The pathophysiology of malignant glioma and treatment strategies
| Project/Area Number |
17390404
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
KURATSU Jun-ichi Kumamoto University, Faculty of Medical and Pharmacentical Sciences, Professor (20145296)
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| Co-Investigator(Kenkyū-buntansha) |
AKAIKE Takaaki Kumamoto University, Faculty of Medical and Pharmacentical Sciences, Professor (20231798)
NAKAMURA Hideo Kumamoto University, University Hospital, Research Associate (30359963)
MAKINO Keishi Kumamoto University, Faculty of Medical and Pharmacentical Sciences, Research Associate (90381011)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,540,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | malignant glioma / cytokine / MCP-1 / IL-6 / proteomix / glioma cancer stem cell / molecular targetting therapy / nano-technology / 薬剤抵抗性 / 分子標的治療 / 血液脳関門 / MGMT / 癌幹細胞 / グリオーマ / CCR-2 / HO-1 / CCR-2阻害剤 / PEG-Zn-PP / ビリルビン |
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| Research Abstract |
We have been investigating for three subjects in analysis of malignant glioma cell biology; 1. Identification and functional analysis of cytokines high expressing in malignant glioma cells. 2. Molecular identification of genes and proteins contributing to malignancy in glioma cells. 3. Characterization of glioma cancer stem cells. We have found that several cytokines such as MCP-1 and IL-6 were overexpressed in malignant glioma cells and they contributed to proliferation or invasion of malignant glioma cells. We have analyzed, the genes related to the malignancy of glioma cells using the methods of DNA microarray, DNA tip and proteomix. However it is necessary for furthermore investigation to confirm whether these genes are involved in the signal of the malignancy of glioma cells. We have confirmed that the glioma cancer stem cells established from the patients with glioma had the potential to grow up in the brain of the mouse and have been investigating for the quality of resistance for the tumor therapy such as chemotherapy or radiotherapy.
Based on the new discovery we have found in these study, we have been tackling to make up the new molecular targeting therapy such as to block the autocline cytokines loop, to suppress the activating signal in the malignancy of glioma cells. Furthermore we have been trying to establish a new technology to deliver the drug through the blood-brain barrier using the nano-technology. We need furthermore investigation for the application to clinical therapeutical methods in the therapies for glioma patients.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Complete response to temozolomide treatment in an elderly patient with recurrent primary central nervous system lymphoma2007
Author(s)
K., Makino, H., Nakamura, M., Kudo, H., Takeshima, J., Kuratsu
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Journal Title
Neurologia medico-chirurgica(Tokyo) 47, (5)
Pages: 229-232
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Single nucleotide polymorphism 309 affects murin-doubleminute 2 protein expression but not glioma tumorigenesis2007
Author(s)
H., Tsuiki, T., Nishi, H., Takeshima, S., Yano, H., Nakamura, K., Makino, J., Kuratsu
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Journal Title
Neurologia medico-chirurgica(Tokyo) 47, (5)
Pages: 203-209
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clinical significance of ABCA2, a possible molecular marker for oligodendrogliomas2007
Author(s)
S., Obara, M., Nakata, H., Takeshima, K., Arita, N., Inagaki, J., Kuratsu
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Journal Title
Neurosurgery 60
Pages: 707-714
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[Journal Article] A long-term ventricular drainage for patients with germ cell Tumors or medulloblastoma2006
Author(s)
J., Matsumoto, M., Kochi, M., Morioka, H., Nakamura, K., Makino, J., Hamada, J., Kuratsu, Y., Ushio
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Journal Title
Surgical Neurology 65, (1)
Pages: 74-80
Description
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[Journal Article] Recurrent intracranial germinoma outside the initial radiation field : a single-institution study2006
Author(s)
H., Nakamura, H., Takeshima, K., Makino, M., Kochi, Y., Ushio, J., Kuratsu
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Journal Title
Acta Oncologica 45
Pages: 476-483
Description
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[Journal Article] Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan2006
Author(s)
K., Makino, H., Nakamura, T., Kino, H., Takeshima, J., Kuratsu
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Journal Title
Surgical Neurology 66
Pages: 503-506
Description
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[Journal Article] CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation2006
Author(s)
S., Tajiri, S., Yano, M., Morioka, J., Kuratsu, M., Mori, T., Gogoh
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Journal Title
FEBS Letters 580
Pages: 3462-3468
Description
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[Journal Article] Diffusion-weighted imaging of metastatic brain tumors : comparison with histologic type and tumor cellularity2006
Author(s)
Y., Hayashida, T., Hirai, S., Morishita, M., Kitajima, R., Murakami, Y., Korogi, K., Makino, H., Nakamura, I., Ikushim, M., Yamura, M., Kochi, J.-I, Kuratsu, Y., Yamashita
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Journal Title
American Journal of Neuroradiology 27
Pages: 1419-1425
Description
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[Journal Article] Comparative clinical study of the anti-emetic effects of oral ramosetron and injected granisetron in patients with malignant glioma undergoing ACNU chemotherapy2005
Author(s)
S., Yano, K., Makino, H., Nakamura, Y., Kai, M., Morioka, J., Hamada, M., Kochi, J., Kuratsu
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Journal Title
Neurologia medico-chirurgica(Tokyo) 45(6)
Pages: 294-299
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages2005
Author(s)
H., Hirano, H., Takeshima, M., Niiro, T., Nagayama, T., Oyoshi, J., Kuratsu
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Journal Title
Oncology Reports 13, (6)
Pages: 1185-1191
Description
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[Journal Article] Effect of oral colestimide on the elimination of high-dose methotrexate in patients with primary central nervous system lymphoma2005
Author(s)
K., Makino, M., Kochi, H., Nakamura, J., Kuroda, Y., Honda, Y., Ushio, J., Kuratsu
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Journal Title
Neurologia medico-chirurgica(Tokyo) 45, (12)
Pages: 650-652
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 悪性神経膠腫の治療成績の検討2006
Author(s)
中村 英夫
Organizer
第65回日本脳神経外科学会総会
Place of Presentation
京都
Year and Date
2006-10-19
Description
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