Development of Highly Sensitive DNA Microarray Sensor Based on Periodic Metallic Nanostructures
| Project/Area Number |
17360110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Hokkaido University |
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Principal Investigator |
MISAWA Hiroaki Hokkaido University, Research Institute for Electronic Science, Professor (30253230)
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| Co-Investigator(Kenkyū-buntansha) |
JUODKAZIS Saulius Hokkaido University, Research Institute for Electronic Science, Associate Professor (80332823)
UENO Kosei Hokkaido University, Research Institute for Electronic Science, Assi. Prof. (00431346)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,810,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 2005: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | DNAMicroarray / Metal Nanostructures / Surface-Enhanced Raman Scattering / Nano-Processing / Bio-Sensing / 金属ナノ周期構造 / ナノギャップ / 光電場増強 / 局在表面プラズモン |
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| Research Abstract |
High-quality periodic metallic nanostructures were fabricated with accuracy of a few nanometers on glass substrates by electron beam lithography and lift off techniques. The unprecedented accuracy of the fabrication has enabled observation of spectrally homogeneous plasmonic resonances that are highly sensitive to nanoscale variations in dielectric environment of the nanoparticles, and exhibit strong plasmonic near-field enhancement due to localization. These features are favorable for various optical sensing applications. For example, spectral red-shift of the plasmonic resonance due to local dielectric permittivity variations at the metals' surface has allowed elucidation of DNA hybridization process, and opened ways for the creation of low-cost DNA micro-analysis arrays in the near future. High local field intensity enhancement has enabled chemical and bio-sensing with plasmonic nanostructures, as is evidenced by the achieved amplification of Surface-Enhanced Raman Scattering (SERS) signal from Pyridine molecules by up to 10^<10> times. Also, intense non-linear photoluminescence from metallic gold at visible wavelengths was observed. Here we present experimental and theoretical studies of these and other effects, as well as issues affecting the fabrication accuracy and design guidelines for the metallic nanostructures. Finally, a novel methodology for the fabrication of large-scale periodic metallic nanostructures by laser interference lithography is presented.
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Report
(4 results)
Research Products
(89 results)
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[Presentation] ナノギャップを有する金属構造体による非線形光重合反応2007
Author(s)
渋谷 俊志, 上野 貢生, 横田 幸恵, V. Mizeikis, S. Juodkazis, 笹木 敬司, 三澤 弘明
Organizer
2006年日本化学会北海道支部冬季研究発表会
Place of Presentation
札幌,北海道大学学術交流会館
Year and Date
2007-02-01
Description
「研究成果報告書概要(和文)」より
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[Presentation] 金属ナノ構造による表面増強ラマン散乱のナノポケットサイズ効果2007
Author(s)
横田 幸恵, 上野 貢生, V. Mizeikis, S. Juodkazis, 笹木 敬司, 三澤 弘明
Organizer
2006年日本化学会北海道支部冬季研究発表会
Place of Presentation
札幌,北海道大学学術交流会館
Year and Date
2007-02-01
Description
「研究成果報告書概要(和文)」より
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[Presentation] シリコン基板上に作製した金ナノ構造体の分光特性2006
Author(s)
三野 雅弘, 上野 貢生, V. Mizeikis S. Juodkazis, 笹木 敬司, 三澤 弘明
Organizer
2006年光化学討論会
Place of Presentation
東北大学
Year and Date
2006-09-12
Description
「研究成果報告書概要(和文)」より
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[Presentation] 顕微分光計測による局在表面プラズモン分光特性の評価2006
Author(s)
岡田 陽平, 上野 貢生, 横田 幸恵, V, Mizeikis, S. Juodkaizis, 笹木 敬司, 三澤弘明
Organizer
2006年光化学討論会
Place of Presentation
東北大学
Year and Date
2006-09-11
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] ナノギャップ金属構造体を用いた非線形光重合反応2006
Author(s)
渋谷俊志, 横田幸恵, 上野貢生, V. Mizeikis, S. Juodkazis, 笹木敬司, 三澤弘明
Organizer
2006年光化学討論会
Place of Presentation
東北大学
Year and Date
2006-09-10
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 金属ナノ構造体による光化学反応場の創製2006
Author(s)
横田幸恵, 渋谷俊志, 上野貢生, V. Mizeikis, S. Juodkazis, 笹木敬司, 三澤弘明
Organizer
第67回応用物理学会学術講演会
Place of Presentation
立命館大学
Year and Date
2006-08-31
Description
「研究成果報告書概要(和文)」より
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[Presentation] ナノギャップ金属ナノ周期構造体が示す光学特性の制御2005
Author(s)
横田幸恵, 上野貢生, V. Mizeikis, S. Juodkazis, 笹木敬司, 三澤弘明
Organizer
秋季 第66回応用物理学会学術講演会
Place of Presentation
徳島大学
Year and Date
2005-09-07
Description
「研究成果報告書概要(和文)」より
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[Presentation] 局在プラズモン共鳴によるDNAチップの開発2005
Author(s)
上野貢生, 三野雅弘, 林田雅行, 横田幸恵, V. Mizeikis, S. Juodkazis, 三澤弘明
Organizer
秋季 第66回応用物理学会学術講演会
Place of Presentation
徳島大学
Year and Date
2005-09-07
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 金属ナノ構造体が拓く分析化学2005
Author(s)
上野 貢生
Organizer
第21回緑陰セミナー
Place of Presentation
小樽おこばち山荘
Year and Date
2005-06-18
Description
「研究成果報告書概要(和文)」より
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[Presentation] 局在プラズモン共鳴による電場増強場の構築2005
Author(s)
上野貢生, V. Mizeikis, S. Juodkazis, 笹木敬司, 三澤弘明
Organizer
2005年春季 第52回応用物理学関係連合講演会
Place of Presentation
埼玉大学
Year and Date
2005-03-29
Description
「研究成果報告書概要(和文)」より
Related Report
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