| Project/Area Number |
17390184
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Nagoya University |
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Principal Investigator |
KONDO Takaaki Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (00195900)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Kenji Nagoya University, School of Medicine, Associate Professor, 医学部, 助教授 (80126870)
TAKAGI Kenzo Nagoya University, School of Medicine, Professor, 医学部, 教授 (50093050)
TOYOSHIMA Hideaki Nagoya University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (10023657)
UEYAMA Jun Nagoya University, School of Medicine, Research Associate, 医学部, 助手 (00397465)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | Polyamine / Spermidine / Spermine / Metabolic syndrome / Advanced glycation end product / Triglyceride / Ornithine decarboxylase / Oxidative stress / メタボリック症候群 / 糖化抑制 / 抗酸化作用 / 遺伝的多型 / 共分散分析 / 閉経 |
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| Research Abstract |
The purpose of this study is to examine the relationship between blood polyamine levels and metabolic risk factors (MRF) in two adult cohorts each from a workplace and a residential populations, and to explore the utility of blood polyamine in predicting the development of lifestyle-related diseases.
A significant association between the polyamine levels and triglyceride (TG) was demonstrated among men, suggesting the contribution of polyamine in activation of TG synthesis and/or inhibition of lipolysis. Moreover, HbAlc was inversely related with polyamine levels among both men and women, suggesting the antiglycating effect of polyamine. Next, the ever-known G316A polymorphism of the gene of ornithine decarboxylase (ODC), one of the rate-limiting enzymes in the polyamine biosynthesis, was assayed for its relationship with blood polyamine levels. The 316AA genotype among men showed a significantly higher blood polyamine levels than 316GG or 316GA genotype, suggesting the possibility of beneficial effects of the AA genotype in the reduction of risk for lifestyle-related diseases owing to the antiglycating mechanism of polyamine. In this respect, however, follow-up observation for more evidence is required to confirm the association between the ODC genotype and the incidence of lifestyle-related diseases.
Exposure to oxidative stress, an established mechanism underlying in the development of atherosclerotic or malignant disorders, was also evaluated with the levels of 8-isoprostane (8-iso-PGF2α). No significant association of blood polyamine levels with oxidative stress marker was demonstrated. Again, further information on disease incidence in the follow-up observation was indispensable to corroborate the association shown in this cross-sectional study.
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