Mechanism of molecular basis for "Tailor-made and measurable physical exercise program "and the educational application, evaluated from stress protein (molecular chaperone).
| Project/Area Number |
17200039
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ATOMI Yoriko The University of Tokyo, Graduate School of Arts and Sciences, Professor (90125972)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Yasumitsu The University of Tokyo, Graduate School of Arts and Sciences, Associate Professor (80303874)
HATTA Hideo The University of Tokyo, Graduate School of Arts and Sciences, Associate Professor (60208535)
YANAGIHARA Dai The University of Tokyo, Graduate School of Arts and Sciences, Associate Professor (90252725)
SAKURAI Takashi The University of Tokyo, Graduate School of Arts and Sciences, Research Associate (60401204)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥48,360,000 (Direct Cost: ¥37,200,000、Indirect Cost: ¥11,160,000)
Fiscal Year 2006: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2005: ¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
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| Keywords | Stress protein / aB-crystallin / HSP47 / mild stress / ECM (Extracellular matrix) / mechanical stimuli / aging / dynamic instability / 脳と筋 / 適応 / 細胞骨格 / 細胞外マトリックス / 張力発揮 / 分子シャペロン / αB-crystallin / 身体運動 / 運動効果 / 適度な運動 / 分子機構 / sHSPs / ミオシン重鎖アイソフォーム / チューブリン |
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| Research Abstract |
The principle of "tailor-made and measurable physical exercise program' has been studied from dual protein fiber structures of the cytoskeleton and extracellular matrix (ECM), and their molecular chaperone (stress proteins) for main tissues creating exercise, muscles and joints, and their constituting cells. Important results are as follows; 1) The C-terminal located crytallin domain in B-crystallin (B) works as chaperone against tubulin aggregation. 2) As GFP-1 B in beating cultured heart cells shows striation, it must function as chaperone for structural proteins. 3) The N terminal region of OB plays to decrease depolymerization of MAP-microtubule. 4) Disuse muscle atrophy induces the decrease of specific collagen chaperone HSP47 in ER. Similar results were obtained in cultured myoblasts. Possible new gravity-response element in the regulatory domain of HSP47 gene will be identified. 5) The increased temperature of 2 11 of cultured muscle cells facilitates muscle differentiation and increase slow myosin expression. 6) Mild running exercise induces type III collagen, hyaluronic acid synthase in rat knee joint, meaning existence of "good exercise" to contribute to change toward younger cellular environment in our body. 7) Phosphorylated CB/HSP27 and ubiquitinated proteins in human sedentary elderly skeletal muscle increase, suggesting lowered protein degradation. 8) HSP70 was coprecipitated with a key enzyme of glucocorticoid synthesis: StAR in adrenal gland, the peripheral tissue of HPA axis. Stress protein is available for a marker of good and measurable, adaptation connecting both cells and body. 1 earning program of cellular changes by exercise was introduced into compulsory curriculum of physical education and health science for 1st year students the University of Tokyo from 2006. Results of questionnaires by students indicated a contribution of the effectiveness of such a mixed education of knowledge learning and experiment using own body.
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Report
(3 results)
Research Products
(173 results)
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[Journal Article] Age-Related Ihcrease of Insoluble, Phosphorylated Small Heat Shock Proteins in Human Skeletal Muscle2007
Author(s)
Yamaguchi, T., Arai, H., Katayama, N., Ishikawa, T., Kikumoto, K and Atomi. Y.
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Journal Title
J Gerontol A: Biol Med Sci 62
Pages: 481-489
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Age-Related Increase of Insoluble, Phosphorylated Small Heat Shock Proteins in Human Skeletal Muscle2007
Author(s)
Yamaguchi, T., Arai, H., Katayama, N., Ishikawa, T., Kikumoto, K. Atomi. Y.
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Journal Title
J Gerontol A : Biol Med Sci 62
Pages: 481-489
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] The Molecular Chaperone HSP47 Rapidly Senses the Gravitational Changes in Myoblasts.2006
Author(s)
Oguro, A., Sakurai, T., Fujita, Y., Lee, S., Kubota, H., Nagata K. and Atomi, Y.
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Journal Title
Genes to Cells 11
Pages: 1253-1265
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] The Molecular Chaperone HSP47 Rapidly Senses the Gravitational Changes in Myoblasts2006
Author(s)
Oguro, A., Sakurai, T., Fujita, Y, Lee, S., Kubota, H., Nagata K., Atomi, Y.
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Journal Title
Genes to Cells 11
Pages: 1253-1265
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Basic Human Sustainability2006
Author(s)
Atomi, Y., Ohtsuki T., Ishii N., Yanagihara D., Sakurai T., Ito K., Nagao Y., Kobayashi H., Kasai Y., Mori I., Naito T.
Organizer
Meeting of Report of Aloance for Global Sustainability
Place of Presentation
Tokyo, Univ. of Tokyo
Year and Date
2006-12-26
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Education to know life and human beings from physical activity and human life science as a base-Life science basis for "Human Sustainability Project"2006
Author(s)
Atomi, Y., Sakurai T, Ohto, E., Fujita, Y., Lee, S., Ti. H., Hatakeyama N., Oguro A., Nagao Y.
Organizer
Symposium at the Network for life science research of the university of Tokyo
Place of Presentation
Tokyo
Year and Date
2006-11-15
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Human individual to obtain adaptability and characteristics of material of cells and regulation of their mobility-centering of consciousness of mobility, body and cellular balance, and flexibility2006
Author(s)
Atomi, Y., Sakurai T, Ohto, E., Fujita, Y., Lee, S., Ti. H., Hatakeyama N., Oguro A., Nagao Y.
Organizer
Symposium at the Network for life science research of the university of Tokyo
Place of Presentation
Tokyo
Year and Date
2006-11-15
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] 太極拳が脳機能に与える影響2006
Author(s)
平工志穂、畠山望、天野勝弘、石水極子、跡見順子
Organizer
第2回日本養生学会大会
Place of Presentation
東京女子大学
Year and Date
2006-03-15
Description
「研究成果報告書概要(和文)」より
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[Presentation] ダイナミック適応重力場の生物学2006
Author(s)
跡見順子、藤田義信、桜井隆史、大戸恵理、小黒麻美
Organizer
宇宙利用シンポジウム
Place of Presentation
相模原市
Year and Date
2006-01-15
Description
「研究成果報告書概要(和文)」より
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[Presentation] 重力と分子シャペロン2005
Author(s)
小黒麻美・桜井隆史・藤田義信・永田和宏・跡見順子
Organizer
第43回生物物理学会
Place of Presentation
北海道札幌市
Year and Date
2005-11-23
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions2005
Author(s)
Oguro, A., Sakurai, T, Fujita Y, Kubota H, Nagata K, Atomi Y.
Organizer
The 56th Conference of Japan Society of Physical Education, Health and Sport Sciences
Place of Presentation
Tsukuba
Year and Date
2005-11-23
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Brain function during Tai-Chi Chuan-by LAIRS-2005
Author(s)
Hiraku S., Amano K., Hatakeyama N., T., Matsuo, Ishimizu M., Sakurai, T. Y. Atomi.
Organizer
The 56th Conference of Japan Society of Physical Education, Health and Sport Sciences
Place of Presentation
Tsukuba
Year and Date
2005-11-23
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Molecular chaperone and gravity2005
Author(s)
Oguro A, Sakurai, T., Fujita Y., Nagata K., Y. Atomi.
Organizer
The 43th Annual Meeting of the Biophysical Society of Japan
Place of Presentation
Hokaido
Year and Date
2005-11-23
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Men live-Physical exercise and body2005
Author(s)
Atomi, Y.
Organizer
(Co) The Engineering Academy of Japan, The Chubu Region Mercury Seminar
Place of Presentation
Nagoya University, Department of Technology No.4
Year and Date
2005-10-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 動いて科学する2005
Author(s)
跡見順子
Organizer
駒場オープンキャンパス
Place of Presentation
東京、東大・101号館
Year and Date
2005-08-03
Description
「研究成果報告書概要(和文)」より
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