Development of new treatment for severe liver diseases using platelets

• Project/Area Number: 17390359
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Tsukuba
• Principal Investigator: OHKOHCHI Nobuhiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, professor (40213673)
• Co-Investigator(Kenkyū-buntansha): OZAKI Michitaka University of Hokkaido, Graduate School of Medicine, professor (80256510) ; TANIGUCHI Hideki Yokohama City University, Department of Regenerative Medicine, professor (70292555) ; YASUE Hiroshi National Institute of Agrobiological Sciences, Associate director (80113497) ; FUKUNAGA Kiyoshi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (20361339) ; MURATA Soichiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (40436275) ; 湯沢 賢治 筑波大学, 大学院・人間総合科学研究科, 講師 (10240160)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥15,970,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000); Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
• Keywords: liver / platelet / treatment of liver failure / Kupffer cell / regeneration / Akt / thrombopoietin / anti-platelet antibody / クッパー細胞 / 胚不全治療 / トロンボポチエン / 小板

Research Abstract

The aim of this research is to develop new treatment strategy of liver regeneration and liver failure using platelet function of hepato-proliferative effect. In 2005, we revealed that platelets promote liver regeneration after hepatectomy using mice. Platelets had direct effect on hepatocytes proliferation via PI3 kinase/Akt pathway. In 2006, we revealed that platelets promote liver regeneration after excessive hepatectomy. We also revealed that HGF and IGF-1 in platelets are the main effector of hepatocytes proliferation. To preserve platelets for a long time, we created a freeze dried platelet which preserved its shape, growth factors, and the effect of hepatocyte proliferation. In 2007, we revealed that platelets prevent progression of fibrosis and promote liver regeneration in cirrhotic rats and mice. The mechanism of reducing fibrosis by platelets was reducing TGF beta and increasing MMP-9 expression. In this research, we indicated that platelets and platelet products would be effective in liver cirrhosis treatment. We will continue clinical studies for treating severe liver diseases using platelets

Research Products

• [Journal Article] Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro (2008)
  • Author(s): R Matsuo, N Ohkohchi, S Murata, O Ikeda, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kubota, H Narimatsu, M Ozaki
  • Journal Title: Journal of Surgical Research 145 Pages: 279-286
  • NAID: 120007138815
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF (2008)
  • Author(s): R Matsuo, N Ohkohchi, S Murata, O Ikeda, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kubota, H Narimatsu, M Ozaki
  • Journal Title: Journal of Surgical Research 145 Pages: 279-286
  • Peer Reviewed
• [Journal Article] Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice (2007)
  • Author(s): S Murata, N Ohkohchi, R Matsuo, O Ikeda, A Myronovych, R Hoshi
  • Journal Title: World Journal of Surgery 31 Pages: 808-816
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Freeze-dried platelets promote hepatocyte proliferation in mice (2007)
  • Author(s): R Hoshi, S Murata, R Matsuo, A Myronovych, I Hashimoto, H Ikeda, N Ohkohchi
  • Journal Title: Cryobiology 55 Pages: 255-260
  • NAID: 120007138990
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Platelets Promote Liver Regeneration in Early Period after Hepatectomy in Mice. (2007)
  • Author(s): Murata S, Ohkohchi N, Matsuo R, Ikeda O, Myronovych A, Hoshi R
  • Journal Title: World Journal of Surgery 31(4) Pages: 808-816
• [Journal Article] Platelet dynamics in the early phase of post-ischemic liver in vivo Journal of Surgical Research
  • Author(s): Y Nakano, T Kondo, R Matsuo, I Hashimoto, T Kawasaki, K Kouno, A Myronovych, S Tadano, K Hisakura, O Ikeda, M Watanabe, S Murata, N Ohkohchi
  • Journal Title: Journal of Surgical Research (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autonomic regulation of liver regeneration after partial hepatectomy in mice.
  • Author(s): Ikeda, M Ozaki, S Murata, R Matsuo, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kawasaki, K Kohno, N Ohkohchi
  • Journal Title: Journal of Surgical Research (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autonomic regulation of liver regeneration after partial hepatectomy in mice
  • Author(s): O Ikeda, M Ozaki, S Murata, R Matsuo, Y Nakano, M Watanabe, K Hisakura, A Myronovych, T Kawasaki, K Kohno, N Ohkohchi
  • Journal Title: Journal of Surgical Research (in press)
  • Peer Reviewed
• [Journal Article] Platelet dynamics in the early phase of post-ischemic liver in vivo Journal of Surgical Research
  • Author(s): Y Nakano, T Kondo, R Matsuo, I Hashimoto, T Kawasaki, K Kouno, A Myronovych, S Tadano, K Hisakura, O Ikeda, M Watanabe, S Murata, N Ohkohchi
  • Journal Title: Journal of Surgical Research (in press)
  • Peer Reviewed
• [Journal Article] Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro.
  • Author(s): Matsuo R, Ohkohchi N, Murata S, Ikeda O, Nakano Y, Watanabe M, Hisakura K, Myronovych A, Kubota T, Narimatsu H, Ozaki M.
  • Journal Title: Journal of Surgical Research (in press)
  • NAID: 120007138815
• [Presentation] 血小板による肝再生とそれを用いた新しい肝疾患治療法の研究 (2007)
  • Author(s): 村田聡一郎・大河内信弘
  • Organizer: 第20回肝再生研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板による新いし肝疾患治療法の開発 (2007)
  • Author(s): 村田聡一郎・アンドリーミロノビッチ・渡辺基信・久倉勝治・松尾亮太・池田治・中野順隆・高野恵輔・川崎卓也・橋本育佳・柴崎佑樹・福永・潔・大河内信弘
  • Organizer: 第3回広島肝臓プロジェクト研究センターシンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2007-06-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板による新しい肝疾患治療法の開発 (2007)
  • Author(s): 村田聡一郎, アンドリーミロノヴィッチ, 渡辺基信, 久倉勝治, 松尾亮太, 池田治, 中野順隆, 高野恵輔, 川崎卓也, 橋本育佳, 柴崎佑樹, 福永潔, 大河内信弘
  • Organizer: 第3回広島肝臓プロジェクト研究センターシンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2007-06-29
• [Presentation] The role of Kupffer cells and platelets after the ischemia-reperfusion of the liver-in vivo study- (2007)
  • Author(s): Y, Nakano・T, Kondo・R, Matsuo・S, Murata・N, Ohkohchi
  • Organizer: European Society for Surgical Research (ESSR)
  • Place of Presentation: Rotterdam, The Netherlands
  • Year and Date: 2007-05-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 副交感神経のもつ肝再生制御メカニズムの解明 (2007)
  • Author(s): 池田治, 村田聡一郎, 松尾亮太, 中野順隆, 渡辺基信, 久倉勝治, 尾崎倫孝, 大河内信弘
  • Organizer: 第107回日本外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-12
• [Presentation] クッパー細胞は肝再生を促進する (2007)
  • Author(s): 松尾亮太, 村田聡一郎, 池田治, 中野順隆, 渡辺基信, 久倉勝治, 福沢淳也, 只野惣介, 大河内信弘
  • Organizer: 第107回日本外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-12
• [Presentation] 血小板による新しい肝再生促進療法の開発 (2007)
  • Author(s): 村田聡一郎, 松尾亮太, 池田治, Myronovych Andriy, 星礼子, 池田博, 大河内信弘
  • Organizer: 第107回日本外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-12
• [Presentation] Effect of freeze-dried platelets on hepatocyte proliferation (2007)
  • Author(s): R., Hoshi・H Ikeda・S, Murata・R, Matsuo・O, Ikeda・N, Ohkohchi
  • Organizer: 17th APASL
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The vagal nerve modulates liver regeneration after partial hepatectomyvia acetylcholine receptor (2007)
  • Author(s): O, Ikeda・M, Ozaki・S, Murata・R, Matsuo・Y, Nakano・M, Watanabe・K, Hisakura・A, Myronovych・N, Ohkohchi
  • Organizer: 17th APASL
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板による肝細胞増殖促進効果の検討とエフェクター蛋白の同定 (2007)
  • Author(s): 松尾亮太・村田聡一郎・池田治・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] humanEPCによるマウス肝線維化モデルにおける線維化抑制効果の検討 (2007)
  • Author(s): 村田聡一郎・高官雅哉・星礼子・大根田修・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス肝線維症モデルにおける血小板増加による肝線維化抑制効果の検討 (2007)
  • Author(s): 渡辺基信・村田聡一郎・橋本育佳・中野順隆・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] レロンボポエチンの抗Fes抗体投与肝障害モデルに対する抗アポトーシス効果 (2007)
  • Author(s): 橋本育佳・中野順隆・村田聡一郎・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] トロンボポエチンの抗Fas抗体投与肝障害モデルに対する抗アポトーシス効果 (2007)
  • Author(s): 久倉勝治・村田聡一郎・松尾亮太・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Kupffer細胞および血小板の肝再生促進作用の検討 (2007)
  • Author(s): 村田聡一郎・松尾亮太・池田治・アンドリーミロノビッチ・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス90%肝切除における血小板の肝再生促進作用の検討 (2007)
  • Author(s): アンドリーミロノビッチ・村田聡一郎・大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 肝再生における迷走神経の作用機序 (2007)
  • Author(s): 池田治・尾崎倫孝・村田聡一郎・大河内信弘
  • Organizer: 第14回日本肝臓学会総会
  • Place of Presentation: 鹿児島
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 劇症肝炎に対する血小板の治療効果の検討 (2007)
  • Author(s): 村田聡一郎・久倉勝治・松尾亮太・池田治・アンドリーミロノビッチ・渡辺基信・中野順隆・高野恵輔・川崎卓也・橋本育佳・柴崎佑樹・福永・潔・大河内信弘
  • Organizer: 第14回日本肝臓学会総会
  • Place of Presentation: 鹿児島
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Platelets promote hepatocyte proliferation with HGF and IGF-1 (2007)
  • Author(s): R, Matsuo・O, Ikeda・Y, Nakno・A, Myronovych・T, Kawasaki・K, Kohno・S, Murata・N, Ohkohchi
  • Organizer: Sixth JSH Single Topic Conference Liver Failure
  • Place of Presentation: 岩手
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Thrombocytosis induced by splenectomy reduces liver fibrosisi in mice (2007)
  • Author(s): M, Watanabe・S, Murata・I, Hashimoto・A, Myronovych・K, Hisakura・Y, Nakano・O, Ikeda・R, Matsuo・N, Ohkohchi
  • Organizer: Sixth JSH Single Topic Conference Liver Failure
  • Place of Presentation: 岩手
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Platelets reduce liver fubrosis in rats (2007)
  • Author(s): I, Hashimoto・Y, Nakano・S, Murata・N, Ohkohchi
  • Organizer: Sixth JSH Single Topic Conference Liver Failure
  • Place of Presentation: 岩手
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 肝線維化に対する脾臓摘出の肝線維化抑制効果 (2007)
  • Author(s): 渡辺基信・村田聡一郎・大河内信弘
  • Organizer: 第11回日本肝臓学会大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板の肝再生促進効果を利用した肝線維化抑制細胞治療法の研究 (2007)
  • Author(s): 村田聡一郎・渡辺基信・大河内信弘
  • Organizer: 第11回日本肝臓学会大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Freeze-dried platelets store growth factors and promote hepatocyte proliferation in mice (2007)
  • Author(s): S, Murata・R, Matsuo・A, Myronovychi・T, Kawasaki・I, Hashimoto・H, Ikeda・N, Ohkochi
  • Organizer: 第34回日本低温医学会総会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect of freeze-dried platelets on hepatocyte proliferation (2007)
  • Author(s): R Hoshi, H Ikeda, S Murata, R Matsuo, 0 Ikeda, N Ohkohchi
  • Organizer: 17th APASL
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The vagal nerve modulates liver regeneration after partial hepatectomy via acetylcholine receptor (2007)
  • Author(s): 0 Ikeda, M Ozaki, S Murata, R Matsuo, Y Nakano, M Watanabe, K Hisakura, A Myronovych, N Ohkohchi
  • Organizer: 17th APAS
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets promote liver regeneration in early period after hepatectomy (2007)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, A Myronovych, R Hoshi, N Ohkochi
  • Organizer: 17th APASL
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Thrombocytosis/thrombopoietin suppresses progression of liver fibrosis in mice (2007)
  • Author(s): M Watanabe, S Murata, I Hashimoto, Y Nakano, R Hoshi, A Myronovych, K Hisakura, 0 Ikeda, R Matsuo, N Ohkohchi
  • Organizer: 17th APASL
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets strongly promote hepatocyte proliferation (2007)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, Y Nakano, K Hisakura, M Watanabe, A Myronovych, T Kubota, H Narimatsu, M Ozaki, N Ohkohchi
  • Organizer: 17th APASL
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of platelets on liver regeneration after 90% hepatectomy in mice (2007)
  • Author(s): A Myronovich, S Murata, N Ohkochi
  • Organizer: 17th APASL
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The mechanism of parasympathetic regulation of liver regenaration (2007)
  • Author(s): O Ikeda, S Murata, R Matsuo, Y Nakano, M Watanebe, K Hisakura, M Ozaki, N Ohkohchi
  • Organizer: The 107th Annual Congress of Japan Surgical Society
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Kupffer cells promote liver regeneration (2007)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, Y Nakano, M Watanabe, K Hisakura, J Fukuzawa, S Tadano, N Ohkohchi
  • Organizer: The 107th Annual Congress of Japan Surgical Society
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of new liver regeneration therapy by platelets (2007)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, A Myronovych, R Hoshi, H Ikeda, N Ohkohchi
  • Organizer: The 107th Annual Congress of Japan Surgical Society
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] THROMBOPOIETINITHROMBOCYTOSIS AND BONE MARROW CELL TRANSPLANTATION REDUCE CCL4 INDUCED LIVER FIBROSIS IN MICE, (2007)
  • Author(s): M Watanabe, S Murata, Y Nakano, A Myronovych, K Hisakura, 0 Ikeda, R Matsuo, N Ohkohchi
  • Organizer: 42nd Annual Meeting of the EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER, Barcelona
  • Place of Presentation: Spain
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The role of Kupffer cells and platelets after the ischemia-reperfusion of the liver-in vivo study (2007)
  • Author(s): Y Nakano, T Kondo, R Matsuo, S Murata, N Ohkohchi
  • Organizer: European Society for Surgical Research(ESSR), Rotterdam
  • Place of Presentation: The Netherlands
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] identification of mitogenic factors of platelet on hepatocyte proliferation (2007)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, N Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-fibrotic effect of human endothelial progenitor cells in cirrhotic mice (2007)
  • Author(s): S Murata, M Takamiya, R Hoshi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-fibrotic effect of thrombocytosis in cirrhotic mice (2007)
  • Author(s): M Watanabe, S Murata, I Hashimoto, Y Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-fibrotic effect of thrombocytosis in cirrhotic rats (2007)
  • Author(s): I Hashimotol, Y Nakano, S Murata, N Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-apoptotic effct of thrombopoietin in acute liver failure induced by anti-Fas antibody (2007)
  • Author(s): K Hisakura, S Murata, R Matsuo, N Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] effect of liver regeneration by platelets and Kupffer cells T (2007)
  • Author(s): S Mstsuo, O Ikeda, A Myronovych, N Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets promote liver regeneration after 90% hepatectomy in mice (2007)
  • Author(s): A Myronobych, S Murata, N Ohkohchi
  • Organizer: The 43rd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The me c hanism of vagus in liver regeneration (2007)
  • Author(s): O Ikeda, M Ozaki, S Murata, N Ohkohchi
  • Organizer: The 14th the Japanese Society for the research of Hepatic Cells
  • Place of Presentation: Kagoshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Treatment of fuhninant hepatitis by platelets (2007)
  • Author(s): S Murata, K Hisakura, R Matuo, O Ikeda, A Myronovych, M Watanabe, Y Nakano, K Kouno, T Kawasaki, I Hashimoto, Y Shibasaki, K Fukunaga, N Ohkohchi
  • Organizer: The 14th the Japanese Society for the research of Hepatic Cells
  • Place of Presentation: Kagoshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of new treatment for liver diseases using platelets (2007)
  • Author(s): S Murata, A Myronovych, M Watanabe, K Hisakura, R Matsuo, 0 Ikeda, Y Nakano, K Kouno, T Kawasaki, I Hashimoto, Y Shibasaki, K Fukunaga, N Ohkohchi
  • Organizer: The 3rd Hiroshima Liver Project Research Center Symposium
  • Place of Presentation: Hiroshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] promote hepatocyte proliferation with HGF and IGF-1 (2007)
  • Author(s): R Matsuo, 0 Ikeda, Y Nakno, A Myronovych, T Kawasaki, K Kohono, S Murata, N Ohkohchi
  • Organizer: Sixth JSH Single Topic Conferenece Liver Failure
  • Place of Presentation: Iwate
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Thrombocytosis induced by splenectomy reduces liver fibrosisi in mice (2007)
  • Author(s): M Watanabe, S Murata, I Hashimoto, A Myronovych, K Hisakura, Y Nakano
  • Organizer: Liver Failure
  • Place of Presentation: Iwate
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets reduce liver fubrosis in rats (2007)
  • Author(s): I Hashimoto, Y Nakano, S Murata, N Ohkohchi
  • Organizer: Sixth JSH Single Topic Conference Liver Failure
  • Place of Presentation: Iwate
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anti-fibrotic effect of splenectomy in liver fibrosis (2007)
  • Author(s): M Watanabe, S Murata, N Ohkohchi
  • Organizer: The 11th General Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Research of anti-fibrotic cell therapy using liver regenerative effect of platelets (2007)
  • Author(s): S Murata, M Watanabe, N Ohokochi
  • Organizer: The 11th General Meeting of Japan Society of Hepatology
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Freeze-dried platelets growth factors and promote hepatocyte proliferation in mice (2007)
  • Author(s): S Murata, R Matsuo, A Myronovychi, T Kawasaki, I Hashimoto, H Ikeda, N Ohkochi
  • Organizer: The 34th Annual Meeting of Japan Society for Temperature Medicine
  • Place of Presentation: Sapporo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Promotion of liver regeneration by platelets and diseases by platelets (2007)
  • Author(s): S Murata, N Ohkohchi
  • Organizer: The 20th Study of Liver Regeneration
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] THROMBOPOIETIN/THROMBOCYTOSIS AND BONE MARROW CELL TRANSPLANTATION REDUCE CCL4 INDUCED LIVER FIBROSIS IN MICE (2007)
  • Author(s): M Watanabe, S Murata, Y Nakano, A Myronovych, K Hisakura, O Ikeda, R Matsuo, N Ohkohchi
  • Organizer: 42nd Annual Meeting of the EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER
  • Place of Presentation: Barcelona, Spain
• [Presentation] 血小板増多作用による肝線維化抑制効果の検討-ラット肝線維化モデルを用いて- (2007)
  • Author(s): 橋本育佳, 中野順隆, 村田聡一郎, 大河内信弘
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] 肝再生における迷走神経の作用機序 (2007)
  • Author(s): 池田 治, 尾崎倫孝, 村田聡一郎, 大河内信弘
  • Organizer: 第14回肝細胞研究会
  • Place of Presentation: 鹿児島
• [Presentation] 劇症肝炎に対する血小板の治療効果の検討 (2007)
  • Author(s): 村田聡一郎, 久倉勝治, 松尾亮太, 池田治, アンドリーミロノビッチ, 渡辺基信, 中野順隆, 高野恵輔, 川崎卓也, 橋本育佳, 柴崎佑樹, 福永潔, 大河内信弘
  • Organizer: 第14回肝細胞研究会
  • Place of Presentation: 鹿児島
• [Presentation] Transplantation of human endothelial progenitor cells reduces liver fibrosis in nude mice (2007)
  • Author(s): O Ikeda, S Murata, R Matsuo, M Watanabe, O Ohneda, N Ohkohchi
  • Organizer: Sixth JSH Single Topic Conference Liver Failure
  • Place of Presentation: 岩手
• [Presentation] 血小板による肝細胞増殖促進効果のメカニズムの解明 (2006)
  • Author(s): 松尾亮太・村田聡一郎・池田治・大河内信弘
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板の肝再生促進作用のメカニズムの解明 (2006)
  • Author(s): 村田聡一郎・松尾亮太・池田治・大河内信弘
  • Organizer: 第106回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Platelets promote hepatocyte regeneration (2006)
  • Author(s): R, Matsuo・S, Murata・O, Ikeda・N, Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mechanisms of liver regeneration after extensive hepatectomy by platelets (2006)
  • Author(s): S, Murata・R, Matsuo・O, Ikeda・N, Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Platelets promote liver regeneration after extensive hepatectomy (2006)
  • Author(s): S, Murata・R, Matsuo・O, Ikeda・N, Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver
  • Place of Presentation: Vienna, Austria
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 凍結乾燥血小板を用いた肝再生治療薬の開発 (2006)
  • Author(s): 星礼子・松尾亮太・村田聡一郎・池田治・大河内信弘
  • Organizer: 第42回日本肝臓学会総会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板の持つ肝再生促進作用の分子生物学的解明=in vivoでの解析 (2006)
  • Author(s): 村田聡一郎・松尾亮太・池田治・大河内信弘
  • Organizer: 第42回日本肝臓学会総会
  • Place of Presentation: 京都
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 肝細胞増殖におけるクッパー細胞の役割の解明 (2006)
  • Author(s): 松尾亮太・村田聡一郎・池田治・中野順隆・只野惣介・久倉勝治・大河内信弘
  • Organizer: 第13回肝細胞研究会
  • Place of Presentation: 旭川
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板による肝細胞増殖促進効果のメカニズムの解明 (2006)
  • Author(s): 松尾亮太・村田聡一郎・池田治・中野順隆・只野惣介・久倉勝治・大河内信弘
  • Organizer: 第13回肝細胞研究会
  • Place of Presentation: 旭川
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 肝切除後の肝再生において自律神経系は関与するか? (2006)
  • Author(s): 池田治・尾崎倫孝・松尾亮太・村田聡一郎・大河内信弘
  • Organizer: 第13回肝細胞研究会
  • Place of Presentation: 旭川
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 生体顕微鏡を用いたラット肝微少循環における血小板動態の評価 (2006)
  • Author(s): 中野順隆・近藤匡・松尾亮太・村田聡一郎・大河内信弘
  • Organizer: 第61回日本消化器外科学会定期学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Platelets promote liver regeneration after hepatectomy (2006)
  • Author(s): S, Murata・R, Matsuo・O, Ikeda・R, Hoshi・A, Myronovych, M, Watanabe・K, Hisakura・Y, Nakano・N, Ohkohchi
  • Organizer: Fifth JSH Single Topic Conference
  • Place of Presentation: Nagasaki
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板のもつ肝再生促進メカニズムの分子生物学的解析 (2006)
  • Author(s): 村田聡一郎・松尾亮太・大河内信弘
  • Organizer: 第10回日本肝臓学会大会
  • Place of Presentation: 鹿児島
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血小板はKupffer細胞の肝再生促進作用を代償する (2006)
  • Author(s): 村田聡一郎・松尾亮太・池田治・アンドリーミロノビッチ・大河内信弘
  • Organizer: 第20回日本肝臓学会大会
  • Place of Presentation: 山梨
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] analysis of the proliferative effect of platelet on hepatocyte (2006)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, N Ohkohchi
  • Organizer: The 106th Annual Congress of Japan Surgical Society
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mechanisms of liver regeneration after hepatectomy by platelets (2006)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, N Ohkohchi
  • Organizer: The 106th Annual Congress of Japan Surgical Society
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets promote hepatocyte regeneration (2006)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, N Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver, Vienna
  • Place of Presentation: Austria
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mechanisms of liver regeneration after extensive hepatectomy by platelets (2006)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, N Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver, Vienna
  • Place of Presentation: Austria
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets promote liver regeneration after extensive hepatectomy (2006)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, N Ohkochi
  • Organizer: 41st Annual Meeting of the European Association for the Study of the Liver, Vienna
  • Place of Presentation: Austria
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] role of Kupffer cell on hepatocyte proliferation (2006)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, Y Nakano, S Tadano, K Hisakura, N Ohkohchi
  • Organizer: The 13rd the Japanese Society for the research of Hepatic Cells
  • Place of Presentation: Asahikawa
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] analysis of the mechanism of proliferative effect of platelet on hepatocyte (2006)
  • Author(s): R Matsuo, S Murata, 0 Ikeda, Y Nakano, S Tadano, K Hisakura, N Ohkohchi
  • Organizer: The 13rd the Japanese Society for the research of Hepatic Cells,
  • Place of Presentation: Asahikawa
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Does the autonomic nerve system regulate liver regeneration after partial hepatectomy? (2006)
  • Author(s): 0 Ikeda, M Ozaki, R Matsuo, S Murata, N Ohkohchi
  • Organizer: The 13rd the Japanese Society for the research of Hepatic Cells
  • Place of Presentation: Asahikawa
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The evaluation of the platelet dynamics in the liver microcirculation by the intravital microscopy (2006)
  • Author(s): Y Nakano, T Kondo, R Matsuo, S Murata, N Ohkohchi
  • Organizer: The 61st Annual Meeting of the Japanese Society of Gastroenterological Surgery,
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of platelets in liver regenration using molecular biological analysis (2006)
  • Author(s): S Murata, R Matsuo, N Ohkohchi
  • Organizer: The 10 th General Meeting of Japan Society of Hepatology
  • Place of Presentation: Kagoshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Platelets compensate liver regeneration effect by Kupffer cell (2006)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, A Myronovych, N Ohkohchi
  • Organizer: The 20th Study of Hepatic Sinusoidal Cells
  • Place of Presentation: Yamanashi
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of liver regeneration drugs using freeze dried platelets (2005)
  • Author(s): R Hoshi, R Matsuo, S Murata, 0 Ikeda, N Ohkohchi
  • Organizer: The 42nd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of platelets in liver regenration using molecular biological analysis in vivo model (2005)
  • Author(s): S Murata, R Matsuo, 0 Ikeda, N Ohkohchi
  • Organizer: The 42nd Annual Meeting of Japan Society of Hepatology
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 肝炎治療剤 (2007)
  • Inventor(s): 大河内信弘・村田聡一郎・久倉勝治
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2007-056087
  • Filing Date: 2007-03-06
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 肝線維化抑製剤 (2007)
  • Inventor(s): 大河内信弘・大根田修・村田聡一郎・高宮雅哉・長野真澄
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2007-112183
  • Filing Date: 2007-04-20
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 肝再生促進剤 (2006)
  • Inventor(s): 大河内信弘・池田博・松尾亮太・星礼子
  • Industrial Property Rights Holder: 筑波大学
  • Patent Publication Number: 2007-197353
  • Filing Date: 2006-01-25
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 肝線維化抑製剤 (2006)
  • Inventor(s): 大河内信弘・村田聡一郎・渡辺基信・中野順隆・橋本育佳
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2006-333692
  • Filing Date: 2006-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 肝再生促進剤 (2005)
  • Inventor(s): 大河内信弘・村田聡一郎・松尾亮太
  • Industrial Property Rights Holder: 筑波大学
  • Patent Publication Number: 2007-023002
  • Filing Date: 2005-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 肝再生促進剤 (2005)
  • Inventor(s): 大河内信弘・松尾亮太・村田聡一郎
  • Industrial Property Rights Holder: 筑波大学
  • Patent Publication Number: 2007-045721
  • Filing Date: 2005-08-08
  • Description: 「研究成果報告書概要(和文)」より