Studies on the formation mechanism and functions of the covalently bound complex of hyaluronan with SHAP, the functional molecular entity of hyaluronan

• Project/Area Number: 17370041
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural biochemistry
• Research Institution: Aichi Medical University
• Principal Investigator: KIMATA Koji Aichi Medical University, Emeritus professor (10022641)
• Co-Investigator(Kenkyū-buntansha): LISHENG Zhuo Aichi Medical University, Institute of Molecular Science of Medicine, Research Associate (00399031)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥15,560,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥1,260,000); Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000); Fiscal Year 2005: ¥6,000,000 (Direct Cost: ¥6,000,000)
• Keywords: hyaluronan / SHAP / inflammation / inter-α-trypsin inhibitor / complex-forming enzyme factor / hepatitis / TSG-6 / compliment / インターα-トリプシンインピビター / ビクニン / サイトカイン / インタ-α-トリプシンインヒビター / factor H-related protein 1 / TSG6

Research Abstract

The covalently bound complex formed from inter-α-trypsin inhibitor (ITI) and hyaluronan (HA) by transesterification reaction, the SHAP (ITI heavy chain)-HA complex was investigated with regard to its physiological functions and serum enz; yme factors involved in the reaction. The candidate protein obtained from one of the library of serum fractions by the beforehand establisehd purification methods using a series of affinity columns was identified FHR-1 (factor H-related protein-1). However, the medium fraction of FHR-1 cDNA-transfected hepatocarcinoma HLF cells did not show any of the activity. Meanwhile, we found that the medium of the transfectants with cDNA of TSG-6 (TNFα-stimulated gene 6 product) had the dramatically increased activity that was yet retained after removal of TSG-6 by passing through the antibody affinity column, suggesting that the enzyme factors could not be TSG-6 itself and be induced with TSG-6 in the cells. Thus, we are now in the processes to the purification and identification of the factors. We previously developed the bikunin (ITI short chain)-knockout mouse system in order to investigate in vivo functions of the SHAP-HA complex where the complex was not formed. We found that the knockout mouse was resistant to the induction of acute hepatitis by the administration of D-galactosamine/E.coli lipopolysaccharide (LPS) in which the CD44-HA interaction-dependent attachment of neutrophils to live capillary sinusoidal cell surfaces was involved in response to the LPS stimuli. We then found using culthred leukocytes that the SHAP-HA complex activates the CD44-HA interaction-dependent cell adhesion more than 100 times, which is a decisive evidence for the involvement of the SHAP-HA complex in inflammatory cell response. We also found the good relationship between the SHAP-HA complex levels and the disease progression in the serum samples from patients of liver diseases, articular cartilage injury, gestoses, ovarian cancer etc, suggesting functional significances of the SHAP-HA complex in those diseases and the high reliability of the complex as a disease marker.

Research Products

• [Journal Article] Impact of the Hyaluronan-Rich Tumor Microenvironment on Cancer Initiation and Progression (2008)
  • Author(s): Itano N, Zhuo L, Kimata K.
  • Journal Title: Cancer Science (In press)
  • NAID: 10024010481
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of a motif for specific binding to hyaluronan in chicken SPACR. (2008)
  • Author(s): Zhao J, Yoneda M, Takeyama M, Miyaishi O, Inoue Y, Kataoka T, Ohno-Jinno A, Isogai Z, Kimata K, Iwaki M, Zako M
  • Journal Title: J Neurochem (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Altered hyaluronan biosynthesis in cancer progression (2008)
  • Author(s): Itano N, Kimata K
  • Journal Title: Semin Cancer Biol (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer (2008)
  • Author(s): Obayashi Y, Yabushita H, Kanyama K, Noguchi M, Zhuo L, Kimata K, Wakatsuki A
  • Journal Title: Oncol Rep 19(5) Pages: 1245-51
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Versican and Fibrillin-1 Form a Major Hyaluronan-Binding Complex in the Ciliary Body (2008)
  • Author(s): Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao JS, Li H, Takeyama M, Keene DR, Sakai LY, Kimata K, Iwaki M, Zako M
  • Journal Title: Invest Ophthalmol Vis Sci (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor (2008)
  • Author(s): Kishida T, Yabushita H, Wakatsuki A, Zhuo L, Kimata K
  • Journal Title: Connect Tissue Res 49(2) Pages: 105-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan (2008)
  • Author(s): Zhu L, Zhuo L, Watanabe H, Kimata K
  • Journal Title: Connect Tissue Res 49(1) Pages: 48-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation (2008)
  • Author(s): Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki K
  • Journal Title: Arch Biochem Biophys 471(1) Pages: 85-93
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis.Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment (2008)
  • Author(s): Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N
  • Journal Title: Am J Pathol 172(1) Pages: 179-193
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impact of the Hyaluronan-Rich Tumor Microenvironment on Cancer Initiation and Progression. (2008)
  • Author(s): Itano N, Zhuo L, Kimata K.
  • Journal Title: Cancer Science (in press)
  • NAID: 10024010481
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a motif for specific binding to hyaluronan in chicken SPACR (2008)
  • Author(s): Zhao J, Yoneda M, Takeyama M, Miyaishi O, Inoue Y, Kataoka T, Ohno-Jinno A, Isogai Z, Kimata K, Iwaki M, Zako M.
  • Journal Title: J Neurochem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alterde hyaluronan biosynthesis in cancer progression. (2008)
  • Author(s): Itano N, Kimata K.
  • Journal Title: Semin Cancer Biol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer. (2008)
  • Author(s): Obayashi Y, Yabushita H, Kanyama K, Noguchi M, Zhuo L, Kimata K, Wakatsuki A.
  • Journal Title: Oncol Rep. 19(5) Pages: 1245-51
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Versican and Fibrillin-1 Form a Major Hyaluronan-Binding C omplex in the Ciliary Body. (2008)
  • Author(s): Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao JS, Li H, Takeyama M, Keene DR, Sakai LY, Kimata K, Iwaki M, Zako M.
  • Journal Title: Invest Ophthalmol Vis Sci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyaluronan(HA) and serum-derived hyaluronan-associated protein(SHAP)-HA complex as predictive markers of cervical ripening in premature labor. (2008)
  • Author(s): Kishida T, Yabushita H, Wakatsuki A, Zhuo L. Kimata K.
  • Journal Title: Connect Tissue Res. 49(2) Pages: 105-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan. (2008)
  • Author(s): Zhu L, Zhuo L, Watanabe H, Kimata K.
  • Journal Title: Connect Tissue Res. 49(1) Pages: 48-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation. (2008)
  • Author(s): Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki K.
  • Journal Title: Arch Biochem Biophys. 471(1) Pages: 85-93
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis. Pivotal Role of a Hyaluronan-Rich Tumor Micro-environment. (2008)
  • Author(s): Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimor M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N.
  • Journal Title: Am J Pathol. 172(1) Pages: 179-193
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyaluronan(HA)and serum-derived hyaluronan-associated protein(SHAP)-HA complex as predictive markers of cervical ripening in premature labor. (2008)
  • Author(s): Kishida T, Yabushita H, Wakatsuki A, Zhuo L, Kimata K
  • Journal Title: Connect Tissue Res 49(2) Pages: 105-108
  • Peer Reviewed
• [Journal Article] Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hvaluronan (2008)
  • Author(s): Zhu L, Zhuo L, Watanabe H, Kimata K
  • Journal Title: Connective Tissue Res. 49(1) Pages: 48-55
  • Peer Reviewed
• [Journal Article] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation (2008)
  • Author(s): Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki K
  • Journal Title: Arch Biochem Biophys 47(1) Pages: 85-93
  • Peer Reviewed
• [Journal Article] Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis. Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment (2008)
  • Author(s): Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N
  • Journal Title: Am J Pathol 172(1) Pages: 179-193
  • Peer Reviewed
• [Journal Article] Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury (2007)
  • Author(s): Garantziotis S, Hollingsworth JW, Ghanayem RB, Timberlake S, Zhuo L, Kimata K, Schwartz DA
  • Journal Title: J Immunol 179 Pages: 4187-4192
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Minute pleomorphic adenoma of the submandibular gland in patients with oralmalignancy: a report of two cases with histological and immunohistochemical examination (2007)
  • Author(s): Kusafuka K, Watanabe H, Kimata K, Hiraki Y, Shukunami C, Kameya T
  • Journal Title: Histopathology 51 Pages: 1258-1261
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recrutitment:possible involvement of versican/PG-M (2007)
  • Author(s): Koyama H, Hibi T, Isogai Z, Yoneda M, Fujimori M, Amano J, Kawakubo M, Kannagi R, Kimata K, Taniguchi S, Itano N
  • Journal Title: Am J Pathol 170 Pages: 1086-99
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of isomeric unsulfated glycosaminoglycan oligosaccharides by mass spectrometry/ mass spectrometry (2007)
  • Author(s): Minamisawa T, Suzuki K, Maeda H, Shimokata S, Sugiura N, Kimata K, Hirabayashi J
  • Journal Title: J Mass Spectrom Soc Jpn 55(1) Pages: 1-6
  • NAID: 10018702910
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-1 play a critical role in chondoroitin sulfate synthesis in cartilage (2007)
  • Author(s): Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H
  • Journal Title: J Biol Chem 282 Pages: 4152-4161
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells (2007)
  • Author(s): Sakai A, Akifusa N, Itano N, Kimata K, Kawamura T, Koseki T, Takahara T, Nishihara T
  • Journal Title: Medical Mycology 45 Pages: 73-79
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] プロテオグリカンの生物学 (2007)
  • Author(s): 幡野 その子、渡辺 秀人、木全 弘治
  • Journal Title: ティッシュエンジニアリング Pages: 82-87
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 細胞接着と細胞増殖を制御するプロテオグリカン (2007)
  • Author(s): 坂井 顕一郎, 木全 弘治, 渡辺 秀人
  • Journal Title: 再生医療の基礎シリーズ2再生医療のための細胞生物学 Pages: 49-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inter-alpha-trypsin inhibitor attenuates comple-ment activation and complement-induced lung injury. (2007)
  • Author(s): Garantziotis S, Hollingsworth JW, Ghanayem RB, Timberlake S, Zhuo L, Kimata K, Schwartz DA.
  • Journal Title: J Immunol. 179 Pages: 4187-4192
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy : a report of two cases with histological and immunohisto-chemical examination. (2007)
  • Author(s): Kusafuka K, Watanabe H, Kimata K, Hiraki Y, Shukunami C, Kameya T.
  • Journal Title: Histopathology 51 Pages: 1258-1261
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of isomeric unsulfated glycosamino-glycan oligosaccharides by mass spectrometry/mass spectrometry. (2007)
  • Author(s): Minamisawa T, Suzuki K, Maeda H, Shimokata S, Sugiura N, Kimata K., Hirabayashi J.
  • Journal Title: J Mass Spectrom Soc Jpn. 55(1) Pages: 1-6
  • NAID: 10018702910
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperproduction of hyaluro-nan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recrutitment : possible involvement of versican/PG-M. (2007)
  • Author(s): Koyama H, Hibi T, Isogai Z, Yoneda M, Fujimori M, Amano J, Kawakubo M, Kannagi R, Kimata K, Taniguchi S, Itano N.
  • Journal Title: Am J Pathol. 170 Pages: 1086-99
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-1 play a critical role in chondoroitin sulfate synthesis in cartilage. (2007)
  • Author(s): Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H.
  • Journal Title: J Biol Chem. 282 Pages: 4152-4161
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells. (2007)
  • Author(s): Sakai A, Akifusa N, Itano N, Kimata K., Kawamura T, Koseki T, Takahara T, Nishihara T.
  • Journal Title: Medical Mycology. 45 Pages: 73-79
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Knockout mice and proteoglycans (2007)
  • Author(s): Kimata K Habuchi O, Habuchi H, Watanabe H.
  • Journal Title: in COMPRIHENSIVE GLYCOSCIENCE. Elsevier(Chapter 4.10) Vol.3 Pages: 159-191
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recrutitment: possible involvement of versican/PG-M (2007)
  • Author(s): Koyama H, Hibi T, Isogai Z, Yoneda M, Fujimori M, Amano J, Kawakubo M, Kannagi R, Kimata K, Taniguchi S, Itano N
  • Journal Title: Am J Pathol 170 Pages: 1086-1099
  • Peer Reviewed
• [Journal Article] プロテオグリカンの生物学 (2007)
  • Author(s): 幡野その子、渡辺秀人、木全弘治
  • Journal Title: ティッシュエンジニアリング 2007年号 Pages: 82-87
• [Journal Article] Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. (2007)
  • Author(s): Garantziotis S.
  • Journal Title: J Immunol. 179巻・6号 Pages: 4187-92
• [Journal Article] Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination. (2007)
  • Author(s): Kusafuka K.
  • Journal Title: Histopathology 51巻・2号 Pages: 258-61
• [Journal Article] Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M. (2007)
  • Author(s): Koyama H.
  • Journal Title: Am J Pathol. 170巻・3号 Pages: 1086-99
• [Journal Article] Identification and characterization of versican/PG-M aggregates in cartilage (2006)
  • Author(s): Matsumoto K, Kamiya N, Suwan K, Atsumi F, Shimizu K, Shinomura T, Yamada Y, Kimata K, Watanabe H
  • Journal Title: J Biol Chem 281 Pages: 18257-1826
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation (2006)
  • Author(s): Kamiya N, Watanabe H, Habuchi H, Takagi H, Shinomura T, Shimizu K, Kimata K
  • Journal Title: J Biol Chem 281(4) Pages: 2390-2400
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum (2006)
  • Author(s): Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K
  • Journal Title: J Biol Chem. 281(29) Pages: 20303-20314
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of chick SPACRCAN (2006)
  • Author(s): Inoue, Y., Yoneda, M., Zhao, J., Miyaishi, O., Ohno-Jinno, A., Kataoka, T., Isogai, Z., Kimata, K., Iwaki, M., Zako, M.
  • Journal Title: J Biol Chem 281 Pages: 10381-10388
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection (2006)
  • Author(s): Shen L, Zhuo L, Okumura A, Ishikawa T, Miyachi M, Owa Y, Ishizawa T, Sugiura N, Nagata Y, Nonami T, Kakumu S, Kimata K
  • Journal Title: Hepatol Res 1376 Pages: 1-9
  • NAID: 10020405409
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 最近の進歩<10>基礎ー軟骨におけるプロテオグリカンの役割 (2006)
  • Author(s): 渡邊 裕規, 渡辺 秀人, 木全 弘治
  • Journal Title: 軟骨代謝の研究-基礎と臨床 16(6) Pages: 146-149
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of versican/PG-M aggregates in cartilage. (2006)
  • Author(s): Matsumoto K, Kamiya N, Suwan K, Atsumi F, Shimizu K, Shinomura T, Yamada Y, Kimata K, Watanabe H.
  • Journal Title: J Biol Chem. 281 Pages: 18257-1826
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensation. (2006)
  • Author(s): Kamiya N, Watanabe H, Habuchi H, Takagi H, Shinomura T, Shimizu K, Kimata K.
  • Journal Title: J Biol Chem. 281(4) Pages: 2390-2400
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum. (2006)
  • Author(s): Zhuo, L., Kanamori, A., Kannagi, R., Itano, N., Wu, J., Hamaguchi, M., Ishiguro, N., Kimata, K.
  • Journal Title: J Biol Chem. 281(29) Pages: 20303-20314
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Molecular cloning and characterization of chick SPACRCAN. (2006)
  • Author(s): Inoue, Y., Yoneda, M., Zhao, J., Miyaishi, O., Ohno-Jinno, A., Kataoka, T., Isogai, Z., Kimata, K., Iwaki, M., Zako, M.
  • Journal Title: J Biol Chem. 281 Pages: 10381-10388
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The SHAP-hyalu-ronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection. (2006)
  • Author(s): Shen L, Zhuo L, Okumura A, Ishikawa T, Miyachi M, Owa Y, Ishizawa T, Sugiura N, Nagata Y, Nonami T, Kakumu S, Kimata K.
  • Journal Title: Hepatol Res. 28, 1376 Pages: 1-9
  • NAID: 10020405409
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection. (2006)
  • Author(s): L.Shen, L.Zhuo, et al.
  • Journal Title: Hepatol Res
• [Journal Article] Expression of a chondroitin sulfate proteoglycan,versican (PG-M),during development of rat cornea (2005)
  • Author(s): Koga T, Inatani M, Hirata A, Inomata Y, Zako M, Kimata K, Oohira A, Gotoh T, Mori M, Tanihara H
  • Journal Title: Curr Eye Res 30 Pages: 455-463
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of photomedins:novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity (2005)
  • Author(s): Furutani Y, Manabe R, Tsutsui K, Yamada T, Sugimoto N, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K
  • Journal Title: Biochem J 389 Pages: 675-684
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyaluronan synthase expression in pleural malignant mesotheliomas (2005)
  • Author(s): Kanomata N, Yokose T, Kamijo T, Yonou H, Hasebe T, Itano N, Kimata K, Ochiai A
  • Journal Title: Virchows Arch 446 Pages: 246-250
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hyaluronan (HA) and serum-derived hyaluronan associated protein (SHAP)-HA complex as markers of pre-eclampsia (2005)
  • Author(s): Kishida T, Yabushita H, Zhuo L, Itano N, Kimata K, Noguchi M
  • Journal Title: J.Aichi Med.Univ.Assoc 33 Pages: 7-19
  • NAID: 110004668800
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of hyaluronan and hyaluronan synthase in endometrial cancer (2005)
  • Author(s): Yabushita H, Kishida T, Fusano K, Kanyama K, Zhuo L, Itano N, Kimata K, Noguchi M
  • Journal Title: Oncol Rep 13 Pages: 1101-1105
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] マウス初代軟骨細胞におけるbone morphogenetic protein-2のヒアルロン酸合成酵素発現制御 (2005)
  • Author(s): 澤井 崇博, 板野 直樹, 木全 弘治
  • Journal Title: 愛知医科大学医学会雑誌 33 Pages: 1-6
  • NAID: 110004668799
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of a chondroitin sulfate proteo-glycan, versican(PG-M), during development of rat cornea (2005)
  • Author(s): Koga T, Inatani M, Hirata A, Inomata Y, Zako M, Kimata K Oohira A, Gotoh T, Mori M, Tanihara H.
  • Journal Title: Curr Eye Res. 30 Pages: 455-463
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of photornedins : novel olfactomedin-domain-contain-ing proteins with chondroitin sulphate-E-binding activity. (2005)
  • Author(s): Furutani Y, Manabe R, Tsutsui K, Yamada T, Sugimoto N, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K.
  • Journal Title: Biochem J. 389 Pages: 675-684
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyaluronan synthase expression in pleural malignant mesothe-liomas. (2005)
  • Author(s): Kanomata N, Yokose T, Kamijo T, Yonou H, Hasebe T, Itano N, Kimata K, Ochiai A.
  • Journal Title: Virchows Arch 446 Pages: 246-2450
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyaluro-nan(HA) and serum-derived hyaluronan associated protein(SHAP)-HA complex as markers of pre-eclampsia. (2005)
  • Author(s): Kishida T, Yabushita H, Zhuo L, Itano N, Kimata K, Noguchi M.
  • Journal Title: J. Aicho Med. Univ. Assoc. 33 Pages: 7-9
  • NAID: 110004668800
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of hyaluronan and hyaluronan synthase in endometrial cancer. (2005)
  • Author(s): Yabushita H, Kishida T, Fusano K, Kanyama K, Zhuo L, Itano N, Kimata K, Noguchi M.
  • Journal Title: Oncol Rep 13 Pages: 1101-1105
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A mechanism for 4-methylumbelliferone-mediated inhibition of hyaluronan biosynthesis. (2005)
  • Author(s): Itano, N., Kakizaki, I., Mita, S., Endo, M., Kimata. K.
  • Journal Title: In Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications(Balazs E. A., and Hascall, V. C., eds), Volume Matrix Biology Institute, New Jersey, U.S.A. Pages: 147-53
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of serum-derived hyaluronan-associated protein in the construction of cumulus matrix and oocyte maturation. (2005)
  • Author(s): Zhuo, L, Salustri, A, Atsumi, F, Kawano, M, Wu, J, Shen, L, Ogura, A, Yasue, H, Hascall, VC, Kimata. K.
  • Journal Title: In Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications(Balazs, E. A., and Hascall, V. C., eds), Volume II Matrix Biology Institute, New Jersey, U.S.A. Pages: 731-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyaluronan synthase expression in pleural malignant mesotheliomas. (2005)
  • Author(s): N.Kanomata, T.Yokose, et al.
  • Journal Title: Virchows Arch 446 Pages: 246-250
• [Journal Article] Role of hyaluronan and hyaluronan synthase in endometrial cancer. (2005)
  • Author(s): H.Yabushita, T.Kishida, et al.
  • Journal Title: Oncol Rep 13 Pages: 1101-1105
• [Journal Article] Enhanced expression of interleukin-18 receptor alpha chain by CD4+ T cells in sarcoidosis. (2005)
  • Author(s): Y.Zhou, E.Yamaguchi, et al.
  • Journal Title: Chest 128 Pages: 2497-2503
• [Journal Article] マウス初代軟骨細胞におけるbone molphogenetic protein-2のヒアルロン酸合成酵素発現制御. (2005)
  • Author(s): 澤井崇博, 板野直樹, 木全弘治
  • Journal Title: 愛知医科大学医学会雑誌 33 Pages: 1-6
• [Journal Article] Proteoglycans and sulfated glycosamino-glycans.
  • Author(s): J. Esko, U. Lindahl, K. Kimata
  • Journal Title: in Essentials of Glycobiology, 2nd edition. Edited by A.Varki, C. Bertozzi, R. Cummings, Etzler M, Esko J, Freeze H, Hart G, Stanle P, Cold Spring Harbor Laboratory (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Versican and Fibrillin-1 Form a Major Hyaluronan-Binding Complex in the Ciliary Body
  • Author(s): Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao JS, Li H, Takeyama M, Keene DR, Sakai LY, Kimata K, Iwaki M, Zako M
  • Journal Title: Invest Ophthalmol Vis Sci 2008(In press)
  • Peer Reviewed
• [Presentation] Serum-Derived Hyaluronan-Associated Proteins(SHAP)-Hyaluronan Complex Functions in Ovalbumin (OA)-induced Asthma (2008)
  • Author(s): Zhu L, Baba K, Zhuo L, Kimata K, Yamaguchi E
  • Organizer: 第48回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Serum-derived hyaluronan-associated proteins(SHAP)-hyaluronan complex functions in ovalbumin(OA)-induced Asthma. (2008)
  • Author(s): Zhu L, Baba K, Zhuo L, Kimata K, Yamaguchi E.
  • Organizer: 48th Annual Meeting of the Japanese Respiratory
  • Place of Presentation: Kobe Kobe Convention Center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Significance of tumor-associated stroma in promotion of intratumonal lymphangio genesis (2007)
  • Author(s): Koyama H, Kobayashi N, Takeoka M, Fujimori M, Amano J, Kannagi R, Kimata Koji, Shunichro Taniguchi, Naoki Itano
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Role of serum derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer (2007)
  • Author(s): Yabushita H, Kimata K
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan (2007)
  • Author(s): Zhu L、Zhuo L、Watanabe H、Kimata K
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 菌体酵素リアクターを用いたコンドロイチンポリマーの合成 (2007)
  • Author(s): 杉浦 信夫、下方 郷嗣、木全 弘治、渡辺 秀人
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SHAP-ヒアルロン酸複合体欠損マウスはLPS肝障害耐性である (2007)
  • Author(s): 卓 麗聖、横地 高志、祝龍、木全 弘治
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ネフロネクチンのドメイン機能の解析 (2007)
  • Author(s): 佐藤 祐哉、上村 俊人、盛満 圭介、杉浦 信夫、木全 弘治、長田 亜樹、眞鍋 理一郎、高木 淳一、山田 雅司、関口 清俊
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 大腸菌由来コンドロイチンポリメラーゼ変異酵素による高分子コンドロイチン多糖の合成 (2007)
  • Author(s): 杉浦 信夫、角田 佳充、大澤 拓男、下方 郷嗣、木全 弘治、渡辺 秀人
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A role of SHAP-hyaluronan complex in inflammation (2007)
  • Author(s): Kimata K, Zhuo L, Yokochi T, Kanamori A, Kanngi R
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston,SC,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The SHAP-hylauornan complex is superior to hyaluornan as a biomarker (2007)
  • Author(s): Zhuo L, Zhu L, Stefan L, Oobayashi Y, Yabushita H, Kimata K
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston,SC,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Up-regulation of hyaluronan synthase genes in cultured human epiderman keratino cytes by UVB irradiation (2007)
  • Author(s): Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki K
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston,SC,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Significance of the hyaluronan-rich tumor microenvironment in promotion of tumor angiogenesis (2007)
  • Author(s): Itano N, Koyama H, Kanngi R, Kimata K, Taniguchi S
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston,SC,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Hyaluronan-Iinked inter-alpha-trypsin inhibitor heavy chain(SHAP),interleukin 8,MMP-3 and hyaluronan in human synovial fluid and serum in osteoarthritis,joint injury and inflammation (2007)
  • Author(s): Lohmander L, Zhu L, Zhuo L, X-Y RS, Ma K, Blake S, Kimata K
  • Organizer: 53rd Annual Meeting of the Orthopaedic Research Society(ORS)
  • Place of Presentation: San Diego,CA,USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Significance of tumor-associated stroma in promotion of intratumonal lymphangiogenesis. (2007)
  • Author(s): Koyama H, Kobayashi N, Takeoka M, Fujimori M, Amano J, Kannagi R, Kimata Koii, Shunichro Taniguchi, Naoki Itano
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama Pacifico Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of serum derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer. (2007)
  • Author(s): Yabushita H, Kimata K.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama Pacifico Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Equivalent involvement of inter alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan. (2007)
  • Author(s): Zhu L, Zhuo L, Watanabe H, Kimata K.
  • Organizer: Biochemical and Molecular Biology 2007
  • Place of Presentation: Yokohama Pacifico Yokohama complexes with hyaluronan.
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Arole of SHAP-hyalu-uronan complex in inflammation. (2007)
  • Author(s): Kimata K, Zhuo L, Yokochi T, Kanamori A, Kanngi R.
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The SHAP-hylauornan complex is superior to hyaluornan as a biomarker. (2007)
  • Author(s): Zhuo L, Zhu L, Stefan L, Oobayashi Y, Yabushita H, Kimata K.
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation. (2007)
  • Author(s): Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki K.
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Significance of the hyaluronan-rich tumor microenvironment in promotion of tumor angio-genesis. (2007)
  • Author(s): Itano N, Koyama H, Kanngi R, Kimata K, Taniguchi S.
  • Organizer: Hyaluronan 2007
  • Place of Presentation: Charleston, SC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hyaluro. nan-Iinked inter-alpha-trypsin inhibitor heavy chain(SHAP), interleukin 8, MMP-3 and hyaluronan in human synovial fluid and serum in osteo-arthritis (2007)
  • Author(s): Lohmander L, Zhu L, Zhuo L, X-Y RS, Ma K, Blake S, Kimata K.
  • Organizer: 53rd Annual Meeting of the Orthopaedic joint injury and inflammation Research Society(ORS)
  • Place of Presentation: San Diego, CA, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Significance of tumor-associated stroma in promotion of intratumonal lymphangio genesis. (2007)
  • Author(s): Koyama H, Kobayashi N, Takeoka M, Fujimori M, Amano J, Kannagi R, Kimata K, Taniguchi S, Itano N,
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: バシフィコ横浜
• [Presentation] Role of serum derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer. (2007)
  • Author(s): Yabushita H, Kimata K.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: バシフィコ横浜
• [Presentation] Equivalent involvement of inter-alpha-trypsin inhibitor heavy chain isoforms in forming covalent complexes with hyaluronan. (2007)
  • Author(s): Zhu L、 Zhuo L、 Watanabe H、 Kimata K.
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: バシフィコ横浜
• [Presentation] SHAP-ヒアルロン酸複合体欠損マウスはLPS肝障害耐性である. (2007)
  • Author(s): 卓麗聖、横地高志、祝龍、木全弘治.
  • Organizer: 第80回日本生化学会大会・第30回日本分子生物学会年会・合同大会
  • Place of Presentation: バシフィコ横浜
• [Presentation] 軟骨におけるコンドロイチン硫酸合成酵素群の解析 (2006)
  • Author(s): 坂井 顕一郎, 木全 弘治, 佐藤 隆, 後藤 雅式, 成松 久, 四宮 謙一
  • Organizer: 第19回日本軟骨代謝学会
  • Place of Presentation: 横浜
  • Year and Date: 2006-03-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 糖鎖によるタンパク質と分子複合体の機能調節 (2006)
  • Author(s): 木全 弘治
  • Organizer: 文部科学省科学研究費補助金特定領域研究・第4回公開シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-01-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of glycosyltransferases involved in chondoitin sulfate synthesis in cartilage (2006)
  • Author(s): 坂井 顕一郎, 木全 弘治, 佐藤 隆, 後藤 雅式, 成松 久, 四宮 謙一, 渡辺 秀人
  • Organizer: 第38回日本結合組織学会学術大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Splicing Factor 3b binds BMPR-IA and negatively regulates osteochondral differentiation (2006)
  • Author(s): 渡邊 裕規, 塩生 真史, 木全 弘治, 木村 友厚, 渡辺 秀人
  • Organizer: 第38回日本結合組織学会学術大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of fibroblasts whose versican/PG-M lacks the A subdomain (2006)
  • Author(s): スワン・ケイティサック, 幡野 その子, 渡辺 秀人, 木全 弘治
  • Organizer: 第38回日本結合組織学会学術大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation (2006)
  • Author(s): 柿崎 育子, 板野 直樹, 木全 弘治, 花田 勝美, 今 淳, 山口 真範, 高橋 照, 高垣 啓一
  • Organizer: 第38回日本結合組織学会学術大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Overexpression of hyaluronan synthase-2 enhances angiogenesis and stroma reaction in neu-induced mammary tumors (2006)
  • Author(s): 板野 直樹, 小山 洋, 磯貝 善蔵, 米田 雅彦, 藤森 実, 神奈 木玲児, 木全 弘治、谷口 俊一郎
  • Organizer: 第38回日本結合組織学会学術大会
  • Place of Presentation: 前橋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Preparation of hyaluronan synthase 2 by baculovirus-infected lnsect cells expression system (2006)
  • Author(s): A.Murakawa, N.Itano, K.Kimata, R.Kannagi, T.Mori, Y.Okahata
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: 淡路
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] NMR and HPLC analyses of substrate recognition by K4 chondroitin polymerase (2006)
  • Author(s): N.Masukane, Y.Yamaguchi, H.Yagi, N.Sugiura, K.Kimata, K.Kato
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: 淡路
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Direct monitoring of carbohydrate elongations by chondroitin polymerase on a 27-MHz quartz-crystal microbalance (2006)
  • Author(s): T.Mori, A.Fujishima, N.Sugiura, K.Kimata, Y.Okahata
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: 淡路
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of phospholipid for stabilization of haluronan synthase 2 expressed by baculovirus-infected insect cells (2006)
  • Author(s): no, K.Kimata, R.Kannagi, T.Mori, Y.Okahata
  • Organizer: 第20回国際生化学、分子生物会議 第11回アジア・オセアニア生化学者・分子生物学者連合会議 第79回日本生化学会大会・第29回日本分子生物学会年会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] VERSICAN/PG-M is essential for mic cardiovascular and dermal development (2006)
  • Author(s): S.Hatano, K.Kima N.Hiraiwa, M.Kusakabe, E.Adachi, Z.Isogai, T.Shinomura, H.Watanabe
  • Organizer: 第20回国際生化学、分子生物会議 第11回アジア・オセアニア生化学者・分子生物学者連合会議 第79回日本生化学会大会・第29回日本分子生物学会年会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] グリコサミノグリカン・オリゴ糖鎖のMSフラグメンテーション挙動 (2006)
  • Author(s): 南澤 俊和, 鈴木 喜義, 前田 浩, 下方 郷嗣, 芦刈-羽田 智子, 杉浦 信夫, 木全 弘治, 平林 淳
  • Organizer: 第26回日本糖質学会年会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] サブドメイン欠失バーシカン/PG-Mによる細胞の不死化およびがん化 (2006)
  • Author(s): 幡野 その子, Keittisak Suwan, 渡辺 秀人, 木全 弘治
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Hyaluronan-iinked inter-alpha-trypsin inhibitor heavy chain (SHAP),interleukin 8,and hyaluronan in human synovial fluid and serum in osteoarthritis,joint injury and inflammation (2006)
  • Author(s): Lohmander L, Zhu L, Zhuo L, X-Y RS, Ma K, Blake S, Kimata K
  • Organizer: The Osteoarthritis research society international(OARSI) world congress on osteoarthritis
  • Place of Presentation: Prague,Czech Republic
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 乳癌発症モデルマウスを用いたヒアルロン酸細胞外マトリックスによる腫瘍内血管新生促進作用の解明 (2006)
  • Author(s): 小山 洋, 磯貝 善蔵, 藤森 実, 天野 純, 神奈 木玲児, 木全 弘治, 谷口 俊一郎
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒアルロン酸糖鎖合成異常が引き起こすがん発展の分子機構 (2006)
  • Author(s): 小山 洋, 神奈 木玲児, 木全 弘治, 谷口 俊一郎, 板野 直樹
  • Organizer: 第26回日本糖質学会年会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 乳癌発症モデルマウスを用いたヒアルロン酸細胞外マトリックスの癌進展促進機構の解明 (2006)
  • Author(s): 小山 洋, 藤森 実, 磯貝 善蔵, 米田 雅彦, 神奈 木玲児, 木全 弘治, 谷口 後一郎
  • Organizer: 第14回日本乳癌学会学術総会
  • Place of Presentation: 石川
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ビクニンノックアウトマウスにおける卵白アルブミン感作及び吸入チャレンジ後の気道反応性について (2006)
  • Author(s): 馬場 研二, 祝龍, 卓 麗聖, 山口 悦郎, 木全 弘治
  • Organizer: 第56回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Prepa-ration of hyaluronan synthase 2 by baculovirus-infected Insect cells expression system. (2006)
  • Author(s): Murakawa A, Itano N, Kimata K, Kannagi R, Mori T, OkahataY.
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: Awaji The hyogo prefectural awaji yumebutai international conference center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] NMR and HPLC analyses of substrate recognition by K4 chondroitin polymerase. (2006)
  • Author(s): Masukane N, Yamaguchi Y, Yagi H, Sugiura N, Kimata K, Kato K.
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: Awaji The hyogo prefectural awaji yumebutai international conference center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Direct monitoring of carbohydrate elongations by chondroitin polymerase on a 27-MHz quartz-crystal microbalabce. (2006)
  • Author(s): Mori T, Fujishima A, Sugiura N, Kimata K, Okahata Y.
  • Organizer: Extracellular glycomatrix in health and disease
  • Place of Presentation: Awaji The hyogo prefectural awaji yumebutai international conference center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effect of phospholipid for stabilization of haluronan synthase 2 expressed by baculovirus-infected insect cells (2006)
  • Author(s): Murakawa A, Itano N, Kimata K, Kannagi R, Mori T, Okahata Y.
  • Organizer: 20th IUBMB international congress of biochemistry and molecular biology and llth FAOBMB congress in conjunction with 79th annual meeting of the Japanese biochemical society and 29th annual meeting of the molecular Biology society of Japan
  • Place of Presentation: Kyoto Kyoto International Conference Center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] VERSICAN/PG-M is essential for mic cardiovascular and dermal development. (2006)
  • Author(s): Hatano S, Kimata K, Hiraiwa N, Kusakabe M, Adachi E, Isogai Z, Shinomura T, Watanabe H.
  • Organizer: 20th IUBMB international congress of biochmistry and molecular biology and 11th FAOBMB congress in conjunction with 79th annual meeting of the Japanese biochemical society and 29th annual meeting of the molecular iology society of Japan
  • Place of Presentation: Kyoto Kyoto International Conference Center
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hyalu-ronan-iinked inter-alpha-trypsin inhibitor heavy chain(SHAP), inter leukin 8, and hyaluronan in human synovial fluid and serum in osteo-arthritis, joint injury and inflammation. (2006)
  • Author(s): Lohmander L, Zhu L, Zhuo L, X-Y RS, Ma K, Blake S, Kimata K.
  • Organizer: International(OARSI) world congress on osteoarthritis
  • Place of Presentation: Prague, Czech Republic
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Versican/PG-M is essential for mice cardiovascular and dermal development (2005)
  • Author(s): Hatano S, Kimata K, Hiraiwa N, K usakabe M, Adachi E, Shinomura T
  • Organizer: 6th Pan Pacific Connective Tissue Societies Symposium
  • Place of Presentation: Hawaii,USA
  • Year and Date: 2005-12-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Watanabe. Versican/PG-M is essential for mice cardiovascular and dermal development. (2005)
  • Author(s): Hatano S, Kimata K, Hiraiwa N, Kusakabe M, Adachi E, Shinomura T, H.
  • Organizer: 6th Pan Pacific Connective Tissue Societies Symposium
  • Place of Presentation: Hawaii, U.S.A
  • Year and Date: 2005-12-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of the proteoglycan aggregate in matrix assembly (2005)
  • Author(s): Watanabe H, Hatano S, Adachi E, Kimata K
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of UV irradiation on hyaluronan synthases in cultured human epidermal keratinocytes (2005)
  • Author(s): Kakizaki I, Itano N, Kon A, Hanada K, Kimata K, Takagaki K
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Roles of 2-O and 6-O sulfated heparan sulfate during Drosophila development (2005)
  • Author(s): Kamimura K, Habuchi H, Kimata K, Nakato H
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Enzymatic synthesis of oligosaccharides derived from highly sulfated nonreducing terminal structures in chondroitin sulfate (2005)
  • Author(s): Ohtake S, Kimata K, Habuchi O
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Knockin fibroblasts whose versican/PG-M lacks the A subdomain (2005)
  • Author(s): Suwan K, Hatano S, Watanabe H, Kimata K
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of UV irradiation on hyaluronan synthases in cultured human epi-dermal keratinocytes. (2005)
  • Author(s): Kakizaki I, Itano N, Kon A, Hanada K, Kimata K, Takagaki K.
  • Organizer: 78th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Gravimetric analysis of carbohydrate elongations by chondroitin syn-thase on a 27-MHz quartz-crystal microbalance. (2005)
  • Author(s): Mori T, Fujishima A, Nihira T, Sugiura N, Kimata K, Okahata Y.
  • Organizer: 78th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Enzymatic synthesis of oligosaccha-rides derived from highly sulfated nonreducing terminal structures in chondroitin sulfate. (2005)
  • Author(s): Ohtake S, Kimata K, Habuchi 0.
  • Organizer: 78th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Kobe
  • Year and Date: 2005-10-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Gravimetric analysis of carbohydrate elongations by chondroitin synthase on a 27-MHz quartz-crystal microbalance (2005)
  • Author(s): Mori T, Fujishima A, Nihira T, Sugiura N, Kimata K, Okahata Y
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression patterns of glycosaminoglycan-synthesizing enzymes during chondrogenesis (2005)
  • Author(s): Sakai K, Kimata K, Narimatsu H, Shinomiya K, Watanabe H
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] MALDI-TOF-MS analysis of chondroitin synthesized by chondroitin polymerase from E. coli strain K4 (2005)
  • Author(s): Sugiura N, Shimokata S, Kimata K
  • Organizer: 第78回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2005-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ウロノシル2-O-硫酸転移酵素によるコンドロイチン硫酸の硫酸化パターンの認識 (2005)
  • Author(s): 大竹 しおり, 木全 弘治, 羽渕 脩躬
  • Organizer: 第25回日本糖質学会年会
  • Place of Presentation: 大津
  • Year and Date: 2005-07-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] バーシカン/PG-Mは真皮の主要なヒアルロン酸結合分子であり、弾性線維の凝集を阻害する (2005)
  • Author(s): 磯貝 善蔵, 長谷川 佳子, 宮石 理, 大野 安季子, 雑喉 正泰, 木全 弘治, 米田 雅彦
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス組織におけるヒアルロン酸リッチマトリックス-SHAP-HA複合体の局在- (2005)
  • Author(s): 河合 育子, 太田 祐理, 白井 智香子, 廣田 未央, 小島 千佳, 平尾 佳美, 卓 麗聖, 木全 弘治, 米田 雅彦
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 軟骨部腫瘍-細胞外マトリックスの役割とその制御- (2005)
  • Author(s): 西田 佳弘, 細野 幸三, 内堀 充敏, 田畑 出, 卓麗 聖, 木全 弘治, 石黒 直樹
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] バーシカンPG-Mはfibrillin microfibrilsの親水性能を毛様体において調節する (2005)
  • Author(s): 大野 安季子, 磯貝 善蔵, 米田 雅彦, 宮石 理, 井上 洋子, 片岡 卓也, 趙勁 松, 岩城 正佳, 木全 弘治, 雑喉 正泰
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Versican/PG-Mの器官形成における役割:ノックインマウスの解析 (2005)
  • Author(s): 幡野 その子, 木全 弘治, 安達 栄治郎, 平岩 典子, 日下 部守昭, 篠村 多摩之, 渡辺 秀人
  • Organizer: 第37回日本結合組織学会学術大会
  • Place of Presentation: 富山
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マトリオーム解析:IV骨格系形成過程における新規細胞外マトリックス因子群の発現パターンの多様性 (2005)
  • Author(s): 筒井 仰, 眞鍋 理一郎, 中野 伊津子, 福田 友彦, 木村 美奈, 小栗 康子, 河合 純, 林崎 良英, 木全 弘治, 関口 清俊
  • Organizer: 第52回マトリックス研究会大会
  • Place of Presentation: 大分
  • Year and Date: 2005-03-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 軟骨分化における糖鎖合成酵素の発現 (2005)
  • Author(s): 坂井 顕一郎, 木全 弘治, 渥美 ふき子, 成松 久, 四宮 謙一, 渡辺 秀人
  • Organizer: 第18回日本軟骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2005-03-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PG-M/バーシカンとヒアルロン酸、リンク蛋白との結合様式の解析(第10回日本軟骨代謝学会賞受賞) (2005)
  • Author(s): 松本 和, 塩生 真史, 郷 通子, 清水 克時, 篠村 多摩之, 木全 弘治, 渡辺 秀人
  • Organizer: 第18回日本軟骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2005-03-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase (2005)
  • Author(s): Habuchi O, Ohtake S, Kimata K
  • Organizer: Proteoglycans in Signaling
  • Place of Presentation: Stockholm,Sweden
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] An inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferon (2005)
  • Author(s): Kakizaki I, Itano N, Kimata K, Kon A, Yamaguchi M, Yoshihara S
  • Organizer: 第9回弘前国際医学フォーラム
  • Place of Presentation: 弘前
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase. (2005)
  • Author(s): Habuchi 0, Ohtake S, Kimata K.
  • Organizer: Proteoglycans in Signaling
  • Place of Presentation: Stockholm, Sweden
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] An inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferon. (2005)
  • Author(s): Kakizaki I, Itano N, Kimata K, Kon A, Yamaguchi M, Yoshihara S, Takagaki K.
  • Organizer: 9th Hirosaki International Medical Forum
  • Place of Presentation: Hirosaki
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Essentials of Glycobiology, 2nd edition (2008)
  • Author(s): J. Esko, U. Lindahl, K. Kimata
  • Total Pages: 19
  • Publisher: Cold Spring Harbor Laboratory
• [Book] COMPRIHENSIVE GLYCOSCIENCE (2007)
  • Author(s): Kimata K, Habuchi O, Habuchi H, Watanabe H.
  • Total Pages: 33
  • Publisher: Elsevier
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Essentials of Glycobiology, 2nd edition (2007)
  • Author(s): J.Esko, U.Lindahl, K.Kimata
  • Total Pages: 19
  • Publisher: Cold Spring Harbor Laboratory
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Knockout mice and proteoglycans (2007)
  • Author(s): Kimata K.
  • Total Pages: 32
  • Publisher: Elsevier
• [Book] Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (2005)
  • Author(s): Itano, N., Kakizaki, I., Mita, S., Endo, M., Kima K
  • Total Pages: 7
  • Publisher: Matrix Biology Institute
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications (2005)
  • Author(s): Zhuo, L., Salustri, A., Atsumi, F., Kawano, M., Wu, J., Shen, L., Ogura, A., Yasue, H., Hascall, V.C., Kimata, K
  • Total Pages: 5
  • Publisher: Matrix Biology Institute
  • Description: 「研究成果報告書概要(和文)」より
• [Book] プロテオグリカン.ティッシュエンジニアリング (2005)
  • Author(s): 蛯沢 克己, 木全 弘治, 渡辺 秀人
  • Total Pages: 6
  • Publisher: 日本医学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 糖鎖科学の新展開-その合成法と医療応用のすべて (2005)
  • Author(s): 卓麗 聖, 木全 弘治
  • Total Pages: 8
  • Publisher: NTS
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 未来を拓く糖鎖科学 (2005)
  • Author(s): 渡辺 秀人, 木全 弘治
  • Total Pages: 3
  • Publisher: 金芳堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 未来を拓く糖鎖科学 (2005)
  • Author(s): 板野 直樹, 木全 弘治
  • Total Pages: 2
  • Publisher: 金芳堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 未来を拓く糖鎖科学 (2005)
  • Author(s): 木全 弘治
  • Total Pages: 7
  • Publisher: 金芳堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 糖鎖科学の新展開 (2005)
  • Author(s): 卓麗聖, 木全弘治
  • Publisher: NTS.
• [Book] 未来を拓く糖鎖科学 (2005)
  • Author(s): 板野直樹, 木全弘治
  • Publisher: 金芳堂.
• [Book] Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications Volume II. (2005)
  • Author(s): L.Zhuo, A.Salustri, et al.
  • Publisher: Matrix Biology Institute.
• [Book] Hyaluronan Structure, Metabolism, Biological Activities, Therapeutic Applications Volume I. (2005)
  • Author(s): N.Itano, I.Kakizaki, et al.
  • Publisher: Matrix Biology Institute.
• [Remarks]
  • URL: http://www.aichi-med-u.ac.jp/site/institute/buniken/index.html