| Project/Area Number |
17390307
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
KUSAKA Takashi Kagawa University, Maternal Perinatal Center, Faculty of Medicine, Maternal Perinatal Center (50274288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yukio University of Electro-Communications, Dept. of Mech. Eng. and Intel. Sys, Japan Professor (10334583)
TANIKAWA Yukari National Institute of Advanced Industrial Science and Technology(AIST), 人間福祉医工学研究部門, Japan (20344202)
NISHIDA Tomoko Kagawa University, Dept of Pediatrics, Assistant Professor (00243759)
NAMBA Masanori Kagawa University, Dept of Pediatrics, Japan. Assistant Professor (90237636)
OKUBO Kensuke Kagawa University, Dept of Pediatrics, Assistant Professor (80335851)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | Near-infrared spectroscopy / Optical tomography / Infant / Hypocapnea / Cerebral blood volume / Periventricular leukomalasia / Time-resolved spectroscopy / Cerebral Hb oxygen saturation / 低出生体重児 / 脳内血液量 / 脳内ヘモグロビン酸素飽和度 / 吸収係数 / 散乱係数 / トモグラフィー / 新生児 / 脳 / 組織Hb酸素飽和度 |
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| Research Abstract |
An optical 3D imaging method using near-infrared diffuse optical tomography (NIR DOT) to estimate the regional light scattering and absorption properties in infants has been developed. The NIR DOT system is consisted of 16 source-detector fibers, pulsed diode lasers operating at the wavelengths of 759 and 835 nm and time correlated single photon counting units. The image reconstruction algorithm is based on the modified generalized pulsed spectral technique. The time-resolved data were used to estimate for concentration of oxyHb and deoxyHb.
DOT was measured in an infant on 29 days after birth, whose gestational age and birth weight was 23 weeks and 658g, assisted by an artificial respirator. Informed consent in writing was obtained from the parents, and the study was approved by the local ethics committee.
The data under two different state, (A) normocapnea and (B) hypocapnea induced by hyperventilation, were obtained. DOT images showed the Hb concentrations obtained at the state (B) subtracted by (A). The results showed that the total Hb concentration in the most parts of the brain decreased, reflecting the decrease in cerebral blood flow, especially white matter regions. The results demonstrated that NIR DOT is capable of reconstructing the images of Hb concentration with a high spatial resolution in infants at the bedside.
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