Basic Research on On-Demand Direct Tissue Engineering

• Project/Area Number: 17300146
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKAMURA Makoto Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor (90301803)
• Co-Investigator(Kenkyū-buntansha): MORITA Ikuo Tokyo Medical and Dental University, Dept. of Cellular Physiological Chemistry, Professor (60100129) ; YOSHIKA Hiroshi Waseda University, Faculty of Science and Engineering, Associate Professor (40288006) ; NISHIYAMA Yuichi Kanagawa Academy of Science and Technology, Researcher (80415976)
• Project Period (FY): 2004 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥15,100,000 (Direct Cost: ¥15,100,000); Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000); Fiscal Year 2005: ¥12,800,000 (Direct Cost: ¥12,800,000)
• Keywords: Tissue engineering / regenerative medicine / inkiet / on demand fabrication / hydrogel / Rapid prototyping / Digital fabrication / three dimensional fabrication / Rapid prtotyping / 組織工学 / オンデマンド / ゲル / ラピッドプロトタイピング / Direct fabrication / ティシュ・エンジニアリング

Research Abstract

Next target organs and tissues of tissue engineering and regenerative medicine are the complicated tissues and organs, in which multiple types of cells and various extracellular matrices are arranged at the respective spatial positions at the resolution of micrometer orders. To construct such complicated tissues artificially from cells and biological materials, we need some effective techniques to control microscopic arrangement and compositions of cells and biomaterials. Then, we suggested an innovative approach of tissue engineering, On-demand direct tissue engineering, in which biological tissues are directly reconstructed by on demand ejection of cells and biomaterials at their respective spatial positions. In this research project, we proposed this new approach and investigated its feasibility in tissue engineering. First of all, we needed some substantial technology and machines to examine this approach. Then, we applied on demand inkjet technology and examined to eject living ce lls and biomaterials, controlling their spatial positions, and tried layer by layer printing..
We examined living cell printing and confirmed that living cells could be ejected safely by inkjet, and that there were no harmful effects to cell proliferation ability. Next, we invented inkjet gel formation technique to construct three dimensional structures with biological materials. With this technique, we successfully made hydrogel fibers and sheets, and succeeded layer by layer printing to fabricate three dimensional structures. By directly ejecting gel precursor with living cells, we also succeeded direct cell patterning and direct fabrication of those structures containing living cells. In addition, we developed custom made inkjet 3D bioprinter and tried to fabricate several 3D structures containing living cells. Then, we finally succeeded to fabricate three dimensional structures arranged with two different types of cells. The feasibility of On-demand direct tissue engineering was demonstrated. A new phase of tissue engineering is beginning with engineering and technology.

Research Products

• [Journal Article] New approaches for tissue engineering:three dimensional cell patterning using inkjet technology (2008)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Journal Title: InfIammation and Regeneration 28(1) Pages: 36-40
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of an effective three dimensional fabrication technique using inkjet technology for tissue modeI samples (2008)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, NakagaNa H.
  • Journal Title: Alternatives to Animal Testing and Experimentation(AATEX) (Accepted)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] New approaches for tissue engineering : threed dimensional cell patterning using inkiet technlolgy. (2008)
  • Author(s): Henmi C, Nakamura M, Nishiyama, Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Journal Title: Inflammation and Regeneration. 28(1) Pages: 36-40
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of an effective three dimensional fabrication technique using inkjet technology for tissue model samples (2008)
  • Author(s): Henmi C, Nakamura M, Nishiyama, Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Journal Title: Alternatives to Animal Testing and Experimentation(AATEX)(Accepted)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] インクジェット式Direct Tissue Engineering (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香
  • Journal Title: Organ Biology 14(1) Pages: 29-39
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fabrication Of 3d Cell Supporting Structures With Multi-Materials Using The Bio-Printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Nakagawa H, Takiura K.
  • Journal Title: Proceedings of MSEC2007, ASME International Manufacturing Science and Engineering Conference(MSEC).October15-18, 2007, Atlanta, Georgia USA (CD-ROM) Pages: 6-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Application of inkiet in tissue engineering and regenerative medicine:Development of inkjet 3D biofabrication technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H, Akito K.
  • Journal Title: Proceedings of IS&T DF2007;International Conference on Digital Fabrication Technologies 2007, Society for Imaging Science and Technology (CD-ROM) Pages: 5-5
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Direct Tissue Engineering using inkjet technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Journal Title: Organ Biology 14(1) Pages: 29-39
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fabrication Of 3d Cell Supporting Structures With Multi-Materials Using The Bio-Printer. (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Nakagawa H, Tadira K.
  • Journal Title: Proceedings of MSEC2007, in CD-ROM, 2007, ASMEInternational Manufacturing Science and Engineering Conference(MSEC). October 15-18, 2007, Atlanta Georgia USA, CD-ROM)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of inkjet in tissue engineering and regenerative medicine : Development of inkjet 3D biofabrication technology. (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Nakagawa H, Tadira K.
  • Journal Title: Proceedings of IS&T DF2007 ; International Conference on Digital Fabrication Technologies 2007, Socidty for Imaging Science and Technology, CD-ROM
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of inkjet technology for 3D cell patterning (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y.
  • Journal Title: Alternatives to animal testing and experimentation 12 Suppl Pages: 143-143
• [Journal Article] インクジェット式Direct Tissue Engineering (2007)
  • Author(s): 中村真人, 西山勇一, 逸見千寿香
  • Journal Title: Organ Biology 14(1) (on printing)
• [Journal Article] 印刷技術での細胞ハンドリング:バイオプリンティング (2006)
  • Author(s): 中村 真人
  • Journal Title: 医学のあゆみ 218(2) Pages: 139-144
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inkiet bioprinting as an effective tool for tissue fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Journal Title: Proceeding of Digital Fabrication 2006 Pages: 89-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Biopringting-Challenge in buliding biological tissues (2006)
  • Author(s): Nakamura M.
  • Journal Title: Igaku no Ayuni(Jonrnal of Clinical and Experimental Medicine) 218(2) Pages: 139-144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inkjet bioprinting as an effective tool for tissue fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Journal Title: Proceeding of Digital Fabrication Pages: 89-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 印刷技術での細胞ハンドリング : バイオプリンティング (2006)
  • Author(s): 中村真人
  • Journal Title: 医学のあゆみ 218(2) Pages: 139-144
• [Journal Article] Inkjet bioprinting as an effective tool for tissue fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Journal Title: Proceeding of Digital Fabrication 2006 Pages: 89-92
• [Journal Article] デジタル・ティシュ・エンジニアリング : 生体画像情報のデジタル化とバイオプリンティング (2006)
  • Author(s): 中村真人, 山口久美子, 西山勇一, 逸見千寿香, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 生体医工学 44 supp.1 Pages: 557-557
• [Journal Article] コンピュータ支援バイオプリンティング・バイオファブリケーション (2006)
  • Author(s): 中村真人, 山口久美子, 西山勇一, 逸見千寿香, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 再生医療 6 supple Pages: 93-93
• [Journal Article] 生体適合性ポリマーのインクジェット印刷による細胞のパターニング (2006)
  • Author(s): 逸見千寿香, 中村真人, 西山勇一, 渡辺昭彦, 岩崎泰彦, 山口久美子, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 再生医療 6 supple Pages: 307-307
• [Journal Article] マイクロゲルプリンターを用いた複数ゲル素材による3次元構造の構築 (2006)
  • Author(s): 西山勇一, 中村真人, 逸見千寿香, 山口久美子, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 再生医療 6 supple Pages: 308-308
• [Journal Article] 生体組織作製用3次元バイオインクジェットプリンターの試作および3次元ゲル構造の構築 (2006)
  • Author(s): 西山勇一, 中村真人, 逸見千寿香, 山口久美子, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 人工臓器 35(2)
• [Journal Article] 3次元バイオプリンティングとバイオファブリケーション (2006)
  • Author(s): 中村真人, 山口久美子, 西山勇一, 逸見千寿香, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 人工臓器 35(2)
• [Journal Article] インクジェット技術を用いた3D Cell Printing法の基礎的検討 (2006)
  • Author(s): 逸見千寿香, 西山勇一, 山口久美子, 望月修一, 瀧浦晃基, 中川英元, 中村真人
  • Journal Title: Inflammation and Regeneration 26(4) Pages: 385-385
• [Journal Article] コンピュータと機械による三次元生体組織構築 (2006)
  • Author(s): 西山勇一, 中村真人, 逸見千寿香, 山口久美子, 望月修一, 瀧浦晃基, 中川英元
  • Journal Title: 第9回日本組織工学会プログラム抄録集 Pages: 146-146
• [Journal Article] Manufacturing of living tissues and organs : Bioprinting, 生きた組織と臓器をつくる : バイオプリンティング (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Horie M
  • Journal Title: 1st International Medical-Engineering Joint Biomechanics Symposium(第1回医工連携・バイオメカニクス国際シンポジウム)抄録集
• [Journal Article] Biocompatible Inkjet Printing Technique For Designed Seeding of Individual Living Cells (2005)
  • Author(s): Nakamura M, Kobayashi A, Takagi F, Watanabe A, Hiruma Y, Ohuchi K, Iwasaki Y, Horie M, Morita I, Takatani S.
  • Journal Title: TISSUE ENGINEERING 11(11/12) Pages: 1658-1666
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Biocompatible Inkjct Printing Tcchnique For Dcsigncd Sccding Of Individual Living Cells. (2005)
  • Author(s): Nakamura M, Kobayashi A, Takagi F, Watanabc A, Hiruma Y, Ohuchi D, Iwasaki Y, Horie M, Morita I, Takatani S.
  • Journal Title: TISSUE ENGINEERING 11(11/12) Pages: 1658-1666
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Application of inkjet in tissue engineering and regenerative medicine:Development of inkjet 3D biofabrication technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H, Akito K.
  • Organizer: PiraTech BioPrinting Conference, Pre-Workshop.(Invited)
  • Place of Presentation: London,UK.
  • Year and Date: 2007-07-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 学際的融合に向けた有機分子・バイオエレクトロニクスの新たな展開;バイオプリンティング技術の現状と課題 (2007)
  • Author(s): 瀧浦 晃基, 中村 真人, 山口 久美子, 西山 勇一, 逸見 千寿香, 中川 英元, 望月 修一
  • Organizer: 応用物理学会・有機分子バイオエレクトロニクス分科会(招待講演)
  • Place of Presentation: 上山
  • Year and Date: 2007-06-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インクジェット技術の生体組織工学への応用の最前線 (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 畢基, 中川 英元
  • Organizer: 色材協会インクジェット部会講演会(招請講演)
  • Place of Presentation: 東京塗料会館,渋谷区東京
  • Year and Date: 2007-05-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 機械工学技術による再生医療・組織工学の新展開 (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 基調講演:日本機械学会主催第19回「電磁力関連のダイナミクス」シンポジウム(SEAD19)(基調講演)
  • Place of Presentation: 早稲田大学,新宿区,東京
  • Year and Date: 2007-05-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インクジェット技術の生体組織工学への応用の最前線 (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 日本化学会第87回春季年会ATP(Advanced Technology Program)講演会(招請講演)
  • Place of Presentation: 関西大学,吹田
  • Year and Date: 2007-03-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] コンピュータ支援バイオプリンティング・バイオファブリケーション (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 第6回日本再生医療学会総会:(シンポジスト)
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 2007-03-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マイクロゲルプリンターを用いた複数ゲル素材による3次元構造の構築 (2007)
  • Author(s): 西山 勇一, 中村 真人, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 第6回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 2007-03-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 生体適合性ポリマーのインクジェット印刷による細胞のパターニング (2007)
  • Author(s): 逸見 千寿香, 中村 真人, 西山 勇一, 渡辺 昭彦, 岩崎 泰彦, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 第6回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 2007-03-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fabrication of Multi-Material 3D Cell Supporting Structures Using the Bio-Printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: ASME International Conference on Manufacturing Scfence & Engineering(MSEC2007)(Symposist)
  • Place of Presentation: Georgia Thech.Atlanta,USA.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 生体組織のデジタルファブリケーションへのチャレンジ (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: レーザー顕微鏡研究会第33回講演会・シンポジウム:(シンポジスト)
  • Place of Presentation: 理化学研究所,和光
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 多種細胞による3次元組織再生工学へのチャレンジ (2007)
  • Author(s): 中村 真人, 西山 勇一, 逸見 千寿香, 岩永 進太郎, 山口 久美子, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 第16回日本形成外科学会基礎学術集会(特別講演)
  • Place of Presentation: クラウンプラザ神戸 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of Functional Micro Gel Beads as a Minimum Dot of Inkiet 3D Biofabrication (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Watanabe A, Suyama K, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 7th.Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto,Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Three dimensional (3D)observation of cell viability in inkjet-fabricated 3D structures (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 7th.Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto,Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Arecipe for the Inkjet Materials to Realize the 3D Cell Supporting Structures Using the Bio-Printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 7th.Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto,Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] An effective three dimensional fabrication technique of tissue model samples using inkJet printing technology (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 6th.World Congress on AIternatives & Animal Use in the Life Sciences 2007
  • Place of Presentation: Tokyo,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inkjet Biofabrication;3D hydrogel fabrication containing nano-particles (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochiauki S, Takiura K, Nakagawa H
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London,UK.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Patterning of endothelial cells for designed capillary formation (2007)
  • Author(s): Henmi C, Nakamura M, Nishivama Y, Watanabe A, Iwasaki Y, Morita I, Yamaguchi K, Mochiauki S, Takiura K, Nakagawa H.
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London,UK.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MorPhological analyses of inkjet-fabricated three-dimensional structures (2007)
  • Author(s): Yamaguchi K, Nakamura M, Henmi C, Nishivama Y, Mochizuki S, Takiura R, Nakagawa H.
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London,UK.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Application of inkiet in tissue engineering and regenerative medicine:Development of inklet 3D biofabrication technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H, Akita K.
  • Organizer: IS&T DF2007;International Conference on Digital Fabrication Technologies 2007, Society for Imaging Science and Technology
  • Place of Presentation: Anchirage, USA.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Application of inkjet in tissue engbeering and regenerative medicine : Development of inkjet 3D biofabrication technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H, AkitaK
  • Organizer: PiraTech BioPr int ing Conference, Workshop.(Invited)
  • Place of Presentation: London, UK
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fabrication of Multi-Material 3D Cell Supporting Structures Using the Bio-Printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: ASME International Conference on Manufacturing Science, Engineering(MSEC2007)(SYmposist)
  • Place of Presentation: Georgia Thech. Atlanta, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Computer aided Bioprinting and Biofabrication (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 6th. Congress of the Japanese Society for Regenerative Medicine(SYmposist)
  • Place of Presentation: Yokohama, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Forefront of the application of inkjet to tissue engineering and regenerative medicine (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 87th. Spring Meeting of the Chemical Sciety of Japan, Advanced Technology Program(Invited)
  • Place of Presentation: Suita
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Evolution of regenerative medisine and tissuee engineering by mechanic engineering (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: Keynote Address : SEAD19 : The Japan Society of Mechanical Engineers
  • Place of Presentation: Tokyo, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Forefront of the appl icat ion of inkj et to tissue engineering and regenerative medicine (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: Japan Society of Colour Material, Lecture meeting(Invited)
  • Place of Presentation: Tokyo, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] State of the art and issues of Bioprinting technology (2007)
  • Author(s): Takiura K, Nakamura M, Yamaguchi K, Nishiyama Y, Henmi Mochizuki S, Nakagawa H
  • Organizer: the Japan Society of Applied Physics : Molecular Electronics and Bioelectronics : (Invited)
  • Place of Presentation: Kamivama Tanan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Challenge on digital fabrication for tissue engineering (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 33rd. symposium on Laser Microscopy : (Symposist)
  • Place of Presentation: Wako, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Challenge of engineering three-dimensional biological tissues with multi-types of cells (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Iwanaga S, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: Challenge of engineering three-dimensional biological tissues with multi-types of cells
  • Place of Presentation: Kobe, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fabrication of 3D structure with various gel materials using micro gel printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 6th. Congress of the Japanese Society for Regenerative Medicine(Symposist)
  • Place of Presentation: Yokohama, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cell Patterning by inkjet printing of biocompatible polymer (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Watanabe A, Iwasaki Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 6th. Congress of the Japanese Society for Regenerative Medicine (SYmposist)
  • Place of Presentation: Yokohama, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of Functional Micro Gel Beads as a Minimum Dot of Inkjet 3D Biofabrication (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Watanabe A, Suyama K, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 7th. Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Three dimensional(3D)observation of rpll viability in inkiPt-fahriratPd 211 striirtnrPs (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 7th. Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A recipe for the Inkjet Materials to Realize the 3D Cell Supporting Structures Using the Bin-printer (2007)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 7th. Annual TERMIS NA Conference and Exposition
  • Place of Presentation: Toronto, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] An effective three dimensional fabrkation technique of tissue model samples using inkjet printing technology (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 6th. World Congress on Alternatives, Animal Use in the Life Sciences 2007
  • Place of Presentation: Tokyo, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet Biofabrication ; 3D hydrogel fabrication containing nano-particles (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London, UK
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Patterning of endothelial cells for designed capillary formation (2007)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Watanabe A, Iwasaki Y, Morita I, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London, UK
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Morphological analyses of inkiet-fabricated three-dimensional structures (2007)
  • Author(s): Yamaguchi K, Nakamura M, Henmi C, Nishiyama Y, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 2007 TERMIS-EU Chapter Meeting
  • Place of Presentation: London, UK
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Application of inkjet in tissue engineering and regenerative medicine : Development of inkjet 3D biofabrication technology (2007)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H, Akita K
  • Organizer: IS, T DF2007 ; International Conference on Digital Fabrication Technologies 2007, Society for Imaging Science and Technology
  • Place of Presentation: Anchorage, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet Bio-Printing as an Effective Tool for Tissue Fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: IS&T DF2006, International Conference on Digital Fabrication 2006, Society for Imaging Science and Technology
  • Place of Presentation: Denver,USA.
  • Year and Date: 2006-09-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Manufacturing of living tissues and organs:Bioprinting (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Horie M
  • Organizer: 1st International Medical-Engineering Joint Biome chanics Symposium(Symposist)
  • Place of Presentation: Tokyo Institute of Techno]ogy:Tokyo,Japan
  • Year and Date: 2006-07-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inkjet Gel Bio-Printing for 3D Tissue Fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 1st International Congress of Tissue Engineering and Regenerative Medicine Society
  • Place of Presentation: Pittsburgh,USA.
  • Year and Date: 2006-04-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 生体組織・臓器の設計と製作:バイオ人工臓器工学 (2006)
  • Author(s): 中村 真人, 山口 久美子, 西山 勇一, 逸見 千寿香, 望月 修一, 瀧浦 晃基, 中川 英元
  • Organizer: 第111回日本解剖学会総会(シンポジスト)
  • Place of Presentation: 北里大学,相模原
  • Year and Date: 2006-03-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evolution of Bioprinting and Biofabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 3rd international symposium on Bioprinting and Biofabrication(Organizer's Address)
  • Place of Presentation: Kanagawa Science Park,KaNasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Micro Gel Beads Produced by Inkjet (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Watanabe A, Suyama K, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inkjet Printing of Biocompatible Polymer for Micro Cell Patterning (2006)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: KaNasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The fabrication machine of 3-d hydro gel structure with the ink-iet tochnology (2006)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fully designed capillary networks formed in vitro by Printing techniques (2006)
  • Author(s): Morita I, Kobavashi A, Nakamura M, Hattori H.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Design of artificial extracellular matrix proteins with activity of promoting angiogenesis (2006)
  • Author(s): Nakamura M, Mie M, Nakamura M, Kobatake E.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of bio-prototyping using temperature-sensitive gel. (2006)
  • Author(s): Ishida K, Kumata T, Morishima K, Otani Y, Umeda N, Nakamura M.
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki,Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Designing of tissues and Bioprinting for Computer Assisted Tissue Engineering (2006)
  • Author(s): Nakamura M
  • Organizer: 1st International Medical-Engineering Joint Biomechanics Symposium(SYmposist)
  • Place of Presentation: Tokyo Institute of Technology : Tokyo, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Manufacturing of living tissues and organs : Bioprinting (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Horie M
  • Organizer: The 3rd international symposium on Bioprinting and Biofabrication(Organizer's Address)
  • Place of Presentation: Kanagawa Science Park, Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Designing and manufacturing of biological tissues and organs ; Bio-artificial organ engineering (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: The 111th. Congress of the Japanese Association of Anatomists
  • Place of Presentation: Sagamihara, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet Gel Bio-Printing for 3D Tissue Fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 1st International Congress of Tissue Engineering and Regenerative Medicine Society
  • Place of Presentation: Pittsburgh, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet Bio-Printing as an Effective Tool for Tissue Fabrication (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: IS, T DF2006, International Conference on Digital Fabrication 2006, Society for Imaging Science and Technology
  • Place of Presentation: Denver, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Micro Gel Beads Produced by Inkiet (2006)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Watanabe A, Suyama K, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet Printing of Biocompatible Polymer for Micro Cell Patterning (2006)
  • Author(s): Henmi C, Nakamura M, Nishiyama Y, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki. Tam
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The fabrication machine of 3-d hydro gel structure with the ink-jet technology (2006)
  • Author(s): Nishiyama Y, Nakamura M, Henmi C, Yamaguchi K, Mochizuki S, Takiura K, Nakagawa H
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fully designed capillary networks formed in vitro by Printing techniques (2006)
  • Author(s): Morita I, Kobayashi A, Nakamura M, Hattori H
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design of artificial extracellular matrix proteins with activity of promoting angiogenesis (2006)
  • Author(s): Nakamura M, Mie M, Nakamura M, Kobatake E
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of bio-prototyping using temperature-sensitive gel (2006)
  • Author(s): Ishida K, Numata T, Morishima K, Otani Y, Umeda N, Nakamura M
  • Organizer: 3rd international symposium on Bioprinting and Biofabrication
  • Place of Presentation: Kawasaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] コンピュータと機械の力で生体組織を創る/Computer Aided Tissue Engineering (2005)
  • Author(s): 中村 真人
  • Organizer: FML研究会(招請講演)
  • Place of Presentation: すみだ産学官連携プラザ,東京都墨田区
  • Year and Date: 2005-08-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] コンピュータと機械の力で生体組織を創る/Computer Aided Tissue Engineering (2005)
  • Author(s): 中村 真人
  • Organizer: マイクロナノ流体研・究会(招請講演)
  • Place of Presentation: 東京大学生産技術研究所,東京都目黒区
  • Year and Date: 2005-08-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Designing of tissues and Bioprinting for Computer Assisted Tissue Engineering (2005)
  • Author(s): Nakamura M
  • Organizer: Biomaterials day & Third Annual NIH-NSF BBSI Svmposium on Innovative Biomaterials 2005(Invited)
  • Place of Presentation: Clemson University,Clemsan,SC,USA.
  • Year and Date: 2005-07-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inkjet 3D Bioprinting for Tissue Engineering (2005)
  • Author(s): Mochizuki S, Nakamura M
  • Organizer: 2nd International Workshop on Biopatterning, Biop rinting and BioAssembly(Invited)
  • Place of Presentation: Medical University of South Carolina,Charleston,SCUSA.
  • Year and Date: 2005-05-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Alginate Micro Gel Beads for Tissue Engineering (2005)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Nakagawa H, Mochizuki S, Takiura K.
  • Organizer: 8th Annual Meeting of Tissue Engineering Society International(TESI)conference and exposition
  • Place of Presentation: Shanghai,China
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inkjet 3D Bioprinting for Tissue Engineering (2005)
  • Author(s): Mochizuki S, Nakamura M
  • Organizer: 2nd International Workshop on Biopatterning, Bioprinting and BioAssembly(Invited)
  • Place of Presentation: Medical University of South Carolina, Charleston, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inkjet 3D Bioprinting for Tissue Engineering (2005)
  • Author(s): Mochizuki S, Nakamura M
  • Organizer: Biomaterials day, 3rd Annual NIH-SF BBSI Symposium on Innovative Biomaterials 2005(Invited)
  • Place of Presentation: Clemson University, Clemson, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Computer Aided Tissue Engineering (2005)
  • Author(s): Nakamura M
  • Organizer: Micro Nano Fluidics Association(Invited)
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Computer Aided Tissue Engineering (2005)
  • Author(s): Nakamura M
  • Organizer: FML Association(Invited)
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Alginate Micro Gel Beads for Tissue Engineering (2005)
  • Author(s): Nakamura M, Nishiyama Y, Henmi C, Yamaguchi K, Nakagawa H, Mochizuki S, Takiura K
  • Organizer: 8th Annual Meeting of Tissue Engineering Society International(TESI)conference and exposition
  • Place of Presentation: Shanghai China
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] バイオプリンティング(インクジェット技術の再生医療への応用), 『細胞分離・操作技術の最前線(仮題)』福田敏男、新井史人監修 (2008)
  • Author(s): 岩永 進太郎, 中村 真人, 西山 勇一, 逸見 千寿香
  • Publisher: シーエムシー出版(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] インクジェット技術を応用した細胞の3次元パターニング, 動物実験代替のためのバイオマテリアル・デバイス, 酒井康行, 民谷栄一監修 (2007)
  • Author(s): 逸見 千寿香, 中村 真人, 西山 勇一
  • Publisher: シーエムシー出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] バイオプリンティング(インクジェット技術の再生医療への応用), インクジェットプリンターの応用と材料II高橋恭介監修 (2007)
  • Author(s): 西山 勇一, 中村 真人, 逸見 千寿香
  • Publisher: シーエムシー出版
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 名称「ゲルの製造方法及びそのための装置」 (2006)
  • Inventor(s): 中村 真人, 西山 勇一, 逸見 千寿香, 須山 紅美子
  • Industrial Property Rights Holder: 神奈川科学技術アカデミー, 東京医科歯科大学
  • Industrial Property Number: 2006-312422
  • Filing Date: 2006-11-20
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] インクジェット微小粒子作製法と作製装置 (2005)
  • Inventor(s): 中村 真人・渡辺 昭彦
  • Industrial Property Rights Holder: 東京医科歯科大学・神奈川科学技術アカデミー
  • Industrial Property Number: 2005-303367
  • Filing Date: 2005-10-18
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] インクジェット微小粒子作製法と作製装置 (2005)
  • Inventor(s): 中村真人・渡辺昭彦
  • Industrial Property Rights Holder: 東京医科歯科大学, 神奈川科学技術アカデミー
  • Industrial Property Number: 2005-303367
  • Filing Date: 2005-10-18