Investigation of contrast ultrasound imaging with microbubble contrast agents for diagnosis of sentinel lymph node metastasis using esophageal cancer animal model
| Project/Area Number |
17300175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
MORIYASU Huminori Tokyo Medical University, School of Medicine, Professor (80191055)
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| Co-Investigator(Kenkyū-buntansha) |
IIZIMA Hiroko Hyogo College of Medicine, Faculty of Medicine, Associate Professor (80289066)
SHIMIZU Masahumi Tokyo Medial University, School of Medicine, Instructor (00372954)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥14,330,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2006: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2005: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | microbubble / ultrasound contrast agent / sentinel lymph node / lymph node metastasis / macrophage / 炎症性リンパ節腫大 / ハーモニック映像法 / Sonazoid / 造影超音波 / リンパ節造影 / 食道癌 / 胃癌 |
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| Research Abstract |
Ultrasound contrast agents are composed of microbubble. Sonazoid[R] is composed of perfluorobutane gas as the inner gas and it has phosphatigyl serine outer shell. Sentinel lymph node is opacified with contrast agent when it is administered into the subcutaneous and submucosal tissues.
The results of the projects are as follows ;
1. Proper conditions for ultrasound imaging of lymph nodes are 1) higher MI (mechanical index) is necessary than contrast imaging of microbubbles flowing in the circulating blood as MI>0.4.
2. Phase modulation harmonic imaging technique is more proper for phagocytosed microbubbles in the Kupffer cells than amplitude modulation harmonic imaging technique.
3. HSP (heat shock protein) expression while ultrasound is exposed and phagocytosed microbubbles are destroyed is dependent on the MI of the emitted ultrasound.
Lymph node swelling models revealed different patterns of contrast imaging between lymph node -'metastatic from VX2 tumor and inflammatory lymph node swelling from bacterial infection.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Dynamic US contrast study of the liver : Vascular and delayed parenchymal phase2007
Author(s)
Iijima, H., Sasaki, S., Moriyasu, F., Suzuki, S., Yoshida, M., Horibe, T., Tsuchiya, K.*
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Journal Title
Hepatol Res 37(1)
Pages: 27-34
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Decrease in accumulation of ultrasound contrast microbubbles in non-alcoholic steatohepatitis2007
Author(s)
Iijima, H.*, Moriyasu, F., Tsuchiya, K.*, Suzuki, S., Yoshida, M, Shimizu., M., Sasaki, S., Nishiguchi, S., Maeyama, S.*
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Journal Title
Hepatol Res 37(9)
Pages: 722-730
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 次世代超音波造影剤の出現を視野に入れ、今後レボビストが担いえる役割 肝腫瘍における造影超音波診断 LevovistとSonoVueの比較2007
Author(s)
杉本 勝俊, 羽山 弥毅, 工藤 幸正, 平良 淳一, 目時 亮, 古市 好宏, 釜本 寛之, 山田 昌彦, 宮原 健夫, 今井 康晴, 堀部 俊哉, 中村 郁夫, 森安 史典
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Journal Title
Rad Fan 5(3)
Pages: 107-110
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Peer Reviewed
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[Journal Article] ソナゾイドによる造影超音波診断:肝腫瘍の診断-Dynamic studyとMFIによる腫瘍性病変の鑑別診断2007
Author(s)
杉本 勝俊, 森安 史典, 佐野 隆友, 村嶋 英学, 平良 淳一, 目時 亮, 古市 好宏, 山田 昌彦, 宮原 健夫, 今井 康晴, 中村 郁夫
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Journal Title
INNERVISION 22(10)
Pages: 25-30
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[Journal Article] Visualization of the drainage veins with contrast-enhanced sonography was useful in diagnosis of small focal nodular hyperplasia2006
Author(s)
Iijima, H., Suzuki, S., Moriyasu, F., Yanagisawa, K., Yamada, M., Miyahara, T., Yokoi, M., Horibe, T., Ito N., Kakizaki, D., Abe, K
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Journal Title
J Ultrasound Med 25(6)
Pages: 799-803
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Quantification of hepatic parenchymal blood flow by contrast ultrasonography with flash-replenishment imaging2006
Author(s)
Metoki, R., Moriyasu, F., Kamiyama, N., Sugimoto, K., Iijima, H., Xu, H.X., Aoki, T., Miyata, Y., Yamamoto, K., Kudo, K., Shimizu, M., Yamada, M.
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Journal Title
Ultrasound Med Biol 32
Pages: 1459-1466
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[Journal Article] Differential diagnosis of pancreatic tumors using ultrasound contrast imaging2005
Author(s)
Sofuni, A., Iijima, H., Moriyasu, F., Nakayama, D., Shimizu, M., Nakamura, K., Itokawa, F., Itoi, T
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Journal Title
J Gastroenterol 40(5)
Pages: 1209-1209
NAID
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Abdominal ultrasound : Real-time 3-dimensional ultrasonography(4D-US) and Contrast 4D-US in radio frequency ablation of Liver tumors(Scientific Session)2007
Author(s)
Yamada, M., Sugimoto, K., Metoki, R., Taira, J., Furuichi, Y., Miyahara, T., Imai, Y., Nakamura, I., Iijima, H., Moriyasu, F
Organizer
2007 AIUM Annual Convention
Place of Presentation
New York, USA
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Noninvasive quantification of parenchymal perfusion of the liver by using a flash-replenishment imaging technique of : contrast ultrasound2005
Author(s)
Metoki, R., Moriyasu, F., Kamiyama, N., Sugimoto, K., Iijima, H., Yoshida, M., Suzuki, S., Shimizu, M
Organizer
2005 AIUM annual convention and 50th anniversary celebration
Place of Presentation
Orlando, Florida
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 「研究成果報告書概要(欧文)」より2005
Author(s)
Sofuni, A., Itoi, T., Itokawa, F., Kurihara, T., Tsuchiya, T., Kawai, T., Moriyasu, F., Yamagishi, T
Organizer
13th United European Gastroenterology Week(UEGW) 2005
Place of Presentation
Copenhargen, Denmark
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