| Co-Investigator(Kenkyū-buntansha) |
ITO Kazuto Gunma University, Graduate school of medicine, Associate Professor (00302472)
SHIBATA Yasuhiro Gunma University, School of Medicine, Assistant professor (90344936)
MATSUI Hiroshi Gunma University, School of Medicine, Assistant professor (40450374)
中里 晴樹 群馬大学, 医学部, 助手 (20375570)
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| Budget Amount *help |
¥11,560,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Research Abstract |
We have studied the likage analysis of sib-pair of familial prostate cancer, and have found suggestive linkage in 1p36 and 8p23 loci. In this project, we further studied the association and functional studies of genes in these regions. One of the know susceptibility gene, macrophase scavenger receptor 1 (MSR1) contains seven missense mutations (Pro36Ala, Ser4lTyr, Val113Ala, Asp174Tyr, Pro275Ala, Gly369Ser, His441Arg) , one nonsense mutation (Arg293X), and 4 sequence variants in introns (PRO3, INDELI, IVS-59, INDEL7). In this study, we did not identified Pro36Ala, Ser41Tyr, Val113Ala, asp194Tyr, Gly369Ser, His441Arg, and IVS-59, however, we observed Lys338X, 3 mutation in promoter, 2 mutation in introns, 6 mutations in Exon 11. Association studied showed that G allele of PRO3 and presence of INDEL1 were significantly associated with prostate cancer risk. We further observed the significant association with rs26545629 of FDFT1 (farnesydiphosphate farnesyltransferase 1) and prostate cancer risk. Knock-down of FDFT1 gene expression led to the significant inhibition of prostate cancer cell proliferation in vitro. Thus, we observed the familial prostate cancer risk in some genes in 8p23 locus.
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