The significance of adipocvte-specific glycerol channel, aquaporin adipose for life-style related diseases.

• Project/Area Number: 17390271
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Osaka University
• Principal Investigator: FUNAHASHI Touru Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (60243234)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Tadashi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 講師 (90252668) ; KIHARA Shinji Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (20332736)
• Project Period (FY): 2005 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥14,600,000 (Direct Cost: ¥14,600,000); Fiscal Year 2006: ¥6,700,000 (Direct Cost: ¥6,700,000); Fiscal Year 2005: ¥7,900,000 (Direct Cost: ¥7,900,000)
• Keywords: gene / internal medicine / cardiovascular disease / proteome / diabetes mellitus

Research Abstract

Metabolic syndrome clusters insulin resistance, elevated blood pressure and dyslipidemia, and is a common cause of cardiovascular diseases in the world. The molecular basis of the metabolic syndrome, however, remained unclear. Accumulation of intra-abdominal adipose tissue caused by overnutrition and physical inactivity locates upstream of the metabolic syndrome. Adipose tissue had been regarded as a simple energy storage organ. Our team clarified the tissue is a huge endocrine organ to express genes for various bioactive substances, and concepualized as 'adipocytokines'. Through the study, we discovered various novel adipocyte-expressed genes. In this study, we focused adipocytokines to clarify molecular mechanism of the metabolic syndrome. Adiponectin is an adipocyte-derived protein present abundantly in plasma. Plasma level of adiponectin is decreased in subjectes with visceral fat. Blood pressure levels of adiponectin deficient mice were almost normal. When the mice were fed with h igh salt-diet, their blood pressure levels were elevated. The expression of endogenous nitric oxide synthetase (eNOS) and prostacyclin synthetase was augmented in the aorta of the KO mice. Adenovirus-mediated supplementation of adiponectin lowered blood pressure level of adiponectin KO mice. The effect was cancelled by the administration of L-NAME, which is a specific inhibitor of eNOS, suggesting salt-sensitive hypertension in adiponectin deficiency is caused by lack of NO and vascular endothelial cell dysfunction. A series of studies revealed that adiponectin deficiency worsened cardiac reperfusion injury, cardiac hypertrophy and vascular thrombosis. Clinical studies demonstrated that decreased plasma adiponectin (hypoadiponectinemia) is related to complexity of coronary artery lesion, coronary spasm and peripheral artery disease. Hypoadiponectinemia increased a risk of cardiovascular events in type 2 diabetic subjects and adverse cardiac events after myocardial infarction, also related to cardiovascular risks of the patients with chronic renal disease. Improvement of life-style including cessation of smoking is important to correct hypoadiponectinemia. We demonstrated blockade of adipose angiotensin receptor decreased reactive oxygen species in adipose tissue and recovered plasma adiponectin level. We also showed a novel mechanism of obesity through the analyses of the mice with lack of aquaporin 7, which we had demonstrated as a glycerol channel molecule in adipocyte. These basic and clinical studies will give an impact on the research field of the metabolic syndrome.

Research Products

• [Journal Article] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • Author(s): Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H
  • Journal Title: Atherosclerosis. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • Author(s): Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H
  • Journal Title: Atherosclerosis. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • Author(s): Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y
  • Journal Title: Diabetes Res Clin Pract (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes : The Korean atherosclerosis study (KAS) A 42-month prospective study. (2007)
  • Author(s): Lim S, Koo BK, Cho SW, Kihara S, Funahashi T, Cho YM, Kim SY, Lee HK, Shimomura I, Park KS
  • Journal Title: Atherosclerosis. (In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • Author(s): Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H.
  • Journal Title: Atherosclerosis. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • Author(s): Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.
  • Journal Title: Atherosclerosis. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • Author(s): Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y.
  • Journal Title: Diabetes Res Clin Pract. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes : The Korean atherosclerosis study (KAS) A 42-month prospective study. (2007)
  • Author(s): Lim S, Koo BK, Cho SW, Kihara S, Funahashi T, Cho YM, Kim SY, Lee HK, Shimomura I, Park KS.
  • Journal Title: Atherosclerosis. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. (2007)
  • Author(s): Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H.
  • Journal Title: Atherosclerosis. (In press)
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. (2007)
  • Author(s): Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.
  • Journal Title: Atherosclerosis. (In press)
• [Journal Article] A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. (2007)
  • Author(s): Matsuhisa M, Yamasaki Y, Emoto M, Shimabukuro M, Funahashi T, Matsuzawa Y.
  • Journal Title: Diabetes Res Clin Pract (In press)
• [Journal Article] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels (2006)
  • Author(s): Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S
  • Journal Title: Int J Cancer 118 Pages: 1414-1419
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (2006)
  • Author(s): Iwashima Y, Horio T, Suzuki Y, Kihara S, Rakugi H, Kangawa K, Funahashi T, Ogihara T, Kawano Y
  • Journal Title: Atherosclerosis. 188 Pages: 384-390
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin acts as an endogenous antithrombotic factor. (2006)
  • Author(s): Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T, Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y
  • Journal Title: Arterioscler Thromb Vasc Biol. 26 Pages: 224-230
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of amino-terminal region of adiponectin as a physiologically functional domain. (2006)
  • Author(s): Ujiie H, Oritani K, Kato H, Yokota T, Takahashi I, Maeda T, Masaie H, Ichii M, Kamada Y, Tamura S, Kihara S, Funahashi T, Tomiyama Y, Kanakura Y
  • Journal Title: J Cell Biochem. 98 Pages: 194-207
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates (2006)
  • Author(s): Pannacciulli N, Bunt JC, Ortega E, Funahashi T, Salbe AD, Bogardus C, Krakoff J
  • Journal Title: J Clin Endocrinol Metab. 91 Pages: 1600-1603
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients. (2006)
  • Author(s): Bakkaloglu SA, Soylemezoglu O, Buyan N, Oktar SO, Funahashi T, Pasaoglu H, Elhan AH, Peru H, Hasanoglu E
  • Journal Title: Pediatr Transplant. 10 Pages: 187-192
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin replenishment ameliorates obesity-related hypertension. (2006)
  • Author(s): Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I
  • Journal Title: Hypertension. 47 Pages: 1108-1116
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice (2006)
  • Author(s): Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM
  • Journal Title: Biochem Biophys Res Commun 345 Pages: 1414-1424
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • Author(s): Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N
  • Journal Title: World J Castroenterol. 12 Pages: 3352-3358
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • Author(s): Nishihawa T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I
  • Journal Title: Gastroenterology 131 Pages: 853-861
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Visfatin in adipocytes is upregulated by hypoxia through HIFlalpha-dependent mechanism. (2006)
  • Author(s): Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I
  • Journal Title: Biochem Biophys Res Commun 349 Pages: 875-882
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin and renal function, and implication as a risk of cardiovascular disease. (2006)
  • Author(s): Iwashima Y, Horio T, Kumada M, Suzuki Y, Kihara S, Rakugi H, Kawano Y, Funahashi T, Ogihara T
  • Journal Title: Am J Cardiol. 98 Pages: 1603-1608
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease (2006)
  • Author(s): Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H
  • Journal Title: J Am Coll Cardiol 48 Pages: 1155-1162
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. (2006)
  • Author(s): Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, Funahashi T, Shimomura I, Fujita T
  • Journal Title: J Clin Endocrinol Metab 91 Pages: 5090-5094
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. (2006)
  • Author(s): Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M
  • Journal Title: Circ J. 7011 Pages: 1437-1442
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women : the hoorn study. (2006)
  • Author(s): Snijder MB, Heine RJ, Seidell JC, Bouter LM, Stehouwer CD, Nijpels G, Funahashi T, Matsuzawa Y, Shimomura I, Dekker JM
  • Journal Title: Diabetes Care. 29 Pages: 2498-2503
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blockade of Angiotensin II type-I receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. (2006)
  • Author(s): Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, Ohashi K, Hibuse T, Fujita K, Yasui A, Hiuge A, Kumada M, Kuriyama H, Shimomura I, Funahashi T
  • Journal Title: Kidney Int. 70 Pages: 1717-1724
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. (2006)
  • Author(s): Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S.
  • Journal Title: Int J Cancer. 118 Pages: 1414-1419
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (2006)
  • Author(s): Iwashima Y, Horio T, Suzuki Y, Kihara S, Rakugi H, Kangawa K, Funahashi T, Ogihara T, Kawano Y.
  • Journal Title: Atherosclerosis. 188 Pages: 384-390
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin acts as an endogenous antithrombotic factor. (2006)
  • Author(s): Kato H, Kashiwagi H, Shiraga M, Tadokoro S, Kamae T, Ujiie H, Honda S, Miyata S, Ijiri Y, Yamamoto J, Maeda N, Funahashi T, Kurata Y, Shimomura I, Tomiyama Y, Kanakura Y.
  • Journal Title: Arterioscler Thromb Vasc Biol. 26 Pages: 224-230
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of amino-terminal region of adiponectin as a physiologically functional domain. (2006)
  • Author(s): Ujiie H, Oritani K, Kato H, Yokota T, Takahashi I, Maeda T, Masaie H, Ichii M, Kamada Y, Tamura S, Kihara S, Funahashi T, Tomiyama Y, Kanakura Y.
  • Journal Title: J Cell Biochem. 98 Pages: 194-207
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. (2006)
  • Author(s): Pannacciulli N, Bunt JC, Ortega E, Funahashi T, Salbe AD, Bogardus C, KrakoffJ
  • Journal Title: J Clin Endocrinol Metab. 91 Pages: 1600-1603
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients. (2006)
  • Author(s): Bakkaloglu SA, Soylemezoglu O, Buyan N, Oktar SO, Funahashi T, Pasaoglu H, Elhan AH, Peru H, Hasanoglu E.
  • Journal Title: Pediatr Transplant. 10 Pages: 187-192
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin replenishment ameliorates obesity-related hypertension. (2006)
  • Author(s): Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I.
  • Journal Title: Hypertension. 47 Pages: 1108-1116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. (2006)
  • Author(s): Bauche IB, Ait El Mkadem S, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM.
  • Journal Title: Biochem Biophys Res Commun. 345 Pages: 1414-1424
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • Author(s): Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N.
  • Journal Title: World J Gastroenterol. 12 Pages: 3352-3358
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • Author(s): Nishihara T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I.
  • Journal Title: Gastroenterology. 131 Pages: 853-861
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. (2006)
  • Author(s): Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I.
  • Journal Title: Biochem Biophys Res Commun. 349 Pages: 875-882
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin and renal function, and implication as a risk of cardiovascular disease. (2006)
  • Author(s): Iwashima Y, Horio T, Kumada M, Suzuki Y, Kihara S, Rakugi H, Kawano Y, Funahashi T, Ogihara T.
  • Journal Title: Am J Cardiol. 98 Pages: 1603-1608
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. (2006)
  • Author(s): Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H.
  • Journal Title: J Am Coll Cardiol. 48 Pages: 1155-1162
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. (2006)
  • Author(s): Kadowaki K, Waguri M, Nakanishi I, Miyashita Y, Nakayama M, Suehara N, Funahashi T, Shimomura I, Fujita T.
  • Journal Title: J Clin Endocrinol Metab. 91 Pages: 5090-5094
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. (2006)
  • Author(s): Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M.
  • Journal Title: Circ J. 701 Pages: 1437-1442
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women : the hoorn study. (2006)
  • Author(s): Snijder MB, Heine RJ, Seidell JC, Bouter LM, Stehouwer CD, Nijpels G, Funahashi T, Matsuzawa Y, Shimomura I, Dekker JM.
  • Journal Title: Diabetes Care. 29 Pages: 2498-2503
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. (2006)
  • Author(s): Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, Ohashi K, Hibuse T, Fujita K, Yasui A, Hiuge A, Kumada M, Kuriyama H, Shimomura I, Funahashi T.
  • Journal Title: Kidney Int. 70 Pages: 1717-1724
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels (2006)
  • Author(s): Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S.
  • Journal Title: Int J Cancer 118 Pages: 1414-1419
• [Journal Article] Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (2006)
  • Author(s): Matsumoto H, Tamura S, Kamada Y, Kiso S, Fukushima J, Wada A, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N
  • Journal Title: World J Gastroenterol. 12 Pages: 3352-3358
• [Journal Article] Effect of adiponectin on murine colitis induced by dextran sulfate sodium. (2006)
  • Author(s): Nishihara T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T, Shimomura I
  • Journal Title: Gastroenterology 131 Pages: 853-861
• [Journal Article] Visfatin in adipocytes is upregulated by hypoxia through HIF lalpha-dependent mechanism. (2006)
  • Author(s): Segawa K, Fukuhara A, Hosogai N, Morita K, Okuno Y, Tanaka M, Nakagawa Y, Kihara S, Funahashi T, Komuro R, Matsuda M, Shimomura I
  • Journal Title: Biochem Biophys Res Commun 349 Pages: 875-882
• [Journal Article] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. (2005)
  • Author(s): Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura
  • Journal Title: Proc Natl Acad Sci U S A. 102 Pages: 10993-10998
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Association of hypoadiponectin-emia with smoking habit in men. (2005)
  • Author(s): Iwashima Y, Katsuya T, Ishikawa K, Kida I, Ohishi M, Horio T, Ouchi N, Ohashi K, Kihara S, Funahashi T, Rakugi H, Ogihara T
  • Journal Title: Hypertension. 45 Pages: 1094-1100
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. (2005)
  • Author(s): Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I
  • Journal Title: Diabetes Care 28 Pages: 451-453
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hypoadiponectinemia is associated with coronary artery spasm in men. (2005)
  • Author(s): Maruyoshi H, Kojima S, Otsuka F, Funahashi T, Kaikita K, Sugiyama S, Sakamoto T, Yoshimura M, Shimomura I, Ogawa H
  • Journal Title: Circ J. 69 Pages: 1154-1156
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. (2005)
  • Author(s): Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K
  • Journal Title: Nat Med 11 Pages: 1096-1103
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. (2005)
  • Author(s): Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I, Hori M, Matsuzawa Y, Funahashi T, Kitakaze M
  • Journal Title: Cardiovasc Res. 67 Pages: 705-713
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin Inhibits Endothelial Synthesis of Interleukin-8. (2005)
  • Author(s): Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M
  • Journal Title: Circ Res. 97 Pages: 1245-1252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • Author(s): Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H
  • Journal Title: Thromb Res. 115 Pages: 483-490
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. (2005)
  • Author(s): Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa JI, Tamura S, Matsuzawa Y, Shimomura I, Shinomura Y
  • Journal Title: Gut. 54 Pages: 789-796
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • Author(s): Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y
  • Journal Title: Am J Hypertens. 18 Pages: 949-957
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. (2005)
  • Author(s): Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D
  • Journal Title: Nephrol Dial Transplant. 20 Pages: 129-134
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. (2005)
  • Author(s): de Courten BV, Hanson RL, Funahashi T, Lindsay RS, Matsuzawa Y, Tanaka S, Thameem F, Gruber JD, Froguel P, Wolford JK
  • Journal Title: Diabetes. 54 Pages: 284-289
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. (2005)
  • Author(s): Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E
  • Journal Title: Pediatr Nephrol. 20 Pages: 474-477
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lifestyle modification improves risk factors in type 2 diabetes relatives. (2005)
  • Author(s): Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA
  • Journal Title: Diabetes Res Clin Pract. 68 Pages: 18-28
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease-a follow-up study. (2005)
  • Author(s): Ignacy W, Chudek J, Adamczak M, Funahashi T, Matsuzawa Y, Kokot F, Wiecek A
  • Journal Title: Nephron Clin Pract. 101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients (2005)
  • Author(s): Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O
  • Journal Title: Perit Dial Int. 25 Pages: 357-361
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders. (2005)
  • Author(s): Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF
  • Journal Title: Am J Clin Nutr 82 Pages: 21-25
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. (2005)
  • Author(s): Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H
  • Journal Title: Diabetologia 48 Pages: 1585-1589
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation. (2005)
  • Author(s): Mertens I, Ballaux D, Funahashi T, Matsuzawa Y, Van der Planken M, Verrijken A, Ruige JB, Van Gaal LF
  • Journal Title: Thromb Haemost 94 Pages: 1190-1195
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. (2005)
  • Author(s): Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I.
  • Journal Title: Proc Natl Acad Sci U S A. 102 Pages: 10993-10998
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of hypoadiponectin-emia with smoking habit in men. (2005)
  • Author(s): Iwashima Y, Katsuya T, Ishikawa K, Kida I, Ohishi M, Horio T, Ouchi N, Ohashi K, Kihara S, Funahashi T, Rakugi H, Ogihara T.
  • Journal Title: Hypertension. 45 Pages: 1094-1100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. (2005)
  • Author(s): Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I.
  • Journal Title: Diabetes Care. 28 Pages: 451-453
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hypoadiponectinemia is associated with coronary artery spasm in men. (2005)
  • Author(s): Maruyoshi H, Kojima S, Otsuka F, Funahashi T, Kaikita K, Sugiyama S, Sakamoto T, Yoshimura M, Shimomura I, Ogawa H.
  • Journal Title: Circ J. 69 Pages: 1154-1156
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK-and COX-2-dependent mechanisms. (2005)
  • Author(s): Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K.
  • Journal Title: Nat Med. 11 Pages: 1096-1103
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. (2005)
  • Author(s): Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I, Hori M, Matsuzawa Y, Funahashi T, Kitakaze M.
  • Journal Title: Cardiovasc Res. 67 Pages: 705-713
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin Inhibits Endothelial Synthesis of Interleukin-8. (2005)
  • Author(s): Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M.
  • Journal Title: Circ Res. 97 Pages: 1245-1252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • Author(s): Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H.
  • Journal Title: Thromb Res. 115 Pages: 483-490
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • Author(s): Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y.
  • Journal Title: Am J Hypertens. 18 Pages: 949-957
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. (2005)
  • Author(s): Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D.
  • Journal Title: Nephrol Dial Transplant. 20 Pages: 129-134
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. (2005)
  • Author(s): de Courten BV, Hanson RL, Funahashi T, Lindsay RS, Matsuzawa Y, Tanaka S, Thameem F, Gruber JD, Froguel P, Wolford JK.
  • Journal Title: Diabetes. 54 Pages: 284-289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. (2005)
  • Author(s): Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E.
  • Journal Title: Pediatr Nephrol. 20 Pages: 474-477
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lifestyle modification improves risk factors in type 2 diabetes relatives. (2005)
  • Author(s): Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA.
  • Journal Title: Diabetes Res Clin Pract. 68 Pages: 18-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease-a follow-up study. (2005)
  • Author(s): Ignacy W, Chudek J, Adamczak M, Funahashi T, Matsuzawa Y, Kokot F, Wiecek A.
  • Journal Title: Nephron Clin Pract. 101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients. (2005)
  • Author(s): Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O.
  • Journal Title: Perit Dial Int. 25 Pages: 357-361
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders. (2005)
  • Author(s): Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF.
  • Journal Title: Am J Clin Nutr. 82 Pages: 21-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. (2005)
  • Author(s): Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H.
  • Journal Title: Diabetologia. 48 Pages: 1585-1589
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation. (2005)
  • Author(s): Mertens I, Ballaux D, Funahashi T, Matsuzawa Y, Van der Planken M, Verrijken A, Ruige JB, Van Gaal LF.
  • Journal Title: Thromb Haemost. 94 Pages: 1190-1195
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase (2005)
  • Author(s): Hibuse T, Maeda N, Funahashi T.Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I
  • Journal Title: Proc Natl Acad Sci U S A. 102 Pages: 10993-10998
• [Journal Article] A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance (2005)
  • Author(s): Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, Nishida M, Yamaguchi T, Funahashi T, Matsuzawa Y, Nakamura T, Shimomura I
  • Journal Title: Diabetes Care. 28 Pages: 451-453
• [Journal Article] Visfatin : A protein secreted by visceral fat that mimics the effects of insulin. (2005)
  • Author(s): Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I
  • Journal Title: Science. 307 Pages: 426-430
• [Journal Article] Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease (2005)
  • Author(s): Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa JI, Tamura S, Matsuzawa Y, Shimomura I, Shinomura Y.
  • Journal Title: Gut 54 Pages: 789-796
• [Journal Article] Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. (2005)
  • Author(s): Kojima S, Funahashi T, Maruyoshi H, Honda o, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H
  • Journal Title: Thromb Res 115 Pages: 483-490
• [Journal Article] Pioglitazone improves left ventricular diastolic function in patients with essential hypertension. (2005)
  • Author(s): Horio T, Suzuki M, Suzuki K, Takamisawa I, Hiuge A, Kamide K, Takiuchi S, Iwashima Y, Kihara S, Funahashi T, Yoshimasa Y, Kawano Y.
  • Journal Title: Am J Hypertens 18 Pages: 949-957
• [Journal Article] Lifestyle modification improves risk factors in type 2 diabetes relatives (2005)
  • Author(s): Brekke HK, Lenner RA, Taskinen MR, Mansson JE, Funahashi T, Matsuzawa Y, Jansson PA.
  • Journal Title: Diabetes Res Clin Pract. 68 Pages: 18-28
• [Journal Article] Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients. (2005)
  • Author(s): Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O
  • Journal Title: Perit Dial Int. 25 Pages: 357-361
• [Journal Article] Resting metabolic rate is an important predictor of serum adiponectin concentrations : potential implications for obesity-related disorders (2005)
  • Author(s): Ruige JB, Ballaux DP, Funahashi T, Mertens IL, Matsuzawa Y, Van Gaal LF
  • Journal Title: Am J Clin Nutr. 82 Pages: 21-25