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Molecular mechanisms for pre-replication complexes assembly and its implication in chromosomal stability in mammalian cells

Research Project

Project/Area Number 17080013
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

FUJITA Masatoshi  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, ウイルス部, 室長 (30270713)

Co-Investigator(Kenkyū-buntansha) NISITANI Hidbo  兵庫県立大学, 大学院・生命理学, 教授 (40253455)
MIZUNO Takeshi  理化学研究所, 今本細胞核機能, 専任研究員 (30281629)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥116,000,000 (Direct Cost: ¥116,000,000)
Fiscal Year 2009: ¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 2008: ¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 2007: ¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 2006: ¥23,600,000 (Direct Cost: ¥23,600,000)
Fiscal Year 2005: ¥23,400,000 (Direct Cost: ¥23,400,000)
Keywords染色体DNA複製 / 細胞周期 / クロマチン / 染色体安定性 / 細胞周期制御 / Cdt1 / SNF2H / クロマチンリモデリング / CRL4ユビキチンリガーゼ / CDC6 / ATR / 複製チェックポイント / ORC / タンパク質分解制御 / テロメア / 染色体不安定性 / TRF2 / 分子生物学 / ゲノム / 遺伝子 / 染色体 / DNA複製
Research Abstract

Chromosomal DNA, an essential genetic element, should be precisely replicated during cell growth, failure of which leads to cell death or cancer development. In this research project, we have clarified molecular mechanisms by which DNA replicates once and only once during cells dividing into two daughter cells. Especially, we found that Cdt1 protein is strictly regulated by multiple mechanisms, which are essential for precise DNA replication. Base on these findings, we think that Cdt1 would be a novel target of anti-cancer drugs and we are now trying to find out such compounds. In addition, it turned out that such mechanisms for DNA replication also contribute to maintenance of other chromosomal functions.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (64 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (43 results) (of which Peer Reviewed: 19 results) Presentation (12 results) Book (4 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.2010

    • Author(s)
      Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M.
    • Journal Title

      J. C e l l S c i. 123

      Pages: 225-235

    • Related Report
      2009 Final Research Report
  • [Journal Article] CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells2010

    • Author(s)
      Kazumasa Yoshida
    • Journal Title

      J.Cell Sci 123

      Pages: 225-235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase MCM proteins2010

    • Author(s)
      J.-G.Lee
    • Journal Title

      J.Biol.Chem (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redundant and differential regulation of multiple licensing factors ensures prevention of rereplication in normal human cells.2009

    • Author(s)
      Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M.
    • Journal Title

      J. C e l l S c i. 122

      Pages: 1184-1191

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.2009

    • Author(s)
      Katsuno Y, Suzuki A, Sugimura K, Okumura K, Zineldeen DH, Shimada M, Niida H, Mizuno T, Hanaoka F, Nakanishi M.
    • Journal Title

      P r o c. N a t l. A c a d. S c i. U S A 106

      Pages: 3184-3189

    • Related Report
      2009 Final Research Report
  • [Journal Article] Redundant and differential regulation of multiple licensing factorsensures prevention of rereplication in normal human cells2009

    • Author(s)
      Nozomi Sugimoto
    • Journal Title

      J.Cell Sci 122

      Pages: 1184-1191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone acetyltransferase Hbol : catalytic activity, cellular abundance, and links to primary cancers2009

    • Author(s)
      Masayoshi Iizuka
    • Journal Title

      Gene 436

      Pages: 108-114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant DNA polymerase α is excluded from the nucleus by defective import and degradation in the nucleus2009

    • Author(s)
      C.S.Eichinger
    • Journal Title

      J.Biol.Chem 284

      Pages: 30604-30614

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells2009

    • Author(s)
      Y Katsuno
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 3184-3189

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redundant and differential regulation of multiple licensing factors ensures prevention of rereplication in normal human cells2009

    • Author(s)
      Nozomi Sugimoto
    • Journal Title

      J. Cell. Sci. 122

      Pages: 1184-1191

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin A-Cdk1 regulates the origin firing program in mammalian cells2009

    • Author(s)
      Yuko Katsuno
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 3184-3189

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel human Cdt1-binding proteins by a proteomics approach: Proteolytic regulation by APC/CCdh1.2008

    • Author(s)
      Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita, M.
    • Journal Title

      M o l. B i o l. C e l l 19

      Pages: 1007-1021

    • Related Report
      2009 Final Research Report
  • [Journal Article] The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Hada T, Maeda N, Sugawara F, Yoshida H, Fujita M.
    • Journal Title

      B i o c h i m i e 90

      Pages: 947-956

    • Related Report
      2009 Final Research Report
  • [Journal Article] Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      B i o c h i m. B i o p h y s. A c t a. 1780

      Pages: 203-213

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres.2008

    • Author(s)
      Tatsumi Y, Ezura K, Yoshida K, Yugawa T, Narisawa-Saito M, Kiyono T, Ohta S, Obuse C, Fujita M.
    • Journal Title

      G e n e s C e l l s 13

      Pages: 1045-1059

    • Related Report
      2009 Final Research Report
  • [Journal Article] CDK inhibitor p21 is degraded by a PCNA coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.2008

    • Author(s)
      Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T.
    • Journal Title

      J. B i o l. C h e m. 283

      Pages: 29045-29052

    • Related Report
      2009 Final Research Report
  • [Journal Article] Idenfitication of novel human Cdt1-binding proteins by a proteomics approach: Proteolytic regulation by APC/C-Cdh12008

    • Author(s)
      Nozomi Sugimoto
    • Journal Title

      Mol. Biol. Cell 19

      Pages: 1007-1021

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres2008

    • Author(s)
      Yasutoshi Tatsumi
    • Journal Title

      Genes Cells 13

      Pages: 1045-1059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction2008

    • Author(s)
      Yoshiyuki Mizushima
    • Journal Title

      Biochimie 90

      Pages: 947-956

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme Q_<10> a potent compound that inhibits Cdt1-geminin interaction2008

    • Author(s)
      Yoshiyuki Mizushima
    • Journal Title

      Biochim. Biophy. Acta 1780

      Pages: 203-213

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CDK inhibitor p21 is degraded by a profilerating cell nuclear antigen-coupled Cu14-DDB1Cdt2 pathway during S phase and after UV irradiation2008

    • Author(s)
      Hideo Nishitani
    • Journal Title

      J. Biol. Chem. 283

      Pages: 29045-29052

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity2008

    • Author(s)
      Motoaki Ohtsubo
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 10396-10401

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel human Cdtl-binding proteins by a proteomics approach:Proteolytic regulation by APC/C-Cdhl2008

    • Author(s)
      Nozomi Sugimoto
    • Journal Title

      Mol.Biol.Cell 19

      Pages: 1007-1021

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme Q10 as a potent compound that inhibits Cdtl-geimeininteraction2008

    • Author(s)
      Yoshiyuki Mizushina
    • Journal Title

      Biochim.Biophys.Acta 1780

      Pages: 203-213

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory action of SQDG(sulfoquinovosyl diacylglycerolfrom spinach on Cdtl-geimein interaction2008

    • Author(s)
      Yoshiyuki Mizushina
    • Journal Title

      Biochimie (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin.2007

    • Author(s)
      Xouri G, Squire A, Dimaki M, Geverts B, Verveer PJ, Taraviras S, Nishitani H, Houtsmuller AB, Bastiaens PI, Lygerou Z.
    • Journal Title

      E M B O J. 26

      Pages: 1303-1314

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cdtl associates dynamically with chromatin throughout Gl and recruits Geminin onto chromatin2007

    • Author(s)
      Georgia Xouri
    • Journal Title

      EMBO J 26

      Pages: 1303-1314

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Licensing regulators Geminin and Cdtl identify progenitor cellsof the mouse CNS in a specific phase of the cell cycle2007

    • Author(s)
      M Spella
    • Journal Title

      Neuroscience 147

      Pages: 373-387

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin.2007

    • Author(s)
      Georgia Xouri
    • Journal Title

      EMBO J. 26

      Pages: 1303-1314

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.2006

    • Author(s)
      Tatsumi Y, Sugimoto N, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M.
    • Journal Title

      J. C e l l S c i. 119

      Pages: 3128-3140

    • Related Report
      2009 Final Research Report
  • [Journal Article] wo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.2006

    • Author(s)
      Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama K-I, Nakayama K, Fujita M, Lygerous Z, Nishimoto T.
    • Journal Title

      E M B O J. 25

      Pages: 1126-1136

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.2006

    • Author(s)
      Fujita M.
    • Journal Title

      C e l l D i v. 1

      Pages: 22-22

    • Related Report
      2009 Final Research Report
  • [Journal Article] Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cu14, target human Cdt1 for proteolysis.2006

    • Author(s)
      Hideo Nishitani
    • Journal Title

      EMBO J. 25

      Pages: 1126-1136

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Deregulation of Cdtl induces chromosomal damage without rereplication and leads to chromosomal instability.2006

    • Author(s)
      Yasutoshi Tatsumi
    • Journal Title

      J. Cell Sci. 119

      Pages: 3128-3140

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cdt1 revisited : complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.2006

    • Author(s)
      Masatoshi Fujita
    • Journal Title

      Cell Div. 1

      Pages: 22-22

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.2006

    • Author(s)
      Hideo Nishitani
    • Journal Title

      EMOBO J. 25

      Pages: 1126-1136

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Activation of ATM DNA damage checkpoint signal transduction elicited by Herpes simplex virus infection.2005

    • Author(s)
      Noriko Shirata
    • Journal Title

      J.Biol.Chem 280

      Pages: 30336-30341

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.2005

    • Author(s)
      Ayumi Kudoh
    • Journal Title

      J.Biol.Chem. 280

      Pages: 8156-8163

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase α.2005

    • Author(s)
      Mirai Nakamura
    • Journal Title

      Mol.Cell.Biol. 25

      Pages: 11073-11088

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.2005

    • Author(s)
      Yasuyuki Miyake
    • Journal Title

      J.Biol.Chem. 280

      Pages: 12643-12652

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.2004

    • Author(s)
      Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M.
    • Journal Title

      J. B i o l. C h e m. 279

      Pages: 19691-19697

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase MCM proteins J.

    • Author(s)
      J. -G. Jee, Mizuno T, Kamada K, Tochio H, Chiba Y, Yanagi K, Yasuda G, Hiroaki H, Hanaoka F, Shirakawa M.
    • Journal Title

      B i o l. C h e m.

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regulation of Notch1 gene expression by p53 in epithelial cells.

    • Author(s)
      Takashi Yugawa
    • Journal Title

      Mol. Cell. Biol. (In press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.2009

    • Author(s)
      Fujita M.
    • Organizer
      I n t e r n a t i o n a l S y m p o s i u m o n C h r o m o s o m e C y c l e a n d G n o m e D y n a m i c s.
    • Place of Presentation
      Nasu, Japan.
    • Year and Date
      2009-11-11
    • Related Report
      2009 Final Research Report
  • [Presentation] CDC6 interaction with ATR regulates activation of areplication checkpoint in higher eukaryotic cells2009

    • Author(s)
      Masatoshi Fujita
    • Organizer
      International Symposium on "Chromosome Cycle and genome dynamics"
    • Place of Presentation
      Nasu, Tochigi
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] CDC6 interaction with ATR regulates activation of areplication checkpoint in higher eukaryotic cells2009

    • Author(s)
      Kazumasa Yoshida
    • Organizer
      Keystone Symposia "Telomere Biology and DNA Repair"
    • Place of Presentation
      Ashmore, Queensland, Australia
    • Year and Date
      2009-10-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A chromatin remodeler SNF2H is involved in pre-RC formation and Cdt1-induced checkpoint activation2009

    • Author(s)
      Nozomi Sugimoto
    • Organizer
      Keystone Symposia "Telomere Biology and DNA Repair"
    • Place of Presentation
      Ashmore, Queensland, Australia
    • Year and Date
      2009-10-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] A chromatin remodeler SNF2H is involved in pre-RC formation and Cdt1-induced checkpoint activation.2009

    • Author(s)
      Sugimoto N, Waga S, Kiyono T, Fujita, M.
    • Organizer
      K e y s t o n e S y m p o s i a " T e l o m e r e B i o l o g y a n d D N A R e p a i r"
    • Place of Presentation
      Ashmore, Queensland, Australia.
    • Year and Date
      2009-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 正確にゲノムを倍加させる:複製開始因子Cdt1の分解制御機構の解明と抗がん剤開発への応用2009

    • Author(s)
      藤田雅俊
    • Organizer
      福井大学大学院工学研究科、招請研究セミナー
    • Place of Presentation
      福井
    • Year and Date
      2009-05-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chromatin-modifying proteins that bind to Cdt1 and promote pre-RC formation2008

    • Author(s)
      Nozomi Sugimoto
    • Organizer
      The Meeting on DNA Replication and Genome Integrity at Salk Institute
    • Place of Presentation
      La Jolla, USA
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cdk phosphorylation-dependent interaction of human CDC6 with ATR is involved in G2/M checkpoint response.2008

    • Author(s)
      Yoshida K, Kiyono T, Fujita M.
    • Organizer
      T h e M e e t i n g o n D N A R e p l i c a t i o n a n d G e n o m e I n t e g r i t y a t S a l k I n s t i t u t e
    • Place of Presentation
      La Jolla, USA.
    • Year and Date
      2008-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Cdk phosphorylation-dependent interaction of human CDC6 with ATR is involved in G2/M checkpoint response2008

    • Author(s)
      Kazumasa Yoshida
    • Organizer
      The Meeting on DNA Replication and Genome Integrity at Salk Institute
    • Place of Presentation
      La Jolla, USA
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres and telomere homeostasis.2007

    • Author(s)
      Tatsumi Y, Ezura K, Yoshida K, Kiyono T, Ohta S, Obuse C, Fujita, M.
    • Organizer
      C o l d S p r i n g H a r b o r L a b o r a t o r y M e e t i n g o n E u k a r y o t i c D N A R e p l i c a t i o n & G e n o m e M a i n t e n a n c e
    • Place of Presentation
      Cold Spring Harbor, USA.
    • Year and Date
      2007-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres and telomere homeostasis2007

    • Author(s)
      Yasutoshi Tatsumi
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication & Genome Maintenance
    • Place of Presentation
      Cold Spring Harbor, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of novel human Cdt1-binding proteins by a proteomics approach:Proteolytic regulation by APC/C-Cdhl2007

    • Author(s)
      Nozomi Sugimoto
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication & Genome Maintenance
    • Place of Presentation
      Cold Spring Harbor, USA
    • Related Report
      2007 Annual Research Report
  • [Book] 蛋白質核酸酵素(正井久雄、升方久夫、釣本敏樹、仁木宏典、篠原彰編集, 染色体動態制御における複製開始複合体因子の新たな機能, 増刊号「染色体サイクル」)2009

    • Author(s)
      藤田雅俊.
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] Encylopedic Reference of Genomics and Proteomics in Molecular Medicine(edited by Ganten, D. and Ruckpaul, K., DNA Replication Initiation.).2006

    • Author(s)
      Fujita M.
    • Publisher
      Springer
    • Related Report
      2009 Final Research Report
  • [Book] DNA Replication Initiation; in Encyclopedic References of Genomics and Proteomics in Molecular Medicine2006

    • Author(s)
      Masatoshi Fujita
    • Publisher
      Springer-Verlag, Berlin Heidelberg & New York
    • Related Report
      2006 Annual Research Report
  • [Book] DNA Replication Initiation ; in Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine

    • Author(s)
      Masatoshi Fujita
    • Publisher
      Springer-Verlag, Heidelberg (In press)
    • Related Report
      2005 Annual Research Report
  • [Remarks] 現所属、九州大学・大学院薬学研究院ホームページ

    • URL

      http://tansaku.phar.kyushu-u.ac.jp/saito/top.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.ncc.go.jp/jp/nccri/divisions/10vir/10vir04.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncc.go.jp/jp/nccri/divisions/10vir/10vir04.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗癌性物質のスクリーニング方法2006

    • Inventor(s)
      藤田雅俊、水品善之
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Industrial Property Number
      2006-281754
    • Filing Date
      2006-10-16
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 抗癌性物質のスクリーニング方法2006

    • Inventor(s)
      藤田雅俊, 水品善之
    • Industrial Property Rights Holder
      国立がんセンター・ヒューマンサイェンス振興財団
    • Industrial Property Number
      2006-281754
    • Filing Date
      2006-10-16
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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