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Damage Analysis by Elongation of Blood Vessels

Research Project

Project/Area Number 17390198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionTohoku University

Principal Investigator

FUNAYAMA Masato  Tohoku University, Tohoku University Graduate School of Medicine, Professor (40190128)

Co-Investigator(Kenkyū-buntansha) KANETAKE Jun  Tohoku University Graduate School of Medicine, 大学院・医学系研究科, Associate professor (90326661)
SAKAI Jun  Tohoku University Graduate School of Medicine, 大学院・医学系研究科, Assistant professor (20431504)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥3,100,000 (Direct Cost: ¥3,100,000)
Keywordsbedding / mathematical evaluation / rebreathing / respiratory simulation / sudden infant death / 乳幼児突然死 / うつぶせ寝 / 人形実験 / 吸気酸素濃度 / うつ伏せ寝 / 人形モデル / 寝具環境
Research Abstract

This study used a mechanical simulation model to establish the relationship between types of bedding and rebreathing potential for an infant placed prone (face down) at different postnatal ages. The infant mannequin was connected to a respirator set to deliver physiologically appropriate combinations of tidal volume (V_T) and respiratory rates (RR) across a range of postnatal ages (0 to 18 months). Before measurements were made, CO_2 flow was regulated to 5%±0.1% of end-tidal PCO_2 (EtCO_2). After the model was placed in a prone position, any increase in the fractional concentration of inspired CO_2 (FiCO_2) was measured. FiCO_2 increased immediately and rapidly, and reached a maximum value within a few minutes. The maximum FiCO_2 ranged from under 2% to over 10%, depending on the bedding. FiCO_2 was also affected by V_T and RR. This model is not applicable to actual infants because of the large tissue stores of CO_2 in infants; however, it is useful for evaluation of gas diffusibility of bedding and will simplify the investigation of sleeping environments when a baby is found dead with its face covered by soft bedding. In general, the higher the FiCO_2, the greater the rebreathing potential. Theoretically, considering the paucity of body stores of O_2, changes in FiO_2 would be affected not by changes in FiCO_2, but by CO_2 production and gas movement around the infant's face. The rapid decrease of FiO_2 is approximated at the inverse of the FiCO_2 timecourse, suggesting the significance of not only CO_2 accumulation but also O_2 deprivation in the potential space around the baby's face.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (16 results)

All 2007 2006 2005

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (7 results)

  • [Journal Article] The relationship between bedding and face-down death in infancy: Mathematical analysis of a respiratory simulation system using an infant mannequin to assess gas diffusibility in bedding.2007

    • Author(s)
      Sakai J, Funayama M, Kanetake J.
    • Journal Title

      Forensic Sci Int 166

      Pages: 14-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The relationship between bedding and face-down death in infancy: Mathematical analysis of a respiratory simulation system using an infant mannequin to assess gas diffusibility in bedding2007

    • Author(s)
      Sakai J, Funayama M, Kanetake J.
    • Journal Title

      Forensic Sci Int 166

      Pages: 14-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The relationship between bedding and face-down death in infancy: Mathematical analysis of a respiratory simulationsystem using an infant mannequin to assess gas diffusibility in bedding.2007

    • Author(s)
      Sakai J, Funayama M, Kanetake J
    • Journal Title

      Forensic Sci Int 166

      Pages: 14-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性喉頭気管炎(仮性クループ)による幼児突然死の一症例.2007

    • Author(s)
      高橋識志、金武潤、橋谷田真樹、境純、舟山眞人
    • Journal Title

      法医学の実際と研究 50

      Pages: 61-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between bedding and face-down death in infancy : Mathematical analysis of a respiratory simulation system using an infant mannequin to assess gas diffusibility in bedding2007

    • Author(s)
      J Sakai, M Funayama, J Kanetake
    • Journal Title

      Forensic Sci Int 166

      Pages: 14-20

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sudden infant collapse: lingual thyroglossal duct cyst versus environm ental factors.2006

    • Author(s)
      Kanawaku Y, Funayama M, Sakai J, Nata M, Kanetake J.
    • Journal Title

      Forensic Sci Int 156

      Pages: 158-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] lingual thyroglossal duct cyst versus environmental factors2006

    • Author(s)
      Kanawaku Y, Funayama M, Sakai J, Nata M, Kanetake J. Sudden infant collapse
    • Journal Title

      Forensic Sci Int 156

      Pages: 158-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sudden infant collapse : lingual thyroglossal duct cyst versus environmental factors.2006

    • Author(s)
      Y Kanawaku, M Funayama, J Sasaki, M Nata, J Kanetake
    • Journal Title

      Forensic Sci Int 156

      Pages: 158-160

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 単冠状動脈症による死亡が疑われた乳児急死の一例2005

    • Author(s)
      美作宗太郎, 那谷雅之, 舟山眞人, 恒成茂行
    • Journal Title

      法医学の実際と研究 48

      Pages: 197-200

    • Related Report
      2005 Annual Research Report
  • [Presentation] 人形実験モデルを用いた乳児突然死症例寝具の酸素濃度変化の検討.2007

    • Author(s)
      境 純, 金武 潤, 高橋識志, 金涌佳雅, 舟山眞人
    • Organizer
      第91次日本法医学会総会
    • Place of Presentation
      秋田
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sudden infant death and sleeping environment: how to quantify the risk of O2 deprivation.2006

    • Author(s)
      Sakai J
    • Organizer
      The 9th SIDS International Conference.
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sudden infant death and sleeping environment: how to quantify the risk of O2 deprivation2006

    • Author(s)
      Sakai J.
    • Organizer
      The 9th SIDS International Conference
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mathematical assesment of O2 depriviation in the potential space around the nares of face-covered infant mannequin.2005

    • Author(s)
      Sakai J, Funayama M.
    • Organizer
      7th Meeting of the International Association of Forensic Sciences.
    • Place of Presentation
      Hong Kong, China.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] うつ伏せ寝再呼吸仮説の人形実験モデルによる乳児突然死例寝具の検討.2005

    • Author(s)
      境 純、金武 潤、那谷雅之、舟山眞人
    • Organizer
      第89次日本法医学会総会.
    • Place of Presentation
      高松
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mathematical assesment of O2 depriviation in the potential space around the nares of face-covered infant mannequin2005

    • Author(s)
      Sakai J, Funayama M.
    • Organizer
      17th Meeting of the International Association of Forensic Sciences
    • Place of Presentation
      Hong Kong, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TThe relationship between bedding and face-down death in infancy using an infant mannequin to assess gas diffusibility in bedding2005

    • Author(s)
      Sakai J, Kanetake J, Nata M. Funayama M.
    • Organizer
      The 89th Congress of the Japanese Society of Legal Medicine
    • Place of Presentation
      Takamatsu, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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