Molecularr epidemiology about unexpected sudden death
| Project/Area Number |
17390205
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
IWAMOTO Sadahiko Jichi Medical University, Dept of Medicine, Professor (10232711)
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| Co-Investigator(Kenkyū-buntansha) |
GOTOH Takaya Jichi Medical University, School of Medicine, Lecturer (80284355)
KUMADA Maki Jichi Medical University, School of Medicine, Assit. Professor (40326830)
OMI Toshinori Nippon Veterinary and Life Science University, 獣医学部, Associate Professor (40296091)
SAKAMOTO Atsushi Jichi Medical University, School of Medicine, Professor (80235168)
KAJII Eiji Jichi Medical University, School of Medicine, Professor (40204391)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥14,190,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥6,600,000 (Direct Cost: ¥6,600,000)
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| Keywords | genome bank / Hypertension / inflammation / retinol binding protein 4 / association stud / type2 diabetes / 本態性高血圧 / 間質性肺炎 |
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| Research Abstract |
We have constructed three genome banks. The first genome bank is consisted with almost 1000 Japanese population mainly collected from clinics for hypertension case-control study. The second bank is consisted with 21000 Japanese general population from rural area of all over Japan. The third bank is consisted with almost 1000 Mongolian population.
Using the hypertension case-control genome panel, we found an association of an intronic variable number of tandem repeat polymorphism in an innate immunity associated gene, that is Cold autoinflammatory syndrome 1 (CIAS1, NLRP3). The repeat number correlated with the transcript level in peripheral leukocytes. The high expresser genotype showed higher blood pressure than the low expresser type, and the. CIAS1 expression level correlated with expression of interleukin-1 (3. The transgenic mice expressing human CIAS1 in leukocytes were susceptible to newborn death from severe pneumonitis and aseptic pneumonitis after injection of low dose lipopol
… More
ysaccharide into adult transgenic mice. The peritoneal -macrophages showed enhanced expression of pre-IL-113 in the cytoplasm and enhanced the extracellular excretion of 1L-1β These data implicated that the expression level of the molecule of innate immunity may be involved in the susceptibility of hypertension through the enhanced inflammatory response.
Insulin resistance is one of the principal pathogenesis of arteriosclerotic disorders. Mongolian diabetic case-control panel was used to survey the association of recently identified adipokine, retinol binding protein. 4 (RBP4). A significant association was shown with a regulatory SNP, minor allele of which enhanced the expression in both hepatocytes and adipocytes. The RBP4 regulatory SNP was also correlated with BMI in Japanese. RBP4 from adipocytes may be involved in the adipogenesis and further insulin resistance.
These population genetics based studies identified several novel loci associated with common diseases. Whether these genetic factors are involved in the forensic cases remains to be assessed. Less
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia.2007
Author(s)
Munkhtulga L, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Erdenebulgan B, Zolzaya K, Lkhagvasuren T, Iwamoto S.
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Journal Title
Hum Genet. 120
Pages: 879-888
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[Journal Article] An intronic variable number of tandem repeat polymotphisms of the cold-induced autoinflammatory syndrome 1(CIAS1) gene modifies gene expression and is associated with essential hypertension.2006
Author(s)
Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
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Journal Title
Eur J Hum Genet. 14
Pages: 1295-305
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[Journal Article] Leptin resistance conferred by a combination of single nucleotide polymorphism and th adoption of a Western lifestyle in urban areas of Thailand.2006
Author(s)
Yanagisawa Y, Iwamoto S, Kawabata T, Nakamura Y, Charupoonphol P, Supannatas S, Sone H, Kaneko Y, Watanabe S, Komatsu F, Sakuma M, Miyagi S, Hasegawa K, Kagawa Y.
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Journal Title
J Nutr Health Aging. 10
Pages: 176-82
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[Journal Article] Aly/REF, a factor for mRNA transport, activates RH gene promoter function.2005
Author(s)
Suganuma H, Kumada M, Omi T, Gotoh T, Lkhagvasuren M, Okuda H, Kamesaki T, Kajii E, Iwamoto S.
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Journal Title
FEBS J. 272
Pages: 2696-2704
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