Creation of single-molecule CMOS hybrid devices
| Project/Area Number |
17206037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAZATO Kazuo Nagoya University, Graduate School of Engineering, Professor (90377804)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAGOSHI Kazuhito Nagoya University, The Institute of Physical and Chemical Research, Sub-Team Leader (50322665)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2005: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
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| Keywords | Single-molecule / analog CMOS circuit / DNA chip / electric detection of DNA / sensor integrated circuit / extended-gate ISFET / hybridization / DNA電気特性 / 温度セルアレイ / 拡張ゲート型MOSFET / ポーラスシリコン |
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| Research Abstract |
On-chip measurement of single-molecule and biosensor army TM, for electrical detection of biomolecular interaction have been developed to create single-molecule CMOS hybrid devices
1.On-chip measurement of single-molecule
Since signal from single-molecule is very small, on-chip measurement under the molecule is essential for the reliable and stable detection. New analog CMOS integrated circuits have been designed. After the fabrication of chip using standard CMOS process, 15 nm gap electrodes were formed by electron beam lithography or molecular ruler method using self-assembled monolayer. Poly(3-octylthiophene-2,5-diyl)was investigated which has electrical resistance of several On. Since CMOS analog integrated circuit converts output impedance, high signal to noise ratio and high speed measurements were achieved.
Another device investigated is the close-packed structure of 3 nm diameter gold colloidal particles between gold electrodes formed by Langmuir-Brodget method. Dodecanthiol molecules are bridged between gold colloidal particles with distance of 4.6 nm, and electrical signals by DNA replacement and hybridization were detected.
2.Fully electrical detection biochip
New analog CMOS circuit was proposed based on the detection of charge associated with specific biomolecular interaction. Extended gate MOSFETs are utilized to sense biomolecular interaction. The sensor interface circuit features high density(1/1000 of conventional circuit), low power(1/1000 of conventional circuit), and high accuracy (x 1000 of conventional circuit), so massively parallel and high throughput detection of biomolecular interactions becomes possible
Gold patterns were formed as extended gate on fabricated CMOS LSI chip, and thiol modified oligonucleotides were immobilized on the extended gate. Immobilization and hybridization of DNA were detected by 16 x 16 sensor array as time development of the two-dimensional spatial distribution.
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Report
(4 results)
Research Products
(51 results)
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[Presentation] Extended-gate MOSFET Biosensor Array LSIs2007
Author(s)
K. Nakazato, M. Ohura, K. Sugimoto, J. Tsukada, and S. Uno
Organizer
Fourth International Conference on Molecular Electronics and Bioelectronics(M&BE4)
Place of Presentation
Tokyo
Year and Date
2007-03-14
Description
「研究成果報告書概要(和文)」より
Related Report
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