Evaluation of aging through oxidative stress and anti-oxidant potential in Mongolian people, and anti-aging expedient for Japanese people

• Project/Area Number: 17406006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kagawa Nutrition University
• Principal Investigator: KAGAWA Yasuo Kagawa Nutrition University, 栄養学部, 教授 (30048962)
• Co-Investigator(Kenkyū-buntansha): KOMATSU Fumio 女子栄養大学, 栄養学部, 教授 (10014250) ; 金子 嘉徳 女子栄養大学, 栄養学部, 教授 (20204571) ; 川端 輝江 女子栄養大学, 栄養学部, 教授 (80190932) ; 渡邊 早苗 女子栄養大学, 栄養学部, 教授 (00076184) ; 佐久間 充 女子栄養大学, 栄養科学研究所, 客員研究員 (90010066) ; 工藤 秀機 (工藤 秀樹) 女子栄養大学, 栄養学部, 教授 (90114751)
• Co-Investigator(Renkei-kenkyūsha): KANEKO Yoshinori 女子栄養大学, 栄養学部, 教授 (20204571) ; KAWABATA Terue 女子栄養大学, 栄養学部, 教授 (80190932) ; WATANABE Sanae 女子栄養大学, 栄養学部, 教授 (00076184) ; SAKUMA Mitsuru 女子栄養大学, 栄養科学研究所, 客員研究員 (90010066) ; KUDOH Hideki 文京学院大学, 保健医療技術学部, 教授 (90114751)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥5,750,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2007: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000); Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
• Keywords: モンゴル人 / 老化 / 酸化ストレス / 抗酸化能 / 生活習慣 / モンゴル / 酸化ストレス度 / 老化・抗老化 / 平均寿命 / 微量金属 / マンガン / 食事調査 / 抗酸化食品 / 血清脂質 / 野菜食 / d-ROMテスト / DHA / 握力 / SOD活性

Research Abstract

モンゴル人は日本人に比べ平均寿命が男女とも15 年以上短い。その理由を知るためにモンゴル人の健康調査を行った。モンゴル人は食生活に偏りがあり、肉食が主で野菜や果物は少なく、酸化ストレスが高く、老化の訪れが早かった。彼らの短寿命を解決するにはこれらの改善が重要であり、日本人の老化を考える上でモンゴル人の食生活と高い酸化ストレス度は重要な警鐘と思われた。

Research Products

• [Journal Article] The association of very high hair manganese accumulation and high oxidative stress in Mongolian people (2009)
  • Author(s): Fumio Komatsu, Yasuo Kagawa, Kiyomi Ishiguro, Terue Kawabata, Baatar Purvee, Jugder Otgon and Ulziiburen Chimedregzen
  • Journal Title: Current Aging Sci. 2 Pages: 28-42
  • Peer Reviewed
• [Journal Article] The association of very high hair manganese accumulation and high oxidative stress in Mongolian people. (2009)
  • Author(s): F. Komatsu, Y. Kagawa, et al
  • Journal Title: Current Aging Science 2 Pages: 28-42
  • Peer Reviewed
• [Journal Article] Relationship of dietary habits and obesity to oxidative stress in Palauan people : compared with Japanese and Mongolian people. (2009)
  • Author(s): F. Komatsu, Y. Kagawa, et al
  • Journal Title: Current Aging Science (in press)
  • Peer Reviewed
• [Journal Article] Dietary habits of Mongolian people, and their influence on lifestyle-related diseases and early aging (2008)
  • Author(s): Fumio Komatsu, Yasuo Kagawa, Terue Kawabata, Yoshinori Kaneko, Baatar Purvee,Jugder Otgon and Ulziiburen Chimedregzen
  • Journal Title: Current Aging Sci. 1 Pages: 84-100
  • Peer Reviewed
• [Journal Article] Dietary habits of Mongolian people, and their in fluence on lifestyle-related diseases and early aging. (2008)
  • Author(s): F. Komatsu, Y. Kagawa, et al
  • Journal Title: Current Aging Science 1 Pages: 84-100
  • Peer Reviewed
• [Journal Article] Dietary habits of Mongolian people,and their influence on lifestyle-related diseases and early aging (2008)
  • Author(s): F.Komatsu, Y.Kagawa, et. al.
  • Journal Title: Current Aging Science 1(in press)
  • Peer Reviewed
• [Journal Article] Evaluation of oxidative stress and effectiveness of low-dose glucocorticoid therapy on exacerbation of chronic obstructive pulmonary disease (2007)
  • Author(s): F.Komatsu, H.Kudoh, Y.Kagawa
  • Journal Title: J.Gerontology:Medical Sciences 62A Pages: 459-464
  • Peer Reviewed
• [Journal Article] Evaluation of oxidative stress and effectiveness of low-dose corticosteroid therapy on exacerbation of chronic obstructive pulmonary disease (2007)
  • Author(s): Fumio Komatsu
  • Journal Title: J. Gerontology : Medical Sciences (In press)
• [Journal Article] Investigation of oxidative stress and dietary habits in Mongolian people, compared to Japanese people (2006)
  • Author(s): Fumio Komatsu, Yasuo Kagawa, Mitsuru Sakuma, Terue Kawabata, Yoshinori Kaneko, Dugee Otgontuya, Ulziiburen Chimedregzen, Luvsanbazar Narantya and Baatar Purvee
  • Journal Title: Nutr. Metabol. 3
  • URL: http://www.nutritionandmetabolism.com/content/3/1/21
  • Peer Reviewed
• [Journal Article] Investigation of oxidative stress and dietary habits in Mongolian people, compared to Japanese people. (2006)
  • Author(s): Fumio Komatsu
  • Journal Title: Nutrition ＆ Metabolism http://www.nutritionandmetabolism. com/content/3/1/21 3
• [Journal Article] Relationship of dietary habits and obesity to oxidative stress in Palauan people: compared with Japanese and Mongolian people
  • Author(s): Fumio Komatsu, Yasuo Kagawa, Terue Kawabata, Yoshinori Kaneko, Kiyomi Ishiguro
  • Journal Title: Current aging Sci.(in press)
  • Peer Reviewed
• [Presentation] Influence of dietary habits on lifestyle- related diseases and early aging in Mongolian people (2008)
  • Author(s): Komatsu, F., Kagawa, Y., Purvee, B., Ulziiburen, C.
  • Organizer: 40^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Clinical effectiveness of electrolyzed reduction water (ERW, which has strong reductive potential) on several diseases (3^<rd> report). (2008)
  • Author(s): Osada, S., Komatsu, F., Komatsu, M., Kagawa, Y.
  • Organizer: 40^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Influence of dietary habits on lifestyle-related diseases and early aging in Mongolian people. (2008)
  • Author(s): F. Komatsu, Y. Kagawa, et al
  • Organizer: 40^<th> Conference of Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Comparison of life style and oxidative stress among Mongolian,Palauan and Japnaese people. (2007)
  • Author(s): F.Komatsu, Y.Kagawa, et. al.
  • Organizer: 39th Conference of Asia-Pacific Academic Consortiumfor Public Health
  • Place of Presentation: Saitama,Japan
  • Year and Date: 2007-11-23
• [Presentation] Sodbileg, D., Komatsu, M., Osada, S. (2007)
  • Author(s): Komatsu, F.
  • Organizer: Anti-oxidant potential in blood after eating of anti-oxidant foods. 39^<th> Asia-Pacific Academic Consortium for Public Health
• [Presentation] Early aging, dietary habits and oxidative stress in Mongolian people. (2007)
  • Author(s): Sodbileg, D., Komatsu, F., Sakuma, M., Kaneko, Y., Kawabata, T., Ishiguro, K.
  • Organizer: 39^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Saitama, Japan
• [Presentation] Effectiveness of electrolyzed reductive water (ERW) with strong reduction potential on several diseases (2007)
  • Author(s): Osada, S., Komatsu, M., Komatsu, F.
  • Organizer: 39^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Saitama, Japan
• [Presentation] Genotype of manganese superoxide dismutase polymorphism of Mongolian people is associated with their short life span. (2007)
  • Author(s): Fukushima, A., Komatsu, F., Sakuma, K., Kagawa, Y.
  • Organizer: 39^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Saitama, Japan
• [Presentation] Comparison of reactive oxygen species among the people of the Republic of Palau, Mongolia and Japan (2006)
  • Author(s): Komatsu, F., Kagawa, Y., Sakuma, M., Kaneko, Y., Kawabata, T.
  • Organizer: 38^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Effectiveness of electrolyzed water with high reduction potential on human health (2006)
  • Author(s): Osada, S., Komatsu, M., Komatsu, F., Kagawa, Y.
  • Organizer: 38^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Oxidative stress in long-bedridden patients who are nourishedwith intravenous high calorie alimentation (IVH) or tube feeding (TF). (2006)
  • Author(s): Komatsu, M., Osada, S., Komatsu, F., Kagawa, Y.
  • Organizer: 38^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Mongolian people show high levels of reactive oxygen species in the blood compared to Japanese people (2005)
  • Author(s): Komatsu, F., Sakuma, M., Kawabata, T., Kaneko, Y., Kagawa, Y., Otgontuya, D., Ulziiburen Ch., Narantuya, L.
  • Organizer: 37^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Psychological aspects of Mongol inhabitants measured by GHQ-28 (2005)
  • Author(s): Sakuma, M., Komatsu, F., Kawabata, T., Kaneko, Y., Kagawa, Y., Otgontuya, D., Ulziiburen Ch., Narantuya, L.
  • Organizer: 37^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Taipei, Taiwan
• [Presentation] A survey on body composition and muscle power of the residents of Muren city, Mongolia (2005)
  • Author(s): Kaneko, Y., Komatsu, F., Sakuma, M., Kawabata, T., Kagawa, Y., Otgontuya, D., Ulziiburen Ch., Narantuya, L.
  • Organizer: 37^<th> Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: Taipei, Taiwan