Molecular imaging ofAlzheimer amyloid

• Project/Area Number: 17300114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Osaka City University
• Principal Investigator: MORI Hiroshi Osaka City University, Medical School, Neuroscience, Professor (10159189)
• Co-Investigator(Kenkyū-buntansha): TOMIYAMA Takami Osaka City University, Medical School, Neuroscience, Associate Professor (10305633) ; WATANABE Yasuyoshi Osaka City University, Medical School, Physiology, Special Appointment Professor (40144399)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥11,970,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥870,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2006: ¥3,600,000 (Direct Cost: ¥3,600,000); Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
• Keywords: Amyloid / Alzheimer / imagin / senile placate / PIB / PET

Research Abstract

This study aimed to develop and compare chemical compounds which bind amyloid structure in brains with Alzheimer's disease. We first started stylbene then flavone and aurone structures as potent ligands for amyloid imaging. We dedicated particularly to compare these compounds with PIB that is well established as the original compound developed by Pittsuberg University research group. All of these compounds mimic thioflavine as the mother structure and examined their high incorporation and exclusion from the brain tissue. One of the major problem was not to detect any positive signal of PIB for transgenic mice named Tg2576 although PIB demonstrated the beautiful imaging for patients with AD. We explored this base by comparison of two line of transgenic mice of APP23 and Tg2576 x PS 1 double transgenic mice. We first reproduced the negative signal for Tg2576 line but succeeded in detect the strong PIB signal for APP23. Then we compared both brain tissues after PET imaging. Both tissues show many amyloid plaques enough to be detected with amyloid antibodies. We examined tissues with several amyloid antibodies and finally reached to find one antibody to distinguish APP23 from Tg2576. This antibody was supposed to specifically recognize pyroglutamate at the third residue of amyloid protein. This post modification was originally found by me. The present result clearly explains the discrepancy between acceleration animal model and human aged patients with AD.

Research Products

• [Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia. (2008)
  • Author(s): Tomiyama, T., Nagata, T., Shimada, H., Teraoka, T., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., Wada, Y., Yoshioka, E., Nishizaki, T., Watanabe, Y, and Mori, H.
  • Journal Title: Ann. Neurol. (In press)(In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A new amyloid βvariant favoring oligomerization in Alzheimer-typedementia. (2008)
  • Author(s): Tomiyama,T.,Nagata,T.,Shimada,H.,Teraoka,T.,Fukushima,A.,Kanemitsu,H,Takuma,H.,Kuwano,R.,Imagawa,M.,Ataka,S.,Wada,Y.,Yoshioka,E.,Nishizaki,T.,Watanabe,Y.,and Mori,H.
  • Journal Title: Ann.Neurol. (In press)
  • Peer Reviewed
• [Journal Article] Structure-activity relationship of chalcones and relatedderivatives as ligands for detecthlg of β-alnyloid plaques in the brain. (2007)
  • Author(s): Ono, M., Hori, M., Haratake, M., Tomiyama, T, Mori, H., and Nakayama, M.
  • Journal Title: Bioorg. Med. Chem. 15 Pages: 6388-6396
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Aurones serve as probes of b-amyloid plaques in Alzheimer's disease. (2007)
  • Author(s): Ono, M., Maya, Y., Haratake, M., Ito, K., Mori, H, and Nakayama, M.
  • Journal Title: Biochem. Biophys. Res. Commun. 361 Pages: 116-121
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cerebral vascular accumulation of Dutch-type Aβ42, but not wild-type Aβ42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type (2007)
  • Author(s): Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Sclueman, M.L., Roos, R.A.C., Iwai, K., and Mori, H.
  • Journal Title: J. Neurosci. Res. 85 Pages: 2917-2923
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inverse correlation between APP and synaptic plasticity in trallsgenic mice. (2007)
  • Author(s): Matsuvama. S., Tbraoka, R., Mori H., and Tomiyama, T.
  • Journal Title: NeuroReport 18 Pages: 1083-1087
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TDP-43 is depositedu in the Guam parkuisonism-dementia complex brains. (2007)
  • Author(s): Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., and Oyanari, K.
  • Journal Title: Brain 130(Pt5) Pages: 1386-1394
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Longitudinal, quantitative assessment of amyloid, neuroinflammation and anti-amyloid treatment in aliving mouse model of Alzheimer's disease enabled by PET. (2007)
  • Author(s): Maeda, J., Ji, B., Irie, T., Tomiyama, T., Maruyama, M., Okauchi, T., Staufenbiel, M., Iwata, N., Ono, M., Saido, T.C., Suzuki, K., Mori, H., Hiuchi, M., and Suhara, T.
  • Journal Title: J. Neurosci. 27 Pages: 10957-10968
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structure-activity relationship of chalcones and related derivatives as ligands for detecting of f3-amyloid plaques in the brain (2007)
  • Author(s): Ono, M., Hori, M., Haratake, M., Tomiyama, T., Mori, H., and Nakayama, M
  • Journal Title: Bioorg. Med. Chem 15 Pages: 6388-6396
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Aurones serve as probes of b-amyloid plaques in Alzheimer's disease. (2007)
  • Author(s): Ono, M., Maya, Y, Haratake, M., Ito, K., Mori, H, Nakayama, M
  • Journal Title: Biochem. Biophys. Res. Commun 361 Pages: 116-121
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cerebral vascular accumulation of Dutch-type Af342, but not wild-type Af342, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (2007)
  • Author(s): Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C., Iwai, K., Mori, H
  • Journal Title: J. Neurosci. Res 85 Pages: 2917-2923
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inverse correlation between APP and synaptic plasticity in transgenic mice (2007)
  • Author(s): Matsuyama, S., Teraoka, R., Mori H., Tomiyama, T
  • Journal Title: NeuroReport 18 Pages: 1083-1087
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains (2007)
  • Author(s): Hasegawa, M., Arai, T., Akiyama, H., Nonaka, T., Mori, H., Hashimoto, T., Yamazaki, M., and Oyanagi, K
  • Journal Title: Brain 130(Pt 5) Pages: 1386-1394
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cerebral vascular accumulation of Dutch-type A1342, but not wild-type A1342, in hereditary cerebral hemorrhage with amyloidosis, Dutch type. (2007)
  • Author(s): Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C.Iwai, K., Mori, H
  • Journal Title: J. Neurosci. Res 85 Pages: 2917-2923
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain. (2007)
  • Author(s): Ono, M., Hori, M., Haratake, M., Tomiyama, T., Mori, H., and Nakayama, M.
  • Journal Title: Bioorg.Med.Chem 15 Pages: 6388-6396
  • Peer Reviewed
• [Journal Article] Aurones serve as probes of b-amyloid plaques in Alzheimer's disease. (2007)
  • Author(s): Ono, M., Maya, Y., Haratake, M., Ito, K., Mori, H, and Nakayama, M.
  • Journal Title: Biochem.Biophys.Res.Commun 361 Pages: 116-121
  • Peer Reviewed
• [Journal Article] Cerebral vascular accumulation of Dutch-type Aβ42,but not wild-type Aβ42,in hereditary cerebral hemorrhage with amyloidosis,Dutch type. (2007)
  • Author(s): Nishitsuji, K., Tomiyama, T., Ishibashi, K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A.C., Iwai, K., and Mori, H.
  • Journal Title: J.Neurosci.Res. 85 Pages: 2917-2923
  • Peer Reviewed
• [Journal Article] Inverse correlation between APP and synaptic plasticity in transgenic mice. (2007)
  • Author(s): Matsuyama, S., Teraoka, R., Mori H., and Tomiyama, T.
  • Journal Title: NeuroReport 18 Pages: 1083-1087
  • Peer Reviewed
• [Journal Article] TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. (2007)
  • Author(s): Hasegawa,M.,Arai,T.,Akiyama,H.,Nonaka,T.,Mori,H.,Hashimoto,T.,Yamazaki,M.,and Oyanagi,K.
  • Journal Title: Brain 130(Pt 5) Pages: 1386-1394
  • Peer Reviewed
• [Journal Article] Longitudinal,quantitative assessment of amyloid,neuroinflammation and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by PET. (2007)
  • Author(s): Maeda,J.,Ji,B.,Irie,T.,Tomiyama,T.,Maruyama,M.,Okauchi,T.,Staufenbiel,M.,Iwata,N.,Ono,M.,Saido,T.C.,Suzuki,K.,Mori,H.,Higuchi,M.,and Suhara,T.
  • Journal Title: J.Neurosci. 27 Pages: 10957-10968
  • Peer Reviewed
• [Journal Article] TDP-43 is deposited in the Guamparkinsonism-dementia complex brains. (2007)
  • Author(s): Masato Hasegawa, Tetsuaki Arai, Hiroshi Mori, et al.
  • Journal Title: Brain in press
• [Journal Article] Novel Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's disease Brains. (2006)
  • Author(s): Ono, M., Kawashima, H., Nonaka, A., Kawai, T., Haratake. M, Mori, H., Kung, M-P., Kung, H.F., Saji, H., and Nakayama, M.
  • Journal Title: J. Med. Chem. 49(9) Pages: 2725-2730
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (2006)
  • Author(s): Arai, T., Hasegawa, M., Akiyama, H., Aeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hasluzume, Y., Oda, T.
  • Journal Title: Biochem. Biophys. Res. Couuuun. 351(3) Pages: 602-611
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The expression of embryoiuc tau protein isoforms persist during adult neurogenesis in the hippocampus. (2006)
  • Author(s): Bullmam, T., Silva, R., Holzer, M., Mori, H., Arendt, T.
  • Journal Title: Hippocampus 17(2) Pages: 98-102
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Improved Long-Term Potentiation and Memory in Young Tau-P301LTransgenic Mice before Onset of Hyperphosphorylation and Tauopathy. (2006)
  • Author(s): Boekhoorn, K., Terwel, D., Biemalls, B., Borghgraef, P., Wiegert, 0., Ramakers, G.J., de Vos, K., Krugers, H., Tomiyalna, T., Mori. H., Joels, M, van Leuven, F., and Lucassen1, P.J.
  • Journal Title: J. Neurosci. 26 Pages: 3514-3523
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Absence of synaptophysin near cortical neurons containing oligomer Aβ in Alzheimer's disease brain. (2006)
  • Author(s): Ishibashi, K., Tomiyama, T., Nishitsuji, K., Hara, M., and Mori, H.
  • Journal Title: J. Neurosci. Res. 84 Pages: 632-636
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Novel benzofuran derivatives for PET imaging of b-amyloid plaques in Alzheimer's disease brains (2006)
  • Author(s): Ono, M., Kawashima, H., Nonaka, A., Kawai, T., Haratake, M., Mori, H., Kung, M-P., Kung, H.F., Saji, H., Nakayama, M
  • Journal Title: J. Med. Chem 49 Pages: 2725-2730
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.c (2006)
  • Author(s): Arai, T., Hasegawa, M., Akiyama, H., Ikeda, K., Nonaka, T., Mori, H., Mann, D., Tsuchiya, K., Yoshida, M., Hashizume, Y., Oda, T
  • Journal Title: Biochem. Biophys. Res. Commun 351 Pages: 602-611
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus (2006)
  • Author(s): Bullmann, T., Silva, R., Holzer, M., Mori, H., Arendt, T
  • Journal Title: Hippocampus 17 Pages: 98-102
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Improved Long-Term Potentiation and Memory in Young Tau-P301 L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy (2006)
  • Author(s): Boekhoorn, K., Terwel, D., Biemans, B., Borghgraef, P., Wiegert, O., Ramakers, GJ., de Vos, K., Krugers, H., Tomiyama, T., Mori, H., Joels, M., van Leuven, F., Lucassenl, P.J
  • Journal Title: J. Neurosci 26 Pages: 3514-3523
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Absence of synaptophysin near cortical neurons containing oligomer A(3 in Alzheimer's disease brain (2006)
  • Author(s): Ishibashi, K., Tomiyama, T., Nishitsuji, K., Hara, M., Mori, H
  • Journal Title: J. Neurosci. Res 84 Pages: 632-636
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in AlzheiMer's disease Brains. (2006)
  • Author(s): Masahiro Ono, Hidekazu Kawashima, Akemi Nonaka, Hiroshi Mori, et al.
  • Journal Title: J. Med. Chem. 49(9) Pages: 2725-2730
• [Journal Article] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (2006)
  • Author(s): Tetsuaki Arai, Masato Hasegawa, Hiroshi Mori, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 351(3) Pages: 602-611
• [Journal Article] The expression. of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus. (2006)
  • Author(s): Torsten Bullmann, Rohan de Ailva, HiroShi Mori, et al.
  • Journal Title: Hippocampus 17(2) Pages: 98-102
• [Journal Article] Regulation of tau exon 10 splicuig by a double stein-loop structure in mouse intron 10 (2005)
  • Author(s): Yamashita, T., Tomiyama, T., Li, Q., Numata, H., and Mori, H.
  • Journal Title: FEBS Lett. 579 Pages: 241-244
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Syllthesis and biological evaluation of(E)-3-styrylpyridine dinederivatives as amyloid imaguig agents forAlzheimer's disease (2005)
  • Author(s): Ono, M., Haratake, M, Nakayama, M., Kaneko, Y., Kawabata, K., Mori, H., Kung, M-P., KUng, H.F.
  • Journal Title: Nucl. Med. Biol. 32(4) Pages: 329-335
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Trallsgenic mice expressillg mutant(N279K) human tau show mutation dependent cogiritive deficits without neurofibrillary tangle formation (2005)
  • Author(s): Taniguchi, T., Doe, N., Matsuyama, S. Kitamura, Y., Mori, H., Saito, N., and Tanaka, C.
  • Journal Title: FEBS Lett. 579(25) Pages: 5704-5712
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Radioiodinated Flavones for In Vivo Imaguig of Ainyloid Plaques in the Brain (2005)
  • Author(s): Ono, M., Yosluda, N., Ishibashi, K., Haratake, M., Arano, Y., Mori, H., and Nakayama, M.
  • Journal Title: J. Med. Chem. 48(23) Pages: 7253-7260
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Syntaxin 5 interacts specifically with presenilin holoprotehls and affects processing of βAPP in neuronal cells. (2005)
  • Author(s): Suga, K., Saito, A., Tomiyama, T., Mori, H., and Akagawa, K.
  • Journal Title: J. Neurochem. 94 Pages: 425-439
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level. (2005)
  • Author(s): Lippa, S.M., Lippa, C.F., and Mori, H.
  • Journal Title: Aiu. J. Alzheimers Dis. Other Demen. 20(5) Pages: 315-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10 (2005)
  • Author(s): Yamashita, T., Tomiyama, T., Li, Q., Numata, H., Mori, H
  • Journal Title: FEBS Lett 579 Pages: 241-244
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease (2005)
  • Author(s): Ono, M., Haratake, M., Nakayama, M., Kaneko, Y, Kawabata, K., Mori, H., Kung, M-P., Kung, H.F
  • Journal Title: Nucl. Ned. Biol 32 Pages: 329-335
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation (2005)
  • Author(s): Taniguchi, T., Doe, N., Matsuyama, S., Kitamura, Y., Mori, H., Saito, N., Tanaka, C
  • Journal Title: FEBS Lett 579 Pages: 5704-5712
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radioiodinated flavones for in vivo imaging of 13-amyloid plaques in the brain (2005)
  • Author(s): Ono, M., Yoshida, N., Ishibashi, K., Haratake, M., Arano, Y., M,ori, H., Nakayama, M
  • Journal Title: J. Med. Chem 48 Pages: 7253-7260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of f3APP in neuronal cells (2005)
  • Author(s): Suga, K., Saito, A., Tomiyama, T., Mori, H., Akagawa, K
  • Journal Title: J. Neurochem 94 Pages: 425-439
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level (2005)
  • Author(s): Lippa, S., M., Lippa, C., F., Mori, H
  • Journal Title: Am. J. Alzheimers Dis. Other Demen 20(5) Pages: 315-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10 (2005)
  • Author(s): Takenari Yamashita
  • Journal Title: FEBS Lett. 579 Pages: 241-244
• [Journal Article] Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimer's disease (2005)
  • Author(s): Masahiro Ono
  • Journal Title: Nucl.Med.Biol. 32(4) Pages: 329-335
• [Journal Article] Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation (2005)
  • Author(s): Taizo Taniguchi
  • Journal Title: FEBS Lett. 579(25) Pages: 5704-5712
• [Journal Article] Radioiodinated Flavones for In Vivo Imaging of Amyloid Plaques in the Brain (2005)
  • Author(s): Masahiro Ono
  • Journal Title: J.Med.Chem. 48(23) Pages: 7253-7260
• [Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia
  • Author(s): Tomiyama, T., Nagata, T., Shimada, H., Teraoka, T., Fukushima, A., Kanemitsu, H., Takuma, H., Kuwano, R., Imagawa, M., Ataka, S., Wada, Y, Yoshioka, E., Nishizaki, T., Watanabe, Y, Mori, H
  • Journal Title: Ann. Neurol (In press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] アミロイド関連疾患診断用組成物 (2007)
  • Inventor(s): 中山 守雄、原武 衛、小野 正博、森 啓
  • Industrial Property Rights Holder: 国立大学法人長崎大学(一部譲渡手続き中)
  • Filing Date: 2007-08-24
• [Patent(Industrial Property Rights)] アミロイド関連疾患診断用組成物 (2007)
  • Inventor(s): 中山 守雄、原武 衛、小野 正博、森 啓
  • Industrial Property Rights Holder: 国立大学法人長崎大学(一部譲渡手続き中)
  • Filing Date: 2007-08-24
• [Patent(Industrial Property Rights)] アミロイド関連疾患診断用組成物 (2006)
  • Inventor(s): 中山 守雄、原武 衛、小野 正博、森 啓
  • Industrial Property Rights Holder: 国立大学法人長崎大学(一部譲渡手続き中)
  • Filing Date: 2006-06-26
  • Acquisition Date: 2007-08-24
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] アミロイド関連疾患診断用組成物 (2005)
  • Inventor(s): 中山 守雄、原武 衛、小野 正博、森 啓
  • Industrial Property Rights Holder: 国立大学法人長崎大学(一部譲渡手続き中)
  • Filing Date: 2005-11-25
  • Acquisition Date: 2007-08-24
  • Description: 「研究成果報告書概要(和文)」より