| Budget Amount *help |
¥14,750,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Research Abstract |
The objective of the present study is to investigate factors that may influence the incidences of life-style-related diseases including stroke, acute myocardial infarction (AMI) as well as malignant neoplasm in a population-based cohort. We have been studying on the cohort constructed from those who are in Takashima county (currently, Takashima City, the population of which is 55,537), in Shiga prefecture. Recruitment was made from those were eligible for the publicly funded regular check-ups (based on either the Act on the health of the elderly, or the Specified health standards), starting in 2002 as a baseline surveys, which were conducted in 5 towns and 1 village in the area. The first round has completed in the final year of the present application period of the grant. We have collected pertinent information including dietary habit and physical activity by questionnaire, present and past medical illness/condition by an interview, examination findings such as ABI (ankle-brachial ind
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ex), baPWV (brachial-ankle pulse wave velocity), laboratory data (BNP, high-sensitivity-CRP, insulin, HbA1c, urinary sodium and potassium, and creatinine) in addition to a set of routine items for the regular check-up. Further more, DNA was collected to analyze SNPs. We have been following this cohort, updating their living status (moving-out), death status, incident stroke, myocardial infarction, and malignant neoplasm on a regular basis.
At the time of the final year of the application, we have enrolled 7,406 men and women to the cohort study, and 6,092 (2,187 men 3,905 women) have agreed to participate (the participating rate 82.3%) for whom we have been following. As of now, the mean (standard deviation) follow-up period is 5.0 (±1.9) years, and we have observed the following number of events; death 180, moving-out 72, stroke 113, AMI 19, malignant neoplasms 24. However, the observed numbers of events are not enough to run a rigorous statistical analysis in evaluating risk factors for death and each-specific disease, thus we were unable to describe the risk assessment in the report. As more events accumulate, we are planning to analyze the data and report such assessment via an academic publication(s).
Along with the above cohort, we have been working on a comprehensive-registration study of stroke and AMI for the whole population of the area (The Takashima Registry). Based on the Takashima Registry, we have observed a trend of declining incident in stroke from 1990 to 2001. At the same time, however, we have observed a clear trend of increase in AMI since 1995 (Am J Epidemiol 2008; 167: 1358-1364). We will take into account this observed trends in assessing risk factors. Less
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