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Molecular epidemiology of HIV in central Africa - Searching for the origin of AIDS virus and its future

Research Project

Project/Area Number 17256004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionKyoto University

Principal Investigator

IDO Eiji  Kyoto University, ウイルス研究所・特別教育研究, 准教授 (70183176)

Co-Investigator(Kenkyū-buntansha) HAYAMI Masanori  理化学研究所, ゲノム医科学研究セン ター, 研究員 (10358236)
HAYAMI Masanori  京都大学, ウイルス研究所, 教授 (40072946)
MIURA Tomoyuki  京都大学, ウイルス研究所, 准教授 (40202337)
IBUKI Kentaro  京都大学, ウイルス研究所, 助教 (00273524)
Co-Investigator(Renkei-kenkyūsha) MIURA Tomoyuki  京都大学, ウイルス研究所, 准教授 (40202337)
IBUKI Kentaro  京都大学, 医学系研究科, 准教授 (00273524)
Research Collaborator MUYEMBE Jean-jacques  National Institute of Biomedical Research, Democratic Republic of Congo, Director
PARRA Henri-joseph  National Laboratory of Public Health, Brazzaville, Republic of Congo, Director
RAPHAEL Taty-taty  Centre de Pathologie Infectieuse, Pointe-Noire, Republic of Congo, Director
NICAISE Ndembi  University of Yaounde,, Cameroon
DORA Mbanya  University of Yaounde, Cameroon, Professor
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2006: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2005: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsウイルス / 進化 / エイズ / HIV / 分子疫学 / HIV-1 / SIV / 遺伝子解析 / 中央アフリカ / レトロウイルス
Research Abstract

エイズウイルスの起源と未来の姿を求めて、今日最も多様な遺伝子型のHIVが混在して流行している中央アフリカの3ヶ国(カメルーン、コンゴ、コンゴ民主)において、HIVに関する最新の分子疫学動向を調査した。今回、コンゴ民主東部地域を世界に先駆けて調査することに成功したが、ここでも西方諸国と同じく多様な遺伝子型が存在することが明らかとなった。またサルのウイルスに関しては、ブラックマンガベイが新種のSIVを保有することを発見した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (15 results) (of which Peer Reviewed: 11 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Distribution and effects of nonsense polymorphisms in human genes2008

    • Author(s)
      Yamaguchi-Kabata, Y., Shimada, M.K., Hayakawa, Y., Minoshima, S., et.al.
    • Journal Title

      Plos ONE 3

      Pages: 1-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups : effects on population-based association studies2008

    • Author(s)
      Yamaguchi-Kabata, Y., Nakazono, K., Takahashi, A., Saito, S., et.al.
    • Journal Title

      Amer. J. Human Genetics 83

      Pages: 445-456

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] エイズウイルスの起源と進化2008

    • Author(s)
      三浦智行
    • Journal Title

      Virus Report 5

      Pages: 82-89

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and effects of nonsense polymorphisms in human genes.2008

    • Author(s)
      Yamaguchi-Kabata, Y., Shimaada, M. K., Hayakawa, Y., Minoshima, S., et al.
    • Journal Title

      Plos ONE 3

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups : effects on population-based association studies.2008

    • Author(s)
      Yamaguchi-Kabata, Y., Nakazono, K., Takahashi, A., Saito, S., et al.
    • Journal Title

      Amer. J. Human Genetics 83

      Pages: 445-456

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to SIVmnd-2 in southern Cameroon : Public health implications2007

    • Author(s)
      Ndembi, N., Ido, E., Mbanya, D., Kaptue, L.
    • Journal Title

      HIV & AIDS Review 8(3)

      Pages: 16-19

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a novel SHIV having an HIV-1-derived protease gene and its infection to rhesus macaques: a useful tool for in vivo efficacy tests of protease inhibitors.2007

    • Author(s)
      Ishimatsu, M., Suzuki, H., Akiyama, H., Miura, T., Hayami, M, , Ido, E.
    • Journal Title

      Microbes Infection 9(4)

      Pages: 475-482

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA vaccination of macaques by a full-genome SHIV plasmid that has an IL-2 gene and produces non-infectious virus particles.2006

    • Author(s)
      Horiuchi R, Akahata W, Kuwata T, Enose Y, Ido E, et al.
    • Journal Title

      Vaccine 24(17)

      Pages: 3677-3685

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel SIV from black mangabey (Lophocebus aterrimus) in Democratic Republic of Congo2005

    • Author(s)
      Takemura, T., Ekwalanga, M., Bikandou, B., Ido, E., Yamaguchi-Kabata, Y., Ohkura, S., Harada, H., Takehisa, J., Ichimura, H., Parra, H.J., Nende, M., Mubwo, E., Sepole, M., Hayami, M., Miura, T.
    • Journal Title

      J. Gen. Virol. 86

      Pages: 1967-1971

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new subtype (subgenotype) Ac(A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon2005

    • Author(s)
      Kurbanov, F., Tanaka, Y., Fujiwara, K., Sugauchi, F., Mbanya, D., Zekeng, L., Ndembi, N., Ngansop, C., Miura, T., Ido, E., Hayami, M., Ichimura, H., Kaptue, L., Mizokami, M.
    • Journal Title

      J. Gen. Virol. 86

      Pages: 2047-2056

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel SIV from black mangabey (Lophocebus aterrimus) in Democratic Republic of Congo.2005

    • Author(s)
      Takemura, T., Ekwalanga, M., Bikandou, B., Ido, E., et al.
    • Journal Title

      J.Gen.Virol. 86

      Pages: 1967-1971

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of evolutionary conservation in Cd1d molecules among primates.2005

    • Author(s)
      Saito, N., Takahashi, M., Akahata, W., Ido, E., et al.
    • Journal Title

      Tissue Antigen 66

      Pages: 674-682

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Exposure to SIVmd-2 in Southern Cameroon: Public Health Implications.

    • Author(s)
      Ndembi, N., Ido, E., Mbanya, D., Kaptue, L.
    • Journal Title

      HIV & AIDS Review (in press 掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction and infection of a new simian/human immunodeficiency chimeric virus (SHIN) containing the integrase gene of the human immunodeficiency virus type 1 genome and analysis of its adaptation to monkey cells.

    • Author(s)
      Akiyama, H., Ishimatsu, M., Miura, T., Hayami, M., Ido, E.
    • Journal Title

      Microbes Infection (in press 掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a novel SHIV having an HIV-1-derived protease gene and its ifection to rhesus macaques : a useful tool for in vivo efficacy tests of protease inhibitors.

    • Author(s)
      Ishimatsu M, Suzuki H, Akiyama H, Miura T, Hayami M, Ido E
    • Journal Title

      Microbes Infect. (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] コンゴ共和国辺境地位域にある地方病院におけるHIVの血清学的調査2009

    • Author(s)
      井戸栄治、Jean-Raoul Chocolat、Fabien Niama、Jean-Vivien Mombouli、多田哲子、梅原綾、岩元静香、Henri-Joseph Parra
    • Organizer
      第27回日本国際保健医療学会西日本地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-28
    • Related Report
      2008 Final Research Report
  • [Presentation] コンゴ共和国西部の町ポイント・ノアールの診療所におけるHIVの遺伝子解析2008

    • Author(s)
      井戸栄治、Raphael Taty-Taty、安永みゆき、田坂暁子、Fabien Niyama、多田哲子、多田秀子、石松美沙、Henri-Joseph Parra
    • Organizer
      第23回日本国際保健医療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] コンゴ民主共和国東部地域におけるHIVの分子疫学2008

    • Author(s)
      井戸栄治、多田哲子、Stormy Karhemere、Masimango Imani、田坂暁子、多田秀子、Steve Ahuka、Zaccharie Kashongwe、Jean-Jacues Muyembe
    • Organizer
      第23回日本国際保健医療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] コンゴ共和国西部の町ポイント・ ノアールの診療所におけるHTVの遺伝子解析2008

    • Author(s)
      井戸栄治, Raphael Taty-Taty, 安永みゆき, 田坂暁子, Fabien Niyama, 多田哲子, 他
    • Organizer
      第23回日本国際保健医療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic diversity of HIV-1 has dramatically increased in Republic of Congo during the last decades2008

    • Author(s)
      Ido,E., Taty-Taty, R., Yasunaga, M., Ishimatsu, M., Niama, F., Parra, H-J.
    • Organizer
      15th East Asia Joint Symposium on Biomedical Research, Seoul
    • Place of Presentation
      Korea
    • Year and Date
      2008-07-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic diversity of HIV-1 has dramatically increased in Republic of Congo during the last decades.2008

    • Author(s)
      Ido, E., Taty-Taty, R., Yasunaga, M., Ishimatsu, M., Niama, F., Parra, H-J.
    • Organizer
      15th East Asia Joint Symposium on Biomedical Research
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-07-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] コンゴ共和国の海岸部都市に流行するHIV遺伝子多様性の解析2007

    • Author(s)
      安永みゆき、Raphael Taty-Taty、Fabien Niyama、Blaise Bikandou、石松美沙、関口永子、米田幸子、Henri-Joseph Parra、井戸栄治
    • Organizer
      第21回日本エイズ学会学術集会・総会
    • Place of Presentation
      広島
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] コンゴ共和国の海岸部都市に流行するHIV遺伝子多様性の解析2007

    • Author(s)
      安永みゆき, Taty-Taty, R., Niyama, F., Bikandou, B., 石松美沙, 関口永子, 米田幸子, Parra, H. J., 井戸栄治
    • Organizer
      第21回日本エイズ学会学術集会・総会
    • Place of Presentation
      広島(広島国際会議場)
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/fukuseikiban.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/fukuseikiban.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/fukuseikiban.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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