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Development of nobel pharmacotherapy for schziphrenia targeted at the NMDA receptor-D-serine system

Research Project

Project/Area Number 17390317
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHIKAWA Toru  Tokyo Medical and Dental University, Graduate School, Professor, 大学院医歯学総合研究科, 教授 (00198441)

Co-Investigator(Kenkyū-buntansha) KURUMAJI Akeo  Tokyo Medical and Dental University, Graduate School, Associate Professor, 大学院医歯学総合研究科, 助教授 (00251504)
YAMAMOTO Naoki  Tokyo Medical and Dental University Medical Hospital, Psychiatry, Assistant Professor, 医学部附属病院, 講師 (70312296)
ISHII Sumikazu  Tokyo Medical and Dental University Medical Hospital, Psychiatry, Research Assistant, 医学部, 教務職員 (20106660)
OSHIMA Kazunari  Tokyo Medical and Dental University Medical Hospital, Psychiatry, Research Associate, 医学部附属病院, 助手 (60345288)
SHIMAZU Dai  Tokyo Medical and Dental University Graduate School, Psychiatry and Behavioral Sciences, Research Associate, 大学院医歯学総合研究科, 助手 (90436642)
古田 光  東京医科歯科大学, 大学院医歯学総合研究科, 助手
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 2005: ¥8,900,000 (Direct Cost: ¥8,900,000)
KeywordsSchizophrenia / Glutamate / D-Serine / NMDA receptor / Antipsychotic-resistant symptoms / Neocortex / D-Cycloserine / Glia / 統合失調症 / 大脳新皮質 / 初代培養グリア / 初代培養ニューロン
Research Abstract

In this research project, we are trying to develop a novel class of anti-schizophrenic drugs that ameliorate the conventional antipsychotic-resistant symptoms of schizophrenia by facilitating the N-methyl-D-aspartate (NMDA) type glutamate receptor functions. To this end, we studied the molecular and cellular basis of the D-serine signaling in the brain that has been considered to maintain the physiological activation of the NMDA receptor. Also, we planned the clinical test to evaluate the effects of the oral application of D-cycloserine, a partial agonist of the glutamate receptor, on the negative symptoms of schizophrenic patients that are refractory to antipsychotics.
A body of evidence has been accumulated indicating that D-serine is an endogenous coagonist for the NMDA receptor in the mammalian brain. Thus, D-serine facilitates the functions of the NMDA receptor by selectively stimulating its glycine site and is present in the tissue and extracellular fluid at high contents througho … More ut life with an NR2B subunit-like distribution. The stimulation of the glycine modulatory site is required for the glutamate-induced neurotransmission. Moreover, the selective elimination of D-serine by application of D-amino acid oxidase or D-serine deaminase has been reported to reduce the NMDA-mediated cGMP formation and long-term potentiation in the rat hippocampus. These findings suggest that extracellular D-serine may play a pivotal role in the regulation of the NMDA receptor. Our previous observations that depolarization stimuli including veratrin and a high concentration of potassium ion or cessation of impulse flow by tetrodotoxin failed to increase or decrease the extracellular D-serine contents, respectively, are consistent with the view that D-serine could be liberated into the extracellular fluid in a manner different from classical neurotransmitters. To get further insight into the cellular and molecular mechanisms of the regulation of extracellular D-serine release, we have investigated the effects of a gliotoxin, fluorocitrate, on the extracellular contents of D-serine in the medial frontal cortex of the rats by using HPLC with fluorometric detection. The intra-cortical infusion of the gliotoxin at the concentration of 1 mM caused a decrease in the cortical extracellular contents of D-serine by peaking at 40 min by -25% but produced an increase in those of glycine and L-serine. The attenuated glial activity by fluorocitrate was verified by a marked reduction in the extracellular glutamine contents. The present findings suggest that a group of glial cells such as a population of the protoplasmic astrocytes could, at least in part, participate differently in the regulation of the extracellular release of D-serine and another NMDA coagonist glycine in the medial frontal cortex of the rat. A double-blind randomized crossover trial of D-cycloserine in schizophrenic patients treated with conventional antipsychotic drugs has currently been under investigation. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (73 results)

All 2007 2006 2005

All Journal Article (59 results) Book (14 results)

  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine2007

    • Author(s)
      Kaneko Y et al.
    • Journal Title

      Neuropsychopharmacol 32

      Pages: 658-664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Perospirone in the treatment of patients with delirium2007

    • Author(s)
      Takeuchi T et al.
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 67-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine.2007

    • Author(s)
      Kaneko Y, et al.
    • Journal Title

      Neuropsychopharmacol 32

      Pages: 658-664

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Perospirone in the treatment of patients with delirium.2007

    • Author(s)
      Takeuchi T, et al.
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 67-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A systematic approach to the brain d-serine system.2007

    • Author(s)
      Nishikawa T.
    • Journal Title

      A New Frontier in Amino Acid and Protein Research (Fujii N, Homma H, Bruecker H, Fisher GH, Konno (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine2007

    • Author(s)
      Kaneko Y, et al.
    • Journal Title

      Neuropsychopharmacol 32

      Pages: 658-664

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Perospirone in the treatment of patients with delirium2007

    • Author(s)
      Takeuchi T, et al.
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 67-70

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantitative magnetic resonance spectroscopy of schizophrenia : relationship between decreased N-acetylaspartate and frontal lobe dysfunction2006

    • Author(s)
      Tanaka Y et al.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 365-372

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of repetitive transcranial magnetic stimulation on [^<11>C] raclopride binding and cognitive function in patients with depression2006

    • Author(s)
      Kuroda Y et al.
    • Journal Title

      J Affect. Disorder 95

      Pages: 35-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain2006

    • Author(s)
      Kanematsu S et al.
    • Journal Title

      J Neural Transm 113

      Pages: 1717-1721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurobiological and molecular bases of methamphetamine-induced behavioral sensitization and spontaneous recurrence of methamphetamine psychosis, and its implication in schizophrenia2006

    • Author(s)
      Yui K et al.
    • Journal Title

      Current Psychiatry Reviews 2

      Pages: 381-383

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 修正型電気けいれん療法(m-ECT)が著効した両心室ペースメーカーを植込まれたうつ病の1症例;特集 電気けいれん療法(ECT)の治療経験-症例を中心に-2006

    • Author(s)
      光定博生 他
    • Journal Title

      臨床精神医学 35

      Pages: 1207-1212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 経過中にせん妄を呈した血管性うつ病の1症例2006

    • Author(s)
      横溝美緒 他
    • Journal Title

      精神科 8

      Pages: 165-170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 統合失調症の分子機構研究の最前線;疾患解明Overview2006

    • Author(s)
      西川徹
    • Journal Title

      実験医学 24

      Pages: 2663-2671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 脳の発達障害としての統合失調症2006

    • Author(s)
      西川徹
    • Journal Title

      日本薬理学雑誌 128

      Pages: 13-18

    • NAID

      10018333470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] アシル化アミノ酸の行動薬理学的評価-脂質による高次脳機能異常改善作用の機序を中心に-2006

    • Author(s)
      日比野英彦 他
    • Journal Title

      オレオサイエンス 6

      Pages: 93-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 統合失調症の薬理学的発展;特集「統合失調症解明へのアプローチ」2006

    • Author(s)
      熱田英範 他
    • Journal Title

      精神科 8

      Pages: 257-263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 新規抗精神病薬-急性期に対する使い方;特集「統合失調症-診断と治療の今日」 治療薬解説2006

    • Author(s)
      熱田英範 他
    • Journal Title

      Current Therapy 24

      Pages: 640-644

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 違法ドラッグと依存性薬物による精神障害の分子病態2006

    • Author(s)
      山本直樹 他
    • Journal Title

      医学のあゆみ 217

      Pages: 1147-1151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] セロトニン作働性薬物によるメタンフェタミン逆耐性の減弱-統合失調症の再発予防にむけて-2006

    • Author(s)
      柏淳 他
    • Journal Title

      精神薬療研究年報 38

      Pages: 11-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of d-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as d-serine modulator-12006

    • Author(s)
      Shimazu D et al.
    • Journal Title

      J Neurochem 96

      Pages: 30-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Quantitative magnetic resonance spectroscopy of schizophrenia : relationship between decreased N-acetylaspartate and frontal lobe dysfunction.2006

    • Author(s)
      Tanaka Y, et al.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 365-372

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of repetitive transcranial magnetic stimulation on [^<II>C] raclopride binding and cognitive function in patients with depression.2006

    • Author(s)
      Kuroda Y, et al.
    • Journal Title

      J Affect.Disorder 95

      Pages: 35-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain.2006

    • Author(s)
      Kanematsu S, et al.
    • Journal Title

      J Neural Transm 113

      Pages: 1717-1721

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurobiological and molecular bases of methamphetamine-induced behavioral sensitization and spontaneous recurrence of methamphetamine psychosis, and its implication in schizophrenia.2006

    • Author(s)
      Yui K, et al.
    • Journal Title

      Current Psychiatry Reviews 2

      Pages: 381-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of d-serine accumulation in the Xenopus oocyte by expression of the rat ortholog of human 3'-phosphoadenosine 5'-phosphosulfate transporter gene isolated from the neocortex as d-serine modulator-1.2006

    • Author(s)
      Shimazu D, et al.
    • Journal Title

      J Neurochem 96

      Pages: 30-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Quantitative magnetic resonance spectroscopy of schizophrenia : relationship between decreased N-acetylaspartate and frontal lobe dysfunction2006

    • Author(s)
      Tanaka Y, et al.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 365-372

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of repetitive transcranial magnetic stimulation on [^<11>C] raclopride binding and cognitive function in patients with depression2006

    • Author(s)
      Kuroda Y, et al.
    • Journal Title

      J.Affect.Disorder 95

      Pages: 35-42

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain2006

    • Author(s)
      Kanematsu S, et al.
    • Journal Title

      J Neural Transm 113

      Pages: 1717-1721

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurobiological and molecular bases of methamphetamine-induced behavioral sensitization and spontaneous recurrence of methamphetamine psychosis, and its implication in schizophrenia2006

    • Author(s)
      Yui K, et al.
    • Journal Title

      Current Psychiatry Reviews 2

      Pages: 381-393

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 修正型電気けいれん療法(m-ECT)が著効した両心室ペースメーカーを植込まれたうつ病の1症例;特集 電気けいれん療法(ECT)の治療経験-症例を中心に-2006

    • Author(s)
      光定博生, 他
    • Journal Title

      臨床精神医学 35

      Pages: 1207-1212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 経過中にせん妄を呈した血管性うつ病の1症例2006

    • Author(s)
      横溝美緒, 他
    • Journal Title

      精神科 8

      Pages: 165-170

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の分子機構研究の最前線; 疾患解明Overview2006

    • Author(s)
      西川徹
    • Journal Title

      実験医学 24

      Pages: 2663-2671

    • Related Report
      2006 Annual Research Report
  • [Journal Article] アシル化アミノ酸の行動薬理学的評価-脂質による高次脳機能異常改善作用の機序を中心に-2006

    • Author(s)
      日比野英彦, 他
    • Journal Title

      オレオサイエンス 6

      Pages: 93-105

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 違法ドラッグと依存性薬物による精神障害の分子病態2006

    • Author(s)
      山本直樹, 他
    • Journal Title

      医学のあゆみ 217

      Pages: 1147-1151

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 統合失調症の薬理学的発展; 特集「統合失調症解明へのアプローチ」2006

    • Author(s)
      熱田英範, 他
    • Journal Title

      精神科 8

      Pages: 257-263

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新規抗精神病薬-急性期に対する使い方; 特集「統合失調症-診断と治療の今日」 治療薬解説2006

    • Author(s)
      熱田英範, 他
    • Journal Title

      Current Therapy 24

      Pages: 640-644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 違法ドラッグと依存性薬物による精神障害の分子病態2006

    • Author(s)
      山本 直樹 他
    • Journal Title

      医学のあゆみ 217(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] セロトニン作動性薬物によるメタンフェタミン逆耐性の減弱-統合失調症の再発予防にむけて-2006

    • Author(s)
      柏 淳 他
    • Journal Title

      精神薬療研究年報 37(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Metabolism and Functional Roles of Endogenous D-Serine in Mammalian Brains2005

    • Author(s)
      Nishikawa T
    • Journal Title

      Biol Pharm Bul 28

      Pages: 1561-1565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology2005

    • Author(s)
      Fujii R et al.
    • Journal Title

      Curr Biol 15

      Pages: 587-593

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia2005

    • Author(s)
      Aoki-Suzuki M et al.
    • Journal Title

      Biol Psychiatry 57

      Pages: 382-393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Cloning of a d-serine-regulated transcript dsr-2from rat cerebral neocortex2005

    • Author(s)
      Taniguchi G et al.
    • Journal Title

      J Neurochem 95

      Pages: 1541-1549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] ヒトの脳に存在する遊離型D-セリンの機能と病態-精神神経疾患の治療への応用-2005

    • Author(s)
      西川 徹
    • Journal Title

      ファルマシア 41

      Pages: 863-868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 統合失調症の分子薬理学的解析- ドーパミン受容体およびNMDA受容体作用薬を用いたアプローチ-.特集1 統合失調症 : 分子から治療まで2005

    • Author(s)
      西川 徹
    • Journal Title

      脳21 8

      Pages: 9-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 統合失調症 標準治療と最新治療-メリットとデメリット法-2005

    • Author(s)
      古田 光 他
    • Journal Title

      Clin Neurosci 23

      Pages: 106-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] モノアミン障害・アンフェタミンモデル 統合失調症の仮説とそのモデル検証2005

    • Author(s)
      嶋津 奈 他
    • Journal Title

      分子精神医学 5

      Pages: 25-63

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 統合失調症の神経発達障害仮説と神経変性仮説.特集-統合失調症の新しい治療の展望-12005

    • Author(s)
      車地暁生
    • Journal Title

      精神科治療学 20

      Pages: 3-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 神経化学.第2章 統合失調症の病理・病態生理・成因2005

    • Author(s)
      車地暁生
    • Journal Title

      最新医学・別冊 新しい診断と治療のABC 32

      Pages: 39-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 治療経過中に退行し、復職プログラムと集団精神療法が有効であった遷延うつ病の症例2005

    • Author(s)
      黒田裕子 他
    • Journal Title

      精神科 6

      Pages: 65-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Metabolism and Functional Roles of Endogenous D-Serine in Mammalian Brains.2005

    • Author(s)
      Nishikawa T
    • Journal Title

      Bio Pharm Bul 28

      Pages: 1561-1565

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.2005

    • Author(s)
      Fujii R, et al.
    • Journal Title

      Curr Biol 15

      Pages: 587-593

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.2005

    • Author(s)
      Aoki-Suzuki M, et al.
    • Journal Title

      Biol Psychiatry 57

      Pages: 382-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cloning of a d-serine-regulated transcript dsr-2from rat cerebral neocortex.2005

    • Author(s)
      Taniguchi G, et al.
    • Journal Title

      J Neurochem 95

      Pages: 1541-1549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroanatomical and molecular changes in stress responses.2005

    • Author(s)
      Nishikawa T, et al.
    • Journal Title

      PTSD brain mechanisms and clinical implications (Kato N, Kawata M and Pitman RK (eds.)), Springer-Verlag, Tokyo

      Pages: 3-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 統合失調症の分子薬理学的解析-ドーパミン受容体およびNMDA受容体作用薬を用いたアプローチ- 特集1 統合失調症:分子から治療まで2005

    • Author(s)
      西川 徹
    • Journal Title

      脳21 8

      Pages: 9-15

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 統合失調症の神経発達障害仮説と神経変性仮説 特集-統合失調症の新しい治療の展望-12005

    • Author(s)
      車地 暁生
    • Journal Title

      精神科治療学 20

      Pages: 3-10

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 神経化学 第2章 統合失調症の病理・病態生理・成因2005

    • Author(s)
      車地 暁生
    • Journal Title

      最新医学・別冊 新しい診断と治療のABC 32

      Pages: 39-47

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 治療経過中に退行し、復職プログラムと集団精神療法が有効であった遷延うつ病の症例2005

    • Author(s)
      黒田 裕子 他
    • Journal Title

      精神科 6

      Pages: 65-70

    • Related Report
      2005 Annual Research Report
  • [Book] A systematic approach to the brain d-serine system. A New Frontier in Amino Acid and Protein Research(Fujii N, Homma H, Bruecker H, Fisher GH, Konno R (eds.))2007

    • Author(s)
      Nishikawa T
    • Publisher
      Nova Science Publishers(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] A New Frontier in Amino Acid and Protein Research (Fujii N,Homma H,Bruecker H,Fisher GH,Konno R(eds.)) A systematic approach to the brain d-serine system.2007

    • Author(s)
      Nishikawa T
    • Publisher
      Nova Science Publishers (in press)
    • Related Report
      2006 Annual Research Report
  • [Book] 1.統合失調症.第7章 神経・精神疾患の分子機構.脳神経科学イラストレイテッド(改訂第2版)(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛編)2006

    • Author(s)
      西川 徹 他
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 抗精神病薬の作用機序.統合失調症の薬物治療アルゴリズム(精神科薬物療法研究会編)2006

    • Author(s)
      濱村貴史 他
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 3.グルタミン酸-D-セリンシステムと統合失調症.V.「グルタミン酸」と「てんかん、統合失調症」.脳とこころの科学(鶴紀子編)2006

    • Author(s)
      谷口 豪 他
    • Publisher
      新興医学出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 身体表現性障害を経過中にBipolarII Disorderを呈し、炭酸リチウム投与によって寛解に至った1症例.Bipolar Disorder 4(Bipolar Disorder研究会編.)2006

    • Author(s)
      車地暁生
    • Publisher
      アルタ出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Neuroanatomical and molecular changes in stress responses. PTSD brain mechanisms and clinical implications.(Kato N, Kawata M and Pitman RK (eds.))2006

    • Author(s)
      Nishikawa T et al.
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 1.統合失調症.第7章 神経・精神疾患の分子機構.(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛編.)脳神経科学イラストレイテッド(改訂第2版)2006

    • Author(s)
      西川 徹, 他
    • Publisher
      羊土社
    • Related Report
      2006 Annual Research Report
  • [Book] 統合失調症の薬物治療アルゴリズム(精神科薬物療法研究会編)2006

    • Author(s)
      濱村貴史, 他
    • Publisher
      医学書院
    • Related Report
      2006 Annual Research Report
  • [Book] 3.グルタミン酸-D-セリンシステムと統合失調症. V.「グルタミン酸」と「てんかん、統合失調症」(鶴紀子編)脳とこころの科学2006

    • Author(s)
      谷口 豪, 他
    • Publisher
      新興医学出版
    • Related Report
      2006 Annual Research Report
  • [Book] 身体表現性障害を経過中にBipolarII Disorderを呈し、炭酸リチウム投与によって寛解に至った1症例.Bipolar Disorder研究会編.Bipolar Disorder 42006

    • Author(s)
      車地暁生
    • Publisher
      アルタ出版
    • Related Report
      2006 Annual Research Report
  • [Book] PTSD brain mechanisms and clinical implications(Kato N, Kawata M, Pitman RK eds.)2006

    • Author(s)
      Nishikawa T
    • Total Pages
      9
    • Publisher
      Springer-Verlag
    • Related Report
      2005 Annual Research Report
  • [Book] 心の科学セレクション 統合失調症(風祭元,山下格 編)2006

    • Author(s)
      西川 徹
    • Total Pages
      18
    • Publisher
      日本評論社
    • Related Report
      2005 Annual Research Report
  • [Book] 6.神経化学から.心の科学セレクション 統合失調症.(風祭元,山下格 編)2005

    • Author(s)
      西川 徹
    • Publisher
      日本評論社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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