoki M, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 301(4) Pages: 1011-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. (2003)
  • Author(s): Kasai K, Yamashita T, Yamaguchi A, Yoshiya K, Kawakita A, Tanaka H, Sugimoto H, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 110(1) Pages: 38-44
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional inhibition of the p75 receptor using a small interfering RNA. (2003)
  • Author(s): Higuchi H, Yamashita T, Yoshikawa H, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 301(3) Pages: 804-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury. (2003)
  • Author(s): Bando Y, Katayama T, Kasai K, Taniguchi M, Tamatani M, Tohyama M.
  • Journal Title: Eur J Neurosci. 18(4) Pages: 829-40
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Disrupted-In-Schizophrenia 1, acandidate gene for schizophrenia, participates in neurite outgrowth. (2003)
  • Author(s): Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M.
  • Journal Title: Mol Psychiatry. 8(7) Pages: 685-94
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induced HMGAla expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease. (2003)
  • Author(s): Manabe T, Katayama T, Sato N, Gomi F, Hitomi J, Yanagita T, Kudo T, Honda A, Mori Y, Matsuzaki S, Imaizumi K, Mayeda A, Tohyama M.
  • Journal Title: Cell Death Differ. 10(6) Pages: 698-708
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] [Recent progress in 'HMGA1a' which causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease] (2003)
  • Author(s): Katayama T, Manabe T, Tohyama M.
  • Journal Title: Nippon Rinsho. 61(4) Pages: 677-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PKA phosphorylates the p75 receptor and regulates its localization to lipidrafts. (2003)
  • Author(s): Higuchi H, Yamashita T, Yoshikawa H, Tohyama M.
  • Journal Title: EMBO J. 22(8) Pages: 1790-800
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The p75 receptor is required for BDNF-induced differentiation of neural precursorcells. (2003)
  • Author(s): Hosomi S, Yamashita T, Aoki M, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 301(4) Pages: 1011-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of mRNAs and proteins for Na/K ATPase alphal and beta1 subunits following hypoxia/reoxygenation in astrocytes. (2003)
  • Author(s): Kasai K, Yamashita T, Yamaguchi A, Yoshiya K, Kawakita A, Tanaka H, Sugimoto H, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 110(1) Pages: 38-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The unfolded protein response is involved in the pathology of Alzheimer's disease. (2002)
  • Author(s): Kudo T, Katayama T, Imaizumi K, Yasuda Y, Yatera M, Okochi M, Tohyama M, Takeda M.
  • Journal Title: Ann N Y Acad Sci. 977 Pages: 349-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays. (2002)
  • Author(s): Kubo T, Yamashita T, Yamaguchi A, Hosokawa K, Tohyama M
  • Journal Title: J Neurochem. 82(5) Pages: 1129-36
  • NAID: 130005442312
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (2002)
  • Author(s): Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M.
  • Journal Title: J Neurosci. 22(19) Pages: 8504-13
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in mRNA for VAMPs following facial nerve transection. (2002)
  • Author(s): Che YH, Yamashita T, Tohyama M.
  • Journal Title: J Chem Neuroanat. 24(2) Pages: 147-52
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] FAD-linked presenilin-1 mutants impede translation regulation under ER stress. (2002)
  • Author(s): Yasuda Y, Kudo T, Katayama T, lmaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. 296(2) Pages: 313-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel mitochondrial tricarboxylate carrier. (2002)
  • Author(s): Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 295(2) Pages: 463-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients. (2002)
  • Author(s): Manabe T, Katayama T, Sato N, Kudo T, Matsuzaki S, Imaizumi K, Tohyama M.
  • Journal Title: Neurosci Lett. 328(2) Pages: 198-200
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytoplasmic p21(Cip1/WAF1)regulates neurite remodeling by inhibiting Rho-kinase activity・ (2002)
  • Author(s): Tanaka H, Yamashita T, Asada M, Mizutani S, Yoshikawa H, Tohyama M.
  • Journal Title: J Cell Biol. 158(2) Pages: 321-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. (2002)
  • Author(s): Suzuki Y, Miura H, Tanemura A, Kobayashi K, Kondoh G, Sano S, OZawa K, Inui S, Nakata A, Takagi T, Tohyama M, Yoshikawa K, Itami S.
  • Journal Title: FEBS Lett. 521(1-3) Pages: 67-71
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. (2002)
  • Author(s): Yamashita T, Higuchi H, Tohyama M.
  • Journal Title: J Cell Biol. 157(4) Pages: 565-70
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. (2002)
  • Author(s): Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Kawai Y, Senba E, Mitsuda N, Hori O, Yamaguchi A, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 100(1-2) Pages: 67-73
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in mRNA for choline transporter-like protein following facial nerve transection. (2002)
  • Author(s): Che YH, Yamashita T, Higuchi H, Tohyama M.
  • Journal Title: Brain Res Mol Brain Res. 101(1-2) Pages: 122-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The unfolded protein response is in volved in the pathology of Alzheimer's disease. (2002)
  • Author(s): Kudo T, Katayama T, Imaizumi K, Yasuda Y, Yatera M, Okochi M, Tohyama M, Takeda M.
  • Journal Title: Ann N Y Acad Sci. 977 Pages: 349-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays. (2002)
  • Author(s): Kubo T, Yamashita T, Yamaguchi A, Hosokawa K, Tohyama M.
  • Journal Title: J Neurochem. 82(5) Pages: 1129-36
  • NAID: 130005442312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. (2002)
  • Author(s): Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M.
  • Journal Title: J Neurochem. 22(19) Pages: 8504-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes in mRNA for VAMPs following facial nerve transection. (2002)
  • Author(s): Che YH, Yamashita T, Tohyama M.
  • Journal Title: J Neurochem. 24(2) Pages: 147-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] FAD-linked presenilin-1 mutants impede translation regulation under ER stress. (2002)
  • Author(s): Yasuda Y, Kudo T, Katayama T, Imaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. 296(2) Pages: 313-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of a novel mitochondrial tricarboxvlate carrier. (2002)
  • Author(s): Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M.
  • Journal Title: Biochem Biophys Res Commun. 295(2) Pages: 463-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differobviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients. (2002)
  • Author(s): Manabe T, Katayama T, Sato N, Kudo T, Matsuzaki S, Imaizumi K, Tohyama M.
  • Journal Title: Neurosci Lett. 328(2) Pages: 198-200
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytoplasmic p21(Cipl/WAFl) regulates neurite remodeling by inhibiting Rho-kinase activity. (2002)
  • Author(s): Tanaka H, Yamashita T, Asada M, Mizutani S, Yoshikawa H, Tohyama M.
  • Journal Title: J Cell Biol. 158(2) Pages: 321-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. (2002)
  • Author(s): Suzuki Y, Miura H, Tanemura A, Kobayashi K, Kondoh G, Sano S, Ozawa K, Inui S, Nakata A, Takagi T, Tohyama M, Yoshikawa K, Itami S.
  • Journal Title: FEBS Lett. 521(1-3) Pages: 67-71
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 神経変性疾患における小胞体ストレスと細胞死 (2007)
  • Author(s): 松崎伸介,片山泰一,遠山正彌
  • Organizer: 日本薬学会第127年回(富山)
  • Place of Presentation: 横浜
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neurodegenerative disease and ER stress (2007)
  • Organizer: The 127 Ammual Meeting of the Pharmaceutical of Japan
  • Place of Presentation: Toyama, Japan
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症発症における分子メカニズム解明 (2006)
  • Author(s): 遠山正彌,松崎伸介
  • Organizer: 蛋白研セミナー「こころ、高次脳機能、疾病と遺伝子」
  • Place of Presentation: 吹田
  • Year and Date: 2006-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanism of schizophrenia (2006)
  • Organizer: Seminar of Institute for Protein Research. Osaka University
  • Place of Presentation: Suita, Japan
  • Year and Date: 2006-11-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症発症における分子メカニズム解明 (2006)
  • Author(s): 松崎仲介,遠山正彌
  • Organizer: 千里ライフサイエンスセミナーブレインサイエンスシリーズ第19回
  • Place of Presentation: 豊中
  • Year and Date: 2006-10-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanism of schizophrenia (2006)
  • Organizer: Senri Life Science: Brain Science Seminar
  • Place of Presentation: Toyonaka, Japan
  • Year and Date: 2006-10-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症関連因子DISC1及びDYSBINDIN機能解析 (2006)
  • Author(s): 松崎伸介,遠山正彌
  • Organizer: 第49回 神経化学会大会(名古屋)
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of Dysbindin and Disrupted-In-Schizophrenia 1, schizophrenia related genes (2006)
  • Organizer: The 48 Ammual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-09-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Functional analysis of Dysbindin and Disrupted-In-Schizophrenia 1, schizophrenia related genes (2006)
  • Organizer: The 79th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2006-05-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症関連因子DISC1及びDYSBINDIN機能解析 (2006)
  • Author(s): 松崎伸介,遠山正庁
  • Organizer: 第79回 日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2006-03-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of Disrupted-In-Schizophrenia l 第3回 武田科学振興財団薬科学シンポジウム (2005)
  • Author(s): 松崎伸介,遠山正価
  • Organizer: 第三回 武田科学振興財団薬科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2005-12-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of Disrupted-In-Schizophrenia 1 (2005)
  • Organizer: The 3rd Takeda Science Foundation Symposium on PharmaSciences
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2005-12-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Functional analysis of new DISC1 binding protein, DBZ (2005)
  • Author(s): 松崎伸介,片山泰一,遠山正価
  • Organizer: 第48回 神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of new DISCI binding protein, DBZ (2005)
  • Organizer: The 48 Ammual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2005-09-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Aberrant splicing products, observed in sporadic Alzheimer's brain (2003)
  • Author(s): Katayama T, Manabe T, Matsuzaki S, Mayeda A, Imaizumi K, Tohyama M.
  • Organizer: Kinki AD forum
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2003-07-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvment of unfolded protein response in Alzheimer's disease (2002)
  • Author(s): Kudo T, Katayama T, Imaizumi K, Kanayama D, Sowa M, Okochi M, Tohyama M, Takeda M
  • Organizer: International Symposium "Molecular Neurobiology of Alzheimer Disease and Related Disorders″
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2002-10-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The RNA-binding protein causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease (2002)
  • Author(s): Katayama T, Manabe T, Matsuzaki S, Imaizumi K, Tohyama M.
  • Organizer: International Symposium "Molecular Neurobiology of Alzheimer Disease and Related Disorders″
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2002-10-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvment of unfolded protein response in Alzheimer's disease (2002)
  • Organizer: International Symposium Molecular Neurobiology of Alzheimer Disease and Related Disorders
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2002-10-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The RNA-binding protein causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease (2002)
  • Organizer: International Symposium Molecular Neurobiology of Alzheimer Disease and Related Disorders
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2002-10-05
  • Description: 「研究成果報告書概要(欧文)」より