Protein from neuronal death by regulation ER stress response.

• Project/Area Number: 17200026
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: University of Miyazaki
• Principal Investigator: IMAIZUMI Kazunori University of Miyazaki, Department of Anatomy, Faculty of Medicine, Prof. (90332767)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000); Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2006: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2005: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
• Keywords: ER stress / neuronal death / molecular chaperone / Neurodegenerative disease / chemical compound / OASIS / 転写因子 / オートファジー

Research Abstract

Various neurodegenerative diseases are reported to be associated with be endoplasmic reticulum (ER) stress. To develop therapeutic strategies for these diseases, the whole aspects of ER stress response should be made clear. In the present study, we demonstrated the following issues ;
1) We identified a novel ER stress sensor BBF2H7, which is expressed in neurons of ischemic brains. The molecules are cleaved at the transmembrane domain in response to ER stress. N-terminal fragments of cleaved BBF2H7 are translocated into the nucleus and activates the transcription of target genes.
2) The formation of autophagosomes that are recognized as the double membrane structure with cytoplasmic contents was promoted in the neurons that were exposed to ER stress. Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress.
3) In screening for compounds that induce the ER-mediated chaperone BiP, we identified BiP Inducer X (BIX). Pretreatment of neuroblastoma cells with BIX reduced cell death induced by ER stress. Intracerebroventricular pretreatment with BIX reduced the area of infarction due to focal cerebral ischemia in mice, suggesting that it may be a potential therapeutic agent for cerebral diseases caused by ER stress.
4) We demonstrated that ER stress sensors, IRE1, PERK, and ATF6 exist in the ER of both soma and dendrites in primary cultured neurons, and that BiP and phosphoryrated eIF2a are induced. These results indicate that the ER in dendrites could respond to ER stress and retain the capacity of protein quality control.

Research Products

• [Journal Article] A molecular chaperone inducer protects neurons from ER stress (2008)
  • Author(s): Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M.
  • Journal Title: Cell death and differentiation 15 Pages: 364-375
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Nerve fiber analysis on the so-called accessory subscapularis muscle and its morphological significance (2008)
  • Author(s): Yoshinaga K, Kawai K, Tanii I, Imaizumi K, Kodama K.
  • Journal Title: Anatomical Science International 83 Pages: 55-59
  • NAID: 10021194852
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A molecular chaperone inducer protects neurons from ER stress (2008)
  • Author(s): Kudo, T., Kanemoto, S., Hara, H., Morimoto, N., Morihara, T., Kimura, R., Tabira, T., Imaizumi, K., Takeda, M.
  • Journal Title: Cell death and differentiation 15 Pages: 364-375
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nerve fiber analysis on the so-called accessory subscapularis muscle and its morphological significance (2008)
  • Author(s): Yoshinaga, K., Kawai, K., Tanii, I., Imaizumi, K., Kodama, K.
  • Journal Title: Anatomical Science International 83(1) Pages: 55-59
  • NAID: 10021194852
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A molecular chaperone inducer protects neurons from ER stress (2008)
  • Author(s): Kudo T, kanemoto S, Hara H, Morimoto N, Morihara T, kimura R, Tabira T, Imaizumi K, Takeda M.
  • Journal Title: Cell death and differentiation 15 Pages: 364-375
  • Peer Reviewed
• [Journal Article] BBF2H7,a novel transmembrane bZIP transcription factor,is a new type of endoplasmic reticulum stress transducer (2007)
  • Author(s): Kondo S, Saito A, Hino S-I, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, and Imaizumi K.
  • Journal Title: Molecular and Cellular Biology 27 Pages: 1716-1729
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1 (2007)
  • Author(s): Hino S-I, Kondo S, Sekiya H, Saito A, Kanemoto S, Murakami T, Chihara K, Aoki Y, Nakamori M, Takahashi MP, Ima i zum i K.
  • Journal Title: Human Molecular Genetics 16 Pages: 2834-2843
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress response in dendrites ofcultured primary neurons (2007)
  • Author(s): Murakami T, Hino S-I, Saito A, Imaizumi K.
  • Journal Title: Neuroscience 146 Pages: 1-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel ER stress transducer,OASIS,expressed in astrocytes (2007)
  • Author(s): Saito A, Hino S-I, Murakami T, Kondo S, Imaizumi K.
  • Journal Title: Antioxidants & Redox Signaling 9 Pages: 563-571
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle (2007)
  • Author(s): Ikezoe K, Nakamori M, Furuya H, Arahata H, Kanemoto S, Kimura T, Imaizumi K, Takahashi MP, Sakoda S, Fui i i N, Kira J-I.
  • Journal Title: Acta Neuropathologica 114 Pages: 527-535
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice (2007)
  • Author(s): Morimoto N, Oida Y, Shimazawa M, Miura M, Kudo T, Imaizumi K, Hara H.
  • Journal Title: Neuroscience 147 Pages: 957-967
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The human endogenous retrovirus envelope glycoprotein, syncytin-1,regulates neuroinflammation and its receptor expression in multiple sclerosis:a role for endoplasmic reticulum chaperones in astrocytes (2007)
  • Author(s): Antony JAI, Ellestad KK, Hammond R, Imaizumi K, Mallet F, Warren KG, Power C.
  • Journal Title: The Journal of Immunology 179 Pages: 1210-1224
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] HMGAla:sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA (2007)
  • Author(s): Manabe T, Ohe K, Katayama T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Imaizumi K, Reeves R, Tohvama M, Maveda A.
  • Journal Title: Genes to Cells 12 Pages: 1179-1191
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer (2007)
  • Author(s): Kondo, S., Saito, A., Hino, S.-I., Murakami, T., Ogata, M., Kanemoto, S., Nara, S., Yamashita, A., Yoshinaga, K., Hara, H., Imaizumi, K.
  • Journal Title: Molecular and Cellular Biology 27 Pages: 1716-1729
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. (2007)
  • Author(s): Hino, S.-I., Kondo, S., Sekiya, H., Saito, A., Kanemoto, S., Murakami T., Chihara, K., Aoki, Y., Nakamori, M., Takahashi, MP, Imaizumi, K.
  • Journal Title: Human Molecular Genetics 16 Pages: 2834-2843
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Endoplasmic reticulum stress response in dendrites of cultured primary neurons (2007)
  • Author(s): Murakami, T., Hino, S.-I., Saito, A., Imaizumi, K.
  • Journal Title: Neuroscience 146 Pages: 1-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anovel ER stress transducer, OASIS, expressed in astrocytes (2007)
  • Author(s): Saito, A., Hino, S.-I., Murakami, T., Kondo, S., Imaizumi, K.
  • Journal Title: Antioxidants & Redox Signaling 9 Pages: 563-571
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle (2007)
  • Author(s): Ikezoe, K., Nakamori, M., Furuya, H., Arahata, H., Kanemoto, S., Kimura, T., Imaizumi, K., Takahashi, MP, Sakoda, S., Fujii, N., Kira, J.-L.
  • Journal Title: Acta Neuropathologica 114 Pages: 527-535
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice (2007)
  • Author(s): Morimoto, N., Oida, Y., Shimazawa, M., Miura, M., Kudo, T., Imaizumi, K., Hara, H.
  • Journal Title: Neuroscience 147 Pages: 957-967
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Warren KG, Power C : The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis : a role for endoplasmic reticulum chaperones in astrocytes. (2007)
  • Author(s): Antony, JM, Ellestad, KK, Hammond, R., Imaizumi, K., Mallet, F.
  • Journal Title: The Journal of Immunology 179 Pages: 1210-1224
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] HMGAla : sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA. (2007)
  • Author(s): Manabe, T., Ohe, K., Katayama, T., Matsuzaki, S., Yanagita, T., Okuda, H., Bando, Y., Imaizumi, K., Reeves, R., Tohyama, M., Mayeda, A.
  • Journal Title: Genes to Cells 12 Pages: 1179-1191
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer (2007)
  • Author(s): Kondo S, Saito A, Hino S-I, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, and Imaizumi K.
  • Journal Title: Molecular and Cellular Biology 27 Pages: 1716-1729
  • Peer Reviewed
• [Journal Article] A novel ER stress transducer, OASIS, expressed in astrocytes (2007)
  • Author(s): Saito A, Hino S-I, Murakami T, Kondo S, and Imaizumi K.
  • Journal Title: Antioxidants & Redox Signaling 9 Pages: 563-571
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress response in dendrites of cultured primary neurons (2007)
  • Author(s): Murakami T, Hino S-I, Saito A, and Imaizumi K.
  • Journal Title: Neuroscience 146 Pages: 1-8
  • Peer Reviewed
• [Journal Article] BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of ER stress transducer (2007)
  • Author(s): Kondo S, Saito A, Hino S-I, Murakami T, Ogata M, Kanemoto S, Nara S, Yamashita A, Yoshinaga K, Hara H, Imaizumi K
  • Journal Title: Molecular and Cellular Biology 27(5) Pages: 1716-1729
• [Journal Article] Endoplasmic reticulum stress response in dendrites of cultured primary neurons (2007)
  • Author(s): Murakami T, Hino S-I, Saito A, Imaizumi K
  • Journal Title: Neuroscience (in press)
• [Journal Article] A novel ER stress transducer, OASIS, expressed in astrocytes (2007)
  • Author(s): Saito A, Hino S-I, Murakami T, Kondo S, Imaizumi K
  • Journal Title: Antioxidants ＆ Redox Signalimg (in press)
• [Journal Article] Autophagy is activated for cell survival after endoplasmic reticulum stress (2006)
  • Author(s): Ogata M, Hino S-I, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Drano F, Imaizumi K.
  • Journal Title: Molecular and Cellular Biology 26 Pages: 9220-9231
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
  • Journal Title: Biochem Biophys Res Commun 344 Pages: 525-530
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress (2006)
  • Author(s): Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, Imaizumi K.
  • Journal Title: Journal of Neurochemistry 96 Pages: 1090-1100
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The pro-apoptotic human BH3-only peptide harakiri isexpressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients (2006)
  • Author(s): Shinoe T, Wanaka A, Nikaido T, Kakuta Y, Masunaga A, Shimizu J, Duyckaerts C, Imaizumi K, Iwamoto A, Kanazawa I.
  • Journal Title: Neuroscience Letters 393 Pages: 102-107
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Autophagy is activated for cell survival after endoplasmic reticulum stress (2006)
  • Author(s): Ogata, M., Hino, S-I, Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback, JA, Urano, F., Imaizumi, K.
  • Journal Title: Molecular and Cellular Biology 26 Pages: 9220-9231
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress (2006)
  • Author(s): Kudo, T., Okumura, M., Imaizumi, K., Araki, W., Morihara, T., Tanimukai, H., Kamagata, E., Tabuchi, N., Kimura, R., Kanayama, D., Fukumori A., Tagami, S., Okochi, M., Kubo, M., Tanii, H., Tohyama, M., Tabira, T., Takeda, M.
  • Journal Title: Biochem Biophys Res Commun 344 Pages: 525-530
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress (2006)
  • Author(s): Murakami, T., Kondo, S., Ogata, M., Kanemoto, S., Saito, A., Wanaka, A., Imaizumi, K.
  • Journal Title: Journal of Neurochemistry 96 Pages: 1090-1100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected periyascular macrophages in HIV-1 encephalitis patients (2006)
  • Author(s): Shinoe, T., Wanaka, A., Nikaido, T., Kakuta, Y., Masunaga, A., Shimizu, J., Duyckaerts, C., Imaizumi, K., Iwamoto, A., Kanazawa, I.
  • Journal Title: Neuroscience Letters 393 Pages: 102-107
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autophagy is activated for cell survival after endoplasmic reticulum stress (2006)
  • Author(s): Ogata M, Hino S-I, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K
  • Journal Title: Molecular and Cellular Biology 26(24) Pages: 9220-9231
• [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress (2006)
  • Author(s): Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
  • Journal Title: Biochemical and Biophysical Research Communications 344 Pages: 525-530
• [Journal Article] Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress. (2006)
  • Author(s): Murakami T, Kondo S, Ogata M, Kanemoto S, Saito A, Wanaka A, Imaizumi K.
  • Journal Title: J Neurochem. 96 Pages: 1090-1100
• [Journal Article] The pro-apoptotic human BH3-only peptide harakiri is expressed in cryptococcus-infected perivascular macrophages in HIV-1 encephalitis patients. (2006)
  • Author(s): Shinoe T, Wanaka A, Nikaido T, Kakuta Y, Masunaga A, Shimizu J, Duyckaerts C, Imaizumi K, Iwamoto A, Kanazawa I.
  • Journal Title: Neurosci Lett. 393 Pages: 102-107
• [Journal Article] OASIS,a CREB/ATF-family member, modulates UPR signalling in astrocytes (2005)
  • Author(s): Kondo S, Murakami T, Tatsumi K, OgataM, Kanemoto S, Otori K, Iseki K, Wanaka A, Imaizumi K.
  • Journal Title: Nature Cell Biology 7 Pages: 186-194
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress (2005)
  • Author(s): Kanemoto S, Rondo S, Ogata M, Murakami T, Urano F, Imaizumi K.
  • Journal Title: Biochem Biophys Res Commun 331 Pages: 1146-1153
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Candidates for tumor-specific alternative splicing (2005)
  • Author(s): Okumura M, Kondo S, Ogata M, Kanemoto S, Murakami T, Yanagida K, Saito A, Imaizumi K.
  • Journal Title: Biochem Biophys Res Commun 334 Pages: 23-29
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes (2005)
  • Author(s): Kondo, S., Murakami, T., Tatsumi, K., Ogata, M., Kanemoto, S., Otori, K., Iseki, K., Wanaka, A., Imaizumi, K.
  • Journal Title: Nature Cell Biology 7 Pages: 186-194
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Candidates for tumor-specific alternative splicing (2005)
  • Author(s): Kanemoto, S., Kondo, S., Dgata, M., Murakami, T., Urano, F., Imaizumi, K.
  • Journal Title: Biochem Biophys Res Commun 331 Pages: 1146-1153
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Candidates for tumor-specific alternative splicing (2005)
  • Author(s): Okumura, M., Kondo, S., Ogata, M., Kanemoto, S., Murakami, T., Yanagida, K., Saito, A., Imaizumi, K.
  • Journal Title: Biochem Biophys Res Commun 334 Pages: 23-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] OASIS, a CREB/ATF family member, modulates the UPR signaling in astrocytes (2005)
  • Author(s): Kondo S, Murakami T, Ogata M, Kanemoto S, Otori K, Iseki K, Tatsumi K, Wanaka A, Imaizumi K.
  • Journal Title: Nature Cell Biology 7(2) Pages: 186-194
• [Journal Article] XBP1 activates the transcription of itstarget genes via an ACGT core sequence under ER stress. (2005)
  • Author(s): Kanemoto S, Kondo S, Ogata M, Murakami T, Urano F, Imaizumi K.
  • Journal Title: Biochem Biophys Res Commun. 331(4) Pages: 1146-1153
• [Journal Article] Candidates for tumor specific alternative splicing. (2005)
  • Author(s): Okumura M, Kondo S, Ogata M, Kanemoto S, Murakami T, Yanagida K, Saito A, Imaizumi K.
  • Journal Title: Biochem.Biophys.Res.Com. 334 Pages: 23-29
• [Presentation] 小胞体ストレスセンサーBBF2H7欠損マウスの生体内機能解析 (2008)
  • Author(s): 日野 真一郎、斎藤 敦、近藤 慎一、今泉 和則
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分
  • Year and Date: 2008-03-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 骨芽細胞における小胞体ストレストランスデューサーOASISの役割 (2008)
  • Author(s): 村上 智彦、金本 聡自、近藤 慎一、吉永 一也、和中 明生、今泉 和則
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分
  • Year and Date: 2008-03-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diversity of ER stress response (2008)
  • Author(s): Imaizumi K.
  • Organizer: CINP Pacific-Asia Regional Meeting
  • Place of Presentation: Kuala Lumpur,Malaysia
  • Year and Date: 2008-03-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diversity of ER stress response (2008)
  • Author(s): Imaizumi, K.
  • Organizer: CINP Pacific-Asia Regional Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2008-03-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 筋強直性ジストロフィータイプ1におけるSERCAIの異常スプライシングの分子機構 (2007)
  • Author(s): 日野 真一郎、高橋 正紀、今泉 和則
  • Organizer: 第30回日本分子生物学会年会(BMB2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーBBF2H7の機能解析 (2007)
  • Author(s): 日野 真一郎、斎藤 敦、近藤 慎一、今泉 和則
  • Organizer: 第2回臨床ストレス応答学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 骨芽細胞における小胞体ストレストランスデューサーOASISの役割 (2007)
  • Author(s): 村上 智彦、金本 聡自、近藤 慎一、吉永 一也、和中 明生、今泉 和則
  • Organizer: 第2回臨床ストレス応答学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OASIS,an endoplasmic reticulum stress transducer,is involved in normalbone formation (2007)
  • Author(s): Kondo S, Murakami T, Imaizumi K.
  • Organizer: International Symposium on Membrane Traffic
  • Place of Presentation: Awaji Island,Japan
  • Year and Date: 2007-11-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OASIS, an endoplasmic reticulum stress transducer, is involved in normal bone formation (2007)
  • Author(s): Kondo, S., Murakami, T., Imaizumi, K.
  • Organizer: International Symposium on Membrane Traffic
  • Place of Presentation: Awaji Island, Japan
  • Year and Date: 2007-11-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] OASISファミリータンパク質の生体内機能 (2007)
  • Author(s): 今泉 和則
  • Organizer: 第2回小胞体ストレス研究会
  • Place of Presentation: 吹田
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーOASISと骨形成 (2007)
  • Author(s): 今泉 和則
  • Organizer: 日本解剖学会第63回九州支部学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2007-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレス応答の多様性 (2007)
  • Author(s): 今泉 和則
  • Organizer: 千里ライフサイエンスセミナー ブレインサイエンスシリーズ第20回「小胞体ストレスと脳神経疾患」
  • Place of Presentation: 豊中
  • Year and Date: 2007-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレス応答の多様性 (2007)
  • Author(s): 今泉和則
  • Organizer: 千里ライフサイエンスセミナーブレインサイエンスシリーズ第20回「小胞体ストレスと脳神経疾患」
  • Place of Presentation: 大阪府豊中市
  • Year and Date: 2007-09-28
• [Presentation] OASIS,an endoplasmic reticulum stress transducer,is involved in normal bone formation (2007)
  • Author(s): Murakami T, kanemoto S, Kondo S, Wanaka A, Imaizumi K.
  • Organizer: The American Society for Bone and Mineral Research(ASBMR)29th Annual Meeting
  • Place of Presentation: Honolulu,Hawaii,USA
  • Year and Date: 2007-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OASIS, an endoplasmic reticulum stress transducer, is involved in normal bone formation (2007)
  • Author(s): Murakami, T., Kanembto, S., Kondo, S., Wanaka, A., Imaizumi, K.
  • Organizer: The American Society for Bone and Mineral Research(ASBMR) 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA.
  • Year and Date: 2007-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ジストロフィータイプ1におけるSERCA1の異常スプライシング (2007)
  • Author(s): 関屋 裕史、日野 真一郎、中森 雅之、高橋 正紀、今泉 和則
  • Organizer: 第50回日本神経化学会大会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ニュータイプの小胞体ストレスセンサーBBF2H7は、障害を受けた神経細胞で発現する (2007)
  • Author(s): 近藤 慎一、原 英彰、今泉 和則
  • Organizer: 第50回日本神経化学会大会(Neuro2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A new type of ER stress transducer, BBF2H7 expresses in injured neurons (2007)
  • Author(s): Kondo, S., Hara, H., Imaizumi, K.
  • Organizer: 50th Japanese Society for Neurochemistry
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2007-09-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ニュータイプの小胞体ストレスセンサーBBF2H7は、障害を受けた神経細胞で発現する (2007)
  • Author(s): 近藤慎一、原 英彰、今泉和則
  • Organizer: 第50回日本神経化学会大会(Neuro2007)
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-11
• [Presentation] スプライシング異常によるヒト疾患 (2007)
  • Author(s): 今泉 和則
  • Organizer: 日本進化学会第9回京都大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 組織・細胞種特異的小胞体ストレス応答と疾患 (2007)
  • Author(s): 今泉 和則
  • Organizer: 平成19年度生理学研究所研究会-細胞死研究の新たな潮流と疾患研究への展開
  • Place of Presentation: 岡崎
  • Year and Date: 2007-08-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーOASISによるosteocalcinの発現制御機構の解析 (2007)
  • Author(s): 金本 聡自、村上 智彦、近藤 慎一、和中 明生、今泉 和則
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーOASISと骨芽細胞 (2007)
  • Author(s): 村上 智彦、金本 聡自、近藤 慎一、和中 明生、今泉 和則
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OASIS,an ER stress transducer,is involved in bone metabolism.-Analysis of OASIS knockout mouse (2007)
  • Author(s): Kanemoto S, Murakami T, Kondo S, Yoshinaga K, Wanaka A, Imaizumi K.
  • Organizer: 17th Scientific Meeting of the International Bone and Mineral Society
  • Place of Presentation: 今泉 和則
  • Year and Date: 2007-06-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OASIS, an ER stress transducer, is involved in bone metabolism. -Analysis of OASIS knockout mouse (2007)
  • Author(s): Kanemoto, S., Murakami, T., Kondo, S., Yoshinaga, K., Wanaka, A., Imaizumi, K.
  • Organizer: 17th Scientific Meeting of the International Bone and Mineral Society
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2007-06-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 日本薬学会第127年会 (2007)
  • Author(s): 骨形成不全を示す小胞体ストレスセンサーOASIS欠損マウスの解析
  • Organizer: 20070330
  • Place of Presentation: 富山
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーOASISと骨形成 (2007)
  • Author(s): 今泉 和則
  • Organizer: 第112回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスによって誘導されるオートファジー (2007)
  • Author(s): 今泉 和則
  • Organizer: 第80回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] BBF2H7,a novel transmenbrane bZIP transcription factor,is a new type of ER stress transducer (2007)
  • Author(s): Kondo S, Imaizumi K.
  • Organizer: 4th International Meeting Steroids and Nervous System
  • Place of Presentation: Torino,Italy
  • Year and Date: 2007-02-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] BBF2H7, a novel transmenbrane bZIP transcription factor, is a new type of ER stress transducer (2007)
  • Author(s): Kondo, S., Imaizumi, K.
  • Organizer: 4th International Meeting Steroids and Nervous System
  • Place of Presentation: Torino,Italy
  • Year and Date: 2007-02-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] BBF2H7,a novel transmenbrane bZIP transcription factor,is a new type of ER stress transducer (2007)
  • Author(s): Kondo S, Imaizumi K.
  • Organizer: Biochemical Society Focused Meeting(Bionanotechnology:from self-assembly to cell biology)
  • Place of Presentation: Cambridge,UK
  • Year and Date: 2007-01-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] BBF2H7, a novel transmenbrane bZIP transcription factor, is a new type of ER stress transducer (2007)
  • Author(s): Kondo, S., Imaizumi, K.
  • Organizer: Biochemical Society Focused Meeting(Bionariotechnology : from self-assembly to cell biology)
  • Place of Presentation: Cambridge, UK.
  • Year and Date: 2007-01-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 筋強直性ジストロフィータイプ1におけるSERCA1の異常スプライシングの分子機構の解析. (2006)
  • Author(s): 日野 真一郎、関屋 裕史、近藤 慎一、中森 雅之、高橋 正紀、今泉 和則
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体分子シャペロンを誘導する新規化合物BIXの薬効解析 (2006)
  • Author(s): 金本 聡自、原 英彰、工藤 喬、今泉 和則
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規小胞体ストレストランスデューサーBBF2H7の機能解析 (2006)
  • Author(s): 近藤 慎一、原 英彰、今泉 和則
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスセンサーOASIS欠損マウスの解析 (2006)
  • Author(s): 村上 智彦、金本 聡自、和中 明生、今泉 和則
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of a novel ER stress transducer BBF2H7 (2006)
  • Author(s): Kondo, S., Hara, H., Imaizumi, K.
  • Organizer: 29th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-12-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 小胞体分子シャペロンを誘導する新規化合物BIXの同定および薬効解析 (2006)
  • Author(s): 金本 聡自、原 英彰、工藤 喬、今泉 和則
  • Organizer: 第1回臨床ストレス応答学会大会
  • Place of Presentation: 京都
  • Year and Date: 2006-11-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autophagy is activated for cell survival after ER stress (2006)
  • Author(s): Hino S-I, Ogata M, Saito A, Urano F, Imaizumi K.
  • Organizer: 第1回臨床ストレス応答学会大会
  • Place of Presentation: 京都
  • Year and Date: 2006-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アストロサイト特異的小胞体ストレスセンサーOASISにより発現制御される遺伝子の探索 (2006)
  • Author(s): 斎藤 敦、今泉 和則
  • Organizer: 日本解剖学会第62回九州支部学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2006-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary hippocampal neurons (2006)
  • Author(s): Murakami T, Imaizumi K.
  • Organizer: The 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta,USA
  • Year and Date: 2006-10-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary hippocampal neurons (2006)
  • Author(s): Murakami, T., Imaizumi, K.
  • Organizer: The 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta, USA.
  • Year and Date: 2006-10-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膜貫通型転写因子OASISファミリーと小胞体ストレス応答 (2006)
  • Author(s): 今泉 和則
  • Organizer: 第1回小胞体ストレス研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2006-10-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel chemical compound, BIX, suppresses neuronal death via the induction of an ER chaperone (2006)
  • Author(s): Kanemoto S, Hara H, Kudo T, Imaizumi K.
  • Organizer: The 6th Annual Meeting of International College of Geriatric Psvchoneuropharmacologv(ICGP)
  • Place of Presentation: Hiroshima
  • Year and Date: 2006-10-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel chemical compound, BIX, suppresses neuronal death via the induction of an ER chaperone (2006)
  • Author(s): Kanemoto, S., Hara, H., Kudo, T., Imaizumi, K.
  • Organizer: The 6th Annual Meeting of International College of Geriatric Psychoneuropharmacology(ICGP)
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2006-10-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2006)
  • Author(s): Murakami, T., Imaizumi, K.
  • Organizer: 48th Japanese Society forNeurochemistry
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2006-09-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Chemical compound, BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2006)
  • Author(s): Kanemoto, S., Kudo, T., Imaizumi, K.
  • Organizer: 48th Japanese Society for Neurochemistry
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2006-09-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Autophagy is activated During ERstress via the ER-resident transmembrane kinase IRE1. (2006)
  • Author(s): Ogata, M., Urano, F., Imaizumi, K.
  • Organizer: 48th Japanese Society for Neurochemistry
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2006-09-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A molecular chaperone inducer as protential anti-Alzheimer treatment (2006)
  • Author(s): Kudo T, Kanemoto S, Imaizumi K, Hara H, Morimoto N, Tabira T, Takeda M.
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel ER molecular chaperone inducible compound,BIX,suppresses neuronal death from ER stress (2006)
  • Author(s): Kanemoto S, Hara H, Kudo T, Imaizumi K.
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanisms responsible for aberrant splicing of SERCAI in mvotonic dystrophy type 1 (2006)
  • Author(s): Hino S-I, Sekiya H, Kondo S, Nakamori M, Takahashi MP, Imaizumi K.
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IRE1-JNK pathway is essential for activation of autophagv after ER stress (2006)
  • Author(s): Ogata M, Hino S-I, Saito A, Urano F, Imaizumi K.
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary hippocampal neurons (2006)
  • Author(s): Murakami T, Imaizumi K.
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type 1. (2006)
  • Author(s): Hino, S.-I., Sekiya, H., Kondo, S., Nakamori, M., Takahashi, MP, Imaizumi, K.
  • Organizer: 49th Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] IRE1-JNK pathway is essential for activation of autophagy after ER stress (2006)
  • Author(s): Ogata, M., Hino, S.-I., Saito, A., Urano, F., Imaizumi, K.
  • Organizer: 49th Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ER stress response in dendrites of primary hippocampal neurons (2006)
  • Author(s): Murakami, T., Imaizumi, K.
  • Organizer: 49th Japanese Society for Neurochemistry
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 小胞体ストレス研究の新展開 (2006)
  • Author(s): 今泉 和則
  • Organizer: 第8回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 松山
  • Year and Date: 2006-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuroprotective effects of an ER molecular chaperone inducible compound,BIX,against ER stress in in vitro and in vivo analysis (2006)
  • Author(s): Kanemoto S, Hara H, Kudo T, Imaizumi K.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna,Austria
  • Year and Date: 2006-07-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuroprotective effects of an ER molecular chaperone inducible compound, BIX,against ER stress in in vitro and in vivo analysis (2006)
  • Author(s): Kanemoto, S., Hara, H., Kudo, T., Imaizumi, K.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2006-07-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Young Investigators Colloquium: The roles of novel transmembrane bZIP transcription fanctors in Unfolded protein response (2006)
  • Author(s): Kondo S, Imaizumi K.
  • Organizer: 7th Biennial Meeting of the Asian Pacif is Society for NeuroChemistry(APSN 2006)
  • Place of Presentation: Singapore
  • Year and Date: 2006-07-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Young Investigators Colloquium : The roles of novel transmembrane bZIP transcription fanctors in Unfolded protein response (2006)
  • Author(s): Kondo, S., Imaizumi, K.
  • Organizer: 7th Biennial Meeting of the Asian Pacific Society for NeuroChemistry(APSN 2006)
  • Place of Presentation: Singapore
  • Year and Date: 2006-07-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2006)
  • Author(s): Murakami T, Imaizumi K.
  • Organizer: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2006-06-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2006)
  • Author(s): Murakami, T., Imaizumi, K.
  • Organizer: The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2006-06-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 新規膜貫通型転写因子と小胞体ストレス応答 (2006)
  • Author(s): 近藤 慎一、今泉 和則
  • Organizer: 第111回日本解剖学会総会・全国学術集会
  • Place of Presentation: 相模原
  • Year and Date: 2006-03-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスによって活性化されるオートファジー (2006)
  • Author(s): 斎藤 敦、緒方 麻衣子、日野 真一郎、浦野 文彦、今泉 和則
  • Organizer: 第111回日本解剖学会総会・全国学術集会
  • Place of Presentation: 相模原
  • Year and Date: 2006-03-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autophagy is activated during ER stress via the ER-resident transmembranekinase IREI. (2005)
  • Author(s): Ogata M, Urano F, Imaizumi K.
  • Organizer: The American Society for Cell Biology 45th Annual Meeting
  • Place of Presentation: Sanfrancisco,USA
  • Year and Date: 2005-12-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autophagy is activated during ER stress via the ER-resident transmembrane kinase IRE1. (2005)
  • Author(s): Ogata, M., Urano, F., Imaizumi, K.
  • Organizer: The American Society for Cell Biology 45th Annual Meeting
  • Place of Presentation: Sanfrancisco, USA.
  • Year and Date: 2005-12-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Autophagy system is activated during ER stress via the ER-resident transmembrane kinase IRE1 (2005)
  • Author(s): Saito A, Ogata M, Urano F, Imaizumi K.
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2005-12-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autophagy system is activated during ER stress via the ER-resident transmembrane kinase IRE1. (2005)
  • Author(s): Saito, A., Ogata, M., Urano, F., Imaizumi, K.
  • Organizer: 28th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2005-12-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Chemical compound,BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2005)
  • Author(s): Kanemoto S, Kudo T, Imaizumi K.
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2005-12-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Chemical compound, BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2005)
  • Author(s): Kanemoto, S., Kudo, T., Imaizumi, K.
  • Organizer: 28th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Fukuoka, Japan.
  • Year and Date: 2005-12-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The roles of novel transmembrane bZIP transcription factors in Unfolded protein response (2005)
  • Author(s): Kondo S, Yamashita A, Imaizumi K.
  • Organizer: Society for Neuroscience 35th Annual Meeting
  • Place of Presentation: Washington,DC,USA
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2005)
  • Author(s): Murakami T., Imaizumi K.
  • Organizer: Society for Neuroscience 35th Annual Meeting
  • Place of Presentation: Washington,DC,USA
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Chemical compound,BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2005)
  • Author(s): Kanemoto S, Kudo T, Imaizumi K.
  • Organizer: Society for Neuroscience 35th Annual Meeting
  • Place of Presentation: Washington,DC,USA
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The roles of novel transmembrane bZIP transcription factors in Unfolded protein response (2005)
  • Author(s): Kondo, S., Yamashita, A., Imaizumi, K.
  • Organizer: Society for Neuroscience 35th AnnualMeeting
  • Place of Presentation: Washington, DC, USA.
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2005)
  • Author(s): Murakami, T., Imaizumi, K.
  • Organizer: Society for Neuroscience 35th AnnualMeeting
  • Place of Presentation: Washington, DC, USA.
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Chemical compound, BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2005)
  • Author(s): Kanemoto, S., Kudo, T., Imaizumi, K.
  • Organizer: Society for Neurosoience 35th Annual Meeting
  • Place of Presentation: Washington, DC, USA.
  • Year and Date: 2005-11-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The regulation of unfolded protein response by OASIS,a transmembrane bZIP transcription factor,in astrocytes (2005)
  • Author(s): Imaizumi, K.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Hyogo
  • Year and Date: 2005-11-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The regulation of unfolded protein response by OASIS, a transmembrane bZIP transcription factor, in astrocytes (2005)
  • Author(s): Imaizumi, K.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2005-11-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 神経細胞における小胞体ストレスのinvivoイメージングー神経変性疾患の病態解明を目指して。 (2005)
  • Author(s): 今泉 和則
  • Organizer: 第36回病態代謝研究会報告会
  • Place of Presentation: 東京
  • Year and Date: 2005-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレス応答の多様性 (2005)
  • Author(s): 今泉 和則
  • Organizer: 平成17年度生理学研究所研究会「細胞死の新たな生理機能と病態における意義」
  • Place of Presentation: 岡崎
  • Year and Date: 2005-10-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスによって誘導されるオートファジー (2005)
  • Author(s): 緒方 麻衣子、今泉 和則
  • Organizer: 第61回日本解剖学会九州支部学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2005-10-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 神経細胞の樹状突起における小胞体ストレス応答 (2005)
  • Author(s): 村上 智彦, 今泉 和則
  • Organizer: 第61回日本解剖学会九州支部学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2005-10-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diversity of ER stress response (2005)
  • Author(s): 今泉 和則
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ER stress response in dendrites of primary neurons (2005)
  • Author(s): 村上 智彦、今泉 和則
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Chemical compound,BIX,protects cells from neuronal death induced by ER stress via induction of ER molecular chaperone (2005)
  • Author(s): 金本 聡自、工藤 喬、今泉 和則
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autophagy is activated During ER stress via the ER-resident transmembrane kinase IRE (2005)
  • Author(s): 緒方 麻衣子、浦野 文彦、今泉 和則
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規膜貫通型転写因子と小胞体ストレス応答 (2005)
  • Author(s): 近藤 慎一、今泉 和則
  • Organizer: 第6回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 白浜
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスによって活性化されるオートファジー (2005)
  • Author(s): 緒方 麻衣子、今泉 和則
  • Organizer: 第6回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 白浜
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体分子シャペロンを誘導する新規化合物BIXの薬効および作用機序に関する解析 (2005)
  • Author(s): 金本 聡自、今泉 和則
  • Organizer: 第6回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 白浜
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 神経細胞の樹状突起における小胞体ストレス応答 (2005)
  • Author(s): 村上 智彦、今泉 和則
  • Organizer: 第6回ORIGIN神経科学研究会夏のワークショップ
  • Place of Presentation: 白浜
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体ストレスとその応答機構 (2005)
  • Author(s): 今泉 和則
  • Organizer: 第2回Neuroscience Frontier Research Conference
  • Place of Presentation: 千葉
  • Year and Date: 2005-08-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 小胞体分子シャペロンを誘導する新規化合物BIXによる神経細胞死抑制効果の検討 (2005)
  • Author(s): 金本 聡自、今泉 和則
  • Organizer: 第9回宮崎Neuroscience研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2005-07-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanisms of aberrant splicing in neurodegenerative disorders (2005)
  • Author(s): Imaizumi, K.
  • Organizer: Kobe Conference on splicing
  • Place of Presentation: Kobe
  • Year and Date: 2005-06-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal death induced by endoplasmic reticulum stress (2005)
  • Author(s): Imaizumi K, Tohyama M.
  • Organizer: 第28回日本基礎老化学会
  • Place of Presentation: Tokyo
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal death induced by endoplasmicreticulum stress (2005)
  • Author(s): Imaizumi, K., Tohyama, M.
  • Organizer: The 28th Annual Meeting of JapanSociety for Biomedical Gerontology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] KEYWORD精神第4版 (2007)
  • Author(s): 今泉 和則
  • Total Pages: 239
  • Publisher: 新規小胞体ストレスセンサー(OASIS)
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 軟骨疾患のモデル非ヒト動物 (2007)
  • Inventor(s): 今泉 和則、日野 真一郎
  • Industrial Property Rights Holder: 国立大学法人宮崎大学
  • Filing Date: 2007-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 軟骨疾患のモデル非ヒト動物 (2007)
  • Inventor(s): 今泉和則、日野真一郎
  • Industrial Property Rights Holder: 国立大学法人宮崎大学
  • Filing Date: 2007-11-29