Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination

• Project/Area Number: 17109015
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: UEDA Hiroshi Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (00145674)
• Co-Investigator(Kenkyū-buntansha): SUMIKAWA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60028660) ; INOUE Makoto 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60380987) ; FUJITA Ryousuke 長崎大学, 大学院・医歯薬学総合研究科, 助教 (70380855) ; UCHIDA Hitoshi 長崎大学, 大学院・医歯薬学総合研究科, 技術補佐員 (30549621)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥108,290,000 (Direct Cost: ¥83,300,000、Indirect Cost: ¥24,990,000); Fiscal Year 2009: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2008: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000); Fiscal Year 2007: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000); Fiscal Year 2006: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000); Fiscal Year 2005: ¥28,340,000 (Direct Cost: ¥21,800,000、Indirect Cost: ¥6,540,000)
• Keywords: 脳・神経 / 脂質 / 神経因性疼痛 / 脱髄 / 神経回路 / リゾホスファチジン酸 / WGAトランスジーン法 / 脊髄損傷 / LPA de novo合成 / 線維筋痛症 / Mass imaging / ミエリン蛋白質 / LPA合成酵素 / ex vivo解析 / LPA産生 / 神経発芽 / スプラウティング / 神経因性疹痛

Research Abstract

We successfully identified various molecular targets for medicines to cure neuropathic pain. They are related to the lysophospahtidic acid (LPA)-mediated mechanisms underlying injury-induced demyelination, gene regulation, microglia activation and supra-spinal pain. Feed-forward amplification of these mechanisms and epigenetic gene regulation of key pain-related molecules were suggested to underlie the chronic status of neuropathic pain.

Research Products

• [Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain. (2010)
  • Author(s): Uchida H, Ma L, Ueda H.
  • Journal Title: J Neurosci 30(13) Pages: 4806-14
  • Peer Reviewed
• [Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain. (2010)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.
  • Journal Title: J Pharmacol Exp Ther. (in press)
  • Peer Reviewed
• [Journal Article] Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia. (2010)
  • Author(s): Nishiyori M, Nagai J, Nakazawa T, Ueda H.
  • Journal Title: Neurosci Lett. 472(3) Pages: 184-7
  • Peer Reviewed
• [Journal Article] Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain. (2010)
  • Author(s): Matsumoto M, Kondo S, Usdin TB, Ueda H.
  • Journal Title: J Neurochem 112(2) Pages: 521-30
  • Peer Reviewed
• [Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4. 3 gene after peripheral nerve injury. (2010)
  • Author(s): Uchida H, Sasaki K, Ma L, Ueda H.
  • Journal Title: Neuroscience 166(1) Pages: 1-4
  • Peer Reviewed
• [Journal Article] Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain (2010)
  • Author(s): Misaki Matsumoto
  • Journal Title: Journal of Neurochemistry 112 Pages: 521-530
  • Peer Reviewed
• [Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain (2010)
  • Author(s): Lin Ma
  • Journal Title: The Journal of Pharmacology and Experimental Therapeutics (In press)
  • Peer Reviewed
• [Journal Article] Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia (2010)
  • Author(s): Michiko Nishiyori
  • Journal Title: Neuroscience Letters 472 Pages: 184-187
  • Peer Reviewed
• [Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury (2010)
  • Author(s): Hitoshi Uchida
  • Journal Title: Neuroscience 166 Pages: 1-4
  • Peer Reviewed
• [Journal Article] Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropo athic pain (2010)
  • Author(s): Weijiao Xie
  • Journal Title: Journal of Neurochemistry (In press)
  • Peer Reviewed
• [Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain (2010)
  • Author(s): Hitoshi Uchida
  • Journal Title: The Journal of Neuroscience (In press)
  • Peer Reviewed
• [Journal Article] 化学療法に伴う神経因性疼痛メカニズム (2010)
  • Author(s): 植田弘師
  • Journal Title: 日本整形外科学会雑誌 84 Pages: 24-30
  • NAID: 10026311285
• [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. (2009)
  • Author(s): Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
  • Journal Title: Mol Pain 5 Pages: 64-64
  • NAID: 120001897705
  • Peer Reviewed
• [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. (2009)
  • Author(s): Ma L, Matsumoto M, Xie W, Inoue M, Ueda H.
  • Journal Title: J Neurochem 109(2) Pages: 603-10
  • Peer Reviewed
• [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid:ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia. (2009)
  • Author(s): Uchida H, Matsumoto M, Ueda H.
  • Journal Title: Neurochem Int 54(3-4) Pages: 215-21
  • Peer Reviewed
• [Journal Article] Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation (2009)
  • Author(s): Yosuke Matsushita
  • Journal Title: Neuroreport 20 Pages: 63-68
  • Peer Reviewed
• [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid : ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia (2009)
  • Author(s): Hitoshi Uchida
  • Journal Title: Neurochemistry International 54 Pages: 215-221
  • Peer Reviewed
• [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 (2009)
  • Author(s): Lin Ma
  • Journal Title: Journal of Neurochemistry 109 Pages: 603-610
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid : an initiator of nerve injury-induced neuropathic pain (2009)
  • Author(s): Lin Ma
  • Journal Title: Molecular Pain 5 Pages: 64-64
  • Peer Reviewed
• [Journal Article] オピオイド耐性機構に関与するグルタミン酸-NMDA受容体アンチオピオイド機構 (2009)
  • Author(s): 植田弘師
  • Journal Title: 麻酔 58 Pages: 1136-1142
• [Journal Article] 神経障害性疼痛におけるリゾリン脂質のフィードフォワード性産生制御機構と病態生理機構 (2009)
  • Author(s): 植田弘師
  • Journal Title: 生体の化学 60 Pages: 490-491
• [Journal Article] 神経障害性疼痛を担うフィードフォワード増幅機構 (2009)
  • Author(s): 植田弘師
  • Journal Title: ペインクリニック 30 Pages: 1539-1544
• [Journal Article] Mechanisms underlying morphine analgesic tolerance and dependence (2009)
  • Author(s): Hiroshi Ueda
  • Journal Title: Frontiers in Bioscience (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia (2009)
  • Author(s): Hitoshi Uchida
  • Journal Title: Neurochemistry International 54 Pages: 215-221
  • Peer Reviewed
• [Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist (2009)
  • Author(s): Lin Ma
  • Journal Title: Journal of Neurochemistry 109 Pages: 603-610
  • Peer Reviewed
• [Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain. (2008)
  • Author(s): Inoue M, Ma L, Aoki J, Ueda H.
  • Journal Title: J Neurochem 107(6) Pages: 1556-65
  • Peer Reviewed
• [Journal Article] Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia. (2008)
  • Author(s): Nishiyori M, Ueda H.
  • Journal Title: Mol Pain 4 Pages: 52-52
  • NAID: 120001048780
  • Peer Reviewed
• [Journal Article] Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. (2008)
  • Author(s): Xie W, Matsumoto M, Chun J, Ueda H.
  • Journal Title: Mol Pain 4 Pages: 46-46
  • NAID: 120001048773
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid-induced membrane ruffling and BDNF gene expression are mediated by ATP release in primary microglia. (2008)
  • Author(s): Fujita R, Ma Y, Ueda H.
  • Journal Title: J Neurochem 107(1) Pages: 152-60
  • Peer Reviewed
• [Journal Article] Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury. (2008)
  • Author(s): Matsumoto M, Xie W, Ma L, Ueda H.
  • Journal Title: Mol Pain 4 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Peripheral mechanisms of neuropathic pain-involvement of lysophosphatidic acid receptor-mediated demyelination. (2008)
  • Author(s): Ueda H.
  • Journal Title: Mol Pain 4 Pages: 11-11
  • NAID: 120000916861
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid. (2008)
  • Author(s): Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.
  • Journal Title: Neuroscience 152(2) Pages: 296-8
  • Peer Reviewed
• [Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. (2008)
  • Author(s): Inoue M, Ma L, Aoki J, Chun J, Ueda H.
  • Journal Title: Mol Pain 4 Pages: 6-6
  • NAID: 120000912026
  • Peer Reviewed
• [Journal Article] Adhesiolysis and targeted steroid/local anesthetic injection during epiduroscopy alleviates pain and reduces sensory nerve dysfunction in patients with chronic sciatica. (2008)
  • Author(s): Sakai T, Aoki H, Hojo M, Takada M, Murata H, Sumikawa K.
  • Journal Title: J Anesth 22(3) Pages: 242-7
  • NAID: 10021942370
  • Peer Reviewed
• [Journal Article] Peripheral mechanisms of neuropathic pain-involvement of lysophosphatidic acid receptor-mediated demyelination (2008)
  • Author(s): Hiroshi Ueda
  • Journal Title: Molecular Pain 4 Pages: 11-11
  • NAID: 120000916861
  • Peer Reviewed
• [Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid (2008)
  • Author(s): Makoto Inoue
  • Journal Title: Neuroscience 152 Pages: 296-298
  • Peer Reviewed
• [Journal Article] Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury (2008)
  • Author(s): Misaki Matsumoto
  • Journal Title: Molecular Pain 4 Pages: 25-25
  • Peer Reviewed
• [Journal Article] Lysophosphtidic acid-induced membrane ruffling and brain-derived neurotropic factor gene expression are mediated by ATP release in primary microglia (2008)
  • Author(s): Ryousuke Fujita
  • Journal Title: Journal of Neurochemistry 107 Pages: 152-160
  • Peer Reviewed
• [Journal Article] Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury (2008)
  • Author(s): Xie Weijiao
  • Journal Title: Molecular Pain 4 Pages: 46-46
  • Peer Reviewed
• [Journal Article] Prolonged ganapentin analgesia in an experimental mouse model of fibromyalgia (2008)
  • Author(s): Michiko Nishiyori
  • Journal Title: Molecular Pain 4 Pages: 52-52
  • Peer Reviewed
• [Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain (2008)
  • Author(s): Makoto Inoue
  • Journal Title: Journal of Neurochemistry 107 Pages: 1556-1565
  • Peer Reviewed
• [Journal Article] ニューロメーターを用いた新しい知覚線維選択的侵害受容評価法 (2008)
  • Author(s): 植田弘師
  • Journal Title: 日薬理雑誌 131 Pages: 367-371
  • NAID: 10024382821
• [Journal Article] 疼痛疾患とオピオイド受容体遺伝子発現のエピジェネティック制御機構 (2008)
  • Author(s): 植田弘師
  • Journal Title: ペインクリニック 29 Pages: 315-322
• [Journal Article] 脱髄性神経因性疼痛におけるLPAの役割 (2008)
  • Author(s): 植田弘師
  • Journal Title: 医学のあゆみ Pages: 16-22
• [Journal Article] Peripheral mechanisms of neuropathic pain -involvement of lysophosphatidic acid receptor-mediated demyelination (2008)
  • Author(s): Hiroshi Ueda
  • Journal Title: Molecular Pain (In press)
  • NAID: 120000916861
  • Peer Reviewed
• [Journal Article] (2008)
  • Journal Title: Neuroscienci (E-pub)
  • Peer Reviewed
• [Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain (2008)
  • Author(s): Makoto Inoue
  • Journal Title: Molecular Pain (E-pub)
  • NAID: 120000912026
  • Peer Reviewed
• [Journal Article] 疼痛疾患とオピオイド受容体遺伝子発現のエピジェネティック制御機構 (2008)
  • Author(s): 植田 弘師
  • Journal Title: ペインクリニック 29 Pages: 199-205
• [Journal Article] LPA-mediated demyelination in ex vivo culture of dorsal root. (2007)
  • Author(s): Fujita R, Kiguchi N, Ueda H.
  • Journal Title: Neurochem Int. 50(2) Pages: 351-5
  • Peer Reviewed
• [Journal Article] Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents (2007)
  • Author(s): Misaki Matsumoto
  • Journal Title: Molecular Pain 3 Pages: 41-41
  • Peer Reviewed
• [Journal Article] Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task (2007)
  • Author(s): Jun Nagai
  • Journal Title: J Pharmacol Exp Ther. 321 Pages: 195-201
  • Peer Reviewed
• [Journal Article] Cancer pain model and morphine analgesia (2007)
  • Author(s): Mutsumi Ueda
  • Journal Title: Nippon Rinsho 65 Pages: 2-4
• [Journal Article] 脱髄性神経因性疼痛におけるLPAの役割 (2007)
  • Author(s): 植田 弘師
  • Journal Title: 医学のあゆみ 223 Pages: 674-680
• [Journal Article] 神経傷害時の有髄A線維におけるトランスアクティベーション機構 (2007)
  • Author(s): 井上 誠
  • Journal Title: ペインクリニック 28 Pages: 1013-1018
• [Journal Article] LPA-mediated demyelination in ex vivo culture of dorsal root. (2007)
  • Author(s): Fujita R
  • Journal Title: Neurochem Int 50 Pages: 351-355
• [Journal Article] Circadian-dependent learning and memory enhancement in nociceptin receptor (NOP)-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task. (2007)
  • Author(s): Nagai J
  • Journal Title: J Pharmacol Exp Ther (In press)
• [Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain. (2006)
  • Author(s): Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.
  • Journal Title: Mol Pain 2 Pages: 25-25
  • NAID: 120000912031
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. (2006)
  • Author(s): Ueda H.
  • Journal Title: Pharmacol Ther. 109(1-2) Pages: 57-77
  • Peer Reviewed
• [Journal Article] Evaluation of allodynia and pain associated with postherpetic neuralgia using current perception threshold testing. (2006)
  • Author(s): Sakai T, Tomiyasu S, Yamada H, Sumikawa K.
  • Journal Title: Clin J Pain 22(4) Pages: 359-62
  • Peer Reviewed
• [Journal Article] Inhibition of paclitaxel-Induced A-Fiber hypersensitization by gabapentin. (2006)
  • Author(s): Matsumoto M, Inoue M, Hald A, Xie W, Ueda H
  • Journal Title: J Pharmacol Exp Ther. 318(2) Pages: 735-40
  • Peer Reviewed
• [Journal Article] Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test. (2006)
  • Author(s): Matsumoto M
  • Journal Title: Mol.Pain 2 Pages: 16-20
• [Journal Article] Inhibition of paclitaxel-induced A-hypersensitization by gabapentin. (2006)
  • Author(s): Matsumoto M
  • Journal Title: J Pharmacol Exp Ther. 318 Pages: 735-740
• [Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain. (2006)
  • Author(s): Inoue M
  • Journal Title: Mol Pain 2 Pages: 25-29
  • NAID: 120000912031
• [Journal Article] Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms (2006)
  • Author(s): UEDA H
  • Journal Title: Pharmacol.Ther. 109 Pages: 57-77
• [Journal Article] NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings (2006)
  • Author(s): Matsumoto M
  • Journal Title: Neurosci Lett (In press)
• [Journal Article] Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.
  • Author(s): Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.
  • Journal Title: J Neurochem. (in press)
  • Peer Reviewed
• [Presentation] 慢性疼痛時の神経可塑性を担うリゾホスファチジン酸 (2010)
  • Author(s): 植田弘師
  • Organizer: 第39回日本慢性疼痛学会
  • Place of Presentation: 東京
• [Presentation] 線維筋痛症治療へのシーズ創出 (2010)
  • Author(s): 植田弘師
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 線維筋痛症モデルとしての繰り返し低温ストレス(ICS)マウスにおける塩酸ピロカルピンの鎮痛効果 (2010)
  • Author(s): 西依倫子
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 繰り返し低温ストレス(ICS)によるマウス線維筋痛症モデルの作成と正当性の薬理学的検証 (2010)
  • Author(s): 西依倫子
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] In vivo electroporation法を用いたmuオピオイド受容体遺伝子の脳局所導入とモルヒネ鎮痛の特異性 (2010)
  • Author(s): 佐々木恵太
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 神経因性疼痛を担う疼痛関連遺伝子のエピジェネティクス異常 (2010)
  • Author(s): 内田仁司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 神経因性疼痛の初発分子機構を担うリゾホスファチジン酸(LPA)ミクログリア活性化における関与 (2010)
  • Author(s): 永井潤
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 神経因性疼痛を担うリゾホスファチジン酸特異的脱髄 (2010)
  • Author(s): 永井潤
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] エピジェノミクス制御物質クルクミンによるモルヒネ耐性抑制とBDNF産生制御 (2009)
  • Author(s): 植田弘師
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] モルヒネ鎮痛耐性の形成初期における脳責任領域PAGでのミクロクリア活性化 (2009)
  • Author(s): 松下洋輔
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] The de novo biosynthesis of lysophosphatidic acid (LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber (2009)
  • Author(s): 井上 誠
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] Profiling of pain-related genes induced by lysophosphatidic acid, an initiator of neuropathic pain (2009)
  • Author(s): 内田仁司
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] Neural pathological roles for receptor mediated LPA signaling (2009)
  • Author(s): Ueda H
  • Organizer: FASEB SUMMER RESEARCH CONFERENCE
  • Place of Presentation: Arizona(USA)
• [Presentation] 神経の可塑性について-慢性疼痛機構におけるフィードフォワード増幅機構 (2009)
  • Author(s): 植田弘師
  • Organizer: 第23回日本ニューロモジュレーション学会
  • Place of Presentation: 東京
• [Presentation] 神経因性疼痛とリゾホスファチジン酸生合成 (2009)
  • Author(s): 植田弘師
  • Organizer: 第31回日本疼痛学会
  • Place of Presentation: 名古屋
• [Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常 (2009)
  • Author(s): 植田弘師
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 線維筋痛症患者における血清中リゾホスファチジルコリン濃度の上昇 (2009)
  • Author(s): 澤智華
  • Organizer: 第1回日本線維筋痛症学会
  • Place of Presentation: 大阪
• [Presentation] 線維筋痛症モデルとしてのICSモデルの有用性 (2009)
  • Author(s): 西依倫子
  • Organizer: 第1回日本線維筋痛症学会
  • Place of Presentation: 大阪
• [Presentation] リゾホスファチジン酸と神経因性疼痛と視床痛-ミクログリア関与の相違 (2009)
  • Author(s): 永井潤
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] リゾホスファチジン酸と神経因性疼痛-ミクログリアの関与の有無 (2009)
  • Author(s): 小川智世
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] リゾホスファチジン酸と神経因性疼痛-オートタキシンを介する生合成機構と病態発現における関与 (2009)
  • Author(s): 馬琳
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] リゾホスファチジン酸と神経因性疼痛-脱髄の関与と分子機構 (2009)
  • Author(s): 謝維嬌
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] リゾホスファチジン酸によるミクログリア活性化とATP遊離を介する間接的BDNF産生機構 (2009)
  • Author(s): 植村朋香
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸
• [Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常 (2009)
  • Author(s): 内田仁司
  • Organizer: 第26回日本薬学会九州支部総会
  • Place of Presentation: 福岡
• [Presentation] 神経障害によるリゾホスファチジン酸依存的な後根神経特異的脱髄に関する研究 (2009)
  • Author(s): 永井潤
  • Organizer: 第26回日本薬学会九州支部総会
  • Place of Presentation: 福岡
• [Presentation] エピジェネティクス制御物質クルクミンによるモルヒネ鎮痛耐性の抑制とBDNF発現調節 (2009)
  • Author(s): 三浦裕
  • Organizer: 第26回日本薬学会九州支部総会
  • Place of Presentation: 福岡
• [Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), initiates the sciatic nerve injury-induced neuropathic pain (2008)
  • Author(s): Makoto Inoue
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington D. C
  • Year and Date: 2008-11-17
• [Presentation] Microglia acivation is related to the initiation of morphine analgesic tolerance (2008)
  • Author(s): Yousuke Matsushita
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington D. C
  • Year and Date: 2008-11-16
• [Presentation] プロサイモシン・アルファによるPKCβを介した虚血神経ネクローシス抑制とPET解析 (2008)
  • Author(s): 藤田亮介
  • Organizer: 第114会日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] Experimental Models for Thalamic Pain and Fibromyalgia (2008)
  • Author(s): Hiroshi Ueda
  • Organizer: 13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIAIIONS FOR RHEUMATOLOGY
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-25
• [Presentation] Experimental fibromyalgia model and its characterization including gender difference (2008)
  • Author(s): Miroshi Ueda
  • Organizer: 13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIATIONS FOR FHEUMATOLOGY
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-24
• [Presentation] Intermittent cold stress causes a long-term allodynia and hyperalgesia in mice, a model for generalized chronic pain syndrome or fibromyalgia (2008)
  • Author(s): Hiroshi Ueda
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: Okinawa
  • Year and Date: 2008-09-04
• [Presentation] 脳梗寒時の胴保護に働くネクローシス抑制タンパク質、プロサイモシンアルフアの発見とその機能解明 (2008)
  • Author(s): 植田弘師
  • Organizer: 第6回鹿児島ニューロフォーラム
  • Place of Presentation: 鹿児島
  • Year and Date: 2008-07-22
• [Presentation] Nicotine analgesia and primary afferent cholinergic neuron (2008)
  • Author(s): Misaki Matsumoto
  • Organizer: Asian Pain 2008 (第30回日本疼痛学会)
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-20
• [Presentation] Sustained central sensitization of pain following lysophosphatidic acid injection into thalamus (2008)
  • Author(s): Hiroshi Ueda
  • Organizer: AsianPain2008
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-19
• [Presentation] 化学寮法に伴う神経因性疼痛のメカニズム (2008)
  • Author(s): 植田弘師
  • Organizer: 第41回日本整形外科学会 骨・軟部腫瘍学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2008-07-18
• [Presentation] Autotaxin mediates the induction of nerve-injured neuropathic pain through the synthetic enzymic action for lysophosphatidic acid (LPA) (2008)
  • Author(s): Lin Ma
  • Organizer: Asian Pain 2008
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Lysophosphatidylcholine (LPC)hydrolyzed by autotoxin/ATX into lysophosphatidic acid (LPA), induces neuropathic pain through LPA1 receptor (2008)
  • Author(s): Weijiao Xie
  • Organizer: Asian Pain 2008
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Lack of the evidence for nerve injury-specific ERK phosphorylation through Aβ-fiber in spinal neurons of LPA1 receptor-knock out mice (2008)
  • Author(s): Misaki Matsumoto
  • Organizer: Asian Pain 2008
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-07-18
• [Presentation] Microglia activation is involved in the initiation of morphine analgesic tolerance (2008)
  • Author(s): Saori Yonekubo
  • Organizer: INRC
  • Place of Presentation: Charleston, SC
  • Year and Date: 2008-07-14
• [Presentation] DIFFERENTIAL EXPRESSION OF BDNF TRANSCRIPTOMES IN MORPHINE-PRIMED MICROGLIA (2008)
  • Author(s): Michiko Horiguchi
  • Organizer: INRC
  • Place of Presentation: Charleston, SC
  • Year and Date: 2008-07-14
• [Presentation] Intra-thalamus injection of LPA induces long-lasting mechanical allodynia, thermal hyperalgesia and hypersensitization of myelinated A-fiber (2008)
  • Author(s): Jun Nagai
  • Organizer: Neuroscience 2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] Critical time period for lysophosphatidic acid (LPA)-signaling in nerve injury-typed neuropathic pain (2008)
  • Author(s): Lin Ma
  • Organizer: Neuroscience 2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), mediates the induction of nerve-injured neuropathic pain (2008)
  • Author(s): Weijiao Xie
  • Organizer: Neuroscience 2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] Prothymosin-alpha as a novel anti-ischemic neuroprotective protein (2008)
  • Author(s): Hiroshi Ueda
  • Organizer: Neuroscience2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-09
• [Presentation] リゾホスファチジン酸受容体と神経因性疼痛 (2008)
  • Author(s): 植田弘師
  • Organizer: 第5回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-09
• [Presentation] Experimental Models for Thalamic Pain and Fibromyalgia (2008)
  • Author(s): Ueda H
  • Organizer: APLAR2008(13TH CONGRESS OF THE ASIA PACIFIC LEAGUE OF ASSOCIATIONS FOR RHEUMATOLOGY)
  • Place of Presentation: 横浜
• [Presentation] 慢性痛と鎮痛薬-その分子機構解明 (2007)
  • Author(s): 植田弘師
  • Organizer: 第29回日本麻酔・薬理学会
  • Place of Presentation: 名古屋
• [Presentation] Molecular mechanisms of neuropathic pain (2007)
  • Author(s): Hiroshi Ueda
  • Organizer: Opioids Past and Future:relevance to pain and addiction
  • Place of Presentation: Salamanca, Spain
• [Presentation] 神経因性疼痛に特異的なニコチン鎮痛効果の分子機構研究-ChATのノックダウンによる痺痛応答解析 (2007)
  • Author(s): 植田 弘師
  • Organizer: 第29回日本疼痛学会
  • Place of Presentation: 横浜
• [Presentation] 神経因性疼痛のAβ線維を介する過敏応答-脊髄後角における新たなERK1/2リン酸化の証明 (2007)
  • Author(s): 松本 みさき
  • Organizer: 第29回日本疼痛学会
  • Place of Presentation: 横浜
• [Presentation] PAGにおけるBDNFの果たすモルヒネ鎮痛耐性維持機構 (2007)
  • Author(s): 松下 洋輔
  • Organizer: 第28回鎮痛薬・オピオイドシンポジウム
  • Place of Presentation: 札幌
• [Presentation] 全身性疼痛症候群(Generalized Pain Syndrome)としての線維筋痛症の動物実験モデル (2007)
  • Author(s): 植田 弘師
  • Organizer: 第1回線維筋痛症研究会
  • Place of Presentation: 東京
• [Presentation] Tonic inhibition of spinal pain transmission through cholinergic primary afferent neurons (2007)
  • Author(s): Misaki Matsumoto
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, California
• [Presentation] Evidence for Aβ-fiber-mediated allodynia; Pharmacological switch of spinal synaptic transmission (2007)
  • Author(s): Lin Ma
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, California
• [Presentation] Evidence for Aβ-fiber-mediated allodynia; novel appearance of pERK in spinal dorsal horn (2007)
  • Author(s): Weijiao Xie
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, California
• [Presentation] 末梢性アセチルコリン神経による内在性鎮痛機構 (2007)
  • Author(s): 松本 みさき
  • Organizer: 第60回日本薬理学会西南部会
  • Place of Presentation: 宮崎
• [Presentation] 疼痛の基礎医学 (2007)
  • Author(s): 植田 弘師
  • Organizer: がん診療連携拠点病院における緩和ケア
  • Place of Presentation: 東京
• [Presentation] 神経因性疼痛の分子機構 (2006)
  • Author(s): 植田弘師
  • Organizer: 第35回日本慢性疼痛学会
  • Place of Presentation: 東京
• [Book] わかる痛み学 (2009)
  • Author(s): 植田弘師, 戸田一雄
  • Total Pages: 177
  • Publisher: ブレーン出版
• [Book] Cellular Mechanisms Underlying Morphine Analgesic Tolerance and Hyperalgesia (2009)
  • Author(s): Ueda H
  • Publisher: Informa Healthcare, Opioid-Induced Hyperalgesia
• [Book] わかる痛み学 (2009)
  • Author(s): 植田弘師
  • Total Pages: 177
  • Publisher: ブレーン出版
• [Book] Opioid-Induced Hyperalgesia (2009)
  • Author(s): 植田弘師
  • Total Pages: 12
  • Publisher: Informa Healthcare
• [Book] 慢性疼痛の理解と医療連携 (2008)
  • Author(s): 植田弘師
  • Publisher: 真興交易
• [Book] 日本薬理学雑誌 (2006)
  • Author(s): 植田弘師
  • Publisher: 傷害性神経因性疼痛誘発を担うリゾホスファチジン酸
• [Book] ペインクリニック (2005)
  • Author(s): 植田弘師
  • Publisher: リゾホスファチジン酸誘発性神経因性疼痛
• [Book] 治療学 (2005)
  • Author(s): 木口倫一
  • Publisher: 疼痛と受容体3 リゾホスファチジン酸受容体
• [Remarks] 長崎大学院医歯薬学総合研究科分子薬理学分野ホームページ
  • URL: http://www.ph.nagasaki-u.ac.jp/lab/neuro/
• [Remarks] 長崎大学重点研究課題「痛み克服の国際的研究教育拠点の形成」ホームページ
  • URL: http://www.mdp.nagasaki-u.ac.jp/pain/
• [Patent(Industrial Property Rights)] 全身性疼痛症候群の治療または予防薬 (2008)
  • Inventor(s): 植田弘師
  • Industrial Property Number: 2008-204762
  • Filing Date: 2008-08-07
• [Patent(Industrial Property Rights)] 線維筋痛症の治療薬 (2007)
  • Inventor(s): 植田弘師
  • Filing Date: 2007-06-27