Development of a QAsystem for intensity-modulated radiation therapy based on Month Carlo dose calculation

• Project/Area Number: 17390333
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MIZOWAKI Takashi Kyoto University, Dept of Radiation Oncology eir Image-applied Therapy, Lactiner (90314210)
• Co-Investigator(Kenkyū-buntansha): HORAOKA Masahiro Kyoto University, Dept of Radiation Oncology & Image-applied Therapy, Professor (70173218) ; NARITA Yuichiro Kyoto University, Dept of Radiation Oncology & Image-applied Therany, Associate Professor (30311385)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥14,710,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥810,000); Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000); Fiscal Year 2005: ¥8,500,000 (Direct Cost: ¥8,500,000)
• Keywords: Medicine / Radiation / Radiotherapy / Month Carlo method / Dose calculation / 線量分布計算 / 放射線治療計画 / 品質保証

Research Abstract

MCRTV (Monte Carlo for Radiotherapy Treatment Plan Verification) system, which is composed of 28-CPU Linux Cluster system and originally developed dose calculation algorithm for Month Carlo method (MC), was developed. Models of the head of a linear accelerator (Clinac 2300/CD, Varian Co.), multileaf collimator (Mark II 80-leaf system, Varian Co.) and body/phantom for MC dose calculation were originally written using the EGS4/PRESTA MC code. The system is also compatible with dose calculations for dynamic multileaf collimator (DMLC) intensity-modulated radiotherapy (IMRT). Dose calculation speed was optimized enough to use in routine clinical course using parallel computation technique.
Calculation results by MCRTV were well accorded with the results of chamber measurements in which only 1-2 % discrepancies were detected in static conditions for both homogeneous and inhomogeneous phantoms. In addition, discrepancies between calculations by MCRTV and chamber measurements were also within 1% for DMLC-IMRT conditions. In additional validation using film measurements, differences between calculations and measurements with respect to clinical DMLC-IMRT plans for prostate cancer were generally less than 2%.

Research Products

• [Journal Article] Comparisons of the impact of systematic uncertainties on doses to the target among different plans of definitive external-beam radiotherapy for prostate cancer. (2008)
  • Author(s): Zhu S., Mizowaki, T., et. al.
  • Journal Title: Int J Clin Oncol 13(1) Pages: 54-61
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a three-dimensionally movable phantom system for dosimetric verifications. (2008)
  • Author(s): Nakayama H, Mizowaki T., et. al.
  • Journal Title: Ned. Phys. 35(5)(in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparisons of the impact of systematic uncertainties on doses to the target among different plans of definitive external-beam radiotherapy for prostate cancer (2008)
  • Author(s): Zhu, S., Norihisa, Y., Takayama, K., Nagata, Y., Hiraoka, M
  • Journal Title: Int J Clin. Oncol 13(1) Pages: 54-61
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a three-dimensionally movable phantom system for dosimetric verifications (2008)
  • Author(s): Nakayama, H., Mizowaki, T., Narita, Y., Kawada, N., Takahashi, K., Mihara, K., Hiraoka, M
  • Journal Title: Ned. Phys 35(5)(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparisons of the impact of systematic uncertainties inpatient setup and prostate motion on doses to the targetamong different plans for definitive external-beam radiotherapy for prostate cancer. (2008)
  • Author(s): Zhu S, Mizowaki T, Norihisa Y, Takayama K, Nagata Y, Hiraoka M.
  • Journal Title: Int J Clin Oncol. 13 Pages: 54-61
  • Peer Reviewed
• [Journal Article] Development of a three-dimensionally movable phantomsystem for dosimetric verifications (2008)
  • Author(s): Nakayama H, Mizowaki T, Narta Y, Kawada N, Takahashi K, Mihara K, Hiraoka M
  • Journal Title: Ned. Phys. (in press)
  • Peer Reviewed
• [Journal Article] An integrated Monte Carlo dosimetric verification system for radiotherapy treatment planning. (2007)
  • Author(s): Yamamoto T, Mizowaki T., et. al.
  • Journal Title: Phys Med Biol 52 Pages: 1991-2008
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 前立腺癌 強度変調放射線治療(IMRT) (2007)
  • Author(s): 溝脇尚志, 他
  • Journal Title: 日本臨床 65(増刊号10) Pages: 381-385
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An integrated Month Carlo dosimetric verification system for radiotherapy treatment planning (2007)
  • Author(s): Yamamoto, T., Mizowaki, T., Miyabe, Y., Takegawa, H., Narita, Y., Yano, S., Nagata, Y., Teshima, T., Hiraoka, M
  • Journal Title: Phys Med Biol 52 Pages: 1991-2008
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prostate cancer. Intensity-modulated radiation therapy (IMRT) (2007)
  • Author(s): Mizowaki, T., Norihisa, Y., Hiraoka, M
  • Journal Title: Nippon Rinsho 65, 10 Pages: 381-385
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An integrated Monte Carlo dosimetric verification system for radiotherapy treatment planning. (2007)
  • Author(s): T.Yamamoto, T.Mizowaki, Y.Miyabe他
  • Journal Title: Physics in Medicine and Biology 52(7) Pages: 1991-2008
• [Journal Article] 最適化アルゴリズムの違いがIMRT治療計画に及ぼす影響 (2006)
  • Author(s): 島田真理、中村光宏、宮部結城、山本時裕、手島昭樹、成田雄一郎、溝脇尚志, 他
  • Journal Title: 医学物理 26 Pages: 97-107
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impact of optimization algorithms on the intensity map in IMRT treatment planning (2006)
  • Author(s): Shimada, M., Nakamura, M., Miyabe, Y., Yamamoto, T., Teshima, T., Narita, Y., Mizowaki, T., Nagata, Y., Hiraoka, M
  • Journal Title: Igaku Butsuri 26 Pages: 97-107
  • NAID: 10024347049
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 最適化アルゴリズムの違いがIMRT治療計画に及ぼす影響 (2006)
  • Author(s): 島田真理, 中村光宏, 宮部結城他
  • Journal Title: 医学物理 26(3) Pages: 97-107
• [Presentation] 前立腺癌に対する強度変調放射線治療(IMRT) (2007)
  • Author(s): 溝脇尚志, 他
  • Organizer: 第95回日本泌尿器科学会学総会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2007-04-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Intensity-modulated radiation therapy (IMRT) for prostate cancer (2007)
  • Author(s): Mizowaki, T., Takayama, K., Norihisa, Y., Hiraoka, M., Kamoto, T., Nakamura, E., Ogawa, O
  • Organizer: 95th Annual Meeting of Japanese Society of Urology
  • Place of Presentation: Kobe
  • Year and Date: 2007-04-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Monte Carloシミュレーションを用いたマルチリーフコリメータモデルの検証 (2007)
  • Author(s): 石原 佳知, 山本 時裕, 宮部 結城, 溝脇 尚志, 他
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] XVMCモンテカルロ線量計算法の不均質体での線量計算精度の検討 (2007)
  • Author(s): 成田 雄一郎, 松尾幸憲、溝脇 尚志, 他
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Validations of a model of a multileaf collimator by Monte Carlo simulation (2007)
  • Author(s): Ishihara, Y.,Yamamoto, T.,Miyabe, Y.,Mizowaki, T.,Narita, Y., Yano, S., Nagata, Y., Teshima, M., Hiraoka, M
  • Organizer: 20th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Fukuoka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Accuracies in dose calculations for inhomogeneous materials by Monte Carlo dose calculation (2007)
  • Author(s): Narita, Y., Matsuo, Y., Mizowaki, T., Hiraoka, M
  • Organizer: 20th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Fukuoka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] IMRTのピットフォールに関する考察 (2006)
  • Author(s): 溝脇尚志
  • Organizer: 第13回日本高精度放射線外部照射研究会
  • Place of Presentation: 山梨
  • Year and Date: 2006-03-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 院内設置PCクラスタを用いたMonte Carlo計算の高速化 (2006)
  • Author(s): 山本 時裕, 溝脇 尚志, 他
  • Organizer: 日本医学物理学会第91回学術大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Intensity-modulated radiation therapy. (2006)
  • Author(s): Mizowaki, T.
  • Organizer: The 20th International Congress and Exhibition of Computer Assisted Radiology and Surgery.
  • Place of Presentation: Osaka, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Benchmarks of a Monte Carlo dose verification system for radiotherapy treatmen t planning (2006)
  • Author(s): T. Yamamoto, Y. Miyabe, H. Takegawa, T. Mizowaki, et. al.
  • Organizer: First European Workshop on Monte Carlo Treatment Planning of the European Workgroup on MCTP
  • Place of Presentation: Ghent University Het Pand, Ghent, Belgium
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 放射線治療計画のための統合Monte Carlo線量検証システム (2006)
  • Author(s): 山本 時裕, 宮部 結城, 武川 英樹, 溝脇 尚志, 他
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 臓器体内移動が線量分布に与える影響の実験的評価 (2006)
  • Author(s): 島田真理, 宮部 結城, 成田 雄一郎, 中山博之, 溝脇 尚志, 他
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 体内線量分布評価を目的とした三次元動体ファントムの測定精度検証シミュレーション (2006)
  • Author(s): 中山博之, 成田 雄一郎, 溝脇 尚志, 他
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Speeding up of Monte Carlo dose calculation by a PC Cluster system (2006)
  • Author(s): Yamamoto, T., Mizowaki, T., Takegawa, H., Miyabe, Y., Teshima, M., Yano, S., Narita, Y., Nagata, Y., Hiraoka, M
  • Organizer: 91th Scientific Meeting of Japan Society of Medical Physics
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Intensity-modulated radiation therapy (2006)
  • Author(s): Mizowaki., T
  • Organizer: The 20th International Congress and Exhibition of Computer Assisted Radiology and Surgery
  • Place of Presentation: Osaka, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Benchmarks of a Monte Carlo dose verification system for radiotherapy treatment planning (2006)
  • Author(s): T., Yamamoto, Y., Miyabe, H., Takegawa, T., Mizowaki, Y., Narita, Y., Nagata, S., Yano, T., Teshima, M., Hiraoka
  • Organizer: First European Workshop on Monte Carlo Treatment Planning of the European Workgroup on MCTP Ghent University Het Pand
  • Place of Presentation: Ghent, Belgium
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] integrated dose evaluation system by Monte Carlo simulation for radiotherapy treatment planning (2006)
  • Author(s): Yamamoto, T.,Miyabe, Y., Takegawa, H., Mizawaki, T.,Narita, Y., Yano, S., Nagata, Y., Teshima, M., Hiraoka, M., A
  • Organizer: 19th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: sendai
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Experimental verifications of the impact of internal organ motion to the dose distribution (2006)
  • Author(s): Mari, S., Miyabe, Y., Narita, Y., Nakayama, H., Mizowaki,T., Takayama, K., Norihisa, Y., Teshima, M., Hiraoka, M
  • Organizer: 19th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: sendai
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Verifications of the accuracy of 3D movable phantom system for the evaluation of dose distribution within the body (2006)
  • Author(s): Nakayama, H., Narita, Y., Mizowaki, T., Kawada, N., Miyabe, Y., Matsugi, K., Nakamura, M., Takayama, K., Hiraoka, M
  • Organizer: 19th Annual Meeting of Japanese Society for Therapeutic Radiology and Oncology
  • Place of Presentation: sendai
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 京都大学におけるIMRTの現状と問題点 -米国との比較検討- (2005)
  • Author(s): 溝脇尚志, 他
  • Organizer: 第12回日本高精度放射線外部照射研究会
  • Place of Presentation: 大阪
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Current status and problems of IMRT at Kyoto University - comparisons to USA (2005)
  • Author(s): Mizowaki, T., Nagata, Y., Yano, S., Okada, T., Yamamoto, T., Narita, Y., Takayama, K., Norihisa, Y., Matsuo, Y., Sakamoto, M., Hiraoka, M
  • Organizer: 12th Semiannual Meeting of Japan 3-D Conformal External Beam Radiotherapy Group
  • Place of Presentation: Osaka
  • Year and Date: 2005-09-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 並列処理によるMonte Carlo線量計算の高速化. (2005)
  • Author(s): 武川 英樹, 山本 時裕, 矢野 慎輔, 手島 昭樹, 功刀 資彰, 溝脇 尚志, 他
  • Organizer: 日本放射線技術学会第61回総会学術大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Monte Carlo法を用いた線量計算における入射電子ビームモデルの影響. (2005)
  • Author(s): 山本 時裕, 矢野 慎輔, 手島 昭樹, 溝脇 尚志, 他
  • Organizer: 日本放射線技術学会第61回総会学術大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Monte Carlo法を用いた前立腺がんIMRT治療計画の線量検証 (2005)
  • Author(s): 宮部 結城, 山本 時裕, 矢野 慎輔, 手島 昭樹, 松本 政雄, 溝脇 尚志, 他
  • Organizer: 日本放射線技術学会第61回総会学術大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IMRT治療計画へのMonte Carlo線量計算の導入 (2005)
  • Author(s): 宮部 結城, 山本 時裕, 矢野 慎輔, 松本 政雄, 手島 昭樹, 溝脇 尚志, 他
  • Organizer: 日本医学物理学会第89回学術大会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Speeding up of Monte Carlo dose calculation by parallel computation (2005)
  • Author(s): Takegawa, H., Yamamoto, T., Yano,S., Teshima, M., Kunugi, T., Mizowaki, T., Nagata, Y., Hiraoka, M
  • Organizer: 61th Scientific meeting of Japanese Society of Radiological Technology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of incident photon beam model for Monte Carlo dose calculation (2005)
  • Author(s): Yamamoto, T., Yano, S., Teshima, M., Mizowaki, T., Nagata, Y., Hiraoka, M
  • Organizer: 61th Scientific meeting of Japanese Society of Radiological Technology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Dose verification for prostate IMRT plans by Monte Carlo dose calculation (2005)
  • Author(s): Miyabe, Y., Yamamoto, T.,Yano, S.,Teshima, M.,Matsumoto, M., Mizowaki, T., Nagata, Y., Hiraoka, M
  • Organizer: 61th Scientific meeting of Japanese Society of Radiological Technology
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Introduction of Monte Carlo dose calculation in IMRT treatment planning (2005)
  • Author(s): Miyabe, Y., Yamamoto, T.,Yano, S., Matsumoto, M., Teshima, M., Mizowaki, T., Nagata, Y., Hiraoka, M
  • Organizer: 89th Scientific Meeting of Japan Society of Medical Physics
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pitfalls in IMRT
  • Author(s): Mizowaki, T
  • Organizer: 13th Semiannual Meeting of Japan 3-D Conformal External Beam Radiotherapy Group
  • Place of Presentation: Yamashina
  • Description: 「研究成果報告書概要(欧文)」より