Effect of weight-bearing after autologous osteochondral grafting surgery on stiffness parameter of articular cartilage of the osteochondral plug and range of knee motion

• Project/Area Number: 17300185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: KUROKI Hiroshi Kyoto University, Graduate School of Medicine, Professor (20170110)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Yasuaki Kyoto University, Orthopaedic Surgery, Lecturer (90293860) ; KOBAYASHI Masahiko Kyoto University, Orthopaedic Surgery, Assistant Professor (20378623) ; SAKAKIMA Harutoshi Kagoshima University, Physical Therapy, Associate Professor (10325780) ; OKA Toru Kyoto University, Physical Therapy, Research Student (20447923)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥14,060,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥660,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2006: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2005: ¥7,700,000 (Direct Cost: ¥7,700,000)
• Keywords: Articular Cartilage / Autologous Osteochondral Transplantation / Ultrasound Stiffness Parameter / Weight Bearing / Range of Motion / 軟骨硬度 / 超音波 / 軟骨 / 硬度 / 家兎 / 膝 / 加齢

Research Abstract

The osteochondral grafting surgery is often used for isolated cartilage lesions. Aim of this study was to investigate the effect of the surgery on articular cartilage of the osteochondral plug, bone healing and range of knee motion. Histology and ultrasound parameters of articular cartilage of the osteochondral plug were studied in the 6-mm model of rabbits. The rabbits were divided into two groups of the weight-bearing model and the non-weight-bearing model. The ultrasound stiffness parameter of articular 'cartilage of the plug decreased up to 12 weeks and then increased at 24 and 52 weeks after the surgery. Postoperative care for up to 12 weeks should be taken after the surgery. Part of this study has been publishedin 'Arthroscopy' and has been presented in the 2007 World Congress on Osteoarthritis.

Research Products

• [Journal Article] Sequential changes in implanted cartilage after autologous osteochondral transplantation: postoperative acoustic properties up to 1 year in an in vivo rabbit model (2007)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, Kobayashi M, Okamoto Y, Yasura K, Nishitani K, Nakamura T
  • Journal Title: Arthroscopy 23 Pages: 647-654
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Authors' Reply (2007)
  • Author(s): Kuroki H, Nakagawa Y, Mori K
  • Journal Title: Arthroscopy 23 Pages: 1139-1141
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Estimation of the mechanical property of meniscus using ultrasound: Examinations of native meniscus and effects of enzymatic digestion (2007)
  • Author(s): Yasura K, Mizuno Y, Nakagawa Y, Mori K, Takenaka M, Ohashi T, Yamada K, Kobayashi M, Ando K, Kuroki H, Suzuki T, Ikeuchi K, Tsutsumi S, Nakamura T
  • Journal Title: Journal of Orthopaedic Research 25 Pages: 884-893
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sequential changes in implanted cartilage after autologous osteochondral transplantation : postoperative acoustic properties up to 1 year in an in vivo rabbit model (2007)
  • Author(s): Hiroshi, Kuroki, Yasuaki, Nakagawa, Koji, Mori, Masahiko, Kobayashi, Yukihiro, Okamoto, Ko, Yasura, Kohei, Nishitani, Takashi, Nakamura
  • Journal Title: Arthroscopy 23 Pages: 647-654
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Authors' Reply (2007)
  • Author(s): Hiroshi, Kurolki, Yasuaki, Nakagawa, Koji, Mori
  • Journal Title: Arthroscopy 23 Pages: 1139-1141
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Estimation of the mechanical property of nieniscus using ultrasound : Examinations of native meniscus and effects of enzymatic digestion (2007)
  • Author(s): Ko, Yasura, Yasuyuki, Mizuno, Yasuaki, Nakagawa, Koji, Mori, Makoto, Takenaka, Tetsuo, Ohasbi, Keisuke, Yamada, Masahiko, Kobayashi, Keiji, Ando, Hiroshi, Kuroki, Takashi, Suzuki, Ken, Ikeuchi, Sadami, Tsutsumi, Takashi, Nakamura
  • Journal Title: Journal of Orthopaedic Research 25 Pages: 884-893
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sequential changes in implanted cartilage after autologous osteochondral transplantation: postoperative (2007)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, Kobayashi M, Okamoto Y. Yasura
  • Journal Title: Arthroscopy 23 Pages: 647-654
  • Peer Reviewed
• [Journal Article] Estimation of the mechanical property of meniscus using ultrasound: Examinations of native meniscus and effects (2007)
  • Author(s): Yasura K, Mizuno Y, Nakagawa Y, Mori K, Takenaka M, Ohashi T,
  • Journal Title: Journal of Orthopaedic Research 25 Pages: 884-893
  • Peer Reviewed
• [Journal Article] Sequential Changes in Implanted Cartilage After Autologous Osteochondral Transplantation : Postoperative (2007)
  • Author(s): H.Kuroki, Y.Nakagawa, K.Mori, M.Kobayashi, Y.Okamoto, K.
  • Journal Title: Arthroscopy (in press)
• [Journal Article] Maturation-dependent change and regional variations in acoustic (2006)
  • Author(s): H.Kuroki, Y.Nakagawa, K.Mori, M.Kobayashi, K.Yasura, Y.
  • Journal Title: Osteoarthritis and Cartilage vol. 14 Pages: 784-792
• [Journal Article] Maturation-dependent change and regional variations in acoustic stiffness of rabbit articular cartilage : an examination of the superficial collagen-rich zone of cartilage (2006)
  • Author(s): H.Kuroki, Y.Nakagawa, K.Mori, M.Kobayashi, K.Yasura, Y.Okamoto, Y.Mizuno, K.Ando, K.Ikeuchi, T.Nakamura
  • Journal Title: Osteoarthritis and Cartilage vol.14(in press)
• [Presentation] Histological observations and ultrasound assessment of afullthickness cartilage defect in a rabbit model (2007)
  • Author(s): Kuroki H, Nakagawa Y, Mori K, Kobayashi M, Okamoto Y, Yasura K, Nishitani K, Nakamura T
  • Organizer: The 2007 World Congress on Osteoarthritis
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2007-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Histological observations and ultrasound assessment of a fullthickness cartilage defect in 'a rabbit model (2007)
  • Author(s): Hiroshi, Kuroki, Yasuaki, Nakagawa, Koji, Mori, Masahiko, Kobayashi, Yukihiro, Okamoto, Ko, Yasura, Kohei, Nishitani, Takashi, Nakamura
  • Organizer: The 2007 World Congress on Osteoarthritis
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2007-09-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.med.kyoto-u.ac.jp/J/grad_school/introduction/5361/
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/J/gradschool/introduction/5361/