Control of critical period development in mouse somatosensory cortex by glutamatergic signal transduction

• Project/Area Number: 17300108
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: HOKKAIDO UNIVERSITY
• Principal Investigator: WATANABE Masahiko Hokkaido Univ., Graduate School of Medicine, Prof, 大学院医学研究科, 教授 (70210945)
• Project Period (FY): 2005 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥15,000,000 (Direct Cost: ¥15,000,000); Fiscal Year 2006: ¥6,500,000 (Direct Cost: ¥6,500,000); Fiscal Year 2005: ¥8,500,000 (Direct Cost: ¥8,500,000)
• Keywords: glutamate / receptor / barrel / plasticity / critical period / 可塑性 / グルタミン酸受容体 / グルタミン酸トランスポーター / 体性感覚野 / 大脳皮質 / 発達 / 遺伝子ノックアウトマウス

Research Abstract

In the present study, I studied on the molecular mechanisms regulating critical period development of the mouse somatosensory cortex using gene knockout mice. In particular, I focused on the roles played by NMDA-type glutamate receptor subunits GluRe2 (NR2B) and GLuRe4 (NR2D) and also by glutamate transporter GLAST and GLT1 in developmental appearance, critical period termination, critical period plasticity of somatosensory barrel structures. Here I found that, compared to wild-type control mice, heterozygous GlnRe2+/-mice showed one-day retardation in developmental appearance and critical period termination, whereas homozygous GluRe4-/-mice did on-day facilitation. No significant change was seen in the magnitude of critical period plasticity, as determined by row-C whisker cautery. In contrast, homozygous GLAST-/-and GLTI-/-mice displayed significant reduction in the magnitude of critical period plasticity, with normal developmental appearance and critical period termination. These results provide experimental evidence that N3IDA receptor activation regulates temporal properties of somatosensory development in a subunit-dependent manner, while transporters regulating extracellular glutamate concentration magnify critical period plasticity. Therefore, armed with the two mechanisms, synaptic refinement during development is shaped normally in a activity-dependent manner.

Research Products

• [Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (2007)
  • Author(s): Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K
  • Journal Title: Mol. Cell. Biochem. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Number and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replica labeling. (2007)
  • Author(s): Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R
  • Journal Title: J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phospholipase Cβ3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. (2007)
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. (2007)
  • Author(s): Takagishi Y, Hashimoto H, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, Kano M, Murata Y
  • Journal Title: J. Neurobiol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly. (2007)
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ca^<2+> permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination. (2007)
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney. (2007)
  • Author(s): Takasaki C, Miura E, Watanabe M
  • Journal Title: Biomed Res (in press)
  • NAID: 130004903731
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Number and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replical labeling. (2007)
  • Author(s): Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R
  • Journal Title: J. Neurosci. (in press)
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney. (2007)
  • Author(s): Takasaki C, Miura E, Watanabe M
  • Journal Title: Biomed Res, (in press)
  • NAID: 130004903731
• [Journal Article] Complementary stripes of phospholipase Cβ3 and Cβ4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna JT, Marzban H, Watanabe M, Hawkes R
  • Journal Title: J. Comp. Neurol. 496 Pages: 303-313
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Impaired cerebellar functions in mutant mice lacking DNER. (2006)
  • Author(s): Tohgo A, Eiraku M, Miyazaki T, Miura E, Ono K, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H
  • Journal Title: Mol. Cell. Neurosci. 31 Pages: 326-333
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Improved methods for ultracryotomy of CNS tissue for ultrastructural and immunogold analyses. (2006)
  • Author(s): Akagi T, Ishida K, Hanasaka T, Hayashi S, Watanabe M, Hashikawa T, Tohoyama K
  • Journal Title: J Neurosci. Methods 153 Pages: 276-282
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic site in the hippocampus and cerebellum. (2006)
  • Author(s): Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M
  • Journal Title: J. Neurosci. 26 Pages: 2991-3001
  • NAID: 120007186992
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M (Corresponding author)
  • Journal Title: J. Neurochem. 97 Pages: 1431-1446
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Diacylglycerol kinase ζ is involved in the process of cerebral infarction. (2006)
  • Author(s): Nakano T, Hozumi Y, Ali H, Saino-Saito S, Kamii H, Sato S, Kayama T, Watanabe M, Kondo H, Goto K
  • Journal Title: Eur. J. Neurosci. 23 Pages: 1427-1435
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Localization of diacylglycerol lipase-α around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006)
  • Author(s): Yoshida T, Fukaya M, Uchigashima M, Kamiya H, Kano M, Watanabe M (Corresponding author)
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse-Possible implications for pain processing. (2006)
  • Author(s): Brumovsky PR, Hygge-Brakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hokfelt T
  • Journal Title: J. Chem. Neuroanat. 31 Pages: 243-262
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells an expression of Atg4B in various rat tissues. (2006)
  • Author(s): Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y
  • Journal Title: Autophagy 2 Pages: 200-208
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia. (2006)
  • Author(s): Sasaki H, Hozumi Y, Hasegawa H, Ito T, Takagi M, Ogino T, Watanabe M, Goto K
  • Journal Title: Cell Tissue Res. 326 Pages: 35-42
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T
  • Journal Title: EMBO J. 25 Pages: 2867-2877
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M (Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 750-760
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional uncoupling between Ca^<2+> release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. (2006)
  • Author(s): Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, Takeshima H
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 10811-10816
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. (2006)
  • Author(s): Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H
  • Journal Title: FEBS Lett. 580 Pages: 4057-4064
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K (Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2177-2190
  • NAID: 120000955769
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Depolarization-induced suppression of inhibition mediated by endocannabinoid at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. (2006)
  • Author(s): Narushima M, Uchigashima M, Hashimoto K, Watanabe M, Kano M
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2246-2252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Indispensability of glutamate transporter GLAST and GLT1 to brain development. (2006)
  • Author(s): Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo K, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K
  • Journal Title: Proc. Natl. Acad. Sci. USA 103 Pages: 12161-12166
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells. (2006)
  • Author(s): Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukai C, Kitagaki S, Miyakoshi N, Terasaki T
  • Journal Title: Pharmacol. Res. 23 Pages: 1235-1242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. (2006)
  • Author(s): Narushima M, Uchigashima M, Matsui M, Manabe T, Watanabe M, Kano M
  • Journal Title: J. Neurosci. 27 Pages: 496-506
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Complementary stripes of phospholipase CB3 and CB4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna JT, Marzban H, Watanabe M, Hawkes R
  • Journal Title: J. Comp. Neurol. 496 Pages: 303-313
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression and distribution of NK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. (2006)
  • Author(s): Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M
  • Journal Title: J. Neurochem. 97 Pages: 1431-1446
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Localization of diacylglycerol lipase-α around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. (2006)
  • Author(s): Yoshida T, Fukaya M, Uchigashima M, Kamiya H, Kano M, Watanabe M
  • Journal Title: J. Neurosci. 26 Pages: 4740-4751
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse-Possible implications for pain processing. (2006)
  • Author(s): Brumovsky PR, Hygge-Brakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, Hafelt T
  • Journal Title: J. Chem. Neuroanat. 31 Pages: 243-262
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells an expression of Ata4B in various rat tissues. (2006)
  • Author(s): Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y
  • Journal Title: Autophagy 2 Pages: 200-208
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M
  • Journal Title: Eur. J. Neurosci. (Corresponding author) 24 Pages: 750-760
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Disturbance of cerebellar synaptic maturation ii mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. (2006)
  • Author(s): Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H
  • Journal Title: FEBS Lett. 580 Pages: 4057-4064
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2177-2190
  • NAID: 120000955769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Depolarization-induced suppression of inhibition mediated by endocannabinoid at synapses from fast-spiking interneurons to medium spiny neurons in the striatum. (2006)
  • Author(s): Narushima M, Uchigashima M, Hashimoto K, Watanabe M, Kano M
  • Journal Title: Eur. J. Neurosci. (Corresponding author) 24 Pages: 2246-2252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC 12 cells an expression of Atg4B in various rat tissues. (2006)
  • Author(s): Yoshimura K, Shibata M, Koike M, Gotoh K, Fukaya M, Watanabe M, Uchiyama Y
  • Journal Title: Autophagy 2 Pages: 200-208
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (2006)
  • Author(s): Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Aroma-Yoshida F, Hooray R, Suds K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T
  • Journal Title: EMBO J. 25 Pages: 2867-2877
• [Journal Article] Distinct expression of Cbln family mRNAs in developing and adult mouse brains. (2006)
  • Author(s): Miura E, Iijima T, Yuzaki M, Watanabe M(Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 750-760
• [Journal Article] Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. (2006)
  • Author(s): Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K(Corresponding author)
  • Journal Title: Eur. J. Neurosci. 24 Pages: 2177-2190
  • NAID: 120000955769
• [Journal Article] Indispensability of glutamate transporter CLAST and GLT1 to brain development. (2006)
  • Author(s): Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo K, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K
  • Journal Title: Proc. Natl. Acad, Sci. USA 103 Pages: 12161-12166
• [Journal Article] Impaired cerebellar functions in mutant mice lacking DNER. (2006)
  • Author(s): Tohgo, A., Eiraku, M., Miyazaki, T., Miura, E., Ono, K., Kawaguchi, S., Nishi, M., Watanabe, M., Hirano, T., Kengaku, M., Takeshima, H.
  • Journal Title: Mol.Cell.Neurosci. (in press)
• [Journal Article] Complementary stripes of phospholipase Cβ3 and Cβ4 expression by Purkinje cell subsets in the mouse cerebellum. (2006)
  • Author(s): Sarna, J.T., Marzban, H., Watanabe, M., W, Hawkes, R.
  • Journal Title: J.Comp.Neurol. (in press)
• [Journal Article] Improved methods for ultracryotomy of CNS tissue for ultrastructural and immunogold analyses. (2006)
  • Author(s): Akagi, T., Ishida, K., Hanasaka, T., Hayashi, S., Watanabe, M., Hashikawa, T., Tohoyama, K.
  • Journal Title: J.Neurosci.Methods (in press)
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2006)
  • Author(s): Kakizawa, S., Miyazaki, T., Iino, M., Watanabe, M., Kano, M.
  • Journal Title: Proc.Natl.Acad.Sci.USA (in press)
• [Journal Article] Rescue of abnbormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. (2005)
  • Author(s): Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: EMBO report 6 Pages: 90-95
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retinotectal transmission in the optic tectum of rainbow trout. (2005)
  • Author(s): Kinoshita M, Fuyaka M, Tojima T, Kojima S, Ando H, Watanabe M, Urano A, Ito E
  • Journal Title: J. Comp. Neurol. 484 Pages: 249-259
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evidence for creatine biosynthesis in Muller glia. (2005)
  • Author(s): Nakashima T, Tomi M, Tachikawa M, Watanabe M, Terasaki T, Hosoya K
  • Journal Title: Glia 52 Pages: 47-52
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya M, Hayashi Y, Watanabe M (Corresponding author)
  • Journal Title: Eur. J. Neurosci. 21 Pages: 1432-1436
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the mature cerebellum. (2005)
  • Author(s): Takeuchi T, Miyazaki T, Watanabe M, Mori H, Sakimura K, Mishina M
  • Journal Title: J. Neurosci. 25 Pages: 2146-2156
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Miyazaki T, Watanabe M, Tanaka K, Ozawa S
  • Journal Title: J. Neurosci. 25 Pages: 8788-8793
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi M, Masuda T, Fukaya M, Kataoka H, Mishina M, Yaginuma H, Watanabe M, Shimizu T
  • Journal Title: Genes to Cells. 10 Pages: 785-792
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ptfla, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y
  • Journal Title: Neuron 47 Pages: 201-213
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. (2005)
  • Author(s): Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashimal T, Terasaki T (Corresponding author)
  • Journal Title: J. Neurochem. 95 Pages: 294-304
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Autoantibodies and cell-mediated autoimmunity to NMDA-type GluTε2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. (2005)
  • Author(s): Takahashi Y, Mori H, Mishina M, Watanabe M, Kondo N, Shomomura J, Kubota Y, Matsuda K, Fukushima K, Shiroma M, Akasaka N, Nishida H, Imamura A, Watanabe H, Sugiyama N, Ikezawa M, Fujiwara T
  • Journal Title: Epilepsia 46 Pages: 152-158
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. (2005)
  • Author(s): Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S
  • Journal Title: Eur. J Neurosci. 22 Pages: 1445-1455
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in εl-knock-out mice. (2005)
  • Author(s): Wu Y, Kawakami R, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R
  • Journal Title: J. Neurosci. 25 Pages: 9213-9226
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains. (2005)
  • Author(s): Fukaya M, Yamazaki M, Sakimura K, Watanabe M
  • Journal Title: Neurosci. Res. 53 Pages: 376-383
  • NAID: 10017131285
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • Author(s): Klausberger T, Marton LF, O'Neill J, Huck JHJ, Dalezios Y, Fuentealba P, Suen W-Y, Papp E, Kaneko T, Watanabe M, Csicsvari J, Somogyi P
  • Journal Title: J. Neurosci. 25 Pages: 9782-9793
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • Author(s): Hirai H, Pang Z, Bao D, Miyazaki T, Li L, Miura E, Parris J, Rong Y, Watanabe M, Yuzaki M, Morgan JI
  • Journal Title: Nature Neurosci. 8 Pages: 1534-1541
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach. (2005)
  • Author(s): Iwanaga T, Goto M, Watanabe M
  • Journal Title: Biomed. Res. 26 Pages: 271-278
  • NAID: 130004903697
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa S, Miyazaki T, Iino M, Watanabe M, Kano M
  • Journal Title: Proc. Natl. Acad. Sci. USA 102 Pages: 19180-19185
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] クレアチンを介した脳内エネルギー代謝の調節機構とニューロンーグリア相関 (2005)
  • Author(s): 立川正憲, 寺崎哲也, 渡辺雅彦
  • Journal Title: Clinical Neuroscience 23 Pages: 158-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 小脳シナプス回路発達の分子機構 (2005)
  • Author(s): 渡辺雅彦
  • Journal Title: 医学のあゆみ 212 Pages: 911-916
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 小脳の構造と神経回路 (2005)
  • Author(s): 渡辺雅彦
  • Journal Title: Clinical Neuroscience 23 Pages: 1357-1360
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. (2005)
  • Author(s): Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: EMBO report 6 Pages: 90-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for creatine biosynthesis in Milner glia. (2005)
  • Author(s): Nakashima T, Tomi M, Tachikawa M, Watanabe M, Terasaki T, Hosoya K
  • Journal Title: Cilia 52 Pages: 47-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya M, Hayashi Y, Watanabe M
  • Journal Title: Eur. J. Neurosci. 21 Pages: 1432-1436
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Takayasu Y, lino M, Kakegawa W, Maeno H, Watase K, Wada K, Miyazaki T, Watanabe M, Tanaka K, Ozawa S
  • Journal Title: J. Neurosci. 25 Pages: 8788-8793
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y
  • Journal Title: Neuron 47 Pages: 201-213
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. (2005)
  • Author(s): Tachikawa M, Watanabe M, Hori S, Fukaya M, Ohtsuki S, Asashimal T, Terasaki T
  • Journal Title: J. Neurochem. 95 Pages: 294-304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in ε1-nock-out mice. (2005)
  • Author(s): Wu Y, Kawakami R, Fukaya M, Sakimura K, Mishina M, Watanabe M, Ito I, Shigemoto R
  • Journal Title: J. Neurosci. 25 Pages: 9213-9226
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. (2005)
  • Author(s): Kakizawa S, Miyazaki T, lino M, Watanabe M, Kano M
  • Journal Title: Proc. Natl. Acad. Sci., USA 102 Pages: 19180-19185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rescue of abnbormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes. (2005)
  • Author(s): Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda, S., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: EMBO report 6 Pages: 90-95
• [Journal Article] Retinotectal transmission in the optic tectum of rainbow trout. (2005)
  • Author(s): Kinoshita, M., Fuyaka, M., Tojima, T., Kojima, S., Ando, H., Watanabe, M., Urano, A., Ito, E.
  • Journal Title: J.Comp.Neurol. 484 Pages: 249-259
• [Journal Article] Evidence for creatine biosynthesis in Muller glia. (2005)
  • Author(s): Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: Glia 52 Pages: 47-52
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons. (2005)
  • Author(s): Fukaya, M., Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 21 Pages: 1432-1436
• [Journal Article] Control of synaptic connection by glutamate receptor δ2 in the mature cerebellum. (2005)
  • Author(s): Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J.Neurosci. 25 Pages: 2143-2156
• [Journal Article] Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. (2005)
  • Author(s): Takayasu, Y., Iino, M., Kakegawa, W., Maeno, H., Watase, K., Wada, K., Miyazaki, T., Watanabe, M., Tanaka, K., Ozawa, S.
  • Journal Title: J.Neurosci. 25 Pages: 8788-8793
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells 10 Pages: 785-792
• [Journal Article] Ptfla, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. (2005)
  • Author(s): Hoshino, M., Nakamura, S., Mori, K., Kawauchi, T., Terao, M., Nishimura, Y.V., Fukuda, A., Fuse, T., Matsuo, N., Sone, M., Watanabe, M., Bito, H., Terashima, T., Wright, C.V.E., Kawaguchi, Y., Nakao, K., Nabeshima, Y.
  • Journal Title: Neuron 47 Pages: 201-213
• [Journal Article] Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. (2005)
  • Author(s): Tachikawa, M., Watanabe, M., Hori, S., Fukaya, M., Ohtsuki, S., Asashimal, T., Terasaki, T.
  • Journal Title: J.Neurochem. 95 Pages: 294-304
• [Journal Article] Autoantibodies and cell-mediated autoimmunity to NMDA-type GluTe2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. (2005)
  • Author(s): Takahashi, Y., Mori, H., Mishina, M., Watanabe, M., Kondo, N., Shomomura, J., Kubota, Y., Matsuda, K., Fukushima, K., Shiroma, M., Akasaka, N., Nishida, H., Imamura, A., Watanabe, H., Sugiyama, N., Ikezawa, M., Fujiwara, T.
  • Journal Title: Epilepsia 46 Pages: 152-158
• [Journal Article] Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. (2005)
  • Author(s): Abe, T., Matsumura, S., Katano, T., Mabuchi, T., Takagi, K., Xu, L., Yamamoto, A., Hattori, K., Yagi, T., Watanabe, M., Nakazawa, T., Yamamoto, T., Mishina, M., Nakai, Y., Ito, S.
  • Journal Title: Eur.J.Nerosci. 22 Pages: 1445-1455
• [Journal Article] Target-cell-specific left-right asymmetry of NMDA receptor content in Schaffer collateral synapses in □1/NR2A knock-out mice. (2005)
  • Author(s): Wu, Y., Kawakami, R., Fukaya, M., Sakimura, K., Mishina, M., Watanabe, M., Ito I., Shigemoto, R.
  • Journal Title: J.Neurosci. 25 Pages: 9213-9226
• [Journal Article] Spatial diversity in gene expression for VDCC□ subunit family in developing and adult mouse brains. (2005)
  • Author(s): Fukaya, M., Yamazaki, M., Sakimura, K., Watanabe, M.
  • Journal Title: Neurosci.Res. 53 Pages: 376-383
• [Journal Article] Complementary roles of cholecystokinin and parvalbumin expressing GABAergic neurons in hippocampal network oscillations. (2005)
  • Author(s): Klausberger, T., Marton, L.F., O'Neill, J., Huck, J.H.J., Dalezios, Y., Fuentealba, P., Suen, W.-Y., Papp, E., Kaneko, T., Watanabe, M., JCsicsvari, J., Somogyi, P.
  • Journal Title: J.Neurosci. 25 Pages: 9782-9793
• [Journal Article] Clbn1 is essential for synaptic integrity and information processing in the cerebellum. (2005)
  • Author(s): 6.Hirai, H., Pang, Z., Bao, D., Miyazaki, T., Li, L., Parris, J., Rong, Y., Watanabe, M., Yuzaki, M., Morgan, J.I.
  • Journal Title: Nature Neurosci. 8 Pages: 1534-1541
• [Journal Article] Cellular distribution of glutamate transporters in the gastrointestinal tract of mice. An immunohistochemical and in situ hybridization approach. (2005)
  • Author(s): Iwanaga, T., Goto, M., Watanabe, M.
  • Journal Title: Biomed.Res. 26 Pages: 271-278
  • NAID: 130004903697
• [Journal Article] ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells.
  • Author(s): Asashima T, Hori S, Ohtsuki S, Tachikawa M, Watanabe M, Mukais C, Kitagaki S, Miyakoshi N, Terasaki T
  • Journal Title: Pharmacol. Res. 23 Pages: 1235-1242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.
  • Author(s): Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K
  • Journal Title: Mol. Cell. Biochem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] umber and density of AMPA receptors in individual synapses in the cerebellum as revealed by SDS-digested freeze-fracture replica labeling.
  • Author(s): Masugi-Tokita M, Tarusawa E, Watanabe M, Molnar E, Fujimoto K, Shigemoto R
  • Journal Title: J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phospholipase CB3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets.
  • Author(s): Nomura S, Fukaya M, Tsujioka T, Wu D, Watanabe M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats.
  • Author(s): Takagishi Y, Hashimoto H, Kayahara T, Watanabe M, Otsuka H, Mizoguchi A, Kano M, Murata Y
  • Journal Title: J. Neurobiol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a transneuronal cytokine family Cbln. regulation of secretion by heteromeric assembly.
  • Author(s): Iijima T, Miura E, Matsuda K, Kondo T, Kamekawa Y, Watanabe M, Yuzaki M
  • Journal Title: Eur. J. Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ca^<2+> permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination.
  • Author(s): Kakegawa W, Miyazaki T., Hirai H, Motohashi J, Mishina M, Watanabe M, Yuzaki M
  • Journal Title: J. Physiol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.
  • Author(s): Takasaki C, Miura E, Watanabe M
  • Journal Title: Biomed Res (in press)
  • NAID: 130004903731
  • Description: 「研究成果報告書概要(欧文)」より