• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination

Research Project

Project/Area Number 17109015
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagasaki University

Principal Investigator

UEDA Hiroshi  Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (00145674)

Co-Investigator(Kenkyū-buntansha) SUMIKAWA Koji  長崎大学, 大学院・医歯薬学総合研究科, 教授 (60028660)
INOUE Makoto  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60380987)
FUJITA Ryousuke  長崎大学, 大学院・医歯薬学総合研究科, 助教 (70380855)
UCHIDA Hitoshi  長崎大学, 大学院・医歯薬学総合研究科, 技術補佐員 (30549621)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥108,290,000 (Direct Cost: ¥83,300,000、Indirect Cost: ¥24,990,000)
Fiscal Year 2009: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2008: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2007: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2006: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2005: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
Keywords脳・神経 / 脂質 / 神経因性疼痛 / 脱髄 / 神経回路 / リゾホスファチジン酸 / WGAトランスジーン法 / 脊髄損傷 / LPA de novo合成 / 線維筋痛症 / Mass imaging / ミエリン蛋白質 / LPA合成酵素 / ex vivo解析 / LPA産生 / 神経発芽 / スプラウティング / 神経因性疹痛
Research Abstract

We successfully identified various molecular targets for medicines to cure neuropathic pain. They are related to the lysophospahtidic acid (LPA)-mediated mechanisms underlying injury-induced demyelination, gene regulation, microglia activation and supra-spinal pain. Feed-forward amplification of these mechanisms and epigenetic gene regulation of key pain-related molecules were suggested to underlie the chronic status of neuropathic pain.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (137 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (66 results) (of which Peer Reviewed: 48 results) Presentation (59 results) Book (8 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.2010

    • Author(s)
      Uchida H, Ma L, Ueda H.
    • Journal Title

      J Neurosci 30(13)

      Pages: 4806-14

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.2010

    • Author(s)
      Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.
    • Journal Title

      J Pharmacol Exp Ther. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia.2010

    • Author(s)
      Nishiyori M, Nagai J, Nakazawa T, Ueda H.
    • Journal Title

      Neurosci Lett. 472(3)

      Pages: 184-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.2010

    • Author(s)
      Matsumoto M, Kondo S, Usdin TB, Ueda H.
    • Journal Title

      J Neurochem 112(2)

      Pages: 521-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4. 3 gene after peripheral nerve injury.2010

    • Author(s)
      Uchida H, Sasaki K, Ma L, Ueda H.
    • Journal Title

      Neuroscience 166(1)

      Pages: 1-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain2010

    • Author(s)
      Misaki Matsumoto
    • Journal Title

      Journal of Neurochemistry 112

      Pages: 521-530

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain2010

    • Author(s)
      Lin Ma
    • Journal Title

      The Journal of Pharmacology and Experimental Therapeutics (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia2010

    • Author(s)
      Michiko Nishiyori
    • Journal Title

      Neuroscience Letters 472

      Pages: 184-187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury2010

    • Author(s)
      Hitoshi Uchida
    • Journal Title

      Neuroscience 166

      Pages: 1-4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropo athic pain2010

    • Author(s)
      Weijiao Xie
    • Journal Title

      Journal of Neurochemistry (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain2010

    • Author(s)
      Hitoshi Uchida
    • Journal Title

      The Journal of Neuroscience (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 化学療法に伴う神経因性疼痛メカニズム2010

    • Author(s)
      植田弘師
    • Journal Title

      日本整形外科学会雑誌 84

      Pages: 24-30

    • NAID

      10026311285

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.2009

    • Author(s)
      Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
    • Journal Title

      Mol Pain 5

      Pages: 64-64

    • NAID

      120006984666

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.2009

    • Author(s)
      Ma L, Matsumoto M, Xie W, Inoue M, Ueda H.
    • Journal Title

      J Neurochem 109(2)

      Pages: 603-10

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid:ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia.2009

    • Author(s)
      Uchida H, Matsumoto M, Ueda H.
    • Journal Title

      Neurochem Int 54(3-4)

      Pages: 215-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation2009

    • Author(s)
      Yosuke Matsushita
    • Journal Title

      Neuroreport 20

      Pages: 63-68

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid : ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia2009

    • Author(s)
      Hitoshi Uchida
    • Journal Title

      Neurochemistry International 54

      Pages: 215-221

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 12009

    • Author(s)
      Lin Ma
    • Journal Title

      Journal of Neurochemistry 109

      Pages: 603-610

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid : an initiator of nerve injury-induced neuropathic pain2009

    • Author(s)
      Lin Ma
    • Journal Title

      Molecular Pain 5

      Pages: 64-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オピオイド耐性機構に関与するグルタミン酸-NMDA受容体アンチオピオイド機構2009

    • Author(s)
      植田弘師
    • Journal Title

      麻酔 58

      Pages: 1136-1142

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経障害性疼痛におけるリゾリン脂質のフィードフォワード性産生制御機構と病態生理機構2009

    • Author(s)
      植田弘師
    • Journal Title

      生体の化学 60

      Pages: 490-491

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経障害性疼痛を担うフィードフォワード増幅機構2009

    • Author(s)
      植田弘師
    • Journal Title

      ペインクリニック 30

      Pages: 1539-1544

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Mechanisms underlying morphine analgesic tolerance and dependence2009

    • Author(s)
      Hiroshi Ueda
    • Journal Title

      Frontiers in Bioscience (In press)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia2009

    • Author(s)
      Hitoshi Uchida
    • Journal Title

      Neurochemistry International 54

      Pages: 215-221

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist2009

    • Author(s)
      Lin Ma
    • Journal Title

      Journal of Neurochemistry 109

      Pages: 603-610

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.2008

    • Author(s)
      Inoue M, Ma L, Aoki J, Ueda H.
    • Journal Title

      J Neurochem 107(6)

      Pages: 1556-65

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia.2008

    • Author(s)
      Nishiyori M, Ueda H.
    • Journal Title

      Mol Pain 4

      Pages: 52-52

    • NAID

      120006983382

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.2008

    • Author(s)
      Xie W, Matsumoto M, Chun J, Ueda H.
    • Journal Title

      Mol Pain 4

      Pages: 46-46

    • NAID

      120006981734

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid-induced membrane ruffling and BDNF gene expression are mediated by ATP release in primary microglia.2008

    • Author(s)
      Fujita R, Ma Y, Ueda H.
    • Journal Title

      J Neurochem 107(1)

      Pages: 152-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury.2008

    • Author(s)
      Matsumoto M, Xie W, Ma L, Ueda H.
    • Journal Title

      Mol Pain 4

      Pages: 25-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral mechanisms of neuropathic pain-involvement of lysophosphatidic acid receptor-mediated demyelination.2008

    • Author(s)
      Ueda H.
    • Journal Title

      Mol Pain 4

      Pages: 11-11

    • NAID

      120006981085

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.2008

    • Author(s)
      Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.
    • Journal Title

      Neuroscience 152(2)

      Pages: 296-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.2008

    • Author(s)
      Inoue M, Ma L, Aoki J, Chun J, Ueda H.
    • Journal Title

      Mol Pain 4

      Pages: 6-6

    • NAID

      120006982424

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesiolysis and targeted steroid/local anesthetic injection during epiduroscopy alleviates pain and reduces sensory nerve dysfunction in patients with chronic sciatica.2008

    • Author(s)
      Sakai T, Aoki H, Hojo M, Takada M, Murata H, Sumikawa K.
    • Journal Title

      J Anesth 22(3)

      Pages: 242-7

    • NAID

      10021942370

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral mechanisms of neuropathic pain-involvement of lysophosphatidic acid receptor-mediated demyelination2008

    • Author(s)
      Hiroshi Ueda
    • Journal Title

      Molecular Pain 4

      Pages: 11-11

    • NAID

      120006981085

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid2008

    • Author(s)
      Makoto Inoue
    • Journal Title

      Neuroscience 152

      Pages: 296-298

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury2008

    • Author(s)
      Misaki Matsumoto
    • Journal Title

      Molecular Pain 4

      Pages: 25-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphtidic acid-induced membrane ruffling and brain-derived neurotropic factor gene expression are mediated by ATP release in primary microglia2008

    • Author(s)
      Ryousuke Fujita
    • Journal Title

      Journal of Neurochemistry 107

      Pages: 152-160

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury2008

    • Author(s)
      Xie Weijiao
    • Journal Title

      Molecular Pain 4

      Pages: 46-46

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged ganapentin analgesia in an experimental mouse model of fibromyalgia2008

    • Author(s)
      Michiko Nishiyori
    • Journal Title

      Molecular Pain 4

      Pages: 52-52

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain2008

    • Author(s)
      Makoto Inoue
    • Journal Title

      Journal of Neurochemistry 107

      Pages: 1556-1565

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ニューロメーターを用いた新しい知覚線維選択的侵害受容評価法2008

    • Author(s)
      植田弘師
    • Journal Title

      日薬理雑誌 131

      Pages: 367-371

    • NAID

      10024382821

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 疼痛疾患とオピオイド受容体遺伝子発現のエピジェネティック制御機構2008

    • Author(s)
      植田弘師
    • Journal Title

      ペインクリニック 29

      Pages: 315-322

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 脱髄性神経因性疼痛におけるLPAの役割2008

    • Author(s)
      植田弘師
    • Journal Title

      医学のあゆみ

      Pages: 16-22

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Peripheral mechanisms of neuropathic pain -involvement of lysophosphatidic acid receptor-mediated demyelination2008

    • Author(s)
      Hiroshi Ueda
    • Journal Title

      Molecular Pain (In press)

    • NAID

      120006981085

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Journal Title

      Neuroscienci (E-pub)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain2008

    • Author(s)
      Makoto Inoue
    • Journal Title

      Molecular Pain (E-pub)

    • NAID

      120006982424

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 疼痛疾患とオピオイド受容体遺伝子発現のエピジェネティック制御機構2008

    • Author(s)
      植田 弘師
    • Journal Title

      ペインクリニック 29

      Pages: 199-205

    • Related Report
      2007 Annual Research Report
  • [Journal Article] LPA-mediated demyelination in ex vivo culture of dorsal root.2007

    • Author(s)
      Fujita R, Kiguchi N, Ueda H.
    • Journal Title

      Neurochem Int. 50(2)

      Pages: 351-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents2007

    • Author(s)
      Misaki Matsumoto
    • Journal Title

      Molecular Pain 3

      Pages: 41-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task2007

    • Author(s)
      Jun Nagai
    • Journal Title

      J Pharmacol Exp Ther. 321

      Pages: 195-201

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer pain model and morphine analgesia2007

    • Author(s)
      Mutsumi Ueda
    • Journal Title

      Nippon Rinsho 65

      Pages: 2-4

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 脱髄性神経因性疼痛におけるLPAの役割2007

    • Author(s)
      植田 弘師
    • Journal Title

      医学のあゆみ 223

      Pages: 674-680

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 神経傷害時の有髄A線維におけるトランスアクティベーション機構2007

    • Author(s)
      井上 誠
    • Journal Title

      ペインクリニック 28

      Pages: 1013-1018

    • Related Report
      2007 Annual Research Report
  • [Journal Article] LPA-mediated demyelination in ex vivo culture of dorsal root.2007

    • Author(s)
      Fujita R
    • Journal Title

      Neurochem Int 50

      Pages: 351-355

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Circadian-dependent learning and memory enhancement in nociceptin receptor (NOP)-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task.2007

    • Author(s)
      Nagai J
    • Journal Title

      J Pharmacol Exp Ther (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.2006

    • Author(s)
      Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.
    • Journal Title

      Mol Pain 2

      Pages: 25-25

    • NAID

      120006982430

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.2006

    • Author(s)
      Ueda H.
    • Journal Title

      Pharmacol Ther. 109(1-2)

      Pages: 57-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of allodynia and pain associated with postherpetic neuralgia using current perception threshold testing.2006

    • Author(s)
      Sakai T, Tomiyasu S, Yamada H, Sumikawa K.
    • Journal Title

      Clin J Pain 22(4)

      Pages: 359-62

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of paclitaxel-Induced A-Fiber hypersensitization by gabapentin.2006

    • Author(s)
      Matsumoto M, Inoue M, Hald A, Xie W, Ueda H
    • Journal Title

      J Pharmacol Exp Ther. 318(2)

      Pages: 735-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test.2006

    • Author(s)
      Matsumoto M
    • Journal Title

      Mol.Pain 2

      Pages: 16-20

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of paclitaxel-induced A-hypersensitization by gabapentin.2006

    • Author(s)
      Matsumoto M
    • Journal Title

      J Pharmacol Exp Ther. 318

      Pages: 735-740

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.2006

    • Author(s)
      Inoue M
    • Journal Title

      Mol Pain 2

      Pages: 25-29

    • NAID

      120006982430

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms2006

    • Author(s)
      UEDA H
    • Journal Title

      Pharmacol.Ther. 109

      Pages: 57-77

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings2006

    • Author(s)
      Matsumoto M
    • Journal Title

      Neurosci Lett (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.

    • Author(s)
      Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.
    • Journal Title

      J Neurochem. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 慢性疼痛時の神経可塑性を担うリゾホスファチジン酸2010

    • Author(s)
      植田弘師
    • Organizer
      第39回日本慢性疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 線維筋痛症治療へのシーズ創出2010

    • Author(s)
      植田弘師
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線維筋痛症モデルとしての繰り返し低温ストレス(ICS)マウスにおける塩酸ピロカルピンの鎮痛効果2010

    • Author(s)
      西依倫子
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 繰り返し低温ストレス(ICS)によるマウス線維筋痛症モデルの作成と正当性の薬理学的検証2010

    • Author(s)
      西依倫子
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo electroporation法を用いたmuオピオイド受容体遺伝子の脳局所導入とモルヒネ鎮痛の特異性2010

    • Author(s)
      佐々木恵太
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛を担う疼痛関連遺伝子のエピジェネティクス異常2010

    • Author(s)
      内田仁司
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛の初発分子機構を担うリゾホスファチジン酸(LPA)ミクログリア活性化における関与2010

    • Author(s)
      永井潤
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛を担うリゾホスファチジン酸特異的脱髄2010

    • Author(s)
      永井潤
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] エピジェノミクス制御物質クルクミンによるモルヒネ耐性抑制とBDNF産生制御2009

    • Author(s)
      植田弘師
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] モルヒネ鎮痛耐性の形成初期における脳責任領域PAGでのミクロクリア活性化2009

    • Author(s)
      松下洋輔
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] The de novo biosynthesis of lysophosphatidic acid (LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber2009

    • Author(s)
      井上 誠
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Profiling of pain-related genes induced by lysophosphatidic acid, an initiator of neuropathic pain2009

    • Author(s)
      内田仁司
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neural pathological roles for receptor mediated LPA signaling2009

    • Author(s)
      Ueda H
    • Organizer
      FASEB SUMMER RESEARCH CONFERENCE
    • Place of Presentation
      Arizona(USA)
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経の可塑性について-慢性疼痛機構におけるフィードフォワード増幅機構2009

    • Author(s)
      植田弘師
    • Organizer
      第23回日本ニューロモジュレーション学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛とリゾホスファチジン酸生合成2009

    • Author(s)
      植田弘師
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常2009

    • Author(s)
      植田弘師
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線維筋痛症患者における血清中リゾホスファチジルコリン濃度の上昇2009

    • Author(s)
      澤智華
    • Organizer
      第1回日本線維筋痛症学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線維筋痛症モデルとしてのICSモデルの有用性2009

    • Author(s)
      西依倫子
    • Organizer
      第1回日本線維筋痛症学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] リゾホスファチジン酸と神経因性疼痛と視床痛-ミクログリア関与の相違2009

    • Author(s)
      永井潤
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] リゾホスファチジン酸と神経因性疼痛-ミクログリアの関与の有無2009

    • Author(s)
      小川智世
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] リゾホスファチジン酸と神経因性疼痛-オートタキシンを介する生合成機構と病態発現における関与2009

    • Author(s)
      馬琳
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] リゾホスファチジン酸と神経因性疼痛-脱髄の関与と分子機構2009

    • Author(s)
      謝維嬌
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] リゾホスファチジン酸によるミクログリア活性化とATP遊離を介する間接的BDNF産生機構2009

    • Author(s)
      植村朋香
    • Organizer
      第82回日本生化学大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常2009

    • Author(s)
      内田仁司
    • Organizer
      第26回日本薬学会九州支部総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経障害によるリゾホスファチジン酸依存的な後根神経特異的脱髄に関する研究2009

    • Author(s)
      永井潤
    • Organizer
      第26回日本薬学会九州支部総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] エピジェネティクス制御物質クルクミンによるモルヒネ鎮痛耐性の抑制とBDNF発現調節2009

    • Author(s)
      三浦裕
    • Organizer
      第26回日本薬学会九州支部総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), initiates the sciatic nerve injury-induced neuropathic pain2008

    • Author(s)
      Makoto Inoue
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D. C
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Microglia acivation is related to the initiation of morphine analgesic tolerance2008

    • Author(s)
      Yousuke Matsushita
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington D. C
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] プロサイモシン・アルファによるPKCβを介した虚血神経ネクローシス抑制とPET解析2008

    • Author(s)
      藤田亮介
    • Organizer
      第114会日本薬理学会近畿部会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Experimental Models for Thalamic Pain and Fibromyalgia2008

    • Author(s)
      Hiroshi Ueda
    • Organizer
      13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIAIIONS FOR RHEUMATOLOGY
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Experimental fibromyalgia model and its characterization including gender difference2008

    • Author(s)
      Miroshi Ueda
    • Organizer
      13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIATIONS FOR FHEUMATOLOGY
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intermittent cold stress causes a long-term allodynia and hyperalgesia in mice, a model for generalized chronic pain syndrome or fibromyalgia2008

    • Author(s)
      Hiroshi Ueda
    • Organizer
      International Conference on Fatigue Science 2008
    • Place of Presentation
      Okinawa
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳梗寒時の胴保護に働くネクローシス抑制タンパク質、プロサイモシンアルフアの発見とその機能解明2008

    • Author(s)
      植田弘師
    • Organizer
      第6回鹿児島ニューロフォーラム
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-07-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nicotine analgesia and primary afferent cholinergic neuron2008

    • Author(s)
      Misaki Matsumoto
    • Organizer
      Asian Pain 2008 (第30回日本疼痛学会)
    • Place of Presentation
      福岡
    • Year and Date
      2008-07-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sustained central sensitization of pain following lysophosphatidic acid injection into thalamus2008

    • Author(s)
      Hiroshi Ueda
    • Organizer
      AsianPain2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化学寮法に伴う神経因性疼痛のメカニズム2008

    • Author(s)
      植田弘師
    • Organizer
      第41回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Autotaxin mediates the induction of nerve-injured neuropathic pain through the synthetic enzymic action for lysophosphatidic acid (LPA)2008

    • Author(s)
      Lin Ma
    • Organizer
      Asian Pain 2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lysophosphatidylcholine (LPC)hydrolyzed by autotoxin/ATX into lysophosphatidic acid (LPA), induces neuropathic pain through LPA1 receptor2008

    • Author(s)
      Weijiao Xie
    • Organizer
      Asian Pain 2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lack of the evidence for nerve injury-specific ERK phosphorylation through Aβ-fiber in spinal neurons of LPA1 receptor-knock out mice2008

    • Author(s)
      Misaki Matsumoto
    • Organizer
      Asian Pain 2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Microglia activation is involved in the initiation of morphine analgesic tolerance2008

    • Author(s)
      Saori Yonekubo
    • Organizer
      INRC
    • Place of Presentation
      Charleston, SC
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] DIFFERENTIAL EXPRESSION OF BDNF TRANSCRIPTOMES IN MORPHINE-PRIMED MICROGLIA2008

    • Author(s)
      Michiko Horiguchi
    • Organizer
      INRC
    • Place of Presentation
      Charleston, SC
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intra-thalamus injection of LPA induces long-lasting mechanical allodynia, thermal hyperalgesia and hypersensitization of myelinated A-fiber2008

    • Author(s)
      Jun Nagai
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Critical time period for lysophosphatidic acid (LPA)-signaling in nerve injury-typed neuropathic pain2008

    • Author(s)
      Lin Ma
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), mediates the induction of nerve-injured neuropathic pain2008

    • Author(s)
      Weijiao Xie
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prothymosin-alpha as a novel anti-ischemic neuroprotective protein2008

    • Author(s)
      Hiroshi Ueda
    • Organizer
      Neuroscience2008
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] リゾホスファチジン酸受容体と神経因性疼痛2008

    • Author(s)
      植田弘師
    • Organizer
      第5回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Experimental Models for Thalamic Pain and Fibromyalgia2008

    • Author(s)
      Ueda H
    • Organizer
      APLAR2008(13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY)
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 慢性痛と鎮痛薬-その分子機構解明2007

    • Author(s)
      植田弘師
    • Organizer
      第29回日本麻酔・薬理学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Molecular mechanisms of neuropathic pain2007

    • Author(s)
      Hiroshi Ueda
    • Organizer
      Opioids Past and Future:relevance to pain and addiction
    • Place of Presentation
      Salamanca, Spain
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経因性疼痛に特異的なニコチン鎮痛効果の分子機構研究-ChATのノックダウンによる痺痛応答解析2007

    • Author(s)
      植田 弘師
    • Organizer
      第29回日本疼痛学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経因性疼痛のAβ線維を介する過敏応答-脊髄後角における新たなERK1/2リン酸化の証明2007

    • Author(s)
      松本 みさき
    • Organizer
      第29回日本疼痛学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] PAGにおけるBDNFの果たすモルヒネ鎮痛耐性維持機構2007

    • Author(s)
      松下 洋輔
    • Organizer
      第28回鎮痛薬・オピオイドシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 全身性疼痛症候群(Generalized Pain Syndrome)としての線維筋痛症の動物実験モデル2007

    • Author(s)
      植田 弘師
    • Organizer
      第1回線維筋痛症研究会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tonic inhibition of spinal pain transmission through cholinergic primary afferent neurons2007

    • Author(s)
      Misaki Matsumoto
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, California
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evidence for Aβ-fiber-mediated allodynia; Pharmacological switch of spinal synaptic transmission2007

    • Author(s)
      Lin Ma
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, California
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evidence for Aβ-fiber-mediated allodynia; novel appearance of pERK in spinal dorsal horn2007

    • Author(s)
      Weijiao Xie
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, California
    • Related Report
      2007 Annual Research Report
  • [Presentation] 末梢性アセチルコリン神経による内在性鎮痛機構2007

    • Author(s)
      松本 みさき
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Related Report
      2007 Annual Research Report
  • [Presentation] 疼痛の基礎医学2007

    • Author(s)
      植田 弘師
    • Organizer
      がん診療連携拠点病院における緩和ケア
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経因性疼痛の分子機構2006

    • Author(s)
      植田弘師
    • Organizer
      第35回日本慢性疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] わかる痛み学2009

    • Author(s)
      植田弘師, 戸田一雄
    • Total Pages
      177
    • Publisher
      ブレーン出版
    • Related Report
      2009 Final Research Report
  • [Book] Cellular Mechanisms Underlying Morphine Analgesic Tolerance and Hyperalgesia2009

    • Author(s)
      Ueda H
    • Publisher
      Informa Healthcare, Opioid-Induced Hyperalgesia
    • Related Report
      2009 Final Research Report
  • [Book] わかる痛み学2009

    • Author(s)
      植田弘師
    • Total Pages
      177
    • Publisher
      ブレーン出版
    • Related Report
      2009 Annual Research Report
  • [Book] Opioid-Induced Hyperalgesia2009

    • Author(s)
      植田弘師
    • Total Pages
      12
    • Publisher
      Informa Healthcare
    • Related Report
      2009 Annual Research Report
  • [Book] 慢性疼痛の理解と医療連携2008

    • Author(s)
      植田弘師
    • Publisher
      真興交易
    • Related Report
      2008 Annual Research Report
  • [Book] 日本薬理学雑誌2006

    • Author(s)
      植田弘師
    • Publisher
      傷害性神経因性疼痛誘発を担うリゾホスファチジン酸
    • Related Report
      2005 Annual Research Report
  • [Book] ペインクリニック2005

    • Author(s)
      植田弘師
    • Publisher
      リゾホスファチジン酸誘発性神経因性疼痛
    • Related Report
      2005 Annual Research Report
  • [Book] 治療学2005

    • Author(s)
      木口倫一
    • Publisher
      疼痛と受容体3 リゾホスファチジン酸受容体
    • Related Report
      2005 Annual Research Report
  • [Remarks] 長崎大学院医歯薬学総合研究科分子薬理学分野ホームページ

    • URL

      http://www.ph.nagasaki-u.ac.jp/lab/neuro/

    • Related Report
      2009 Final Research Report
  • [Remarks] 長崎大学重点研究課題「痛み克服の国際的研究教育拠点の形成」ホームページ

    • URL

      http://www.mdp.nagasaki-u.ac.jp/pain/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 全身性疼痛症候群の治療または予防薬2008

    • Inventor(s)
      植田弘師
    • Industrial Property Number
      2008-204762
    • Filing Date
      2008-08-07
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 線維筋痛症の治療薬2007

    • Inventor(s)
      植田弘師
    • Filing Date
      2007-06-27
    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi